EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000075151 (Gene tree)
Gene ID: 8672
Gene Symbol: EIF4G3
Alias: eIF4GII
Full Name: eukaryotic translation initiation factor 4 gamma 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 371,029 bases
Position: chr1:20,806,292-21,177,320
Accession: 3298
RBP type: canonical RBP
Summary: The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000364071	MA3	PF02847.17	2.3e-30	1	1
ENSP00000264211	MA3	PF02847.17	3.3e-30	1	1
ENSP00000473510	MA3	PF02847.17	3.3e-30	1	1
ENSP00000383274	MA3	PF02847.17	3.5e-30	1	1
ENSP00000489051	MA3	PF02847.17	4.2e-30	1	1
ENSP00000364071	MIF4G	PF02854.19	5.3e-68	1	1
ENSP00000264211	MIF4G	PF02854.19	6.7e-68	1	1
ENSP00000473510	MIF4G	PF02854.19	6.7e-68	1	1
ENSP00000383274	MIF4G	PF02854.19	7e-68	1	1
ENSP00000489051	MIF4G	PF02854.19	8.3e-68	1	1
ENSP00000364071	W2	PF02020.18	8.2e-18	1	1
ENSP00000264211	W2	PF02020.18	1.2e-17	1	1
ENSP00000473510	W2	PF02020.18	1.2e-17	1	1
ENSP00000383274	W2	PF02020.18	1.3e-17	1	1
ENSP00000489051	W2	PF02020.18	1.4e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374935	EIF4G3-204	5567	XM_017002708	ENSP00000364071	1305 (aa)	XP_016858197	O43432
ENST00000634778	EIF4G3-213	1343	-	-	- (aa)	-	-
ENST00000634879	EIF4G3-214	5325	-	ENSP00000489051	1774 (aa)	-	A0A0U1RQK7
ENST00000264211	EIF4G3-201	5802	XM_017002682	ENSP00000264211	1585 (aa)	XP_016858171	O43432
ENST00000374933	EIF4G3-203	1136	-	-	- (aa)	-	-
ENST00000411888	EIF4G3-206	1122	-	ENSP00000396083	220 (aa)	-	B1AN92
ENST00000602326	EIF4G3-212	6196	XM_011542356	ENSP00000473510	1591 (aa)	XP_011540658	O43432
ENST00000435383	EIF4G3-207	616	-	-	- (aa)	-	-
ENST00000438975	EIF4G3-208	1270	-	ENSP00000395381	217 (aa)	-	B1AN91
ENST00000463775	EIF4G3-209	711	-	-	- (aa)	-	-
ENST00000400422	EIF4G3-205	5762	XM_011542371	ENSP00000383274	1621 (aa)	XP_011540673	A0A0A0MSA7
ENST00000356916	EIF4G3-202	2179	XM_024450533	ENSP00000349386	515 (aa)	XP_024306301	O43432
ENST00000476088	EIF4G3-210	406	-	-	- (aa)	-	-
ENST00000485722	EIF4G3-211	449	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000075151's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05416	Viral myocarditis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000075151	Body Weights and Measures	5.07816651189597E-5	17903300
ENSG00000075151	Fibrinogen	1.3810244754191E-5	17903294
ENSG00000075151	Creatinine	5.22973090292975E-6	17903292
ENSG00000075151	Emotions	6E-6	27089181
ENSG00000075151	Cognition Disorders	7E-8	26252872
ENSG00000075151	Cognitive Dysfunction	7E-8	26252872
ENSG00000075151	Emotions	7E-7	27089181
ENSG00000075151	Cognition Disorders	4E-8	26252872
ENSG00000075151	Cognitive Dysfunction	4E-8	26252872
ENSG00000075151	Prefrontal Cortex	8E-9	25335168
