EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000074695 (Gene tree)
Gene ID: 3998
Gene Symbol: LMAN1
Alias: MR60|ERGIC-53|ERGIC53|gp58|MCFD1|FMFD1|F5F8D
Full Name: lectin, mannose binding 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 32,140 bases
Position: chr18:59,327,823-59,359,962
Accession: 6631
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000251047	LMAN1-201	5521	-	ENSP00000251047	510 (aa)	-	P49257
ENST00000587940	LMAN1-204	442	-	-	- (aa)	-	-
ENST00000592562	LMAN1-205	576	-	-	- (aa)	-	-
ENST00000587561	LMAN1-202	1181	-	-	- (aa)	-	-
ENST00000587918	LMAN1-203	678	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000074695's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000074695	Sleep	8.11426262097292E-5	17903308
ENSG00000074695	Heart Diseases	2.2377722259883E-5	17903304
ENSG00000074695	Muscle, Skeletal	5.9200000E-005	-
ENSG00000074695	Language Tests	4.0002000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074695's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	21873635.	IBA	Component
GO:0005515	protein binding	9774442.17805346.18287528.20138881.20142513.22337587.24806965.	IPI	Function
GO:0005537	mannose binding	21873635.	IBA	Function
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635.	IBA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.21525244.	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006457	protein folding	9546392.	TAS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007029	endoplasmic reticulum organization	21873635.	IBA	Process
GO:0007030	Golgi organization	21873635.	IBA	Process
GO:0007030	Golgi organization	18287528.	IMP	Process
GO:0007596	blood coagulation	9546392.	TAS	Process
GO:0010638	positive regulation of organelle organization	18287528.	IMP	Process
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0018279	protein N-linked glycosylation via asparagine	-	TAS	Process
GO:0030017	sarcomere	-	IEA	Component
GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635.	IBA	Component
GO:0032527	protein exit from endoplasmic reticulum	18287528.	IMP	Process
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	-	TAS	Component
GO:0034498	early endosome to Golgi transport	18287528.	IMP	Process
GO:0044220	host cell perinuclear region of cytoplasm	19401338.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0051082	unfolded protein binding	9546392.	TAS	Function
GO:0062023	collagen-containing extracellular matrix	25037231.28675934.	HDA	Component
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:1903215	negative regulation of protein targeting to mitochondrion	24270810.	HMP	Process