EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000074800 (Gene tree)
Gene ID: 2023
Gene Symbol: ENO1
Alias: PPH|MBP-1|ENO1L1|MPB1
Full Name: enolase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,251 bases
Position: chr1:8,861,000-8,879,250
Accession: 3350
RBP type: non-canonical RBP
Summary: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15181102	Determining protein identity from sieve element sap in Ricinus communis L. by quadrupole time of flight (Q-TOF) mass spectrometry.	J Exp Bot	2004 Jul	Barnes A	-
18691435	Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements.	BMC Syst Biol	2008 Aug 10	Jiang W	doi: 10.1186/1752-0509-2-72.
15312140	Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus.	Immunology	2004 Sep	Pereira E	-
23690630	Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.	RNA	2013 Jul	Dionne I	doi: 10.1261/rna.037663.112

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000646660	ENO1-214	581	-	ENSP00000494470	171 (aa)	-	A0A2R8YEM5
ENST00000234590	ENO1-201	1781	-	ENSP00000234590	434 (aa)	-	P06733
ENST00000497492	ENO1-207	647	-	ENSP00000466406	195 (aa)	-	K7EM90
ENST00000646680	ENO1-215	557	-	ENSP00000495946	70 (aa)	-	A0A2R8Y798
ENST00000647408	ENO1-217	1782	-	ENSP00000495530	434 (aa)	-	A0A2R8Y6G6
ENST00000492343	ENO1-206	1247	-	-	- (aa)	-	-
ENST00000646156	ENO1-211	622	-	ENSP00000495581	33 (aa)	-	A0A2R8Y6I8
ENST00000489867	ENO1-205	637	-	ENSP00000468392	83 (aa)	-	K7ERS8
ENST00000645609	ENO1-210	1819	-	-	- (aa)	-	-
ENST00000646539	ENO1-213	2345	-	ENSP00000493526	434 (aa)	-	P06733
ENST00000646370	ENO1-212	1837	-	ENSP00000495568	101 (aa)	-	A0A2R8YEG5
ENST00000464920	ENO1-203	2548	-	-	- (aa)	-	-
ENST00000645600	ENO1-209	605	-	-	- (aa)	-	-
ENST00000414948	ENO1-202	744	-	-	- (aa)	-	-
ENST00000646906	ENO1-216	548	-	ENSP00000496562	125 (aa)	-	A0A2R8Y879
ENST00000643438	ENO1-208	569	-	ENSP00000495805	83 (aa)	-	K7ERS8
ENST00000486051	ENO1-204	536	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000074800's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG
hsa03018	RNA degradation	KEGG
hsa04066	HIF-1 signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000074800	rs115579221	1	8872873	G	Blood protein levels	30072576	[0.24-0.6] unit increase	0.419	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074800's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000074800	ENO1	100	95.322	ENSMUSG00000063524	Eno1	100	95.023	Mus_musculus
ENSG00000074800	ENO1	100	95.322	ENSMUSG00000059040	Eno1b	100	94.700	Mus_musculus
ENSG00000074800	ENO1	99	63.510	YGR254W	ENO1	99	63.510	Saccharomyces_cerevisiae
ENSG00000074800	ENO1	99	62.587	YHR174W	ENO2	99	62.587	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000015	phosphopyruvate hydratase complex	3529090.	IDA	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	2005901.	IDA	Process
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	2005901.	IDA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	2005901.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004634	phosphopyruvate hydratase activity	3529090.	IMP	Function
GO:0005515	protein binding	11134351.12666133.15161933.18194455.19433310.20849852.21274509.23355646.23414517.23823123.28813417.	IPI	Function
GO:0005615	extracellular space	16502470.22664934.23580065.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	2005901.10082554.	IC	Component
GO:0005737	cytoplasm	15459207.25468996.	IDA	Component
GO:0005829	cytosol	12666133.19433310.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	12666133.	IDA	Component
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0009615	response to virus	16548883.	IEP	Process
GO:0009986	cell surface	12666133.19433310.	IDA	Component
GO:0010756	positive regulation of plasminogen activation	12666133.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	19433310.	IDA	Component
GO:0030308	negative regulation of cell growth	10082554.	IDA	Process
GO:0031430	M band	-	IEA	Component
GO:0042803	protein homodimerization activity	3529090.	IDA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	10082554.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	10681589.	IMP	Process
GO:0045933	positive regulation of muscle contraction	15459207.	IGI	Process
GO:0051020	GTPase binding	24337748.	IPI	Function
GO:0061621	canonical glycolysis	3529090.	IMP	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0070062	extracellular exosome	11487543.12519789.19199708.20458337.21362503.23533145.	HDA	Component
GO:0099738	cell cortex region	19433310.	IDA	Component
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	15459207.	IDA	Process
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	15459207.	IGI	Process
GO:2001171	positive regulation of ATP biosynthetic process	15459207.	IDA	Process
GO:2001171	positive regulation of ATP biosynthetic process	15459207.	IGI	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23894455	Surface α-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target.	PLoS One	2013 Jul 19	Hsiao KC	doi: 10.1371/journal.pone.0069354
26144282	Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.	FEBS Lett	2015 Jul 22	Maranto C	doi: 10.1016/j.febslet.2015.06.030
21159241	[ENO1 protein levels in the tumor tissues and circulating plasma samples of non-small cell lung cancer patients].	Zhongguo Fei Ai Za Zhi	2010 Dec	ZHANG Y	doi: 10.3779/j.issn.1009-3419.2010.12.02.