ENSG00000075151	Prefrontal Cortex	2E-6	25335168

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000075151	rs17449243	1	20847936	T	Subjective well-being	27089181	[0.0096-0.0242] unit decrease	0.0169	EFO_0007869
ENSG00000075151	rs12125335	1	21058943	T	Subjective well-being	27089181	[0.014-0.032] unit decrease	0.022959141	EFO_0007869
ENSG00000075151	rs4654899	1	21083738	A	Superior frontal gyrus grey matter volume	25335168	[NR] unit decrease	969.5	EFO_0006516
ENSG00000075151	rs4654899	1	21083738	A	Superior frontal gyrus grey matter volume	25335168	[NR] unit decrease	787	EFO_0006516
ENSG00000075151	rs75578006	1	21019611	G	Cognitive decline rate in late mild cognitive impairment	26252872	[0.37-0.78] unit increase	0.5756	HP_0100543\|EFO_0007710
ENSG00000075151	rs78649275	1	21150540	T	Cognitive decline rate in late mild cognitive impairment	26252872	[0.39-0.8] unit increase	0.5951	HP_0100543\|EFO_0007710
ENSG00000075151	rs143370804	1	21024072	?	Serum alkaline phosphatase levels	29403010	[0.046-0.08] unit increase novel	0.06288284	EFO_0004533
ENSG00000075151	rs540859061	1	20887660	?	Reaction time	29844566	[0.0049-0.0115] unit increase	0.0082092	EFO_0008393
ENSG00000075151	rs2874367	1	20997998	?	Social science traits (pleiotropy) (HIPO component 1)	30289880			EFO_0007660\|EFO_0007869\|EFO_0007006
ENSG00000075151	rs10799667	1	20840000	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000075151	rs115048780	1	20987976	?	Balding type 1	30595370			EFO_0007825
ENSG00000075151	rs17449243	1	20847936	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000075151	rs3767240	1	20837428	?	Morning person	30595370			EFO_0008328
ENSG00000075151	rs2100382	1	20819929	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000075151	rs17410008	1	20894208	?	Red blood cell count	30595370			EFO_0004305
ENSG00000075151	rs12125335	1	21058943	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0073-0.0138] unit increase	0.010535	EFO_0006527
ENSG00000075151	rs6426658	1	21034683	A	General risk tolerance (MTAG)	30643258	[0.0073-0.0121] unit increase	0.0097	EFO_0008579
ENSG00000075151	rs3767247	1	20900845	C	Neuroticism	30643256	[0.0066-0.0126] unit decrease	0.009594261	EFO_0007660
ENSG00000075151	rs3767247	1	20900845	C	Depressive symptoms	30643256	[0.0042-0.008] unit decrease	0.006106563	EFO_0007006
ENSG00000075151	rs57351360	1	20903045	?	Neuroticism	30595370			EFO_0007660
ENSG00000075151	rs4654874	1	20830174	G	Well-being spectrum (multivariate analysis)	30643256	[0.0041-0.0078] unit increase	0.00595871	EFO_0007869
ENSG00000075151	rs10737452	1	20873271	T	Life satisfaction	30643256	[0.005-0.0103] unit increase	0.007646325	EFO_0007869
ENSG00000075151	rs3767247	1	20900845	C	Positive affect	30643256	[0.005-0.0098] unit decrease	0.00741063	EFO_0007869
