EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000075239 (Gene tree)
Gene ID: 38
Gene Symbol: ACAT1
Alias: THIL|ACAT
Full Name: acetyl-CoA acetyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 26,653 bases
Position: chr11:108,121,516-108,148,168
Accession: 93
RBP type: non-canonical RBP
Summary: This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000524833	ACAT1-203	506	-	-	- (aa)	-	-
ENST00000532792	ACAT1-209	674	-	-	- (aa)	-	-
ENST00000265838	ACAT1-201	1761	XM_006718835	ENSP00000265838	427 (aa)	XP_006718898	P24752
ENST00000527942	ACAT1-205	493	-	ENSP00000433568	54 (aa)	-	E9PKF3
ENST00000534773	ACAT1-212	429	-	-	- (aa)	-	-
ENST00000531853	ACAT1-208	526	-	-	- (aa)	-	-
ENST00000528370	ACAT1-206	508	-	ENSP00000436096	136 (aa)	-	H0YEL7
ENST00000299355	ACAT1-202	1345	-	ENSP00000299355	162 (aa)	-	P24752
ENST00000526119	ACAT1-204	729	-	-	- (aa)	-	-
ENST00000533610	ACAT1-211	566	-	-	- (aa)	-	-
ENST00000531813	ACAT1-207	2258	-	ENSP00000435965	141 (aa)	-	E9PRQ6
ENST00000533597	ACAT1-210	558	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000075239's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00071	Fatty acid degradation	KEGG
hsa00072	Synthesis and degradation of ketone bodies	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa00650	Butanoate metabolism	KEGG
hsa00900	Terpenoid backbone biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01212	Fatty acid metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000075239	Stroke	7.1852498E-004	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000075239	rs3741049	11	108139200	?	Scarlet fever	28928442	[0.076-0.18] unit decrease	0.1276	EFO_0008409

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075239's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000075239	ACAT1	92	31.944	WBGene00015125	B0303.3	96	31.944	Caenorhabditis_elegans
ENSG00000075239	ACAT1	100	44.444	FBgn0035203	CG9149	99	43.147	Drosophila_melanogaster
ENSG00000075239	ACAT1	90	37.913	FBgn0040064	yip2	98	37.913	Drosophila_melanogaster
ENSG00000075239	ACAT1	91	30.023	FBgn0025352	Thiolase	90	30.023	Drosophila_melanogaster
ENSG00000075239	ACAT1	91	40.204	ENSG00000167315	ACAA2	99	41.349	Homo_sapiens
ENSG00000075239	ACAT1	96	31.544	ENSG00000138029	HADHB	98	31.544	Homo_sapiens
ENSG00000075239	ACAT1	92	32.483	ENSMUSG00000059447	Hadhb	89	32.483	Mus_musculus
ENSG00000075239	ACAT1	90	34.097	ENSMUSG00000036138	Acaa1a	90	34.097	Mus_musculus
ENSG00000075239	ACAT1	98	54.717	YPL028W	ERG10	99	48.492	Saccharomyces_cerevisiae
ENSG00000075239	ACAT1	98	37.736	YIL160C	POT1	92	34.430	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001889	liver development	-	IEA	Process
GO:0003985	acetyl-CoA C-acetyltransferase activity	21873635.	IBA	Function
GO:0003985	acetyl-CoA C-acetyltransferase activity	17371050.	IDA	Function
GO:0003985	acetyl-CoA C-acetyltransferase activity	1979337.8103405.	IMP	Function
GO:0003988	acetyl-CoA C-acyltransferase activity	21873635.	IBA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006085	acetyl-CoA biosynthetic process	17371050.	IDA	Process
GO:0006550	isoleucine catabolic process	1979337.8103405.	IMP	Process
GO:0006550	isoleucine catabolic process	17371050.	TAS	Process
GO:0006635	fatty acid beta-oxidation	21873635.	IBA	Process
GO:0007420	brain development	-	IEA	Process
GO:0009083	branched-chain amino acid catabolic process	-	TAS	Process
GO:0009725	response to hormone	-	IEA	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0015936	coenzyme A metabolic process	17371050.	IDA	Process
GO:0015937	coenzyme A biosynthetic process	17371050.	IDA	Process
GO:0016453	C-acetyltransferase activity	17371050.	IDA	Function
GO:0019899	enzyme binding	-	IEA	Function
GO:0034435	cholesterol esterification	24608080.	TAS	Process
GO:0042594	response to starvation	-	IEA	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0046356	acetyl-CoA catabolic process	17371050.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046951	ketone body biosynthetic process	-	TAS	Process
GO:0046952	ketone body catabolic process	1979337.	IMP	Process
GO:0046952	ketone body catabolic process	-	TAS	Process
GO:0050662	coenzyme binding	-	IEA	Function
GO:0051260	protein homooligomerization	-	IEA	Process
GO:0060612	adipose tissue development	-	IEA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0072229	metanephric proximal convoluted tubule development	-	IEA	Process
GO:1902224	ketone body metabolic process	17371050.	IC	Process
GO:1902860	propionyl-CoA biosynthetic process	17371050.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24311408	Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression.	Prostate	2014 Apr	Saraon P	doi: 10.1002/pros.22758
23443136	Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression.	Mol Cell Proteomics	2013 Jun	Saraon P	doi: 10.1074/mcp.M112.023887
18000807	Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT).	Prostate	2008 Jan 1	Locke JA	-
27177773	TLR4 siRNA inhibits proliferation and invasion in colorectal cancer cells by downregulating ACAT1 expression.	Life Sci	2016 Jun 15	Ye K	doi: 10.1016/j.lfs.2016.05.012
19851860	High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.	Breast Cancer Res Treat	2010 Aug	Antalis CJ	doi: 10.1007/s10549-009-0594-8
29793481	Insulin promotes progression of colon cancer by upregulation of ACAT1.	Lipids Health Dis	2018 May 24	Chen X	doi: 10.1186/s12944-018-0773-x.
