EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000075218 (Gene tree)
Gene ID: 51512
Gene Symbol: GTSE1
Alias: GTSE-1|B99
Full Name: G2 and S-phase expressed 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 37,686 bases
Position: chr22:46,296,014-46,333,699
Accession: 13698
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491863	GTSE1-204	751	-	-	- (aa)	-	-
ENST00000454366	GTSE1-201	3112	XM_005261627	ENSP00000415430	739 (aa)	XP_005261684	Q9NYZ3
ENST00000479645	GTSE1-203	1111	-	-	- (aa)	-	-
ENST00000466510	GTSE1-202	1330	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000075218's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04115	p53 signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075218's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005515	protein binding	20577264.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005881	cytoplasmic microtubule	10974554.	IDA	Component
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	10974554.	NAS	Process
GO:0007017	microtubule-based process	10974554.	NAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030335	positive regulation of cell migration	-	TAS	Process
GO:0046827	positive regulation of protein export from nucleus	-	TAS	Process
GO:0050821	protein stabilization	-	TAS	Process
GO:1900182	positive regulation of protein localization to nucleus	-	TAS	Process
GO:1902749	regulation of cell cycle G2/M phase transition	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26209226	GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.	BMC Cancer	2015 Jul 25	Subhash VV	doi: 10.1186/s12885-015-1550-0.
30414902	Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer.	Int J Biol Macromol	2019 Feb 15	Liu A	doi: 10.1016/j.ijbiomac.2018.11.032
22292647	Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.	Asian Pac J Cancer Prev	2011	Tian T	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	46312152	Missense_Mutation	novel	E258D	0.25
BLCA	chr22	46326496	Silent	novel	L522L	0.56
BLCA	chr22	46329498	Silent	NA	L689L	0.33
BLCA	chr22	46308701	Silent	novel	L174L	0.27
BLCA	chr22	46329450	Silent	rs61737807	C673C	0.17
BLCA	chr22	46308495	Missense_Mutation	NA	A105V	0.17
BLCA	chr22	46297472	Silent	NA	K24K	0.23
BLCA	chr22	46329236	Intron	novel		0.21
BLCA	chr22	46326652	Missense_Mutation	novel	M574I	0.39
BLCA	chr22	46326635	Missense_Mutation	rs528775411	R569C	0.24
BLCA	chr22	46326549	Frame_Shift_Ins	novel	*L541Pfs27**	0.17
BLCA	chr22	46329251	Intron	novel		0.35
BLCA	chr22	46316346	Missense_Mutation	novel	L456I	0.07
BRCA	chr22	46308419	Missense_Mutation	novel	P80S	0.15
BRCA	chr22	46308441	Missense_Mutation	rs535759667	P87R	0.4
BRCA	chr22	46330697	3'UTR	novel		0.12
BRCA	chr22	46316202	Missense_Mutation	NA	E408Q	0.29
BRCA	chr22	46316329	Missense_Mutation	NA	R450K	0.29
BRCA	chr22	46323253	Missense_Mutation	NA	S499L	0.16
BRCA	chr22	46316181	Missense_Mutation	NA	D401N	0.68
BRCA	chr22	46329071	Intron	novel		0.14
BRCA	chr22	46326527	Missense_Mutation	NA	P533T	0.41
BRCA	chr22	46316338	Missense_Mutation	NA	D453V	0.31