ENSG00000075151	rs7556221	1	21129066	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000075151	rs10916892	1	20874832	C	Chronotype	30696823		1.035102	EFO_0008328
ENSG00000075151	rs10916892	1	20874832	C	Morning person	30696823		1.0335917	EFO_0008328
ENSG00000075151	rs6680486	1	20976281	C	Morning person	30696823		1.0313531	EFO_0008328
ENSG00000075151	rs957163	1	21089688	T	Morning person	30696823		1.0316	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075151's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000075151	EIF4G3	89	59.768	ENSG00000114867	EIF4G1	96	53.933

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000075151	EIF4G3	56	83.566	ENSAPOG00000012338	eif4g3a	98	84.615	Acanthochromis_polyacanthus
ENSG00000075151	EIF4G3	100	96.000	ENSAMEG00000002847	EIF4G3	100	93.309	Ailuropoda_melanoleuca
ENSG00000075151	EIF4G3	92	68.756	ENSACIG00000011915	eif4g3a	99	56.739	Amphilophus_citrinellus
ENSG00000075151	EIF4G3	99	65.152	ENSAOCG00000011942	eif4g3a	91	57.504	Amphiprion_ocellaris
ENSG00000075151	EIF4G3	99	65.152	ENSAPEG00000019343	eif4g3a	78	65.596	Amphiprion_percula
ENSG00000075151	EIF4G3	99	66.129	ENSATEG00000025156	eif4g3a	98	54.232	Anabas_testudineus
ENSG00000075151	EIF4G3	100	89.823	ENSAPLG00000005049	EIF4G3	100	82.329	Anas_platyrhynchos
ENSG00000075151	EIF4G3	99	81.069	ENSACAG00000017755	EIF4G3	99	72.553	Anolis_carolinensis
ENSG00000075151	EIF4G3	100	99.539	ENSANAG00000037410	EIF4G3	100	99.541	Aotus_nancymaae
ENSG00000075151	EIF4G3	87	71.750	ENSACLG00000002006	eif4g3a	79	71.853	Astatotilapia_calliptera
ENSG00000075151	EIF4G3	97	63.452	ENSAMXG00000004488	eif4g3a	76	63.452	Astyanax_mexicanus
ENSG00000075151	EIF4G3	99	70.455	ENSAMXG00000024785	eif4g3b	83	74.466	Astyanax_mexicanus
ENSG00000075151	EIF4G3	100	99.545	ENSBTAG00000040215	EIF4G3	100	94.784	Bos_taurus
ENSG00000075151	EIF4G3	100	99.541	ENSCJAG00000006258	EIF4G3	100	99.541	Callithrix_jacchus
ENSG00000075151	EIF4G3	100	99.541	ENSCAFG00000014975	EIF4G3	100	92.976	Canis_familiaris
ENSG00000075151	EIF4G3	100	100.000	ENSCAFG00020009953	EIF4G3	100	93.296	Canis_lupus_dingo
ENSG00000075151	EIF4G3	100	99.083	ENSCHIG00000018873	EIF4G3	100	93.565	Capra_hircus
ENSG00000075151	EIF4G3	99	99.519	ENSTSYG00000002604	EIF4G3	100	100.000	Carlito_syrichta
ENSG00000075151	EIF4G3	99	74.795	ENSCAPG00000011433	EIF4G3	100	72.994	Cavia_aperea
ENSG00000075151	EIF4G3	100	96.313	ENSCPOG00000013487	EIF4G3	100	88.965	Cavia_porcellus
ENSG00000075151	EIF4G3	100	99.539	ENSCCAG00000033501	EIF4G3	100	99.541	Cebus_capucinus
ENSG00000075151	EIF4G3	100	99.539	ENSCATG00000034614	EIF4G3	100	99.541	Cercocebus_atys
ENSG00000075151	EIF4G3	100	100.000	ENSCLAG00000016985	EIF4G3	100	92.293	Chinchilla_lanigera
