EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000074071 (Gene tree)
Gene ID
65993
Gene Symbol
MRPS34
Alias
MRP-S12|MGC2616
Full Name
mitochondrial ribosomal protein S34
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
1,266 bases
Position
chr16:1,771,890-1,773,155
Accession
16618
RBP type
non-canonical RBP
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000397375MRPS34-2021024-ENSP00000380531218 (aa)-P82930
ENST00000177742MRPS34-2011040XM_017023595ENSP00000177742225 (aa)XP_016879084C9JJ19
ENST00000569585MRPS34-203713--- (aa)--
Gene Model
Click here to download ENSG00000074071's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074071's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003735structural constituent of ribosome28777931.IMPFunction
GO:0005739mitochondrion-IDAComponent
GO:0005743mitochondrial inner membrane-TASComponent
GO:0005763mitochondrial small ribosomal subunit-ISSComponent
GO:0032543mitochondrial translation28777931.IMPProcess
GO:0032543mitochondrial translation-ISSProcess
GO:0070125mitochondrial translational elongation-TASProcess
GO:0070126mitochondrial translational termination-TASProcess

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr161772519Splice_RegionNA0.33
BLCAchr161772221Silentrs753331473*219*0.37
BLCAchr161772450Missense_MutationNAP143R0.24
BLCAchr161772510Missense_MutationNAK123R0.03
BLCAchr161772509Missense_MutationnovelK123N0.35
BRCAchr161772499Missense_MutationNAE127K0.27
COADchr161773003Missense_MutationnovelE39D0.32
ESCAchr161772499Missense_MutationnovelE127Q0.24
ESCAchr161772357In_Frame_InsnovelI174delinsTPWSIQPLGGPHTFF0.2
HNSCchr1617720923'UTRnovel0.41
HNSCchr1617720373'UTRnovel0.57
KICHchr161772531Intronnovel0.3
LUADchr161772356SilentnovelI174I0.56
LUSCchr161772362SilentnovelA172A0.15
LUSCchr161772485Missense_MutationnovelI131M0.05
LUSCchr161772350SilentnovelA176A0.44
PAADchr161772317Missense_MutationnovelE187D0.19
READchr161772398SilentNAS160S0.42
READchr1617721593'UTRnovel0.38
SKCMchr161772334Missense_MutationNAG182R0.19
SKCMchr161772441Missense_MutationNAE146V0.22
SKCMchr1617721943'UTRnovel0.21
UCECchr1617721943'UTRnovel0.3
UCECchr1617720523'UTRnovel0.18
UCECchr1617721593'UTRnovel0.45
UCECchr1617721593'UTRnovel0.44
UCECchr1617721223'UTRnovel0.34
UCECchr1617719733'UTRnovel1
UCECchr161772227Frame_Shift_DelNAV218Sfs*?0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.55560.22898
CHOLDEL0.11110.23475
LUADDEL0.1240.1886
UCSDEL0.44640.13407

Survival Analysis
CancerP-value Q-value
KIRC0.0022

Kaplan-Meier Survival Analysis

STAD0.012

Kaplan-Meier Survival Analysis

MESO0.023

Kaplan-Meier Survival Analysis

PCPG0.04

Kaplan-Meier Survival Analysis

READ0.041

Kaplan-Meier Survival Analysis

LAML0.01

Kaplan-Meier Survival Analysis

LIHC0.02

Kaplan-Meier Survival Analysis

CHOL0.013

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.026

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us