EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000075420 (Gene tree)
Gene ID: 64778
Gene Symbol: FNDC3B
Alias: FAD104|DKFZp762K137|FLJ23399|PRO4979|YVTM2421
Full Name: fibronectin type III domain containing 3B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 362,038 bases
Position: chr3:172,039,628-172,401,665
Accession: 24670
RBP type: non-canonical RBP
Summary: (Fibronectin Type III Domain Containing 3B) is a Protein Coding gene. Diseases associated with FNDC3B include Urethra Adenocarcinoma and Urethra Clear Cell Adenocarcinoma. An important paralog of this gene is FNDC3A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421757	FNDC3B-204	946	-	ENSP00000408496	71 (aa)	-	Q53EP0
ENST00000476794	FNDC3B-208	682	-	-	- (aa)	-	-
ENST00000490832	FNDC3B-211	772	-	-	- (aa)	-	-
ENST00000423424	FNDC3B-205	408	-	ENSP00000392471	71 (aa)	-	Q53EP0
ENST00000483344	FNDC3B-210	666	-	-	- (aa)	-	-
ENST00000336824	FNDC3B-201	7904	XM_017007063	ENSP00000338523	1204 (aa)	XP_016862552	Q53EP0
ENST00000415807	FNDC3B-202	5083	XM_017007062	ENSP00000411242	1204 (aa)	XP_016862551	Q53EP0
ENST00000478016	FNDC3B-209	554	-	-	- (aa)	-	-
ENST00000443501	FNDC3B-206	678	-	ENSP00000389064	208 (aa)	-	C9JKH7
ENST00000494000	FNDC3B-212	2600	-	-	- (aa)	-	-
ENST00000469491	FNDC3B-207	2916	-	-	- (aa)	-	-
ENST00000416957	FNDC3B-203	3684	-	ENSP00000389094	1204 (aa)	-	Q53EP0

Gene Model

Click here to download ENSG00000075420's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000075420	Arteries	9.5170000E-005	-
ENSG00000075420	Arteries	6.3960000E-006	-
ENSG00000075420	Leukocyte Count	8.1760000E-005	-
ENSG00000075420	Leukocyte Count	3.3010000E-005	-
ENSG00000075420	Leukocyte Count	2.0130000E-005	-
ENSG00000075420	Leukocyte Count	2.8310000E-005	-
ENSG00000075420	Platelet Function Tests	7.2938223E-006	-
ENSG00000075420	Platelet Function Tests	1.2553200E-005	-
ENSG00000075420	Body Height	4E-16	23563607
ENSG00000075420	Body Height	3E-39	25282103
ENSG00000075420	Body Mass Index	5E-9	25673412
ENSG00000075420	Waist Circumference	5E-9	25673412
ENSG00000075420	Body Height	7E-11	20881960
ENSG00000075420	Intraocular Pressure	7E-13	28073927
ENSG00000075420	Body Mass Index	8E-10	25673412
ENSG00000075420	Waist Circumference	8E-10	25673412
ENSG00000075420	Corneal Topography	5E-12	23291589
ENSG00000075420	Intraocular Pressure	3E-12	28073927
ENSG00000075420	Heart Rate	1E-9	23583979
ENSG00000075420	Hip	3E-12	25673412
ENSG00000075420	Body Mass Index	3E-12	25673412
ENSG00000075420	Aggression	7E-6	26121980
ENSG00000075420	Cell Survival	7E-6	26121980
ENSG00000075420	Intraocular Pressure	4E-8	25173106
ENSG00000075420	Hip	1E-9	25673412
ENSG00000075420	Body Mass Index	1E-9	25673412
ENSG00000075420	Body Height	2E-23	25429064

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000075420	rs7635832	3	172271486	T	Intraocular pressure	29617998	[0.23-0.3] unit increase	0.2614	EFO_0004695
ENSG00000075420	rs4380442	3	172212591	G	Intraocular pressure	29617998	[0.22-0.31] unit decrease	0.262	EFO_0004695
ENSG00000075420	rs6445046	3	172215462	T	Central corneal thickness	29760442	[2.76-4.22] unit increase	3.49	EFO_0005213
ENSG00000075420	rs6445055	3	172274597	A	Intraocular pressure	25173106	[0.12-0.24] mm Hg decrease	0.177	EFO_0004695
ENSG00000075420	rs7652177	3	172251287	?	Height	20881960	[NR]		EFO_0004339