BRCA	chr22	46308403	Frame_Shift_Del	NA	*V75Ffs69**	0.81
BRCA	chr22	46308672	Missense_Mutation	NA	E164V	0.13
CESC	chr22	46316341	Missense_Mutation	novel	S454F	0.09
CESC	chr22	46313957	Missense_Mutation	rs765217704	S332L	0.11
CESC	chr22	46308692	Missense_Mutation	NA	S171G	0.23
CESC	chr22	46326579	Missense_Mutation	NA	P550R	0.25
COAD	chr22	46328905	Intron	novel		0.36
COAD	chr22	46297418	Silent	NA	G6G	0.26
COAD	chr22	46308616	Frame_Shift_Ins	NA	*L147Qfs4**	0.45
COAD	chr22	46329393	Silent	rs756426814	A654A	0.42
COAD	chr22	46328718	Silent	novel	K585K	0.21
COAD	chr22	46329541	Missense_Mutation	NA	A704T	0.29
COAD	chr22	46308403	Silent	rs147042849	P74P	0.37
COAD	chr22	46326872	Intron	novel		0.25
COAD	chr22	46313897	Missense_Mutation	novel	L312P	0.21
COAD	chr22	46308184	Silent	rs149744214	F38F	0.29
COAD	chr22	46308901	Silent	NA	A240A	0.17
COAD	chr22	46308331	Silent	novel	D50D	0.25
ESCA	chr22	46330620	3'UTR	novel		0.52
ESCA	chr22	46312204	Missense_Mutation	rs766749646	R276W	0.06
ESCA	chr22	46316070	Missense_Mutation	novel	S364P	0.23
ESCA	chr22	46329227	Intron	novel		0.62
GBM	chr22	46308936	Missense_Mutation	rs147669373	A252V	0.41
GBM	chr22	46329446	Missense_Mutation	NA	F672S	0.46
GBM	chr22	46330103	Frame_Shift_Del	novel	*V732Gfs21**	0.22
GBM	chr22	46308940	Missense_Mutation	novel	E253D	0.77
GBM	chr22	46312233	Silent	rs749506319	P285P	0.47
GBM	chr22	46328754	Silent	novel	R597R	0.09
HNSC	chr22	46308914	Missense_Mutation	rs748370009	G245R	0.2
HNSC	chr22	46308858	Missense_Mutation	rs767426101	A226V	0.23
HNSC	chr22	46326521	Missense_Mutation	novel	P531S	0.34
HNSC	chr22	46329450	Silent	rs61737807	C673C	0.25
HNSC	chr22	46308451	Nonsense_Mutation	novel	W90*	0.08
HNSC	chr22	46313916	Missense_Mutation	novel	K318N	0.38
HNSC	chr22	46308773	Missense_Mutation	novel	R198S	0.34
HNSC	chr22	46326471	Missense_Mutation	novel	S514C	0.33
HNSC	chr22	46316190	Missense_Mutation	novel	E404Q	0.09
HNSC	chr22	46326608	Missense_Mutation	novel	P560S	0.19
KIRC	chr22	46329375	Frame_Shift_Del	novel	*K649Nfs34**	0.25
KIRC	chr22	46312277	Missense_Mutation	NA	G300V	0.2
KIRP	chr22	46308434	Missense_Mutation	novel	E85K	0.58
KIRP	chr22	46328824	Missense_Mutation	NA	K621Q	0.18
LAML	chr22	46308844	Silent	novel	A221A	0.08
LGG	chr22	46308329	Missense_Mutation	novel	D50Y	0.08
LGG	chr22	46308620	Missense_Mutation	novel	L147I	0.15
LGG	chr22	46316407	Missense_Mutation	rs563396011	S476Y	0.41
LIHC	chr22	46308629	Frame_Shift_Ins	novel	*S157Rfs3**	0.04
LIHC	chr22	46323251	Silent	NA	T498T	0.41
LUAD	chr22	46329312	Intron	novel		0.32
LUAD	chr22	46308892	Silent	novel	L237L	0.17
LUAD	chr22	46328835	Silent	NA	A624A	0.12
LUAD	chr22	46312182	Silent	novel	I268I	0.2
LUAD	chr22	46308936	Missense_Mutation	novel	A252E	0.1
LUAD	chr22	46316304	Missense_Mutation	NA	Q442E	0.23
LUAD	chr22	46326695	Intron	novel		0.26
LUAD	chr22	46329417	Missense_Mutation	novel	Q662H	0.27
LUAD	chr22	46313889	Splice_Site	novel	X310_splice	0.27
LUAD	chr22	46330178	3'UTR	novel		0.6
LUSC	chr22	46308770	Missense_Mutation	novel	A197S	0.45
LUSC	chr22	46308569	Missense_Mutation	rs765658379	R130W	0.21
