EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000075292 (Gene tree)
Gene ID: 27332
Gene Symbol: ZNF638
Alias: NP220|MGC26130|Zfp638|ZFML
Full Name: zinc finger protein 638
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 158,509 bases
Position: chr2:71,276,561-71,435,069
Accession: 17894
RBP type: canonical RBP
Summary: The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000485192	zf-C2H2_jaz	PF12171.8	9.8e-06	1	1
ENSP00000485667	zf-C2H2_jaz	PF12171.8	2.6e-05	1	1
ENSP00000264447	zf-C2H2_jaz	PF12171.8	0.0005	1	1
ENSP00000386433	zf-C2H2_jaz	PF12171.8	0.0005	1	1
ENSP00000264447	RRM_1	PF00076.22	1.2e-07	1	1
ENSP00000386433	RRM_1	PF00076.22	1.2e-07	1	1
ENSP00000485608	RRM_1	PF00076.22	9.7e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12824700	Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC.	J Biomed Sci	2003 Jul-Aug	Warder DE	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409544	ZNF638-203	6821	XM_005264263	ENSP00000386433	1978 (aa)	XP_005264320	Q14966
ENST00000488126	ZNF638-221	842	-	-	- (aa)	-	-
ENST00000494621	ZNF638-226	871	-	ENSP00000485618	153 (aa)	-	A0A096LPI0
ENST00000409407	ZNF638-202	4470	-	-	- (aa)	-	-
ENST00000493576	ZNF638-224	1107	-	ENSP00000485667	285 (aa)	-	A0A096LPK8
ENST00000455226	ZNF638-209	585	-	ENSP00000408557	62 (aa)	-	C9JMR2
ENST00000454278	ZNF638-208	595	-	ENSP00000402875	62 (aa)	-	C9JMR2
ENST00000491843	ZNF638-222	332	-	-	- (aa)	-	-
ENST00000466975	ZNF638-214	560	-	ENSP00000485154	171 (aa)	-	A0A096LNQ0
ENST00000461991	ZNF638-211	846	-	ENSP00000485192	158 (aa)	-	A0A096LNS4
ENST00000492262	ZNF638-223	537	-	-	- (aa)	-	-
ENST00000475743	ZNF638-216	590	-	ENSP00000485169	90 (aa)	-	A0A096LNR2
ENST00000486494	ZNF638-218	973	-	-	- (aa)	-	-
ENST00000466330	ZNF638-213	746	-	ENSP00000485494	184 (aa)	-	A0A096LPB4
ENST00000483421	ZNF638-217	2076	-	-	- (aa)	-	-
ENST00000601581	ZNF638-227	574	-	-	- (aa)	-	-
ENST00000437658	ZNF638-206	931	-	ENSP00000388164	197 (aa)	-	C9JWN0
ENST00000264447	ZNF638-201	6505	XM_006711989	ENSP00000264447	1978 (aa)	XP_006712052	Q14966
ENST00000487638	ZNF638-219	4233	-	-	- (aa)	-	-
ENST00000460310	ZNF638-210	648	-	-	- (aa)	-	-
ENST00000417778	ZNF638-205	760	-	ENSP00000396909	29 (aa)	-	C9JHV0
ENST00000410075	ZNF638-204	3518	XM_017003812	ENSP00000485608	918 (aa)	XP_016859301	Q14966
ENST00000487707	ZNF638-220	592	-	-	- (aa)	-	-
ENST00000494241	ZNF638-225	703	-	-	- (aa)	-	-
ENST00000464375	ZNF638-212	626	-	ENSP00000485266	98 (aa)	-	A0A096LNX0
ENST00000454122	ZNF638-207	731	-	ENSP00000409647	36 (aa)	-	C9JSD0
ENST00000472758	ZNF638-215	535	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000075292's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000075292	Blood Pressure	2.2317604E-005	-
ENSG00000075292	Body Height	2E-10	23456168
ENSG00000075292	Body Height	3E-13	25282103
ENSG00000075292	Electrocardiography	4E-8	27958378
ENSG00000075292	Sulfonylurea Compounds	4E-8	27958378
ENSG00000075292	Body Height	8E-19	25429064

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000075292	rs1990774	2	71341076	?	Cognitive ability	29186694	z score decrease	5.629	EFO_0004337
ENSG00000075292	rs7595140	2	71324491	?	QRS interval (sulfonylurea treatment interaction)	27958378	[3.74-7.66] ms decrease	5.7	EFO_0005055\|EFO_0007922
