EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000074054 (Gene tree)
Gene ID: 23332
Gene Symbol: CLASP1
Alias: KIAA0622|MAST1
Full Name: cytoplasmic linker associated protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 311,812 bases
Position: chr2:121,337,776-121,649,587
Accession: 17088
RBP type: non-canonical RBP
Summary: CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000455322	CLASP1-208	5660	XM_006712377	ENSP00000389372	1478 (aa)	XP_006712440	F8WA11
ENST00000452274	CLASP1-207	3966	XM_006712385	ENSP00000400562	1275 (aa)	XP_006712448	H0Y5T1
ENST00000449975	CLASP1-206	555	-	ENSP00000402101	110 (aa)	-	C9JP76
ENST00000418989	CLASP1-204	663	-	ENSP00000392886	150 (aa)	-	C9J151
ENST00000474065	CLASP1-211	516	-	-	- (aa)	-	-
ENST00000463621	CLASP1-209	536	-	-	- (aa)	-	-
ENST00000397587	CLASP1-202	7915	XM_017003657	ENSP00000380717	1479 (aa)	XP_016859146	Q7Z460
ENST00000491646	CLASP1-214	599	-	-	- (aa)	-	-
ENST00000480007	CLASP1-212	569	-	-	- (aa)	-	-
ENST00000263710	CLASP1-201	8092	-	ENSP00000263710	1538 (aa)	-	Q7Z460
ENST00000430234	CLASP1-205	582	-	-	- (aa)	-	-
ENST00000485112	CLASP1-213	869	-	-	- (aa)	-	-
ENST00000409078	CLASP1-203	8002	XM_006712382	ENSP00000386442	1471 (aa)	XP_006712445	Q7Z460
ENST00000541377	CLASP1-215	7909	XM_006712381	ENSP00000441625	1477 (aa)	XP_006712444	Q7Z460
ENST00000646274	CLASP1-216	7867	-	ENSP00000496269	1538 (aa)	-	Q7Z460
ENST00000472776	CLASP1-210	1982	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000074054's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000074054	Coronary Disease	4.2800000E-005	-
ENSG00000074054	Angiotensin-Converting Enzyme Inhibitors	1E-9	28084903
ENSG00000074054	Cough	1E-9	28084903
ENSG00000074054	Angiotensin-Converting Enzyme Inhibitors	1E-7	28084903
ENSG00000074054	Cough	1E-7	28084903

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000074054	rs4848713	2	121605302	?	Chloride levels	29403010	[0.017-0.034] unit decrease	0.02538	EFO_0009284
ENSG00000074054	rs12465752	2	121355564	?	Potassium levels	29403010	[0.021-0.037] unit decrease novel	0.02934	EFO_0009283
ENSG00000074054	rs62151096	2	121498964	?	Cough in response to angiotensin-converting enzyme inhibitor drugs	28084903	[3.54-2.22]	3.54	EFO_0005325\|HP_0012735
ENSG00000074054	rs62151109	2	121644122	?	Cough in response to angiotensin-converting enzyme inhibitor drugs	28084903	[2.39-6.59]	3.97	EFO_0005325\|HP_0012735

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074054's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000074054	CLASP1	100	97.905	ENSMUSG00000064302	Clasp1	100	97.905	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000226	microtubule cytoskeleton organization	15631994.	IGI	Process
GO:0000226	microtubule cytoskeleton organization	24859005.	IMP	Process
GO:0000776	kinetochore	12837247.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0001578	microtubule bundle formation	12837247.	IMP	Process
GO:0002162	dystroglycan binding	23940118.	IPI	Function
GO:0005515	protein binding	11290329.15631994.17342765.17543864.20852589.21646404.	IPI	Function
GO:0005794	Golgi apparatus	15631994.	IDA	Component
GO:0005813	centrosome	12837247.15631994.21399614.	IDA	Component
GO:0005828	kinetochore microtubule	12837247.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005876	spindle microtubule	12837247.	IDA	Component
GO:0005881	cytoplasmic microtubule	11290329.	IDA	Component
GO:0005925	focal adhesion	24859005.	IDA	Component
GO:0005938	cell cortex	17113391.	IDA	Component
GO:0006903	vesicle targeting	24859005.	IMP	Process
GO:0007020	microtubule nucleation	17543864.	IMP	Process
GO:0007026	negative regulation of microtubule depolymerization	15631994.	IGI	Process
GO:0007026	negative regulation of microtubule depolymerization	16866869.	IMP	Process
GO:0007030	Golgi organization	24859005.	IMP	Process
GO:0007052	mitotic spindle organization	16866869.	IMP	Process
GO:0007163	establishment or maintenance of cell polarity	15928712.	NAS	Process
GO:0008017	microtubule binding	11290329.	IDA	Function
GO:0008017	microtubule binding	12837247.	IMP	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0010458	exit from mitosis	16866869.	IMP	Process
GO:0010470	regulation of gastrulation	23940118.	IMP	Process
GO:0010634	positive regulation of epithelial cell migration	24859005.	IMP	Process
GO:0010717	regulation of epithelial to mesenchymal transition	23940118.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030953	astral microtubule organization	23783028.	IMP	Process
GO:0030981	cortical microtubule cytoskeleton	12837247.	IDA	Component
GO:0031023	microtubule organizing center organization	17543864.	IMP	Process
GO:0031111	negative regulation of microtubule polymerization or depolymerization	12837247.	IMP	Process
GO:0031116	positive regulation of microtubule polymerization	23727231.	ISS	Process
GO:0031592	centrosomal corona	16914514.	IDA	Component
GO:0034453	microtubule anchoring	17543864.24859005.	IMP	Process
GO:0035371	microtubule plus-end	23727231.	ISS	Component
GO:0040001	establishment of mitotic spindle localization	23783028.	IMP	Process
GO:0043515	kinetochore binding	12837247.	IMP	Function
GO:0045180	basal cortex	23940118.	IDA	Component
GO:0045921	positive regulation of exocytosis	24859005.	IMP	Process
GO:0051010	microtubule plus-end binding	12837247.	IDA	Function
GO:0051294	establishment of spindle orientation	21822276.	IDA	Process
GO:0051294	establishment of spindle orientation	21822276.	IGI	Process
GO:0051294	establishment of spindle orientation	21822276.	IMP	Process
GO:0051301	cell division	21822276.	IDA	Process
GO:0051497	negative regulation of stress fiber assembly	24859005.	IMP	Process
GO:0051893	regulation of focal adhesion assembly	24859005.	IMP	Process
GO:0070507	regulation of microtubule cytoskeleton organization	23940118.	IGI	Process
GO:0090091	positive regulation of extracellular matrix disassembly	24859005.	IMP	Process
GO:0090162	establishment of epithelial cell polarity	23940118.	ISS	Process
GO:0090307	mitotic spindle assembly	23727231.	ISS	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:1903690	negative regulation of wound healing, spreading of epidermal cells	24859005.	IMP	Process
GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	23940118.	IGI	Process
GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	23940118.	IMP	Process