EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000075413 (Gene tree)
Gene ID: 4140
Gene Symbol: MARK3
Alias: CTAK1|KP78|PAR-1A
Full Name: microtubule affinity regulating kinase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 118,468 bases
Position: chr14:103,385,364-103,503,831
Accession: 6897
RBP type: canonical RBP
Summary: The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000454169	RIO1	PF01163.22	0.0012	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556463	MARK3-210	3584	-	-	- (aa)	-	-
ENST00000335102	MARK3-203	2331	-	ENSP00000335347	776 (aa)	-	J3KNR0
ENST00000559268	MARK3-217	560	-	-	- (aa)	-	-
ENST00000429436	MARK3-205	3371	XM_005267641	ENSP00000411397	753 (aa)	XP_005267698	P27448
ENST00000561225	MARK3-225	523	-	ENSP00000452829	129 (aa)	-	H0YKJ3
ENST00000560417	MARK3-220	579	-	ENSP00000454169	178 (aa)	-	H0YNV4
ENST00000555235	MARK3-209	2282	-	-	- (aa)	-	-
ENST00000560603	MARK3-221	572	-	-	- (aa)	-	-
ENST00000558787	MARK3-215	758	-	-	- (aa)	-	-
ENST00000559328	MARK3-219	533	-	-	- (aa)	-	-
ENST00000560731	MARK3-222	432	-	-	- (aa)	-	-
ENST00000440884	MARK3-206	2643	-	ENSP00000402104	659 (aa)	-	P27448
ENST00000559274	MARK3-218	1053	-	-	- (aa)	-	-
ENST00000416682	MARK3-204	2969	-	ENSP00000408092	752 (aa)	-	P27448
ENST00000216288	MARK3-201	2911	XM_017021292	ENSP00000216288	713 (aa)	XP_016876781	P27448
ENST00000558223	MARK3-212	908	-	-	- (aa)	-	-
ENST00000554627	MARK3-208	1571	XM_017021306	ENSP00000450460	505 (aa)	XP_016876795	H0YIY6
ENST00000561314	MARK3-226	724	-	ENSP00000452893	222 (aa)	-	H0YKP9
ENST00000556744	MARK3-211	1051	-	ENSP00000451623	331 (aa)	-	A2SY06
ENST00000303622	MARK3-202	3283	XM_005267643	ENSP00000303698	729 (aa)	XP_005267700	P27448
ENST00000553942	MARK3-207	2298	XM_017021291	ENSP00000450772	744 (aa)	XP_016876780	P27448
ENST00000558698	MARK3-214	498	-	-	- (aa)	-	-
ENST00000561164	MARK3-224	598	-	-	- (aa)	-	-
ENST00000558953	MARK3-216	507	-	-	- (aa)	-	-
ENST00000558611	MARK3-213	687	-	-	- (aa)	-	-
ENST00000561071	MARK3-223	746	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000075413's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000075413	Bone Density	5E-16	22504420

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000075413	rs11623869	14	103417296	T	Bone mineral density	22504420	[NR] unit decrease	0.04	EFO_0003923
ENSG00000075413	rs35816040	14	103415225	TAACA	Heel bone mineral density	28869591	[0.031-0.052] unit increase	0.0417568	EFO_0009270
ENSG00000075413	rs35816040	14	103415225	TAACA	Heel bone mineral density	28869591	[0.036-0.05] unit increase	0.0425841	EFO_0009270
ENSG00000075413	rs35816040	14	103415225	TAACA	Heel bone mineral density	28869591	[0.032-0.051] unit increase	0.0418853	EFO_0009270
ENSG00000075413	rs7149767	14	103397208	A	Endometriosis	28881265	[1.361-2.213]	1.736	EFO_0001065
ENSG00000075413	rs35816040	14	103415225	?	Heel bone mineral density	30048462	[0.019-0.027] unit decrease	0.0232417	EFO_0009270
ENSG00000075413	rs62007686	14	103433007	?	Heel bone mineral density	30048462	[0.039-0.048] unit increase	0.0436142	EFO_0009270
ENSG00000075413	rs17679259	14	103428965	A	Systolic blood pressure	30578418	[0.26-0.42] mmHg increase	0.3393	EFO_0006335