ENSG00000075292	rs12612930	2	71298655	C	Height	23456168	[0.069-0.131] unit increase	0.1	EFO_0004339
ENSG00000075292	rs7578166	2	71402911	A	Heel bone mineral density	28869591	[0.016-0.029] unit decrease	0.0224212	EFO_0009270
ENSG00000075292	rs7578166	2	71402911	A	Heel bone mineral density	28869591	[0.014-0.032] unit decrease	0.0227096	EFO_0009270
ENSG00000075292	rs6731420	2	71306170	T	Intelligence (MTAG)	29326435	[0.011-0.022] unit decrease	0.016438717	EFO_0004337
ENSG00000075292	rs4470366	2	71307487	A	Cognitive performance	30038396	[0.013-0.024] unit increase	0.0182	EFO_0008354
ENSG00000075292	rs4852252	2	71312171	T	Cognitive performance (MTAG)	30038396	[0.0098-0.0188] unit decrease	0.0143	EFO_0008354
ENSG00000075292	rs6746731	2	71345787	T	Intelligence	28530673	z score decrease	4.591	EFO_0004337
ENSG00000075292	rs3771381	2	71333535	A	Height	25429064	[0.033-0.057] unit decrease	0.045	EFO_0004339
ENSG00000075292	rs7568069	2	71357355	A	Height	25282103	[0.016-0.028] unit decrease	0.022	EFO_0004339
ENSG00000075292	rs6746731	2	71345787	T	Intelligence	28530673	z score decrease	5.456	EFO_0004337
ENSG00000075292	rs4852252	2	71312171	T	General cognitive ability	29844566	z-score decrease	6.191	EFO_0004337
ENSG00000075292	rs4852778	2	71317824	?	Reaction time	29844566	[0.0062-0.0131] unit decrease	0.0096549	EFO_0008393
ENSG00000075292	rs4852252	2	71312171	T	Intelligence	29942086	z-score decrease	7.566	EFO_0004337
ENSG00000075292	rs2058898	2	71297627	A	Intelligence	29942086	z-score increase	6.535	EFO_0004337
ENSG00000075292	rs2419075	2	71307368	T	Intelligence	29942086	z-score increase	5.618	EFO_0004337
ENSG00000075292	rs13035834	2	71355123	A	Intelligence	29942086	z-score decrease	5.998	EFO_0004337
ENSG00000075292	rs12477570	2	71281055	A	Intelligence	29942086	z-score decrease	6.042	EFO_0004337
ENSG00000075292	rs7578166	2	71402911	?	Heel bone mineral density	30048462	[0.0082-0.0165] unit decrease	0.0123592	EFO_0009270
ENSG00000075292	rs10445946	2	71367404	?	Heel bone mineral density	30048462	[0.0081-0.0162] unit decrease	0.0121493	EFO_0009270
ENSG00000075292	rs4470366	2	71307487	T	Heel bone mineral density	30598549	[0.0088-0.0161] unit decrease	0.0124535	EFO_0009270
ENSG00000075292	rs6745907	2	71381943	A	Extremely high intelligence	29520040	NR z score decrease decrease	5.82	EFO_0004337
ENSG00000075292	rs4852780	2	71392981	T	Pulse pressure	30578418	[0.1-0.2] mmHg increase	0.1526	EFO_0005763
ENSG00000075292	rs56408212	2	71357071	?	Fat-free mass	30593698	[0.12-0.26] unit decrease	0.19204	EFO_0004995
ENSG00000075292	rs7605066	2	71302201	C	Pulse pressure	27841878	unit increase	0.149	EFO_0005763
ENSG00000075292	rs56408212	2	71357071	?	Fat-free mass	30593698	[0.11-0.2] unit decrease	0.15542	EFO_0004995
ENSG00000075292	rs12478953	2	71391469	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000075292	rs17743415	2	71335373	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075292's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000075292	ZNF638	56	31.073	ENSG00000015479	MATR3	59	30.899

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000075292	ZNF638	100	98.387	ENSAMEG00000015791	ZNF638	100	86.428	Ailuropoda_melanoleuca