ENSG00000075151	EIF4G3	99	99.519	ENSCSAG00000000901	EIF4G3	96	98.262	Chlorocebus_sabaeus
ENSG00000075151	EIF4G3	83	98.165	ENSCHOG00000006118	EIF4G3	93	96.689	Choloepus_hoffmanni
ENSG00000075151	EIF4G3	99	91.284	ENSCPBG00000008943	EIF4G3	90	85.205	Chrysemys_picta_bellii
ENSG00000075151	EIF4G3	100	100.000	ENSCANG00000007015	EIF4G3	100	100.000	Colobus_angolensis_palliatus
ENSG00000075151	EIF4G3	100	99.541	ENSCGRG00001021343	Eif4g3	100	88.139	Cricetulus_griseus_chok1gshd
ENSG00000075151	EIF4G3	100	99.545	ENSCGRG00000012487	Eif4g3	100	88.139	Cricetulus_griseus_crigri
ENSG00000075151	EIF4G3	91	69.335	ENSCSEG00000013061	eif4g3a	78	69.142	Cynoglossus_semilaevis
ENSG00000075151	EIF4G3	97	64.920	ENSCVAG00000016918	eif4g3a	97	55.178	Cyprinodon_variegatus
ENSG00000075151	EIF4G3	98	65.552	ENSDARG00000077215	eif4g3a	97	65.060	Danio_rerio
ENSG00000075151	EIF4G3	99	69.175	ENSDARG00000074331	eif4g3b	98	58.546	Danio_rerio
ENSG00000075151	EIF4G3	99	97.115	ENSDNOG00000001924	EIF4G3	99	97.143	Dasypus_novemcinctus
ENSG00000075151	EIF4G3	78	87.805	ENSDORG00000005331	-	100	93.637	Dipodomys_ordii
ENSG00000075151	EIF4G3	89	98.446	ENSETEG00000018847	EIF4G3	82	100.000	Echinops_telfairi
ENSG00000075151	EIF4G3	100	100.000	ENSEASG00005011857	EIF4G3	99	94.039	Equus_asinus_asinus
ENSG00000075151	EIF4G3	100	100.000	ENSECAG00000011147	EIF4G3	100	93.896	Equus_caballus
ENSG00000075151	EIF4G3	97	98.844	ENSEEUG00000000960	EIF4G3	96	84.394	Erinaceus_europaeus
ENSG00000075151	EIF4G3	92	68.462	ENSELUG00000009920	eif4g3a	83	67.981	Esox_lucius
ENSG00000075151	EIF4G3	100	98.618	ENSFCAG00000000802	EIF4G3	100	98.624	Felis_catus
ENSG00000075151	EIF4G3	98	85.520	ENSFALG00000003676	EIF4G3	100	76.633	Ficedula_albicollis
ENSG00000075151	EIF4G3	100	93.652	ENSFDAG00000004311	EIF4G3	97	87.663	Fukomys_damarensis
ENSG00000075151	EIF4G3	96	65.893	ENSFHEG00000012583	eif4g3a	99	54.693	Fundulus_heteroclitus
ENSG00000075151	EIF4G3	88	63.590	ENSGMOG00000000038	eif4g3a	80	63.387	Gadus_morhua
ENSG00000075151	EIF4G3	100	89.498	ENSGALG00000010084	EIF4G3	100	78.342	Gallus_gallus
ENSG00000075151	EIF4G3	92	68.702	ENSGAFG00000015571	eif4g3a	85	68.225	Gambusia_affinis
ENSG00000075151	EIF4G3	97	66.845	ENSGACG00000004607	eif4g3a	100	57.478	Gasterosteus_aculeatus
ENSG00000075151	EIF4G3	100	99.539	ENSGGOG00000005832	EIF4G3	99	95.870	Gorilla_gorilla
ENSG00000075151	EIF4G3	96	68.244	ENSHBUG00000012960	eif4g3a	85	68.022	Haplochromis_burtoni
ENSG00000075151	EIF4G3	100	99.078	ENSHGLG00000015724	EIF4G3	100	90.721	Heterocephalus_glaber_female
ENSG00000075151	EIF4G3	100	99.078	ENSHGLG00100015026	EIF4G3	100	91.104	Heterocephalus_glaber_male
ENSG00000075151	EIF4G3	98	63.872	ENSHCOG00000001899	eif4g3a	97	54.276	Hippocampus_comes