ENSG00000075413	rs62007684	14	103427886	T	Heel bone mineral density	30598549	[0.039-0.046] unit increase	0.0424002	EFO_0009270
ENSG00000075413	rs55859054	14	103487329	?	Blond vs. brown/black hair color	30531825	NR	1.0513036	EFO_0003924
ENSG00000075413	rs8014182	14	103393625	T	Systolic blood pressure	30224653	[0.27-0.41] mmHg decrease	0.3397	EFO_0006335
ENSG00000075413	rs1951389	14	103432188	?	White blood cell count	30595370			EFO_0004308
ENSG00000075413	rs3825566	14	103386388	?	Hair color	30595370			EFO_0007822
ENSG00000075413	rs62007686	14	103433007	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075413's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000075413	MARK3	100	83.889	ENSACIG00000023826	mark3a	100	81.173	Amphilophus_citrinellus
ENSG00000075413	MARK3	100	85.000	ENSAPEG00000003620	mark3a	100	81.053	Amphiprion_percula
ENSG00000075413	MARK3	100	85.000	ENSATEG00000017350	mark3a	100	80.894	Anabas_testudineus
ENSG00000075413	MARK3	94	93.525	ENSATEG00000006494	MARK3	85	93.525	Anabas_testudineus
ENSG00000075413	MARK3	100	83.889	ENSACLG00000010884	mark3a	100	80.815	Astatotilapia_calliptera
ENSG00000075413	MARK3	100	88.398	ENSAMXG00000001870	mark3a	90	88.398	Astyanax_mexicanus
ENSG00000075413	MARK3	97	93.865	ENSAMXG00000001388	mark3b	96	86.622	Astyanax_mexicanus
ENSG00000075413	MARK3	93	85.714	ENSCSAVG00000004326	-	90	85.075	Ciona_savignyi
ENSG00000075413	MARK3	100	85.000	ENSCSEG00000013207	mark3a	100	79.763	Cynoglossus_semilaevis
ENSG00000075413	MARK3	100	85.000	ENSCVAG00000018949	mark3a	99	80.458	Cyprinodon_variegatus
ENSG00000075413	MARK3	99	83.799	ENSDARG00000019345	mark3a	90	83.799	Danio_rerio
ENSG00000075413	MARK3	96	81.699	ENSEBUG00000014231	-	89	81.699	Eptatretus_burgeri
ENSG00000075413	MARK3	100	79.082	ENSFHEG00000011355	MARK3	95	74.447	Fundulus_heteroclitus
ENSG00000075413	MARK3	100	85.556	ENSFHEG00000010724	mark3a	99	81.658	Fundulus_heteroclitus
ENSG00000075413	MARK3	100	85.000	ENSGAFG00000011875	mark3a	98	81.058	Gambusia_affinis
ENSG00000075413	MARK3	100	78.184	ENSGACG00000004742	mark3a	99	78.184	Gasterosteus_aculeatus
ENSG00000075413	MARK3	94	78.571	ENSHBUG00000023278	mark3a	99	73.027	Haplochromis_burtoni
ENSG00000075413	MARK3	100	75.127	ENSHCOG00000000039	mark3a	51	89.544	Hippocampus_comes
ENSG00000075413	MARK3	100	83.978	ENSIPUG00000003398	mark3	100	75.978	Ictalurus_punctatus
ENSG00000075413	MARK3	100	93.889	ENSIPUG00000018616	mark3b	100	87.049	Ictalurus_punctatus
ENSG00000075413	MARK3	100	96.687	ENSJJAG00000022266	Mark3	100	95.565	Jaculus_jaculus
ENSG00000075413	MARK3	100	83.425	ENSKMAG00000017897	mark3a	100	80.842	Kryptolebias_marmoratus
ENSG00000075413	MARK3	100	87.778	ENSKMAG00000014622	MARK3	90	87.778	Kryptolebias_marmoratus
ENSG00000075413	MARK3	100	84.444	ENSLBEG00000004943	mark3a	100	80.242	Labrus_bergylta
ENSG00000075413	MARK3	100	95.652	ENSLOCG00000009889	mark3a	100	90.741	Lepisosteus_oculatus
ENSG00000075413	MARK3	100	88.333	ENSMAMG00000002003	MARK3	100	79.057	Mastacembelus_armatus
ENSG00000075413	MARK3	100	83.889	ENSMAMG00000000065	mark3a	100	80.326	Mastacembelus_armatus
ENSG00000075413	MARK3	100	83.889	ENSMZEG00005001972	mark3a	100	80.815	Maylandia_zebra