ENSG00000075292	ZNF638	59	30.220	ENSACAG00000016233	-	52	56.000	Anolis_carolinensis
ENSG00000075292	ZNF638	100	100.000	ENSANAG00000027400	ZNF638	100	92.825	Aotus_nancymaae
ENSG00000075292	ZNF638	100	95.939	ENSBTAG00000009242	ZNF638	100	83.679	Bos_taurus
ENSG00000075292	ZNF638	100	100.000	ENSCJAG00000019436	-	100	96.222	Callithrix_jacchus
ENSG00000075292	ZNF638	100	98.387	ENSCAFG00000009067	ZNF638	100	85.851	Canis_familiaris
ENSG00000075292	ZNF638	100	98.387	ENSCAFG00020001829	ZNF638	99	91.579	Canis_lupus_dingo
ENSG00000075292	ZNF638	76	89.908	ENSCHIG00000022714	-	100	89.908	Capra_hircus
ENSG00000075292	ZNF638	100	93.548	ENSTSYG00000012849	ZNF638	100	86.371	Carlito_syrichta
ENSG00000075292	ZNF638	100	91.667	ENSCAPG00000003141	ZNF638	100	70.370	Cavia_aperea
ENSG00000075292	ZNF638	100	100.000	ENSCCAG00000028170	ZNF638	100	96.330	Cebus_capucinus
ENSG00000075292	ZNF638	100	100.000	ENSCATG00000032207	ZNF638	100	98.039	Cercocebus_atys
ENSG00000075292	ZNF638	100	98.387	ENSCLAG00000006418	ZNF638	100	87.379	Chinchilla_lanigera
ENSG00000075292	ZNF638	100	100.000	ENSCSAG00000015261	ZNF638	100	96.010	Chlorocebus_sabaeus
ENSG00000075292	ZNF638	100	93.909	ENSCHOG00000013922	ZNF638	92	79.731	Choloepus_hoffmanni
ENSG00000075292	ZNF638	100	100.000	ENSCANG00000014119	ZNF638	100	97.712	Colobus_angolensis_palliatus
ENSG00000075292	ZNF638	100	95.161	ENSCGRG00001021120	Zfp638	100	76.699	Cricetulus_griseus_chok1gshd
ENSG00000075292	ZNF638	100	95.161	ENSCGRG00000008044	Zfp638	100	76.696	Cricetulus_griseus_crigri
ENSG00000075292	ZNF638	57	31.492	ENSDNOG00000037723	-	55	56.000	Dasypus_novemcinctus
ENSG00000075292	ZNF638	100	97.222	ENSDNOG00000002173	ZNF638	96	83.056	Dasypus_novemcinctus
ENSG00000075292	ZNF638	100	98.387	ENSDORG00000007360	Zfp638	99	89.263	Dipodomys_ordii
ENSG00000075292	ZNF638	99	70.846	ENSETEG00000013272	ZNF638	92	80.309	Echinops_telfairi
ENSG00000075292	ZNF638	100	98.477	ENSEASG00005007611	ZNF638	100	91.089	Equus_asinus_asinus
ENSG00000075292	ZNF638	100	98.477	ENSECAG00000007715	ZNF638	100	86.609	Equus_caballus
ENSG00000075292	ZNF638	100	98.387	ENSFCAG00000004356	ZNF638	100	86.913	Felis_catus
ENSG00000075292	ZNF638	100	98.387	ENSFDAG00000005076	ZNF638	100	86.201	Fukomys_damarensis
ENSG00000075292	ZNF638	100	100.000	ENSGGOG00000012511	ZNF638	100	99.346	Gorilla_gorilla
ENSG00000075292	ZNF638	100	98.387	ENSHGLG00000015789	ZNF638	100	85.939	Heterocephalus_glaber_female
ENSG00000075292	ZNF638	100	98.387	ENSHGLG00100018962	ZNF638	100	84.806	Heterocephalus_glaber_male
ENSG00000075292	ZNF638	100	98.387	ENSSTOG00000003995	ZNF638	99	91.964	Ictidomys_tridecemlineatus
ENSG00000075292	ZNF638	100	96.774	ENSJJAG00000016049	Zfp638	100	85.823	Jaculus_jaculus
ENSG00000075292	ZNF638	57	31.609	ENSLACG00000006743	-	59	59.091	Latimeria_chalumnae
ENSG00000075292	ZNF638	100	97.222	ENSLAFG00000008513	ZNF638	100	82.317	Loxodonta_africana
ENSG00000075292	ZNF638	100	100.000	ENSMFAG00000034359	ZNF638	100	97.930	Macaca_fascicularis
ENSG00000075292	ZNF638	100	100.000	ENSMMUG00000007175	ZNF638	100	97.603	Macaca_mulatta
ENSG00000075292	ZNF638	100	100.000	ENSMNEG00000028987	ZNF638	100	97.930	Macaca_nemestrina
