EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000074590 (Gene tree)
Gene ID: 9891
Gene Symbol: NUAK1
Alias: ARK5|KIAA0537|NuaK1
Full Name: NUAK family kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 76,694 bases
Position: chr12:106,063,340-106,140,033
Accession: 14311
RBP type: canonical RBP
Summary: NUAK1 (NUAK Family Kinase 1) is a Protein Coding gene. Diseases associated with NUAK1 include Omphalocele. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NUAK2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261402	RIO1	PF01163.22	0.00019	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25412236	MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1.	Br J Cancer	2014 Dec 9	Shi L	doi: 10.1038/bjc.2014.580

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549704	NUAK1-203	569	-	ENSP00000449990	74 (aa)	-	F8VXF0
ENST00000553094	NUAK1-204	547	-	ENSP00000446873	118 (aa)	-	F8VZ96
ENST00000548902	NUAK1-202	560	-	ENSP00000448288	152 (aa)	-	F8VSH4
ENST00000261402	NUAK1-201	6828	-	ENSP00000261402	661 (aa)	-	O60285

Gene Model

Click here to download ENSG00000074590's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000074590	Attention Deficit Disorder with Hyperactivity	8.3490000E-005	18937294
ENSG00000074590	Attention Deficit Disorder with Hyperactivity	1.5560000E-004	18937294
ENSG00000074590	Erythrocyte Indices	1.8080000E-006	-
ENSG00000074590	Erythrocyte Indices	5.7350000E-005	-
ENSG00000074590	Attention	6E-7	26174813
ENSG00000074590	Attention Deficit Disorder with Hyperactivity	6E-7	26174813
ENSG00000074590	Attention	3E-6	26174813
ENSG00000074590	Attention Deficit Disorder with Hyperactivity	3E-6	26174813

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000074590	rs6539247	12	106066124	T	Attention function in attention deficit hyperactive disorder	26174813	[0.49-1.15] unit decrease	0.82	EFO_0003888\|EFO_0007636
ENSG00000074590	rs6539247	12	106066124	T	Attention function in attention deficit hyperactive disorder	26174813	[0.12-0.28] unit decrease	0.2	EFO_0003888\|EFO_0007636
ENSG00000074590	rs12146713	12	106083027	T	Lateral ventricular volume in normal aging	30258056	z score decrease	7.28	EFO_0008487

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074590's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000074590	NUAK1	100	94.079	ENSAPOG00000010655	nuak1b	95	60.979	Acanthochromis_polyacanthus
ENSG00000074590	NUAK1	100	99.342	ENSAMEG00000015604	NUAK1	99	92.576	Ailuropoda_melanoleuca
ENSG00000074590	NUAK1	100	93.421	ENSACIG00000002275	nuak1b	96	60.914	Amphilophus_citrinellus
ENSG00000074590	NUAK1	100	94.079	ENSAOCG00000004289	nuak1b	95	61.276	Amphiprion_ocellaris
ENSG00000074590	NUAK1	100	94.079	ENSAPEG00000007974	nuak1b	95	61.276	Amphiprion_percula
ENSG00000074590	NUAK1	100	92.763	ENSATEG00000018910	nuak1b	93	62.229	Anabas_testudineus
ENSG00000074590	NUAK1	100	99.342	ENSACAG00000015532	NUAK1	96	81.392	Anolis_carolinensis
ENSG00000074590	NUAK1	100	100.000	ENSANAG00000034880	NUAK1	100	98.761	Aotus_nancymaae
ENSG00000074590	NUAK1	100	93.421	ENSACLG00000026981	nuak1b	92	62.986	Astatotilapia_calliptera
ENSG00000074590	NUAK1	100	94.079	ENSAMXG00000037988	nuak1a	99	59.492	Astyanax_mexicanus
ENSG00000074590	NUAK1	100	100.000	ENSBTAG00000010457	NUAK1	100	94.127	Bos_taurus
ENSG00000074590	NUAK1	100	100.000	ENSCJAG00000043728	NUAK1	100	97.301	Callithrix_jacchus
ENSG00000074590	NUAK1	100	100.000	ENSCAFG00000001879	NUAK1	100	91.742	Canis_familiaris
ENSG00000074590	NUAK1	100	100.000	ENSCAFG00020005117	NUAK1	100	91.742	Canis_lupus_dingo
ENSG00000074590	NUAK1	100	100.000	ENSCHIG00000026094	NUAK1	100	93.675	Capra_hircus
ENSG00000074590	NUAK1	100	100.000	ENSTSYG00000033717	NUAK1	88	97.074	Carlito_syrichta
ENSG00000074590	NUAK1	100	92.105	ENSCAPG00000008884	NUAK1	96	87.650	Cavia_aperea
ENSG00000074590	NUAK1	100	90.196	ENSCPOG00000036136	NUAK1	100	87.219	Cavia_porcellus
ENSG00000074590	NUAK1	100	100.000	ENSCCAG00000032382	NUAK1	100	97.451	Cebus_capucinus
ENSG00000074590	NUAK1	100	100.000	ENSCATG00000040119	NUAK1	100	98.201	Cercocebus_atys
ENSG00000074590	NUAK1	100	100.000	ENSCLAG00000010291	NUAK1	100	91.237	Chinchilla_lanigera