ENSG00000075420	rs9647379	3	172067378	C	Heart rate	23583979	[0.11-0.30] unit increase	0.206	EFO_0004326
ENSG00000075420	rs9854411	3	172203779	?	Triptolide cytotoxicity	26121980	unit decrease	0.57	EFO_0007663\|EFO_0006952
ENSG00000075420	rs4535251	3	172208583	T	Height	23563607	[NR]	1.18	EFO_0004339
ENSG00000075420	rs4894535	3	172277815	T	Corneal structure	23291589	[0.061-0.139] unit decrease	0.1	EFO_0004345
ENSG00000075420	rs6445055	3	172274597	?	Intraocular pressure	29235454	[NR] unit increase	0.23	EFO_0004695
ENSG00000075420	rs7635832	3	172271486	?	Intraocular pressure	29235454	[NR] unit increase	0.23	EFO_0004695
ENSG00000075420	rs4894799	3	172077750	A	Glycated hemoglobin levels	28898252	[0.0052-0.0126] unit increase	0.0089	EFO_0004541
ENSG00000075420	rs4894803	3	172082466	A	Coronary artery disease	29212778	[0.017-0.045] unit decrease	0.031	EFO_0000378
ENSG00000075420	rs12897	3	172398112	A	Coronary artery disease	29212778	[0.029-0.055] unit decrease	0.042	EFO_0000378
ENSG00000075420	rs12897	3	172398112	A	Coronary artery disease	29212778	[0.024-0.047] unit decrease	0.0358	EFO_0000378
ENSG00000075420	rs553685	3	172371463	?	Colonoscopy-negative controls vs population controls	29228715	[NR]	2.2507315	EFO_0008460
ENSG00000075420	rs4894529	3	172241894	A	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score increase	5.646	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000075420	rs16856911	3	172082708	?	Intraocular pressure	30054594	[0.11-0.23] unit increase	0.1713	EFO_0004695
ENSG00000075420	rs12492846	3	172208901	?	Intraocular pressure	30054594	[0.068-0.138] unit increase	0.1027	EFO_0004695
ENSG00000075420	rs397778518	3	172081355	CT	Immature fraction of reticulocytes	27863252	[0.015-0.03] unit increase	0.02259686	EFO_0007986
ENSG00000075420	rs6763687	3	172059856	T	Red cell distribution width	27863252	[0.027-0.041] unit increase	0.03430676	EFO_0005192
ENSG00000075420	rs13094143	3	172255997	C	Monokine induced by gamma interferon levels	27989323	[0.061-0.156] SD units decrease	0.1085	EFO_0008236
ENSG00000075420	rs181124723	3	172350452	G	TRAIL levels	27989323	[0.29-0.47] SD units decrease	0.3815	EFO_0008300
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI in smokers	28443625	[0.025-0.054] unit decrease	0.0399	EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for body mass index	28448500	[0.018-0.041] cm increase	0.0294	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for body mass index	28448500	[0.017-0.032] cm increase	0.0243	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for body mass index	28448500	[0.018-0.039] cm increase	0.0281	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for body mass index	28448500	[0.018-0.04] cm increase	0.0288	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for body mass index	28448500	[0.017-0.031] cm increase	0.0239	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for BMI in active individuals	28448500	[0.023-0.047] cm increase	0.0347	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for BMI in active individuals	28448500	[0.018-0.035] cm increase	0.0261	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for BMI in active individuals	28448500	[0.022-0.046] cm increase	0.0337	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for BMI in active individuals	28448500	[0.022-0.046] cm increase	0.0339	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	