30092298	MiR-21 regulates the ACAT1 gene in MCF-7 cells.	Life Sci	2018 Sep 15	Chanyshev MD	doi: 10.1016/j.lfs.2018.08.010

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	108146341	Missense_Mutation	novel	S382F	0.27
BLCA	chr11	108138939	Silent	NA	V159V	0.23
BLCA	chr11	108142601	Intron	novel		0.14
BLCA	chr11	108138898	Missense_Mutation	novel	D146N	0.19
BLCA	chr11	108147476	3'UTR	novel		0.07
BLCA	chr11	108146222	Frame_Shift_Ins	novel	*E345Rfs10**	0.21
BLCA	chr11	108135159	Missense_Mutation	novel	P118A	0.25
BLCA	chr11	108135193	Missense_Mutation	novel	G129E	0.05
BRCA	chr11	108142516	Missense_Mutation	novel	K302N	0.15
BRCA	chr11	108138924	Silent	NA	E154E	0.11
BRCA	chr11	108142635	Intron	novel		0.19
BRCA	chr11	108146326	Missense_Mutation	NA	N377T	0.26
CESC	chr11	108143930	Intron	novel		0.45
CESC	chr11	108146265	Missense_Mutation	NA	S357C	0.16
CESC	chr11	108147353	Missense_Mutation	rs777462355	G416E	0.42
COAD	chr11	108142823	Intron	novel		0.5
COAD	chr11	108121558	5'UTR	novel		0.41
COAD	chr11	108133865	Silent	NA	L56L	0.41
COAD	chr11	108146338	Missense_Mutation	rs768448235	V381A	0.31
COAD	chr11	108146327	Silent	novel	N377N	0.23
COAD	chr11	108133861	Frame_Shift_Del	NA	L56*	0.48
COAD	chr11	108133861	Frame_Shift_Del	NA	L56*	0.34
COAD	chr11	108140108	Missense_Mutation	rs370720208	R208Q	0.09
COAD	chr11	108121618	Silent	novel	L4L	0.16
COAD	chr11	108140107	Nonsense_Mutation	rs532190594	R208*	0.33
COAD	chr11	108147326	Missense_Mutation	NA	Y407C	0.25
ESCA	chr11	108133861	Frame_Shift_Del	NA	L56*	0.21
ESCA	chr11	108135202	Frame_Shift_Ins	novel	*I133Sfs3**	0.24
GBM	chr11	108146241	Missense_Mutation	novel	M349V	0.07
GBM	chr11	108140163	Nonsense_Mutation	novel	W226*	0.15
GBM	chr11	108147534	3'UTR	novel		0.54
KIRC	chr11	108147492	3'UTR	novel		0.2
KIRC	chr11	108142591	Intron	novel		0.42
KIRP	chr11	108143878	Intron	novel		0.44
LAML	chr11	108139017	Silent	NA	T185T	0.41
LIHC	chr11	108140117	Missense_Mutation	NA	Q211R	0.21
LIHC	chr11	108147374	Missense_Mutation	novel	L423R	0.4
LUAD	chr11	108146264	Silent	rs139657823	F356F	0.38
LUAD	chr11	108133882	Silent	novel	L61L	0.18
LUAD	chr11	108140185	Nonsense_Mutation	NA	E234*	0.05
LUAD	chr11	108131940	Missense_Mutation	novel	K36Q	0.22
LUSC	chr11	108140204	Missense_Mutation	NA	V240D	0.35
LUSC	chr11	108146358	Missense_Mutation	novel	G388W	0.15
LUSC	chr11	108134279	Missense_Mutation	novel	E99D	0.23
OV	chr11	108141657	Silent	NA	F261F	0.74
OV	chr11	108135197	Missense_Mutation	NA	M130I	0.42
OV	chr11	108135223	Missense_Mutation	NA	S139N	0.44
OV	chr11	108133826	Missense_Mutation	novel	V43I	0.04
OV	chr11	108142574	Intron	NA		0.21
PAAD	chr11	108143982	Splice_Site	novel	X314_splice	0.18
PAAD	chr11	108146260	Missense_Mutation	novel	A355V	0.04
PAAD	chr11	108147367	Missense_Mutation	rs749463321	A421T	0.16
PRAD	chr11	108143994	Missense_Mutation	novel	A318T	0.34
SARC	chr11	108140093	Missense_Mutation	novel	K203R	0.42