ENSG00000074590	NUAK1	100	100.000	ENSCSAG00000002962	NUAK1	100	97.901	Chlorocebus_sabaeus
ENSG00000074590	NUAK1	100	98.684	ENSCPBG00000023206	NUAK1	94	82.344	Chrysemys_picta_bellii
ENSG00000074590	NUAK1	100	100.000	ENSCANG00000004231	NUAK1	98	98.137	Colobus_angolensis_palliatus
ENSG00000074590	NUAK1	100	98.684	ENSCGRG00001020114	Nuak1	100	90.332	Cricetulus_griseus_chok1gshd
ENSG00000074590	NUAK1	100	98.684	ENSCGRG00000008032	Nuak1	100	91.572	Cricetulus_griseus_crigri
ENSG00000074590	NUAK1	100	94.079	ENSCSEG00000010041	nuak1b	92	60.983	Cynoglossus_semilaevis
ENSG00000074590	NUAK1	100	93.421	ENSCVAG00000002632	nuak1b	96	61.667	Cyprinodon_variegatus
ENSG00000074590	NUAK1	100	93.421	ENSDARG00000028676	nuak1b	97	61.621	Danio_rerio
ENSG00000074590	NUAK1	100	92.763	ENSDARG00000020086	nuak1a	95	61.442	Danio_rerio
ENSG00000074590	NUAK1	100	100.000	ENSDNOG00000043723	NUAK1	100	91.803	Dasypus_novemcinctus
ENSG00000074590	NUAK1	100	100.000	ENSDORG00000014495	Nuak1	100	92.204	Dipodomys_ordii
ENSG00000074590	NUAK1	100	80.263	ENSEBUG00000003709	nuak1a	98	52.821	Eptatretus_burgeri
ENSG00000074590	NUAK1	100	100.000	ENSEASG00005021171	NUAK1	100	95.052	Equus_asinus_asinus
ENSG00000074590	NUAK1	100	100.000	ENSECAG00000002145	NUAK1	100	95.202	Equus_caballus
ENSG00000074590	NUAK1	100	94.079	ENSELUG00000009225	nuak1b	98	61.103	Esox_lucius
ENSG00000074590	NUAK1	100	90.789	ENSELUG00000021236	nuak1a	91	59.816	Esox_lucius
ENSG00000074590	NUAK1	100	100.000	ENSFCAG00000046248	NUAK1	100	95.652	Felis_catus
ENSG00000074590	NUAK1	100	98.026	ENSFALG00000013432	NUAK1	99	83.411	Ficedula_albicollis
ENSG00000074590	NUAK1	100	100.000	ENSFDAG00000016131	NUAK1	96	93.506	Fukomys_damarensis
ENSG00000074590	NUAK1	100	93.421	ENSFHEG00000023219	nuak1b	98	60.000	Fundulus_heteroclitus
ENSG00000074590	NUAK1	100	90.789	ENSGMOG00000009000	nuak1b	94	77.716	Gadus_morhua
ENSG00000074590	NUAK1	100	98.026	ENSGALG00000012662	NUAK1	97	82.246	Gallus_gallus
ENSG00000074590	NUAK1	100	93.421	ENSGAFG00000001723	nuak1b	98	61.281	Gambusia_affinis
ENSG00000074590	NUAK1	100	93.421	ENSGACG00000003957	nuak1b	99	59.527	Gasterosteus_aculeatus
ENSG00000074590	NUAK1	100	98.684	ENSGAGG00000020926	NUAK1	90	84.652	Gopherus_agassizii
ENSG00000074590	NUAK1	100	100.000	ENSGGOG00000010793	NUAK1	100	99.697	Gorilla_gorilla
ENSG00000074590	NUAK1	100	93.421	ENSHBUG00000015817	nuak1b	92	62.986	Haplochromis_burtoni
ENSG00000074590	NUAK1	100	99.342	ENSHGLG00000009643	NUAK1	99	87.344	Heterocephalus_glaber_female
ENSG00000074590	NUAK1	100	99.342	ENSHGLG00100015643	NUAK1	100	84.932	Heterocephalus_glaber_male
ENSG00000074590	NUAK1	100	94.079	ENSHCOG00000005640	nuak1b	94	62.519	Hippocampus_comes
ENSG00000074590	NUAK1	100	92.105	ENSIPUG00000006548	nuak1	96	59.876	Ictalurus_punctatus
ENSG00000074590	NUAK1	100	94.079	ENSIPUG00000012794	NUAK1	97	61.574	Ictalurus_punctatus
ENSG00000074590	NUAK1	100	100.000	ENSSTOG00000027258	NUAK1	100	94.313	Ictidomys_tridecemlineatus
ENSG00000074590	NUAK1	100	100.000	ENSJJAG00000020827	Nuak1	100	92.308	Jaculus_jaculus
ENSG00000074590	NUAK1	100	92.763	ENSKMAG00000009701	nuak1b	97	59.797	Kryptolebias_marmoratus
ENSG00000074590	NUAK1	100	93.421	ENSLBEG00000012814	nuak1b	92	61.479	Labrus_bergylta
ENSG00000074590	NUAK1	100	70.395	ENSLACG00000007984	-	99	51.817	Latimeria_chalumnae
ENSG00000074590	NUAK1	100	97.368	ENSLACG00000004945	NUAK1	100	72.876	Latimeria_chalumnae
ENSG00000074590	NUAK1	100	72.368	ENSLOCG00000013096	-	71	55.268	Lepisosteus_oculatus
ENSG00000074590	NUAK1	100	100.000	ENSLAFG00000010298	NUAK1	99	94.795	Loxodonta_africana
ENSG00000074590	NUAK1	100	100.000	ENSMFAG00000000816	NUAK1	100	98.201	Macaca_fascicularis
ENSG00000074590	NUAK1	100	100.000	ENSMMUG00000020951	NUAK1	100	98.941	Macaca_mulatta
ENSG00000074590	NUAK1	100	100.000	ENSMNEG00000036867	NUAK1	100	98.201	Macaca_nemestrina
ENSG00000074590	NUAK1	100	100.000	ENSMLEG00000040273	NUAK1	97	98.428	Mandrillus_leucophaeus
ENSG00000074590	NUAK1	100	93.421	ENSMAMG00000023166	nuak1b	96	61.037	Mastacembelus_armatus
ENSG00000074590	NUAK1	100	93.421	ENSMZEG00005008818	nuak1b	92	62.986	Maylandia_zebra