ENSG00000075413	MARK3	100	77.863	ENSMMOG00000014764	mark3a	99	78.326	Mola_mola
ENSG00000075413	MARK3	97	87.117	ENSNBRG00000003333	-	87	87.117	Neolamprologus_brichardi
ENSG00000075413	MARK3	100	82.065	ENSONIG00000012410	mark3a	100	74.662	Oreochromis_niloticus
ENSG00000075413	MARK3	100	87.222	ENSONIG00000019014	-	90	87.222	Oreochromis_niloticus
ENSG00000075413	MARK3	100	93.333	ENSPKIG00000019336	mark3b	99	87.347	Paramormyrops_kingsleyae
ENSG00000075413	MARK3	98	76.503	ENSPMGG00000011367	mark3a	99	75.238	Periophthalmus_magnuspinnatus
ENSG00000075413	MARK3	100	77.551	ENSPFOG00000019488	MARK3	99	82.186	Poecilia_formosa
ENSG00000075413	MARK3	100	85.000	ENSPLAG00000013552	mark3a	99	81.522	Poecilia_latipinna
ENSG00000075413	MARK3	100	85.000	ENSPREG00000005436	mark3a	99	81.028	Poecilia_reticulata
ENSG00000075413	MARK3	100	83.889	ENSPNYG00000017025	mark3a	100	80.815	Pundamilia_nyererei
ENSG00000075413	MARK3	100	95.000	ENSPNAG00000018462	mark3b	100	87.335	Pygocentrus_nattereri
ENSG00000075413	MARK3	100	87.845	ENSPNAG00000029687	mark3a	100	78.649	Pygocentrus_nattereri
ENSG00000075413	MARK3	100	95.556	ENSSFOG00015014033	mark3b	100	88.571	Scleropages_formosus
ENSG00000075413	MARK3	100	84.444	ENSSMAG00000005737	mark3a	100	80.754	Scophthalmus_maximus
ENSG00000075413	MARK3	100	84.444	ENSSMAG00000010713	MARK3	100	75.636	Scophthalmus_maximus
ENSG00000075413	MARK3	100	84.444	ENSSDUG00000004553	mark3a	100	81.386	Seriola_dumerili
ENSG00000075413	MARK3	96	83.889	ENSTRUG00000006908	mark3a	100	80.000	Takifugu_rubripes
ENSG00000075413	MARK3	100	82.320	ENSTNIG00000012393	mark3a	100	80.851	Tetraodon_nigroviridis
ENSG00000075413	MARK3	100	95.000	ENSXETG00000012767	mark3	91	95.000	Xenopus_tropicalis
ENSG00000075413	MARK3	95	81.967	ENSXCOG00000004394	MARK3	95	82.166	Xiphophorus_couchianus
ENSG00000075413	MARK3	100	77.551	ENSXMAG00000014822	MARK3	90	69.355	Xiphophorus_maculatus
ENSG00000075413	MARK3	100	85.556	ENSXMAG00000006647	MARK3	100	75.033	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9543386.16980613.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	28386764.	NAS	Function
GO:0005515	protein binding	9543386.12556533.14676191.15161933.15778465.16169070.16189514.16306228.16959763.16980613.17979178.23666762.24255178.25852190.28087714.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23666762.	IDA	Component
GO:0005737	cytoplasm	9543386.	NAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	21145462.	IDA	Component
GO:0006468	protein phosphorylation	23666762.	IMP	Process
GO:0018105	peptidyl-serine phosphorylation	9543386.	IDA	Process
GO:0030010	establishment of cell polarity	-	IEA	Process
GO:0030425	dendrite	23666762.	IDA	Component
GO:0032092	positive regulation of protein binding	9543386.	IDA	Process
GO:0035331	negative regulation of hippo signaling	28087714.	IDA	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0036289	peptidyl-serine autophosphorylation	9543386.	IDA	Process
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0050321	tau-protein kinase activity	21873635.	IBA	Function
GO:0050321	tau-protein kinase activity	23666762.	IMP	Function
GO:0050321	tau-protein kinase activity	28386764.	NAS	Function
GO:0070062	extracellular exosome	18570454.	HDA	Component