ENSG00000075151	EIF4G3	98	63.909	ENSIPUG00000013302	eif4g3a	99	52.999	Ictalurus_punctatus
ENSG00000075151	EIF4G3	99	68.416	ENSIPUG00000020618	eif4g3	96	59.919	Ictalurus_punctatus
ENSG00000075151	EIF4G3	100	98.624	ENSSTOG00000005127	EIF4G3	100	94.737	Ictidomys_tridecemlineatus
ENSG00000075151	EIF4G3	78	91.202	ENSJJAG00000019005	-	99	91.381	Jaculus_jaculus
ENSG00000075151	EIF4G3	98	66.085	ENSKMAG00000017233	eif4g3a	79	69.867	Kryptolebias_marmoratus
ENSG00000075151	EIF4G3	93	68.517	ENSLBEG00000005966	eif4g3a	94	58.395	Labrus_bergylta
ENSG00000075151	EIF4G3	100	75.320	ENSLACG00000017636	EIF4G3	98	68.270	Latimeria_chalumnae
ENSG00000075151	EIF4G3	99	73.786	ENSLOCG00000003549	eif4g3b	97	63.198	Lepisosteus_oculatus
ENSG00000075151	EIF4G3	99	99.048	ENSLAFG00000012534	EIF4G3	100	93.304	Loxodonta_africana
ENSG00000075151	EIF4G3	100	100.000	ENSMFAG00000033446	EIF4G3	100	100.000	Macaca_fascicularis
ENSG00000075151	EIF4G3	100	100.000	ENSMMUG00000004149	EIF4G3	100	100.000	Macaca_mulatta
ENSG00000075151	EIF4G3	100	100.000	ENSMNEG00000035435	EIF4G3	100	100.000	Macaca_nemestrina
ENSG00000075151	EIF4G3	100	100.000	ENSMLEG00000042409	EIF4G3	100	100.000	Mandrillus_leucophaeus
ENSG00000075151	EIF4G3	95	64.646	ENSMAMG00000002783	eif4g3a	96	55.260	Mastacembelus_armatus
ENSG00000075151	EIF4G3	96	67.502	ENSMZEG00005001359	eif4g3a	99	55.246	Maylandia_zebra
ENSG00000075151	EIF4G3	99	86.735	ENSMGAG00000007151	EIF4G3	87	89.109	Meleagris_gallopavo
ENSG00000075151	EIF4G3	63	87.879	ENSMAUG00000009111	-	100	87.933	Mesocricetus_auratus
ENSG00000075151	EIF4G3	100	99.541	ENSMICG00000008548	EIF4G3	99	99.512	Microcebus_murinus
ENSG00000075151	EIF4G3	99	98.558	ENSMOCG00000015735	Eif4g3	99	87.492	Microtus_ochrogaster
ENSG00000075151	EIF4G3	93	71.505	ENSMMOG00000013300	eif4g3a	93	57.752	Mola_mola
ENSG00000075151	EIF4G3	99	94.231	ENSMODG00000015988	EIF4G3	99	82.852	Monodelphis_domestica
ENSG00000075151	EIF4G3	91	70.349	ENSMALG00000002314	eif4g3a	88	69.894	Monopterus_albus
ENSG00000075151	EIF4G3	100	97.706	MGP_CAROLIEiJ_G0026684	Eif4g3	100	91.879	Mus_caroli
ENSG00000075151	EIF4G3	100	96.774	ENSMUSG00000028760	Eif4g3	99	91.381	Mus_musculus
ENSG00000075151	EIF4G3	100	97.696	MGP_PahariEiJ_G0029015	Eif4g3	100	86.655	Mus_pahari
ENSG00000075151	EIF4G3	100	96.774	MGP_SPRETEiJ_G0027664	Eif4g3	99	91.185	Mus_spretus
ENSG00000075151	EIF4G3	100	96.000	ENSMPUG00000016068	EIF4G3	100	91.884	Mustela_putorius_furo
ENSG00000075151	EIF4G3	99	97.596	ENSMLUG00000000787	EIF4G3	99	92.640	Myotis_lucifugus
ENSG00000075151	EIF4G3	78	92.466	ENSNGAG00000011879	-	100	92.466	Nannospalax_galili
ENSG00000075151	EIF4G3	87	72.802	ENSNBRG00000010386	eif4g3a	79	72.290	Neolamprologus_brichardi
ENSG00000075151	EIF4G3	100	98.612	ENSNLEG00000007976	EIF4G3	100	99.348	Nomascus_leucogenys