G	Waist circumference adjusted for BMI in active individuals	28448500	[0.017-0.034] cm increase	0.0254	EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for body mass index	25673412	[0.018-0.037] unit decrease	0.0279	EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for body mass index	25673412	[0.014-0.028] unit decrease	0.0209	EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI in smokers	28443625	[0.026-0.067] unit decrease	0.0464	EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000075420	rs12493901	3	172204265	?	Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)	28448500			EFO_0007789\|EFO_0008002
ENSG00000075420	rs7635832	3	172271486	G	Intraocular pressure	28073927	[0.17-0.33] unit decrease	0.25	EFO_0004695
ENSG00000075420	rs7635832	3	172271486	G	Intraocular pressure	28073927	[0.16-0.28] unit decrease	0.22	EFO_0004695
ENSG00000075420	rs4243400	3	172253069	A	Hip circumference adjusted for BMI	25673412	[0.018-0.032] unit decrease	0.0249	EFO_0008039
ENSG00000075420	rs4243400	3	172253069	A	Hip circumference adjusted for BMI	25673412	[0.019-0.037] unit decrease	0.0276	EFO_0008039
ENSG00000075420	rs4243400	3	172253069	A	Height	25429064	[0.036-0.06] unit decrease	0.048	EFO_0004339
ENSG00000075420	rs7652177	3	172251287	C	Height	25282103	[0.032-0.044] unit decrease	0.038	EFO_0004339
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.012-0.03] unit decrease	0.0214	EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.018-0.037] unit decrease	0.0275	EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.017-0.031] unit decrease	0.0239	EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000075420	rs12493901	3	172204265	A	Waist circumference adjusted for BMI in non-smokers	28443625	[0.013-0.028] unit decrease	0.0203	EFO_0007789
ENSG00000075420	rs35461662	3	172056222	A	Red cell distribution width	28957414	[0.025-0.041] unit increase	0.0328056	EFO_0005192
ENSG00000075420	rs62283814	3	172103766	C	Intraocular pressure	29785010	[0.13-0.24] unit decrease	0.182	EFO_0004695
ENSG00000075420	rs12492846	3	172208901	C	Intraocular pressure	29785010	[0.076-0.146] unit decrease	0.111	EFO_0004695
ENSG00000075420	rs16856859	3	172066946	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000075420	rs9647379	3	172067378	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000075420	rs7636026	3	172096231	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000075420	rs4894535	3	172277815	C	Pulse pressure	30224653	[0.13-0.24] unit decrease	0.1848	EFO_0005763
ENSG00000075420	rs146690225	3	172232611	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000075420	rs4894797	3	172065756	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000075420	rs12152414	3	172363569	A	Breast cancer	29059683	[0.048-0.118] unit increase	0.083	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000075420's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000075420	FNDC3B	100	92.543	ENSMUSG00000039286	Fndc3b	100	98.387	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0016021	integral component of membrane	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22510613	Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B.	Cell Cycle	2012 May 1	Cai C	doi: 10.4161/cc.20121
19472311	Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression.	Hepatology	2009 Aug	Zhang X	doi: 10.1002/hep.23008.