ENSG00000074590	NUAK1	100	98.026	ENSMGAG00000012894	NUAK1	100	83.993	Meleagris_gallopavo
ENSG00000074590	NUAK1	100	99.342	ENSMAUG00000011975	Nuak1	100	90.634	Mesocricetus_auratus
ENSG00000074590	NUAK1	100	100.000	ENSMICG00000043070	NUAK1	100	93.403	Microcebus_murinus
ENSG00000074590	NUAK1	100	98.684	ENSMOCG00000018296	Nuak1	100	90.030	Microtus_ochrogaster
ENSG00000074590	NUAK1	100	94.079	ENSMMOG00000000667	nuak1b	99	61.883	Mola_mola
ENSG00000074590	NUAK1	100	99.342	ENSMODG00000001926	NUAK1	100	82.267	Monodelphis_domestica
ENSG00000074590	NUAK1	100	92.763	ENSMALG00000012814	nuak1b	94	62.632	Monopterus_albus
ENSG00000074590	NUAK1	100	99.342	MGP_CAROLIEiJ_G0015674	Nuak1	100	91.390	Mus_caroli
ENSG00000074590	NUAK1	100	99.342	ENSMUSG00000020032	Nuak1	100	90.785	Mus_musculus
ENSG00000074590	NUAK1	100	99.342	MGP_PahariEiJ_G0031410	Nuak1	100	90.937	Mus_pahari
ENSG00000074590	NUAK1	100	99.342	ENSMPUG00000012127	NUAK1	100	93.413	Mustela_putorius_furo
ENSG00000074590	NUAK1	100	99.342	ENSMLUG00000006906	NUAK1	100	93.093	Myotis_lucifugus
ENSG00000074590	NUAK1	100	100.000	ENSNGAG00000011987	Nuak1	100	91.541	Nannospalax_galili
ENSG00000074590	NUAK1	100	93.421	ENSNBRG00000019617	nuak1b	98	60.819	Neolamprologus_brichardi
ENSG00000074590	NUAK1	100	100.000	ENSNLEG00000027950	NUAK1	100	98.201	Nomascus_leucogenys
ENSG00000074590	NUAK1	100	90.541	ENSMEUG00000015464	NUAK1	99	82.424	Notamacropus_eugenii
ENSG00000074590	NUAK1	100	100.000	ENSOPRG00000008531	NUAK1	100	93.643	Ochotona_princeps
ENSG00000074590	NUAK1	100	100.000	ENSODEG00000011149	NUAK1	99	88.088	Octodon_degus
ENSG00000074590	NUAK1	100	93.421	ENSONIG00000008772	nuak1b	94	62.986	Oreochromis_niloticus
ENSG00000074590	NUAK1	100	99.342	ENSOANG00000005541	NUAK1	98	83.584	Ornithorhynchus_anatinus
ENSG00000074590	NUAK1	100	100.000	ENSOCUG00000004958	NUAK1	100	92.135	Oryctolagus_cuniculus
ENSG00000074590	NUAK1	100	91.447	ENSORLG00000027517	nuak1b	95	61.948	Oryzias_latipes
ENSG00000074590	NUAK1	100	91.447	ENSORLG00020018532	nuak1b	98	60.767	Oryzias_latipes_hni
ENSG00000074590	NUAK1	100	91.447	ENSORLG00015011714	nuak1b	95	61.796	Oryzias_latipes_hsok
ENSG00000074590	NUAK1	100	91.447	ENSOMEG00000009190	nuak1b	97	61.061	Oryzias_melastigma
ENSG00000074590	NUAK1	100	99.342	ENSOGAG00000027031	NUAK1	100	94.856	Otolemur_garnettii
ENSG00000074590	NUAK1	100	100.000	ENSOARG00000017296	NUAK1	99	93.598	Ovis_aries
ENSG00000074590	NUAK1	100	100.000	ENSPPAG00000030878	NUAK1	100	99.849	Pan_paniscus
ENSG00000074590	NUAK1	100	100.000	ENSPPRG00000014460	NUAK1	100	96.520	Panthera_pardus
ENSG00000074590	NUAK1	100	100.000	ENSPTIG00000004616	NUAK1	88	97.074	Panthera_tigris_altaica
ENSG00000074590	NUAK1	100	100.000	ENSPTRG00000005386	NUAK1	100	99.697	Pan_troglodytes
ENSG00000074590	NUAK1	100	100.000	ENSPANG00000019452	NUAK1	100	98.201	Papio_anubis
ENSG00000074590	NUAK1	100	92.763	ENSPKIG00000022728	nuak1b	93	60.667	Paramormyrops_kingsleyae
ENSG00000074590	NUAK1	100	88.816	ENSPKIG00000002368	-	93	53.198	Paramormyrops_kingsleyae
ENSG00000074590	NUAK1	100	67.763	ENSPKIG00000023049	-	93	49.381	Paramormyrops_kingsleyae
ENSG00000074590	NUAK1	100	98.684	ENSPSIG00000015908	NUAK1	99	83.125	Pelodiscus_sinensis
ENSG00000074590	NUAK1	100	92.763	ENSPFOG00000008728	nuak1b	97	60.954	Poecilia_formosa
ENSG00000074590	NUAK1	100	92.763	ENSPLAG00000020482	nuak1b	98	60.819	Poecilia_latipinna
ENSG00000074590	NUAK1	100	92.763	ENSPMEG00000015607	nuak1b	97	60.863	Poecilia_mexicana
ENSG00000074590	NUAK1	100	93.421	ENSPREG00000010290	nuak1b	98	60.408	Poecilia_reticulata
ENSG00000074590	NUAK1	100	100.000	ENSPPYG00000004902	NUAK1	100	99.646	Pongo_abelii
ENSG00000074590	NUAK1	100	98.026	ENSPCAG00000006819	NUAK1	100	92.604	Procavia_capensis
ENSG00000074590	NUAK1	100	100.000	ENSPCOG00000023506	NUAK1	100	95.202	Propithecus_coquereli
ENSG00000074590	NUAK1	100	99.342	ENSPVAG00000000010	NUAK1	100	94.705	Pteropus_vampyrus
ENSG00000074590	NUAK1	100	93.421	ENSPNYG00000006291	nuak1b	92	62.986	Pundamilia_nyererei
ENSG00000074590	NUAK1	100	93.421	ENSPNAG00000023611	nuak1a	95	61.972	Pygocentrus_nattereri
ENSG00000074590	NUAK1	100	94.737	ENSPNAG00000027935	nuak1b	95	63.183	Pygocentrus_nattereri