27210467	Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma.	Int J Oncol	2016 Jul	Niccolai E	doi: 10.3892/ijo.2016.3524
18033204	[Enolase on the surface of prockaryotic and eukaryotic cells is a receptor for human plasminogen].	Postepy Hig Med Dosw (Online)	2007 Nov 15	Seweryn E	-
22895339	Passenger deletions generate therapeutic vulnerabilities in cancer.	Nature	2012 Aug 16	Muller FL	doi: 10.1038/nature11331.
18691435	Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements.	BMC Syst Biol	2008 Aug 10	Jiang W	doi: 10.1186/1752-0509-2-72.
28824297	Over-Expression of Alpha-Enolase as a Prognostic Biomarker in Patients with Pancreatic Cancer.	Int J Med Sci	2017 Jun 22	Sun L	doi: 10.7150/ijms.18736
15805119	c-myc Promoter-binding protein 1 (MBP-1) regulates prostate cancer cell growth by inhibiting MAPK pathway.	J Biol Chem	2005 Apr 8	Ghosh AK	-
25805497	STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.	J Biol Chem	2015 May 8	Didiasova M	doi: 10.1074/jbc.M114.598425
26734996	Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest.	Oncotarget	2016 Feb 2	Capello M	doi: 10.18632/oncotarget.6798.
21950004	[The expressions of alpha-enolase in the nasopharyngeal cancer tissue].	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi	2011 Jun	Cheng C	-
19655245	Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells.	Breast Cancer Res Treat	2010 Jun	Tu SH	doi: 10.1007/s10549-009-0492-0
20435467	ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction.	Eur J Cancer	2010 Jun	Tsai ST	doi: 10.1016/j.ejca.2010.03.018.
25887760	Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway.	J Hematol Oncol	2015 Mar 8	Fu QF	doi: 10.1186/s13045-015-0117-5.
16762917	Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression.	J Biol Chem	2006 Aug 18	Ghosh AK	-
21751384	Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells.	Proteomics	2011 Sep	Yan GR	doi: 10.1002/pmic.201100215
24984566	Identification of ENO1 as a potential sputum biomarker for early-stage lung cancer by shotgun proteomics.	Clin Lung Cancer	2014 Sep	Yu L	doi: 10.1016/j.cllc.2014.05.003
25860938	Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells.	Oncotarget	2015 May 10	Principe M	-
19846662	MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2.	Mol Biol Cell	2009 Dec	Hsu KW	doi: 10.1091/mbc.E09-05-0386.
27996156	α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer.	Mol Carcinog	2017 May	Zhan P	doi: 10.1002/mc.22603
28415822	Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells.	Oncotarget	2017 May 2	Chen X	doi: 10.18632/oncotarget.16328.
28548950	Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer.	Oncotarget	2017 Jul 18	Qian X	doi: 10.18632/oncotarget.17868.