SKCM	chr11	108138952	Frame_Shift_Del	novel	*R165Tfs8**	0.4
STAD	chr11	108147492	3'UTR	novel		0.3
STAD	chr11	108146280	Missense_Mutation	NA	A362T	0.11
STAD	chr11	108142443	Frame_Shift_Ins	novel	*T279Nfs10**	0.35
STAD	chr11	108133861	Frame_Shift_Del	NA	L56*	0.1
STAD	chr11	108146287	Missense_Mutation	NA	I364T	0.21
STAD	chr11	108133861	Frame_Shift_Del	NA	L56*	0.17
STAD	chr11	108142512	Missense_Mutation	rs747860630	A301V	0.23
TGCT	chr11	108121573	5'UTR	novel		0.28
UCEC	chr11	108131914	Missense_Mutation	NA	R27I	0.31
UCEC	chr11	108139036	Missense_Mutation	NA	H192N	0.29
UCEC	chr11	108133929	Frame_Shift_Del	novel	*K78Rfs9**	0.24
UCEC	chr11	108133861	Frame_Shift_Del	NA	L56*	0.49
UCEC	chr11	108133863	Missense_Mutation	NA	F55C	0.4
UCEC	chr11	108140108	Missense_Mutation	rs370720208	R208Q	0.32
UCEC	chr11	108136130	Intron	novel		0.44
UCEC	chr11	108133832	Missense_Mutation	NA	V45L	0.38
UCEC	chr11	108140200	Missense_Mutation	NA	T239A	0.61
UCEC	chr11	108143784	Intron	novel		0.38
UCEC	chr11	108147521	3'UTR	novel		0.31
UCEC	chr11	108133860	Frame_Shift_Ins	novel	*L56Ffs11**	0.41
UCEC	chr11	108142496	Missense_Mutation	rs368802454	M296V	0.33
UCEC	chr11	108143866	Intron	novel		0.37
UCEC	chr11	108133923	Missense_Mutation	novel	A75V	0.28
UCEC	chr11	108141694	Nonsense_Mutation	novel	E274*	0.23
UCEC	chr11	108144043	Missense_Mutation	novel	S334F	0.42
UCEC	chr11	108136161	Intron	novel		0.38
UCEC	chr11	108147489	3'UTR	novel		0.43
UCEC	chr11	108135154	Missense_Mutation	novel	S116Y	0.14
UCEC	chr11	108133861	Frame_Shift_Del	NA	L56*	0.22
UCEC	chr11	108140108	Missense_Mutation	rs370720208	R208Q	0.22
UCEC	chr11	108141652	Missense_Mutation	novel	D260N	0.32
UCEC	chr11	108121604	5'UTR	novel		0.2
UCEC	chr11	108140108	Missense_Mutation	rs370720208	R208Q	0.36
UCEC	chr11	108147454	3'UTR	novel		0.3
UCEC	chr11	108134235	Nonsense_Mutation	rs748425041	E85*	0.44
UCEC	chr11	108135156	Missense_Mutation	novel	T117P	0.4
UCEC	chr11	108147455	3'UTR	novel		0.36
UCEC	chr11	108143994	Missense_Mutation	novel	A318T	0.42
UCEC	chr11	108147565	3'UTR	novel		0.35
UCEC	chr11	108140121	Silent	rs759659537	D212D	0.04
UCEC	chr11	108142458	Missense_Mutation	novel	A283D	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2868	0.00015732
CESC	DEL	0.478	1.0762e-32
CHOL	DEL	0.3056	0.048655
ESCA	AMP	0.1196	0.018342
KIRP	DEL	0.1042	2.839e-05
LIHC	DEL	0.1946	0.00030497
LUAD	DEL	0.1725	4.2393e-06
MESO	DEL	0.1609	0.0023183
PRAD	DEL	0.0752	0.00026046
READ	DEL	0.2121	0.054114
SARC	DEL	0.4163	1.8105e-09
STAD	DEL	0.1429	8.3734e-05
TGCT	DEL	0.7467	0.21504
UCS	DEL	0.4107	0.086462

Survival Analysis

Cancer	P-value	Q-value
THYM	0.036	Kaplan-Meier Survival Analysis
PRAD	0.049	Kaplan-Meier Survival Analysis
BRCA	0.05	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.023	Kaplan-Meier Survival Analysis
BLCA	0.0064	Kaplan-Meier Survival Analysis
LAML	0.026	Kaplan-Meier Survival Analysis
GBM	0.038	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742