ENSG00000074590	NUAK1	100	99.342	ENSRNOG00000008061	Nuak1	100	90.498	Rattus_norvegicus
ENSG00000074590	NUAK1	100	100.000	ENSRBIG00000042009	NUAK1	100	99.115	Rhinopithecus_bieti
ENSG00000074590	NUAK1	100	100.000	ENSRROG00000045377	NUAK1	100	98.351	Rhinopithecus_roxellana
ENSG00000074590	NUAK1	100	100.000	ENSSBOG00000034859	NUAK1	100	97.001	Saimiri_boliviensis_boliviensis
ENSG00000074590	NUAK1	100	99.342	ENSSHAG00000009945	NUAK1	100	84.192	Sarcophilus_harrisii
ENSG00000074590	NUAK1	100	84.868	ENSSFOG00015001383	nuak1a	94	55.860	Scleropages_formosus
ENSG00000074590	NUAK1	100	70.395	ENSSFOG00015018163	-	89	52.921	Scleropages_formosus
ENSG00000074590	NUAK1	100	94.079	ENSSMAG00000007503	nuak1b	99	59.970	Scophthalmus_maximus
ENSG00000074590	NUAK1	100	94.079	ENSSDUG00000023118	nuak1b	96	60.709	Seriola_dumerili
ENSG00000074590	NUAK1	100	94.079	ENSSLDG00000023219	nuak1b	96	60.561	Seriola_lalandi_dorsalis
ENSG00000074590	NUAK1	100	98.684	ENSSPUG00000004751	NUAK1	99	84.161	Sphenodon_punctatus
ENSG00000074590	NUAK1	100	94.079	ENSSPAG00000022025	nuak1b	92	62.229	Stegastes_partitus
ENSG00000074590	NUAK1	100	100.000	ENSSSCG00000032861	NUAK1	100	94.336	Sus_scrofa
ENSG00000074590	NUAK1	100	98.026	ENSTGUG00000011069	NUAK1	98	84.252	Taeniopygia_guttata
ENSG00000074590	NUAK1	100	93.421	ENSTNIG00000015976	nuak1b	98	60.902	Tetraodon_nigroviridis
ENSG00000074590	NUAK1	100	93.220	ENSTBEG00000001311	NUAK1	100	80.484	Tupaia_belangeri
ENSG00000074590	NUAK1	100	99.342	ENSTTRG00000016310	NUAK1	100	93.544	Tursiops_truncatus
ENSG00000074590	NUAK1	100	99.342	ENSUAMG00000003869	NUAK1	100	92.846	Ursus_americanus
ENSG00000074590	NUAK1	100	99.342	ENSUMAG00000017528	NUAK1	94	92.255	Ursus_maritimus
ENSG00000074590	NUAK1	100	100.000	ENSVVUG00000023089	NUAK1	94	91.525	Vulpes_vulpes
ENSG00000074590	NUAK1	100	68.421	ENSXETG00000023522	-	99	51.405	Xenopus_tropicalis
ENSG00000074590	NUAK1	100	98.684	ENSXETG00000018772	nuak1	99	75.342	Xenopus_tropicalis
ENSG00000074590	NUAK1	100	93.421	ENSXMAG00000004754	nuak1b	98	60.699	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0002039	p53 binding	21317932.	IPI	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	19927127.20354225.21317932.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	19927127.20354225.21317932.25329316.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21317932.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	21317932.	IDA	Component
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0006468	protein phosphorylation	25329316.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	-	IEA	Process
GO:0007155	cell adhesion	-	IEA	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0030155	regulation of cell adhesion	20354225.	IDA	Process
GO:0035507	regulation of myosin-light-chain-phosphatase activity	20354225.	IDA	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0042127	regulation of cell proliferation	21317932.	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:2000772	regulation of cellular senescence	19927127.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15354411	Strong association of ARK5 with tumor invasion and metastasis.	J Exp Clin Cancer Res	2004 Jun	Kusakai G	-
26255969	MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.	Biochem Biophys Res Commun	2015 Sep 18	Xiong X	doi: 10.1016/j.bbrc.2015.08.013
15060171	ARK5 is a tumor invasion-associated factor downstream of Akt signaling.	Mol Cell Biol	2004 Apr	Suzuki A	-
12409306	Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.	J Biol Chem	2003 Jan 3	Suzuki A	-
16488889	NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.	J Biol Chem	2006 May 19	Suzuki A	-
21317932	A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.	Oncogene	2011 Jun 30	Hou X	doi: 10.1038/onc.2011.19
26151663	Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer.	Oncol Rep	2015 Sep	Zhang HY	doi: 10.3892/or.2015.4113
28662499	Knockdown of ARK5 Expression Suppresses Invasion and Metastasis of Gastric Cancer.	Cell Physiol Biochem	2017	Chen D	doi: 10.1159/000478685
29566768	Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.	Breast Cancer Res	2018 Mar 22	Tang YC	doi: 10.1186/s13058-018-0949-3.