ENSG00000075151	EIF4G3	99	95.814	ENSMEUG00000010333	EIF4G3	94	95.135	Notamacropus_eugenii
ENSG00000075151	EIF4G3	73	99.387	ENSOPRG00000011002	-	74	99.387	Ochotona_princeps
ENSG00000075151	EIF4G3	78	93.249	ENSODEG00000015879	-	100	93.249	Octodon_degus
ENSG00000075151	EIF4G3	99	65.775	ENSONIG00000000697	eif4g3a	100	58.499	Oreochromis_niloticus
ENSG00000075151	EIF4G3	81	88.472	ENSOANG00000012444	-	97	91.460	Ornithorhynchus_anatinus
ENSG00000075151	EIF4G3	100	94.761	ENSOCUG00000002451	EIF4G3	100	91.055	Oryctolagus_cuniculus
ENSG00000075151	EIF4G3	96	66.033	ENSORLG00000017007	eif4g3a	97	56.146	Oryzias_latipes
ENSG00000075151	EIF4G3	92	68.648	ENSORLG00015006137	eif4g3a	88	68.208	Oryzias_latipes_hsok
ENSG00000075151	EIF4G3	91	68.601	ENSOMEG00000015799	eif4g3a	81	68.126	Oryzias_melastigma
ENSG00000075151	EIF4G3	99	99.524	ENSOGAG00000013147	EIF4G3	99	91.569	Otolemur_garnettii
ENSG00000075151	EIF4G3	100	98.165	ENSOARG00000008710	EIF4G3	100	93.632	Ovis_aries
ENSG00000075151	EIF4G3	100	100.000	ENSPPAG00000038299	EIF4G3	100	100.000	Pan_paniscus
ENSG00000075151	EIF4G3	100	98.618	ENSPPRG00000011350	EIF4G3	100	98.624	Panthera_pardus
ENSG00000075151	EIF4G3	100	98.618	ENSPTIG00000016730	EIF4G3	100	98.624	Panthera_tigris_altaica
ENSG00000075151	EIF4G3	100	100.000	ENSPTRG00000000297	EIF4G3	100	100.000	Pan_troglodytes
ENSG00000075151	EIF4G3	100	100.000	ENSPANG00000017237	EIF4G3	100	100.000	Papio_anubis
ENSG00000075151	EIF4G3	51	82.663	ENSPKIG00000010849	eif4g3a	94	86.364	Paramormyrops_kingsleyae
ENSG00000075151	EIF4G3	99	85.965	ENSPSIG00000013798	EIF4G3	98	78.333	Pelodiscus_sinensis
ENSG00000075151	EIF4G3	92	70.645	ENSPMGG00000013068	eif4g3a	83	70.164	Periophthalmus_magnuspinnatus
ENSG00000075151	EIF4G3	77	91.683	ENSPEMG00000019075	-	100	91.683	Peromyscus_maniculatus_bairdii
ENSG00000075151	EIF4G3	100	98.182	ENSPCIG00000010019	EIF4G3	97	86.990	Phascolarctos_cinereus
ENSG00000075151	EIF4G3	96	66.817	ENSPFOG00000016418	eif4g3a	100	56.558	Poecilia_formosa
ENSG00000075151	EIF4G3	96	66.817	ENSPLAG00000015334	eif4g3a	98	55.411	Poecilia_latipinna
ENSG00000075151	EIF4G3	90	69.612	ENSPMEG00000003029	eif4g3a	99	56.974	Poecilia_mexicana
ENSG00000075151	EIF4G3	87	69.641	ENSPREG00000013883	eif4g3a	82	69.128	Poecilia_reticulata
ENSG00000075151	EIF4G3	100	100.000	ENSPPYG00000001764	EIF4G3	100	98.423	Pongo_abelii
ENSG00000075151	EIF4G3	100	99.078	ENSPCAG00000005945	EIF4G3	83	98.343	Procavia_capensis
ENSG00000075151	EIF4G3	100	86.708	ENSPCOG00000000173	EIF4G3	100	86.713	Propithecus_coquereli
ENSG00000075151	EIF4G3	100	99.541	ENSPVAG00000013869	EIF4G3	94	95.276	Pteropus_vampyrus
ENSG00000075151	EIF4G3	96	67.671	ENSPNYG00000003941	eif4g3a	85	67.452	Pundamilia_nyererei