29986635	Silencing of ENO1 by shRNA Inhibits the Proliferation of Gastric Cancer Cells.	Technol Cancer Res Treat	2018 Jan 1	Qiao H	doi: 10.1177/1533033818784411.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	8871979	Silent	rs778997836	F31F	0.16
BLCA	chr1	8870514	Splice_Region	novel		0.11
BLCA	chr1	8867246	Silent	NA	K105K	0.29
BLCA	chr1	8874902	Missense_Mutation	rs759744149	I3V	0.47
BLCA	chr1	8870496	Missense_Mutation	novel	V66I	0.35
BLCA	chr1	8870556	Intron	novel		0.42
BLCA	chr1	8871744	Intron	novel		0.33
BLCA	chr1	8861277	3'UTR	rs562450138		0.38
BLCA	chr1	8861259	3'UTR	novel		0.31
BRCA	chr1	8866480	Missense_Mutation	rs750183904	G156S	0.1
CESC	chr1	8865424	Silent	NA	I242I	0.09
CESC	chr1	8863329	Frame_Shift_Ins	novel	*Q361Pfs17**	0.14
CESC	chr1	8861425	Missense_Mutation	NA	E414K	0.28
CESC	chr1	8866318	Missense_Mutation	novel	E210K	0.26
CESC	chr1	8861430	Splice_Site	novel	X412_splice	0.24
CESC	chr1	8866494	Missense_Mutation	rs527568599	N151S	0.29
CESC	chr1	8870639	Intron	novel		0.12
COAD	chr1	8861379	Missense_Mutation	novel	R429K	0.35
COAD	chr1	8867235	Missense_Mutation	NA	N109S	0.22
COAD	chr1	8864006	Frame_Shift_Del	novel	*D318Mfs5**	0.43
COAD	chr1	8867174	Silent	NA	P129P	0.27
COAD	chr1	8863988	Missense_Mutation	novel	N324D	0.2
COAD	chr1	8867198	Silent	novel	A121A	0.23
COAD	chr1	8874863	Missense_Mutation	rs745490999	G16R	0.37
COAD	chr1	8861260	3'UTR	novel		0.23
COAD	chr1	8868013	Silent	NA	I95I	0.19
COAD	chr1	8866335	Missense_Mutation	NA	A204V	0.21
COAD	chr1	8868013	Silent	NA	I95I	0.32
COAD	chr1	8870469	Missense_Mutation	novel	P75A	0.3
COAD	chr1	8870664	Intron	novel		0.6
DLBC	chr1	8867227	Missense_Mutation	novel	L112V	0.18
ESCA	chr1	8868045	Missense_Mutation	novel	T85A	0.63
ESCA	chr1	8868052	Silent	novel	L82L	0.17
ESCA	chr1	8867234	Silent	rs569194886	N109N	0.38
GBM	chr1	8867171	Silent	novel	L130L	0.31
GBM	chr1	8865294	Missense_Mutation	novel	D286H	0.1
GBM	chr1	8863292	Silent	novel	S373S	0.08
GBM	chr1	8867176	Missense_Mutation	novel	P129A	0.2
GBM	chr1	8874880	Frame_Shift_Del	novel	*E10Gfs38**	0.12
HNSC	chr1	8870468	Missense_Mutation	novel	P75H	0.11
HNSC	chr1	8870606	Intron	novel		0.18
HNSC	chr1	8866324	In_Frame_Del	novel	V207del	0.66
HNSC	chr1	8868052	Silent	novel	L82L	0.07
KICH	chr1	8863270	Missense_Mutation	novel	I381F	0.19
KICH	chr1	8862924	Nonsense_Mutation	rs745709432	R400*	0.06
KIRC	chr1	8866451	Missense_Mutation	novel	M165I	0.22
KIRP	chr1	8866500	Missense_Mutation	novel	A149E	0.39
LGG	chr1	8870471	Missense_Mutation	rs369657785	A74V	0.31
LUAD	chr1	8874837	Silent	NA	L24L	0.12
LUAD	chr1	8865389	Missense_Mutation	novel	S254Y	0.15
LUAD	chr1	8867224	Missense_Mutation	NA	G113W	0.53
LUAD	chr1	8866410	Missense_Mutation	novel	R179M	0.41
LUAD	chr1	8861389	Missense_Mutation	novel	R426W	0.37
LUAD	chr1	8871892	Splice_Region	novel	K60K	0.25
LUSC	chr1	8871881	Intron	novel		0.15
LUSC	chr1	8871835	Intron	novel		0.12
LUSC	chr1	8868010	Missense_Mutation	novel	E96D	0.08
OV	chr1	8863959	Silent	rs146867004	N333N	0.22
OV	chr1	8866412	Silent	NA	F178F	0.09
PAAD	chr1	8863284	Missense_Mutation	rs753708347	T376I	0.06
PAAD	chr1	8871917	Missense_Mutation	novel	N52I	0.12
PRAD	chr1	8862947	Splice_Site	NA	X393_splice	0.1
PRAD	chr1	8861244	3'UTR	novel		0.19
PRAD	chr1	8870471	Missense_Mutation	rs369657785	A74V	0.24
SKCM	chr1	8866412	Silent	NA	F178F	0.46
SKCM	chr1	8863965	Silent	rs267598749	A331A	0.28
SKCM	chr1	8863966	Missense_Mutation	rs267598750	A331D	0.29