23215946	High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion.	Exp Lung Res	2013 Feb	Chen P	doi: 10.3109/01902148.2012.744115
24943992	Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.	Med Oncol	2014 Jul	Ye XT	doi: 10.1007/s12032-014-0061-1
26882562	microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer.	Oncotarget	2016 Feb 16	Obayashi M	doi: 10.18632/oncotarget.6972.
29106388	Calcium signalling links MYC to NUAK1.	Oncogene	2018 Feb 22	Monteverde T	doi: 10.1038/onc.2017.394

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr12	106067573	Missense_Mutation	novel	S405R	0.15
BLCA	chr12	106072814	Silent	novel	Y203Y	0.29
BLCA	chr12	106066994	Silent	rs375170008	I598I	0.25
BLCA	chr12	106106438	Missense_Mutation	NA	L110V	0.31	RIO1
BLCA	chr12	106067668	Missense_Mutation	NA	E374Q	0.41
BLCA	chr12	106106475	Missense_Mutation	NA	M97I	0.86
BLCA	chr12	106066868	Silent	NA	L640L	0.06
BLCA	chr12	106067899	Missense_Mutation	rs769881661	I297V	0.24
BLCA	chr12	106067300	Silent	rs772269401	V496V	0.34
BLCA	chr12	106067701	Missense_Mutation	novel	E363Q	0.21
BRCA	chr12	106086874	Nonsense_Mutation	novel	F122_K125delins*	0.32	RIO1
BRCA	chr12	106067839	Missense_Mutation	NA	C317S	0.36
BRCA	chr12	106067406	Missense_Mutation	rs757219955	T461M	0.24
BRCA	chr12	106070870	Missense_Mutation	NA	L246V	0.15
BRCA	chr12	106072800	Missense_Mutation	NA	F208C	0.41
BRCA	chr12	106067384	Missense_Mutation	NA	L468F	0.14
BRCA	chr12	106067089	Missense_Mutation	rs759029750	R567C	0.36
BRCA	chr12	106086802	Missense_Mutation	rs779923959	R149S	0.12	RIO1
BRCA	chr12	106067461	Missense_Mutation	NA	P443S	0.35
BRCA	chr12	106067273	Missense_Mutation	novel	S505R	0.1
BRCA	chr12	106106506	Missense_Mutation	novel	R87P	0.27
CESC	chr12	106067213	Silent	NA	L525L	0.23
CESC	chr12	106067139	Missense_Mutation	NA	S550F	0.3
CESC	chr12	106063969	3'UTR	novel		0.14
CESC	chr12	106063500	3'UTR	novel		0.24
CESC	chr12	106066897	Missense_Mutation	rs552453023	R631W	0.42
CESC	chr12	106065740	3'UTR	novel		0.44
COAD	chr12	106067173	Missense_Mutation	NA	A539S	0.51
COAD	chr12	106070772	Splice_Site	novel	X278_splice	0.14
COAD	chr12	106066841	Silent	NA	V649V	0.14
COAD	chr12	106066966	Missense_Mutation	novel	L608I	0.24
COAD	chr12	106067688	Missense_Mutation	rs139881229	S367L	0.39
COAD	chr12	106067219	Silent	novel	G523G	0.33
COAD	chr12	106066925	Silent	novel	R621R	0.34
COAD	chr12	106067379	Missense_Mutation	NA	K470T	0.31
COAD	chr12	106086732	Splice_Site	NA	X171_splice	0.4
COAD	chr12	106086864	Missense_Mutation	novel	I128T	0.36	RIO1
COAD	chr12	106066844	Missense_Mutation	novel	Q648H	0.1
COAD	chr12	106138493	Missense_Mutation	rs752539069	R54H	0.4
COAD	chr12	106086760	Missense_Mutation	rs139582229	V163I	0.29	RIO1
COAD	chr12	106070847	Silent	novel	F253F	0.14
COAD	chr12	106067047	Missense_Mutation	rs778868101	D581N	0.3
COAD	chr12	106072762	Missense_Mutation	NA	P221S	0.31
COAD	chr12	106067060	Missense_Mutation	NA	S576R	0.2
COAD	chr12	106067623	Missense_Mutation	novel	P389T	0.08
COAD	chr12	106138549	Silent	NA	E35E	0.33
COAD	chr12	106067048	Silent	rs540753037	S580S	0.19
COAD	chr12	106067692	Missense_Mutation	novel	R366W	0.5
COAD	chr12	106067914	Missense_Mutation	rs546010292	D292N	0.55
COAD	chr12	106067324	Silent	rs141601761	S488S	0.39
COAD	chr12	106070818	Missense_Mutation	rs753772566	R263Q	0.22
COAD	chr12	106070884	Missense_Mutation	NA	V241A	0.3
COAD	chr12	106070886	Frame_Shift_Ins	novel	*V241Gfs49**	0.06
COAD	chr12	106138538	Missense_Mutation	NA	P39L	0.21