27862769	NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis.	Cancer Sci	2017 Jan	Feng S	doi: 10.1111/cas.13117.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	172333110	Frame_Shift_Ins	novel	*K536Tfs6**	0.83
ACC	chr3	172352925	Silent	novel	P879P	0.38
BLCA	chr3	172352880	Silent	novel	V864V	0.12
BLCA	chr3	172310837	Missense_Mutation	novel	D404N	0.29
BLCA	chr3	172335002	Missense_Mutation	rs149280961	T567M	0.14
BLCA	chr3	172362684	Silent	novel	F949F	0.29
BLCA	chr3	172251356	Missense_Mutation	rs555914186	R202H	0.43
BLCA	chr3	172381006	Missense_Mutation	NA	I1072M	0.4
BLCA	chr3	172397297	Missense_Mutation	NA	A1146V	0.45
BLCA	chr3	172330707	Missense_Mutation	rs779364384	D516N	0.59
BLCA	chr3	172397549	3'UTR	novel		0.29
BLCA	chr3	172329063	Missense_Mutation	rs749631576	D456N	0.21
BLCA	chr3	172251429	Silent	novel	G226G	0.06
BLCA	chr3	172307384	Silent	novel	S361S	0.14
BLCA	chr3	172346414	Missense_Mutation	novel	D780N	0.43
BLCA	chr3	172310870	Missense_Mutation	NA	E415Q	0.03
BLCA	chr3	172295360	Splice_Region	novel		0.1
BLCA	chr3	172362759	Silent	novel	L974L	0.53
BLCA	chr3	172344259	Splice_Site	novel	X750_splice	0.18
BLCA	chr3	172344121	Missense_Mutation	NA	E705K	0.09
BLCA	chr3	172251300	Silent	novel	R183R	0.12
BLCA	chr3	172346408	Missense_Mutation	NA	T778S	0.21
BRCA	chr3	172353075	Silent	NA	T929T	0.38
BRCA	chr3	172397407	Missense_Mutation	rs762666819	I1183V	0.38
BRCA	chr3	172133474	Missense_Mutation	NA	I39V	0.26
BRCA	chr3	172398863	3'UTR	novel		0.16
BRCA	chr3	172346414	Missense_Mutation	novel	D780N	0.06
BRCA	chr3	172381024	Silent	rs368498048	P1078P	0.53
BRCA	chr3	172330576	Missense_Mutation	novel	G472A	0.57
BRCA	chr3	172398327	3'UTR	novel		0.16
BRCA	chr3	172347332	Missense_Mutation	NA	P829S	0.05
BRCA	chr3	172337437	Intron	novel		0.09
BRCA	chr3	172329030	Missense_Mutation	NA	M445L	0.19
CESC	chr3	172251345	Silent	NA	R198R	0.27
CESC	chr3	172298780	Missense_Mutation	NA	H352Y	0.35
CESC	chr3	172341120	Silent	NA	Q620Q	0.1
CESC	chr3	172397185	Missense_Mutation	novel	T1109A	0.34
CESC	chr3	172251336	Silent	NA	L195L	0.15
CESC	chr3	172400387	3'UTR	novel		0.43
CESC	chr3	172112504	Missense_Mutation	rs780399563	D9N	0.19
CESC	chr3	172334966	Frame_Shift_Ins	novel	*S557Kfs14**	0.2
CHOL	chr3	172400579	3'UTR	novel		0.55
CHOL	chr3	172397463	Missense_Mutation	novel	F1201L	0.28
COAD	chr3	172362694	Nonsense_Mutation	NA	K953*	0.09
COAD	chr3	172378300	Missense_Mutation	novel	H1013Q	0.21
COAD	chr3	172251344	Missense_Mutation	novel	R198H	0.16
COAD	chr3	172397335	Missense_Mutation	novel	G1159W	0.12
COAD	chr3	172341129	Silent	novel	V623V	0.05
COAD	chr3	172330683	Missense_Mutation	novel	T508A	0.04
COAD	chr3	172343086	Missense_Mutation	NA	P683S	0.24
COAD	chr3	172352898	Silent	novel	L870L	0.34
COAD	chr3	172307371	Missense_Mutation	novel	A357V	0.31
COAD	chr3	172334999	Missense_Mutation	rs770426040	T566M	0.17