ENSG00000075292	ZNF638	57	31.492	ENSMNEG00000042856	-	50	56.000	Macaca_nemestrina
ENSG00000075292	ZNF638	57	31.492	ENSMLEG00000041178	-	50	56.000	Mandrillus_leucophaeus
ENSG00000075292	ZNF638	100	100.000	ENSMLEG00000037705	ZNF638	100	97.930	Mandrillus_leucophaeus
ENSG00000075292	ZNF638	100	95.161	ENSMAUG00000009740	Zfp638	99	80.208	Mesocricetus_auratus
ENSG00000075292	ZNF638	98	96.721	ENSMICG00000005419	ZNF638	99	87.563	Microcebus_murinus
ENSG00000075292	ZNF638	100	93.401	ENSMOCG00000017661	Zfp638	100	79.612	Microtus_ochrogaster
ENSG00000075292	ZNF638	100	98.387	ENSMPUG00000007422	ZNF638	95	85.275	Mustela_putorius_furo
ENSG00000075292	ZNF638	100	93.909	ENSMLUG00000011904	ZNF638	99	82.576	Myotis_lucifugus
ENSG00000075292	ZNF638	100	100.000	ENSNLEG00000010274	ZNF638	100	99.541	Nomascus_leucogenys
ENSG00000075292	ZNF638	100	97.462	ENSOPRG00000011644	ZNF638	81	97.436	Ochotona_princeps
ENSG00000075292	ZNF638	100	98.477	ENSOCUG00000010045	ZNF638	100	84.317	Oryctolagus_cuniculus
ENSG00000075292	ZNF638	100	100.000	ENSOGAG00000001152	ZNF638	100	86.630	Otolemur_garnettii
ENSG00000075292	ZNF638	100	95.939	ENSOARG00000011388	ZNF638	100	82.964	Ovis_aries
ENSG00000075292	ZNF638	100	100.000	ENSPPAG00000039298	ZNF638	100	99.564	Pan_paniscus
ENSG00000075292	ZNF638	100	98.387	ENSPPRG00000010571	ZNF638	100	86.812	Panthera_pardus
ENSG00000075292	ZNF638	100	98.387	ENSPTIG00000019660	ZNF638	100	86.710	Panthera_tigris_altaica
ENSG00000075292	ZNF638	100	100.000	ENSPTRG00000012048	ZNF638	100	99.564	Pan_troglodytes
ENSG00000075292	ZNF638	100	100.000	ENSPANG00000016789	ZNF638	100	98.148	Papio_anubis
ENSG00000075292	ZNF638	100	93.103	ENSPEMG00000010423	Zfp638	100	77.442	Peromyscus_maniculatus_bairdii
ENSG00000075292	ZNF638	98	97.419	ENSPPYG00000029854	-	100	97.486	Pongo_abelii
ENSG00000075292	ZNF638	99	95.918	ENSPCOG00000015676	ZNF638	99	88.271	Propithecus_coquereli
ENSG00000075292	ZNF638	100	98.387	ENSPVAG00000008368	ZNF638	94	95.954	Pteropus_vampyrus
ENSG00000075292	ZNF638	100	100.000	ENSRBIG00000029826	ZNF638	100	97.248	Rhinopithecus_bieti
ENSG00000075292	ZNF638	100	100.000	ENSRROG00000045431	ZNF638	100	97.059	Rhinopithecus_roxellana
ENSG00000075292	ZNF638	100	100.000	ENSSBOG00000029960	ZNF638	100	96.330	Saimiri_boliviensis_boliviensis
ENSG00000075292	ZNF638	100	98.387	ENSSARG00000000956	ZNF638	100	73.990	Sorex_araneus
ENSG00000075292	ZNF638	100	98.477	ENSSSCG00000022708	ZNF638	100	85.498	Sus_scrofa
ENSG00000075292	ZNF638	100	91.878	ENSTBEG00000004110	ZNF638	80	89.342	Tupaia_belangeri
ENSG00000075292	ZNF638	100	98.477	ENSTTRG00000014220	ZNF638	95	96.000	Tursiops_truncatus
ENSG00000075292	ZNF638	100	97.222	ENSUAMG00000015042	ZNF638	99	87.121	Ursus_americanus
ENSG00000075292	ZNF638	100	97.222	ENSUMAG00000021680	ZNF638	99	91.579	Ursus_maritimus
ENSG00000075292	ZNF638	100	98.387	ENSVPAG00000004117	ZNF638	91	90.638	Vicugna_pacos
ENSG00000075292	ZNF638	100	98.387	ENSVVUG00000007369	ZNF638	100	86.003	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003690	double-stranded DNA binding	8647861.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	8647861.	TAS	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component