COAD	chr12	106067849	Silent	rs143829749	S313S	0.52
COAD	chr12	106067268	Frame_Shift_Del	novel	*P507Rfs6**	0.5
DLBC	chr12	106067088	Missense_Mutation	rs752050315	R567H	0.25
ESCA	chr12	106067229	Missense_Mutation	rs117517173	R520Q	0.18
ESCA	chr12	106063646	3'UTR	novel		0.44
ESCA	chr12	106066966	Missense_Mutation	novel	L608F	0.2
ESCA	chr12	106066746	3'UTR	novel		0.64
ESCA	chr12	106066985	Silent	rs149780357	C601C	0.39
ESCA	chr12	106065807	3'UTR	novel		0.32
ESCA	chr12	106070819	Missense_Mutation	rs757243977	R263W	0.47
GBM	chr12	106066762	3'UTR	novel		0.27
GBM	chr12	106083905	Nonsense_Mutation	novel	K180*	0.09	RIO1
GBM	chr12	106066927	Missense_Mutation	rs757600015	R621W	0.27
HNSC	chr12	106067649	Missense_Mutation	novel	S380F	0.29
HNSC	chr12	106067675	Silent	novel	S371S	0.31
HNSC	chr12	106070847	Silent	novel	F253F	0.13
HNSC	chr12	106072790	Silent	novel	T211T	0.28
HNSC	chr12	106066791	3'UTR	rs199583723		0.1
KIRC	chr12	106072822	Missense_Mutation	NA	N201D	0.28
KIRP	chr12	106067209	Missense_Mutation	NA	H527N	0.4
LGG	chr12	106066830	Missense_Mutation	rs757681052	A653V	0.38
LGG	chr12	106067091	Missense_Mutation	novel	S566N	0.42
LGG	chr12	106067929	Missense_Mutation	novel	L287M	0.38
LUAD	chr12	106086741	Missense_Mutation	novel	C169F	0.21	RIO1
LUAD	chr12	106067091	Missense_Mutation	NA	S566I	0.41
LUAD	chr12	106067769	Missense_Mutation	novel	G340V	0.09
LUAD	chr12	106086822	Missense_Mutation	novel	D142G	0.23	RIO1
LUAD	chr12	106106508	Silent	novel	I86I	0.88
LUAD	chr12	106067029	Missense_Mutation	NA	D587Y	0.32
LUAD	chr12	106066859	Missense_Mutation	novel	M643I	0.24
LUAD	chr12	106067698	Missense_Mutation	rs147705634	R364W	0.22
LUAD	chr12	106083926	Missense_Mutation	NA	G173C	0.81	RIO1
LUAD	chr12	106067738	Missense_Mutation	NA	K350N	0.14
LUAD	chr12	106066931	Silent	rs368538085	R619R	0.14
LUAD	chr12	106067101	Missense_Mutation	rs777522611	R563W	0.27
LUAD	chr12	106083926	Missense_Mutation	NA	G173C	0.75	RIO1
LUSC	chr12	106083889	Missense_Mutation	NA	L185Q	0.53	RIO1
LUSC	chr12	106070808	Missense_Mutation	novel	S266R	0.2
LUSC	chr12	106066810	Missense_Mutation	NA	L660V	0.08
LUSC	chr12	106070896	Missense_Mutation	novel	W237L	0.16
LUSC	chr12	106066954	Missense_Mutation	NA	D612Y	0.16
LUSC	chr12	106106402	Splice_Region	novel		0.42
LUSC	chr12	106072830	Missense_Mutation	novel	G198V	0.28	RIO1
LUSC	chr12	106138477	Missense_Mutation	novel	E59D	0.82
LUSC	chr12	106067191	Missense_Mutation	novel	A533T	0.34
LUSC	chr12	106067529	Missense_Mutation	novel	V420A	0.05
LUSC	chr12	106067267	Silent	NA	P507P	0.64
LUSC	chr12	106106457	Missense_Mutation	novel	E103D	0.32	RIO1
LUSC	chr12	106067714	Silent	novel	S358S	0.19
LUSC	chr12	106086846	Missense_Mutation	rs557272627	Y134C	0.15	RIO1
OV	chr12	106067513	Silent	novel	L425L	0.05
OV	chr12	106067120	Silent	NA	V556V	0.21
OV	chr12	106067201	Missense_Mutation	novel	S529R	0.08
OV	chr12	106067697	Missense_Mutation	rs145399889	R364Q	0.39
OV	chr12	106067601	Missense_Mutation	novel	R396M	0.07
PAAD	chr12	106066830	Missense_Mutation	rs757681052	A653V	0.26
PAAD	chr12	106067849	Silent	rs143829749	S313S	0.21
PAAD	chr12	106138430	Missense_Mutation	novel	R75M	0.16
READ	chr12	106086761	Silent	rs267603280	I162I	0.42
READ	chr12	106138549	Silent	NA	E35E	0.3
READ	chr12	106067365	Nonsense_Mutation	NA	E475*	0.05
READ	chr12	106070847	Silent	novel	F253F	0.48
SARC	chr12	106067631	Missense_Mutation	novel	P386H	0.25
SARC	chr12	106067011	Missense_Mutation	novel	P593S	0.08
SARC	chr12	106066993	Missense_Mutation	rs147896976	R599C	0.36