COAD	chr3	172352939	Missense_Mutation	rs201267676	A884V	0.11
COAD	chr3	172333129	Missense_Mutation	NA	T532S	0.42
COAD	chr3	172352824	Missense_Mutation	novel	G846W	0.12
COAD	chr3	172330554	Missense_Mutation	novel	E465Q	0.13
COAD	chr3	172251496	Nonsense_Mutation	novel	R249*	0.11
COAD	chr3	172329057	Nonsense_Mutation	novel	R454*	0.16
COAD	chr3	172381006	Missense_Mutation	NA	I1072M	0.23
COAD	chr3	172329029	Silent	NA	A444A	0.21
COAD	chr3	172251475	Frame_Shift_Ins	novel	*P242Lfs5**	0.12
COAD	chr3	172378419	Frame_Shift_Ins	rs769012096	*T1056Hfs16**	0.43
COAD	chr3	172247737	Missense_Mutation	novel	P157T	0.37
COAD	chr3	172352855	Missense_Mutation	rs202127932	T856M	0.2
DLBC	chr3	172307384	Silent	rs756597691	S361S	0.49
ESCA	chr3	172378420	Frame_Shift_Del	rs776920749	*T1056Pfs7**	0.35
ESCA	chr3	172381017	Missense_Mutation	rs752282685	T1076M	0.09
ESCA	chr3	172400291	3'UTR	novel		0.17
ESCA	chr3	172251383	Missense_Mutation	novel	S211F	0.12
ESCA	chr3	172398330	3'UTR	novel		0.1
ESCA	chr3	172186790	Intron	novel		0.6
ESCA	chr3	172399921	3'UTR	novel		0.25
ESCA	chr3	172397279	Missense_Mutation	novel	G1140V	0.17
ESCA	chr3	172397518	3'UTR	novel		0.2
GBM	chr3	172352967	Silent	rs764625583	P893P	0.42
GBM	chr3	172328994	Missense_Mutation	novel	Q433K	0.05
GBM	chr3	172251357	Silent	novel	R202R	0.09
GBM	chr3	172346353	Missense_Mutation	novel	E759D	0.11
GBM	chr3	172247724	Silent	rs201662937	P152P	0.39
GBM	chr3	172251496	Nonsense_Mutation	novel	R249*	0.46
GBM	chr3	172251364	Missense_Mutation	rs371734932	R205C	0.81
GBM	chr3	172378353	Missense_Mutation	NA	Q1031R	0.29
GBM	chr3	172330701	Nonsense_Mutation	novel	Q514*	0.05
GBM	chr3	172378290	Missense_Mutation	NA	G1010E	0.39
GBM	chr3	172329017	Missense_Mutation	novel	K440N	0.14
HNSC	chr3	172352952	Silent	NA	L888L	0.27
HNSC	chr3	172307425	Missense_Mutation	novel	H375L	0.21
HNSC	chr3	172285966	Silent	rs115364239	S277S	0.25
HNSC	chr3	172352899	Missense_Mutation	novel	E871Q	0.28
HNSC	chr3	172329026	Silent	novel	P443P	0.15
HNSC	chr3	172251479	Missense_Mutation	novel	G243E	0.2
HNSC	chr3	172378364	Missense_Mutation	rs751522795	E1035K	0.55
HNSC	chr3	172341229	Nonsense_Mutation	novel	Q657*	0.53
HNSC	chr3	172285973	Missense_Mutation	NA	E280K	0.33
KIRC	chr3	172378423	Silent	NA	P1054P	0.08
KIRC	chr3	172343107	Missense_Mutation	rs557648244	L690V	0.45
KIRP	chr3	172251350	Missense_Mutation	NA	I200N	0.6
KIRP	chr3	172347221	Missense_Mutation	novel	S792C	0.49
KIRP	chr3	172307402	Silent	NA	S367S	0.3
LAML	chr3	172329017	Missense_Mutation	novel	K440N	0.29
LGG	chr3	172251386	Missense_Mutation	novel	S212F	0.31
LGG	chr3	172347213	Missense_Mutation	novel	S789I	0.36
LGG	chr3	172337472	Intron	novel		0.22
LGG	chr3	172337473	Intron	novel		0.22
LIHC	chr3	172226939	Missense_Mutation	novel	I86L	0.26
LIHC	chr3	172330626	Missense_Mutation	NA	T489S	0.18