LUSC	chr22	46308404	Missense_Mutation	NA	V75I	0.52
LUSC	chr22	46328965	Intron	novel		0.24
LUSC	chr22	46330144	3'UTR	novel		0.15
LUSC	chr22	46326553	Silent	novel	L541L	0.26
LUSC	chr22	46330185	3'UTR	novel		0.14
LUSC	chr22	46312213	Missense_Mutation	NA	L279F	0.33
LUSC	chr22	46329482	Missense_Mutation	NA	S684F	0.52
LUSC	chr22	46326465	Missense_Mutation	rs144394568	R512H	0.27
OV	chr22	46313920	Missense_Mutation	NA	P320S	0.23
PAAD	chr22	46308494	Missense_Mutation	novel	A105S	0.22
PAAD	chr22	46316246	Missense_Mutation	novel	Q422H	0.15
PAAD	chr22	46329284	Intron	novel		0.18
PCPG	chr22	46308507	Missense_Mutation	novel	A109V	0.11
PRAD	chr22	46329532	Frame_Shift_Del	novel	*N702Mfs13**	0.32
READ	chr22	46326717	Intron	novel		0.14
READ	chr22	46316407	Missense_Mutation	rs563396011	S476Y	0.33
READ	chr22	46326585	Missense_Mutation	NA	A552V	0.35
READ	chr22	46326515	Frame_Shift_Del	novel	*A529Pfs14**	0.46
SARC	chr22	46308476	Missense_Mutation	rs200240747	V99M	0.4
SKCM	chr22	46308473	Missense_Mutation	NA	F98L	0.29
SKCM	chr22	46329200	Intron	novel		0.5
SKCM	chr22	46328761	Missense_Mutation	NA	P600S	0.53
SKCM	chr22	46326692	Intron	novel		0.42
SKCM	chr22	46326614	Missense_Mutation	rs201142261	R562W	0.14
SKCM	chr22	46308660	Missense_Mutation	rs747868772	S160F	0.4
SKCM	chr22	46329299	Intron	novel		0.33
SKCM	chr22	46330143	3'UTR	novel		0.49
SKCM	chr22	46297426	Missense_Mutation	novel	E9G	0.32
SKCM	chr22	46308347	Missense_Mutation	rs141526579	G56R	0.3
SKCM	chr22	46308348	Missense_Mutation	novel	G56E	0.3
SKCM	chr22	46329221	Intron	novel		0.12
SKCM	chr22	46308475	Silent	rs200946263	F98F	0.26
SKCM	chr22	46316113	Missense_Mutation	NA	P378L	0.44
SKCM	chr22	46312199	Missense_Mutation	NA	S274F	0.54
SKCM	chr22	46329001	Intron	novel		0.23
SKCM	chr22	46326645	Missense_Mutation	novel	S572F	0.27
SKCM	chr22	46323201	Missense_Mutation	novel	D482N	0.31
SKCM	chr22	46329393	Silent	rs756426814	A654A	0.31
SKCM	chr22	46308695	Missense_Mutation	novel	P172S	0.11
SKCM	chr22	46308696	Missense_Mutation	novel	P172L	0.11
SKCM	chr22	46329255	Intron	novel		0.3
SKCM	chr22	46329554	Missense_Mutation	rs748997173	P708L	0.16
SKCM	chr22	46316377	Missense_Mutation	NA	P466L	0.37
SKCM	chr22	46312298	Missense_Mutation	NA	P307L	0.42
SKCM	chr22	46312290	Silent	NA	I304I	0.15
SKCM	chr22	46328726	Missense_Mutation	rs750967626	S588F	0.25
STAD	chr22	46329360	Splice_Region	novel	A643A	0.26
STAD	chr22	46312251	Silent	rs150217285	P291P	0.48
STAD	chr22	46316318	Silent	rs757579901	T446T	0.07
STAD	chr22	46323220	Missense_Mutation	NA	L488R	0.11
STAD	chr22	46329441	Silent	NA	I670I	0.17
STAD	chr22	46330257	3'UTR	novel		0.6
STAD	chr22	46328761	Missense_Mutation	NA	P600S	0.32
STAD	chr22	46308936	Missense_Mutation	novel	A252G	0.71
STAD	chr22	46308568	Silent	NA	P129P	0.16
STAD	chr22	46316334	Nonsense_Mutation	rs780615307	R452*	0.06
UCEC	chr22	46308421	Silent	rs370968604	P80P	0.35
UCEC	chr22	46308204	Nonsense_Mutation	NA	S45*	0.39
UCEC	chr22	46329216	Intron	novel		0.38
UCEC	chr22	46312232	Missense_Mutation	rs778042976	P285L	0.43
UCEC	chr22	46308931	Silent	novel	G250G	0.44