SKCM	chr12	106138424	Missense_Mutation	novel	S77F	0.2
SKCM	chr12	106066764	3'UTR	rs756370113		0.16
SKCM	chr12	106067799	Missense_Mutation	rs748065457	R330Q	0.1
SKCM	chr12	106067072	Silent	NA	I572I	0.38
SKCM	chr12	106067228	Silent	NA	R520R	0.21
SKCM	chr12	106067797	Missense_Mutation	novel	I331F	0.4
SKCM	chr12	106086878	Silent	novel	E123E	0.21
SKCM	chr12	106086880	Missense_Mutation	novel	E123K	0.19	RIO1
SKCM	chr12	106106423	Missense_Mutation	novel	I115V	0.59	RIO1
SKCM	chr12	106086823	Missense_Mutation	rs753190492	D142N	0.36	RIO1
SKCM	chr12	106066957	Nonsense_Mutation	NA	Q611*	0.44
SKCM	chr12	106067752	Missense_Mutation	rs374885903	E346K	0.2
SKCM	chr12	106066967	Silent	NA	F607F	0.74
SKCM	chr12	106066910	Silent	NA	K626K	0.52
SKCM	chr12	106086815	Silent	NA	I144I	0.23
SKCM	chr12	106083899	Missense_Mutation	NA	E182K	0.07	RIO1
SKCM	chr12	106067124	Missense_Mutation	NA	G555A	0.41
SKCM	chr12	106070860	Missense_Mutation	NA	G249E	0.2
SKCM	chr12	106067598	Missense_Mutation	NA	P397R	0.39
SKCM	chr12	106106421	Silent	NA	I115I	0.21
SKCM	chr12	106106461	Missense_Mutation	rs781345878	R102Q	0.43	RIO1
SKCM	chr12	106066874	Silent	novel	S638S	0.32
SKCM	chr12	106072777	Missense_Mutation	novel	P216S	0.86
SKCM	chr12	106067708	Silent	NA	V360V	0.46
SKCM	chr12	106067378	Silent	rs751534999	K470K	0.54
SKCM	chr12	106067433	Missense_Mutation	NA	G452E	0.55
SKCM	chr12	106067684	Silent	rs745518035	L368L	0.12
SKCM	chr12	106067124	Missense_Mutation	NA	G555D	0.62
SKCM	chr12	106067047	Missense_Mutation	rs778868101	D581N	0.17
SKCM	chr12	106067874	Nonsense_Mutation	NA	W305*	0.24
SKCM	chr12	106067412	Missense_Mutation	novel	S459L	0.26
SKCM	chr12	106066932	Missense_Mutation	rs757960457	R619Q	0.35
STAD	chr12	106086802	Missense_Mutation	rs779923959	R149C	0.21	RIO1
STAD	chr12	106067949	Missense_Mutation	NA	R280Q	0.12
STAD	chr12	106067325	Missense_Mutation	rs200489873	S488L	0.31
STAD	chr12	106067436	Missense_Mutation	rs747705556	P451L	0.24
STAD	chr12	106067617	Missense_Mutation	NA	K391Q	0.16
STAD	chr12	106066992	Missense_Mutation	rs762178790	R599H	0.35
STAD	chr12	106067650	Missense_Mutation	NA	S380A	0.26
STAD	chr12	106138566	Frame_Shift_Del	novel	*A30Rfs13**	0.3
STAD	chr12	106066715	3'UTR	rs775958450		0.06
STAD	chr12	106067068	Missense_Mutation	rs186215853	D574N	0.54
STAD	chr12	106067059	Missense_Mutation	rs768722408	V577M	0.23
STAD	chr12	106067153	Missense_Mutation	NA	M545I	0.34
STAD	chr12	106070772	Splice_Site	NA	X278_splice	0.08
STAD	chr12	106066769	3'UTR	rs200911999		0.08
STAD	chr12	106072786	Frame_Shift_Del	novel	*C213Vfs75**	0.11
STAD	chr12	106067559	Missense_Mutation	rs771843801	R410H	0.3
STAD	chr12	106138479	Nonsense_Mutation	NA	E59*	0.22
STAD	chr12	106067323	Nonsense_Mutation	NA	E489*	0.37
STAD	chr12	106138553	Missense_Mutation	rs751592845	L34R	0.37
STAD	chr12	106086816	Missense_Mutation	novel	I144T	0.28	RIO1
STAD	chr12	106067014	Missense_Mutation	rs777676118	R592C	0.09
STAD	chr12	106072791	Missense_Mutation	novel	T211M	0.48
STAD	chr12	106070809	Missense_Mutation	NA	S266N	0.16
STAD	chr12	106086761	Silent	rs267603280	I162I	0.25
STAD	chr12	106067638	Missense_Mutation	NA	A384S	0.16
THCA	chr12	106066766	3'UTR	novel		0.39
THCA	chr12	106067093	Silent	rs142540856	Y565Y	0.16
THYM	chr12	106067229	Missense_Mutation	rs117517173	R520Q	0.16
UCEC	chr12	106106408	Nonsense_Mutation	novel	E120*	0.31	RIO1
UCEC	chr12	106067558	Silent	novel	R410R	0.21
UCEC	chr12	106067324	Silent	rs141601761	S488S	0.41
UCEC	chr12	106067361	Missense_Mutation	novel	S476L	0.1