LIHC	chr3	172380983	Silent	NA	L1065L	0.32
LIHC	chr3	172247680	Missense_Mutation	NA	H138Y	0.4
LUAD	chr3	172307483	Silent	NA	S394S	0.31
LUAD	chr3	172344250	Missense_Mutation	novel	D748H	0.08
LUAD	chr3	172344254	Missense_Mutation	novel	G749A	0.11
LUAD	chr3	172341179	Missense_Mutation	NA	G640V	0.28
LUAD	chr3	172247680	Missense_Mutation	NA	H138Y	0.22
LUAD	chr3	172397292	Silent	rs180793348	P1144P	0.12
LUAD	chr3	172381017	Missense_Mutation	NA	T1076R	0.21
LUAD	chr3	172112536	Silent	NA	L19L	0.2
LUAD	chr3	172247558	Missense_Mutation	NA	R97L	0.2
LUAD	chr3	172307398	Missense_Mutation	novel	C366F	0.2
LUAD	chr3	172335003	Silent	rs768206589	T567T	0.31
LUAD	chr3	172334946	Splice_Region	NA	L548L	0.11
LUAD	chr3	172347266	Missense_Mutation	novel	D807N	0.4
LUAD	chr3	172310875	Missense_Mutation	novel	W416C	0.14
LUAD	chr3	172347260	Nonsense_Mutation	novel	G805*	0.09
LUAD	chr3	172362633	Splice_Region	novel	R932R	0.22
LUAD	chr3	172310879	Missense_Mutation	NA	E418Q	0.16
LUSC	chr3	172330670	Silent	rs143644974	P503P	0.7
LUSC	chr3	172251532	Missense_Mutation	novel	D261Y	0.9
LUSC	chr3	172362681	Missense_Mutation	novel	Q948H	0.16
LUSC	chr3	172397199	Silent	novel	S1113S	0.06
LUSC	chr3	172112566	Missense_Mutation	novel	L29F	0.1
LUSC	chr3	172298752	Silent	novel	L342L	0.11
LUSC	chr3	172335035	Missense_Mutation	rs144437924	P578L	0.09
LUSC	chr3	172337416	Intron	novel		0.06
LUSC	chr3	172247656	Missense_Mutation	NA	H130Y	0.59
LUSC	chr3	172334999	Missense_Mutation	novel	T566R	0.16
LUSC	chr3	172378437	Splice_Site	novel	X1059_splice	0.33
LUSC	chr3	172362630	Splice_Region	novel		0.13
LUSC	chr3	172381082	Missense_Mutation	NA	E1098Q	0.04
LUSC	chr3	172381048	Missense_Mutation	novel	N1086K	0.44
LUSC	chr3	172362660	Silent	novel	I941I	0.19
LUSC	chr3	172346381	Missense_Mutation	novel	Q769E	0.25
LUSC	chr3	172251409	Missense_Mutation	NA	T220A	0.49
LUSC	chr3	172362686	Missense_Mutation	NA	I950T	0.43
OV	chr3	172352808	Missense_Mutation	novel	F840L	0.14
OV	chr3	172247767	Missense_Mutation	novel	G167C	0.06
OV	chr3	172353058	Missense_Mutation	novel	D924H	0.05
OV	chr3	172310875	Frame_Shift_Ins	novel	D417*	0.11
OV	chr3	172352842	Missense_Mutation	novel	V852I	0.4
OV	chr3	172352824	Missense_Mutation	novel	G846W	0.05
OV	chr3	172362743	Missense_Mutation	NA	A969D	0.13
PAAD	chr3	172310837	Missense_Mutation	novel	D404H	0.03
PRAD	chr3	172378280	Missense_Mutation	novel	I1007V	0.49
PRAD	chr3	172295511	Missense_Mutation	novel	Y333C	0.09
PRAD	chr3	172329022	Missense_Mutation	novel	C442Y	0.4
READ	chr3	172251465	Silent	NA	S238S	0.36
READ	chr3	172347337	Silent	NA	A830A	0.21
READ	chr3	172251521	Missense_Mutation	rs768417527	S257L	0.4
READ	chr3	172295367	Missense_Mutation	novel	S285Y	0.4
READ	chr3	172295461	Silent	rs139237887	Y316Y	0.38
READ	chr3	172344129	Missense_Mutation	novel	S707R	0.08
READ	chr3	172346403	Missense_Mutation	novel	S776Y	0.46