SKCM	chr1	8870518	Splice_Region	novel		0.29
SKCM	chr1	8871830	Intron	novel		0.13
SKCM	chr1	8865358	Silent	rs370319386	P264P	0.55
SKCM	chr1	8865359	Missense_Mutation	novel	P264L	0.56
SKCM	chr1	8866294	Silent	novel	L218L	0.5
SKCM	chr1	8864019	Silent	rs750605240	I313I	0.11
SKCM	chr1	8865360	Missense_Mutation	novel	P264S	0.67
SKCM	chr1	8871876	Intron	novel		0.54
SKCM	chr1	8870518	Splice_Region	novel		0.2
SKCM	chr1	8867159	Silent	rs369611743	I134I	0.28
SKCM	chr1	8862930	Missense_Mutation	NA	P398S	0.22
STAD	chr1	8866294	Missense_Mutation	NA	L218M	0.07
STAD	chr1	8865382	Missense_Mutation	NA	K256N	0.05
STAD	chr1	8871939	Missense_Mutation	novel	E45K	0.05
STAD	chr1	8867173	Frame_Shift_Del	novel	*L130Cfs40**	0.34
STAD	chr1	8861316	3'UTR	novel		0.14
STAD	chr1	8867148	Missense_Mutation	novel	A138V	0.2
STAD	chr1	8862925	Silent	NA	C399C	0.22
STAD	chr1	8861304	3'UTR	novel		0.13
UCEC	chr1	8867142	Missense_Mutation	NA	N140S	0.37
UCEC	chr1	8867125	Missense_Mutation	novel	P146S	0.14
UCEC	chr1	8870904	Intron	novel		0.21
UCEC	chr1	8871869	Intron	novel		0.4
UCEC	chr1	8863315	Frame_Shift_Del	NA	*N363Rfs11**	0.38
UCEC	chr1	8862921	Missense_Mutation	novel	S401T	0.44
UCEC	chr1	8865397	Missense_Mutation	novel	F251L	0.29
UCEC	chr1	8861218	3'UTR	rs549636657		0.44
UCEC	chr1	8865315	Missense_Mutation	novel	L279M	0.54
UCEC	chr1	8866480	Missense_Mutation	rs750183904	G156S	0.13
UCEC	chr1	8871925	Silent	NA	L49L	0.23
UCEC	chr1	8863951	Missense_Mutation	NA	S336F	0.3
UCEC	chr1	8871757	Intron	novel		0.3
UCEC	chr1	8867191	Missense_Mutation	rs11544519	V124I	0.45
UCEC	chr1	8861244	3'UTR	novel		0.48
UCEC	chr1	8863313	Silent	rs576937282	G366G	0.53
UCEC	chr1	8865389	Missense_Mutation	NA	S254F	0.41
UCEC	chr1	8867159	Silent	rs369611743	I134I	0.67
UCEC	chr1	8867989	Splice_Region	novel	K103K	0.42
UCEC	chr1	8862932	Missense_Mutation	novel	A397V	0.33
UCEC	chr1	8864082	Silent	rs780727797	I292I	0.26
UCEC	chr1	8863965	Silent	rs267598749	A331A	0.06
UCEC	chr1	8866488	Missense_Mutation	novel	I153T	0.08
UCEC	chr1	8866494	Missense_Mutation	rs527568599	N151S	0.2
UCEC	chr1	8864081	Missense_Mutation	rs769359480	E293K	0.25
UCEC	chr1	8865334	Silent	rs751946897	S272S	0.47
UCEC	chr1	8870472	Missense_Mutation	novel	A74T	0.22
UCEC	chr1	8866398	Missense_Mutation	rs779265966	R183H	0.31
UCEC	chr1	8867238	Missense_Mutation	NA	A108V	0.34
UCEC	chr1	8871871	Intron	novel		0.35
UCEC	chr1	8863891	Missense_Mutation	rs776573770	A356V	0.29
UCEC	chr1	8864082	Silent	rs780727797	I292I	0.44
UCEC	chr1	8870466	Missense_Mutation	novel	A76T	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1119	0.00029523
CHOL	DEL	0.7778	3.3987e-23
DLBC	DEL	0.125	0.011841
HNSC	DEL	0.1379	7.0766e-07
KIRC	DEL	0.1458	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LUAD	DEL	0.1473	0.0024765
LUSC	DEL	0.3533	2.5882e-07
MESO	DEL	0.3448	2.434e-07
READ	DEL	0.3818	2.1758e-10
TGCT	DEL	0.18	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.004	Kaplan-Meier Survival Analysis
SARC	0.006	Kaplan-Meier Survival Analysis
ACC	0.0043	Kaplan-Meier Survival Analysis
HNSC	0.002	Kaplan-Meier Survival Analysis
PAAD	0.00041	Kaplan-Meier Survival Analysis
BLCA	0.0015	Kaplan-Meier Survival Analysis
CESC	0.03	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
KICH	0.00018	Kaplan-Meier Survival Analysis
GBM	0.0049	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00025	Kaplan-Meier Survival Analysis
LUAD	0.01	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742