UCEC	chr22	46329503	Missense_Mutation	novel	D691G	0.48
UCEC	chr22	46326450	Missense_Mutation	NA	S507I	0.3
UCEC	chr22	46313973	Silent	rs143072372	S337S	0.33
UCEC	chr22	46328905	Intron	novel		0.26
UCEC	chr22	46330273	3'UTR	novel		0.33
UCEC	chr22	46326608	Missense_Mutation	novel	P560A	0.27
UCEC	chr22	46330185	3'UTR	novel		0.35
UCEC	chr22	46297443	Missense_Mutation	novel	A15T	0.3
UCEC	chr22	46316139	Missense_Mutation	novel	A387T	0.3
UCEC	chr22	46312286	Missense_Mutation	rs746573864	A303V	0.36
UCEC	chr22	46316181	Missense_Mutation	NA	D401N	0.31
UCEC	chr22	46312287	Silent	rs753934434	A303A	0.37
UCEC	chr22	46328809	Missense_Mutation	novel	D616N	0.24
UCEC	chr22	46326498	Missense_Mutation	novel	S523N	0.41
UCEC	chr22	46330127	Missense_Mutation	novel	F739L	0.2
UCEC	chr22	46329450	Silent	rs61737807	C673C	0.38
UCEC	chr22	46329242	Intron	novel		0.31
UCEC	chr22	46316261	Silent	novel	G427G	0.58
UCEC	chr22	46330085	Silent	novel	P725P	0.38
UCEC	chr22	46312152	Missense_Mutation	novel	E258D	0.17
UCEC	chr22	46326640	Missense_Mutation	novel	K570N	0.19
UCEC	chr22	46329442	Missense_Mutation	rs762000503	D671N	0.13
UCEC	chr22	46329133	Intron	novel		0.69
UCEC	chr22	46330175	3'UTR	novel		0.35
UCEC	chr22	46329304	Intron	novel		0.41
UCEC	chr22	46308707	Frame_Shift_Del	novel	*P177Lfs136**	0.53
UCEC	chr22	46323220	Missense_Mutation	NA	L488R	0.37
UCEC	chr22	46329192	Intron	novel		0.57
UCEC	chr22	46326621	Missense_Mutation	rs139655645	R564H	0.24
UCEC	chr22	46323245	Silent	rs146608263	S496S	0.41
UCEC	chr22	46308520	Missense_Mutation	novel	E113D	0.16
UCEC	chr22	46312287	Silent	rs753934434	A303A	0.27
UCEC	chr22	46308352	Silent	novel	P57P	0.36
UCEC	chr22	46308185	Missense_Mutation	rs765830833	D39N	0.2
UCEC	chr22	46326621	Missense_Mutation	rs139655645	R564H	0.26
UCEC	chr22	46329237	Intron	novel		0.07
UCEC	chr22	46313924	Missense_Mutation	novel	G321D	0.05
UCEC	chr22	46297444	Missense_Mutation	rs369196344	A15V	0.4
UCEC	chr22	46323239	Silent	rs762711989	P494P	0.31
UCEC	chr22	46323242	Silent	rs568343475	Q495Q	0.5
UCS	chr22	46326666	Intron	novel		0.24
UVM	chr22	46308648	Missense_Mutation	novel	K156T	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.4157	0.036477
DLBC	DEL	0.0833	0.21158
LGG	DEL	0.1267	0.0042376
LIHC	DEL	0.1676	0.05307
LUSC	DEL	0.1637	0.006888
PAAD	DEL	0.2391	0.0001774
PCPG	DEL	0.3333	0.044123
READ	DEL	0.3455	0.00082955
SARC	DEL	0.2646	0.016841
STAD	DEL	0.2562	0.010201
THYM	DEL	0.0732	0.063154
UCS	DEL	0.6607	0.0013619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0034	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.0095	Kaplan-Meier Survival Analysis
SARC	0.0048	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00019	Kaplan-Meier Survival Analysis
UCS	0.049	Kaplan-Meier Survival Analysis
SKCM	0.0013	Kaplan-Meier Survival Analysis
PRAD	0.032	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
COAD	0.0069	Kaplan-Meier Survival Analysis
PAAD	0.00029	Kaplan-Meier Survival Analysis
READ	0.01	Kaplan-Meier Survival Analysis
KICH	0.0049	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742