UCEC	chr12	106066925	Silent	novel	R621R	0.34
UCEC	chr12	106063646	3'UTR	novel		0.28
UCEC	chr12	106066864	Missense_Mutation	novel	D642N	0.58
UCEC	chr12	106070836	Missense_Mutation	NA	D257A	0.18
UCEC	chr12	106072803	Missense_Mutation	NA	K207R	0.27
UCEC	chr12	106066791	3'UTR	rs199583723		0.43
UCEC	chr12	106067166	Missense_Mutation	NA	V541A	0.08
UCEC	chr12	106067615	Missense_Mutation	NA	K391N	0.12
UCEC	chr12	106083884	Missense_Mutation	rs770705202	D187N	0.39	RIO1
UCEC	chr12	106086808	Missense_Mutation	rs771291112	R147W	0.51	RIO1
UCEC	chr12	106066346	3'UTR	novel		0.21
UCEC	chr12	106066897	Missense_Mutation	rs552453023	R631W	0.36
UCEC	chr12	106063932	3'UTR	novel		0.37
UCEC	chr12	106138454	Missense_Mutation	novel	G67D	0.31
UCEC	chr12	106067411	Silent	rs750598493	S459S	0.25
UCEC	chr12	106067337	Missense_Mutation	rs111758972	R484H	0.24
UCEC	chr12	106070847	Silent	novel	F253F	0.47
UCEC	chr12	106063576	3'UTR	novel		0.5
UCEC	chr12	106067577	Missense_Mutation	rs142935663	R404Q	0.48
UCEC	chr12	106070772	Splice_Site	novel	X278_splice	0.45
UCEC	chr12	106063645	3'UTR	novel		0.34
UCEC	chr12	106083927	Splice_Region	rs112658697	N172N	0.15
UCEC	chr12	106086752	Silent	novel	A165A	0.49
UCEC	chr12	106064164	3'UTR	novel		0.47
UCEC	chr12	106066839	Missense_Mutation	novel	Y650C	0.35
UCEC	chr12	106064008	3'UTR	novel		0.3
UCEC	chr12	106067752	Missense_Mutation	rs374885903	E346K	0.19
UCEC	chr12	106067914	Missense_Mutation	rs546010292	D292N	0.13
UCEC	chr12	106067692	Missense_Mutation	novel	R366W	0.4
UCEC	chr12	106067048	Silent	rs540753037	S580S	0.17
UCEC	chr12	106086840	Missense_Mutation	NA	S136N	0.48	RIO1
UCEC	chr12	106066546	3'UTR	novel		0.25
UCEC	chr12	106070837	Missense_Mutation	rs748336286	D257N	0.29
UCEC	chr12	106063646	3'UTR	novel		0.36
UCEC	chr12	106067336	Silent	novel	R484R	0.27
UCEC	chr12	106086823	Missense_Mutation	rs753190492	D142N	0.39	RIO1
UCEC	chr12	106067881	Missense_Mutation	novel	H303N	0.09
UCEC	chr12	106067752	Missense_Mutation	rs374885903	E346K	0.27
UCEC	chr12	106067365	Nonsense_Mutation	NA	E475*	0.24
UCEC	chr12	106067800	Missense_Mutation	rs771180903	R330W	0.36
UCEC	chr12	106064009	3'UTR	novel		0.21
UCEC	chr12	106067932	Missense_Mutation	novel	M286V	0.21
UCEC	chr12	106067405	Silent	rs753985820	T461T	0.23
UCEC	chr12	106072803	Missense_Mutation	NA	K207T	0.44
UCEC	chr12	106086867	Missense_Mutation	NA	K127T	0.37	RIO1
UCEC	chr12	106065635	3'UTR	novel		0.42
UCEC	chr12	106067566	Missense_Mutation	NA	E408K	0.25
UCEC	chr12	106138581	Nonsense_Mutation	NA	E25*	0.52
UCEC	chr12	106106506	Missense_Mutation	rs769008203	R87H	0.39
UCEC	chr12	106067013	Missense_Mutation	rs147065969	R592H	0.95
UCEC	chr12	106067337	Missense_Mutation	rs111758972	R484H	0.39
UCEC	chr12	106067853	Missense_Mutation	novel	S312N	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0333	0.20414
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0613	0.22646
LUAD	DEL	0.1492	0.0059643
LUSC	DEL	0.0958	0.038823
PAAD	DEL	0.1848	0.0030251
PRAD	AMP	0.0549	0.016187
READ	DEL	0.0909	0.064633
SKCM	DEL	0.1935	0.00079981

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.01	Kaplan-Meier Survival Analysis
STAD	0.0043	Kaplan-Meier Survival Analysis
MESO	0.00039	Kaplan-Meier Survival Analysis
ACC	0.024	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
BLCA	0.019	Kaplan-Meier Survival Analysis
UCEC	0.00074	Kaplan-Meier Survival Analysis
GBM	0.037	Kaplan-Meier Survival Analysis
LGG	0.041	Kaplan-Meier Survival Analysis
OV	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742