ENSG00000075151	EIF4G3	99	70.481	ENSPNAG00000019346	eif4g3b	97	61.066	Pygocentrus_nattereri
ENSG00000075151	EIF4G3	99	98.077	ENSRNOG00000014368	Eif4g3	100	83.487	Rattus_norvegicus
ENSG00000075151	EIF4G3	100	100.000	ENSRBIG00000036003	EIF4G3	100	100.000	Rhinopithecus_bieti
ENSG00000075151	EIF4G3	100	100.000	ENSRROG00000041075	EIF4G3	100	100.000	Rhinopithecus_roxellana
ENSG00000075151	EIF4G3	100	99.541	ENSSBOG00000026901	EIF4G3	100	99.541	Saimiri_boliviensis_boliviensis
ENSG00000075151	EIF4G3	99	94.712	ENSSHAG00000003774	EIF4G3	100	87.296	Sarcophilus_harrisii
ENSG00000075151	EIF4G3	100	69.032	ENSSFOG00015005193	eif4g3a	88	68.660	Scleropages_formosus
ENSG00000075151	EIF4G3	100	64.069	ENSSFOG00015016664	eif4g3b	100	56.159	Scleropages_formosus
ENSG00000075151	EIF4G3	92	68.936	ENSSMAG00000002016	eif4g3a	93	68.316	Scophthalmus_maximus
ENSG00000075151	EIF4G3	99	65.547	ENSSDUG00000018177	eif4g3a	98	55.759	Seriola_dumerili
ENSG00000075151	EIF4G3	92	70.865	ENSSLDG00000018945	eif4g3a	99	57.200	Seriola_lalandi_dorsalis
ENSG00000075151	EIF4G3	84	100.000	ENSSARG00000003179	EIF4G3	84	100.000	Sorex_araneus
ENSG00000075151	EIF4G3	100	92.237	ENSSPUG00000001152	EIF4G3	99	79.246	Sphenodon_punctatus
ENSG00000075151	EIF4G3	91	67.885	ENSSPAG00000010299	eif4g3a	84	67.720	Stegastes_partitus
ENSG00000075151	EIF4G3	100	99.545	ENSSSCG00000003512	EIF4G3	100	93.695	Sus_scrofa
ENSG00000075151	EIF4G3	100	88.128	ENSTGUG00000002122	EIF4G3	100	79.006	Taeniopygia_guttata
ENSG00000075151	EIF4G3	92	69.903	ENSTRUG00000011593	eif4g3a	79	69.892	Takifugu_rubripes
ENSG00000075151	EIF4G3	92	69.149	ENSTNIG00000003169	eif4g3a	81	66.265	Tetraodon_nigroviridis
ENSG00000075151	EIF4G3	100	98.157	ENSTBEG00000001280	EIF4G3	89	99.605	Tupaia_belangeri
ENSG00000075151	EIF4G3	100	99.083	ENSTTRG00000011287	EIF4G3	100	91.546	Tursiops_truncatus
ENSG00000075151	EIF4G3	75	96.821	ENSUAMG00000010058	-	96	96.542	Ursus_americanus
ENSG00000075151	EIF4G3	100	100.000	ENSUMAG00000015096	EIF4G3	100	92.875	Ursus_maritimus
ENSG00000075151	EIF4G3	100	99.541	ENSVPAG00000007343	EIF4G3	100	89.779	Vicugna_pacos
ENSG00000075151	EIF4G3	100	100.000	ENSVVUG00000029639	EIF4G3	95	97.837	Vulpes_vulpes
ENSG00000075151	EIF4G3	99	74.387	ENSXETG00000009483	eif4g3	100	62.181	Xenopus_tropicalis
ENSG00000075151	EIF4G3	96	66.577	ENSXMAG00000017701	eif4g3a	97	54.821	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000339	RNA cap binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006413	translational initiation	-	IEA	Process
GO:0006446	regulation of translational initiation	9418880.	TAS	Process
GO:0008135	translation factor activity, RNA binding	9418880.	TAS	Function
GO:0010507	negative regulation of autophagy	18426977.	IMP	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	21873635.	IBA	Component