READ	chr3	172337494	Intron	novel		0.11
SKCM	chr3	172285973	Missense_Mutation	NA	E280K	0.28
SKCM	chr3	172247641	Missense_Mutation	novel	P125S	0.4
SKCM	chr3	172307401	Missense_Mutation	novel	S367F	0.34
SKCM	chr3	172295462	Missense_Mutation	rs753474526	E317K	0.31
SKCM	chr3	172307445	Missense_Mutation	novel	P382S	0.33
SKCM	chr3	172307403	Missense_Mutation	rs757580289	E368K	0.26
SKCM	chr3	172334949	Silent	NA	T549T	0.1
SKCM	chr3	172362700	Missense_Mutation	rs751768080	R955W	0.3
SKCM	chr3	172247671	Missense_Mutation	NA	H135Y	0.21
SKCM	chr3	172337404	Splice_Region	novel		0.26
SKCM	chr3	172329040	Missense_Mutation	NA	T448I	0.21
SKCM	chr3	172247739	Silent	NA	P157P	0.26
SKCM	chr3	172295497	Silent	NA	K328K	0.12
SKCM	chr3	172330602	Missense_Mutation	novel	P481T	0.29
SKCM	chr3	172330603	Missense_Mutation	novel	P481L	0.29
SKCM	chr3	172247655	Silent	NA	H129H	0.17
SKCM	chr3	172378341	Missense_Mutation	novel	S1027F	0.48
SKCM	chr3	172378342	Silent	novel	S1027S	0.47
SKCM	chr3	172247585	Missense_Mutation	NA	P106L	0.49
SKCM	chr3	172353081	Splice_Region	novel	Y931Y	0.46
SKCM	chr3	172353082	Missense_Mutation	rs373434503	R932W	0.46
SKCM	chr3	172344198	Silent	rs200807692	V730V	0.45
SKCM	chr3	172307420	Silent	NA	T373T	0.37
SKCM	chr3	172251476	Missense_Mutation	NA	P242L	0.23
SKCM	chr3	172344098	Missense_Mutation	rs755249189	S697L	0.22
SKCM	chr3	172298765	Missense_Mutation	NA	P347S	0.33
SKCM	chr3	172362750	Silent	NA	P971P	0.16
SKCM	chr3	172337333	Missense_Mutation	novel	P595L	0.33
STAD	chr3	172344199	Missense_Mutation	rs780973777	G731S	0.2
STAD	chr3	172247557	Missense_Mutation	NA	R97C	0.09
STAD	chr3	172344148	Missense_Mutation	rs141201285	E714K	0.1
STAD	chr3	172397413	Missense_Mutation	novel	L1185F	0.13
STAD	chr3	172247591	Missense_Mutation	NA	C108Y	0.46
STAD	chr3	172247633	Missense_Mutation	NA	H122R	0.24
STAD	chr3	172295515	Splice_Site	NA	X334_splice	0.24
STAD	chr3	172247560	Missense_Mutation	NA	R98W	0.33
STAD	chr3	172247723	Missense_Mutation	rs754538002	P152L	0.22
STAD	chr3	172347283	Silent	NA	E812E	0.19
STAD	chr3	172397453	Missense_Mutation	NA	L1198S	0.29
UCEC	chr3	172133516	Missense_Mutation	novel	A53S	0.14
UCEC	chr3	172247738	Missense_Mutation	novel	P157L	0.05
UCEC	chr3	172251351	Silent	rs777654052	I200I	0.24
UCEC	chr3	172307376	Missense_Mutation	NA	Y359H	0.47
UCEC	chr3	172347225	Missense_Mutation	NA	S793Y	0.18
UCEC	chr3	172352807	Missense_Mutation	NA	F840S	0.2
UCEC	chr3	172247589	Silent	novel	E107E	0.41
UCEC	chr3	172341113	Missense_Mutation	rs139658890	A618V	0.34
UCEC	chr3	172399654	3'UTR	novel		0.39
UCEC	chr3	172381006	Missense_Mutation	NA	I1072M	0.17
UCEC	chr3	172334982	Missense_Mutation	NA	S560R	0.05
UCEC	chr3	172397601	3'UTR	novel		0.53
UCEC	chr3	172399220	3'UTR	novel		0.45
UCEC	chr3	172344098	Missense_Mutation	rs755249189	S697L	0.36
UCEC	chr3	172328974	Missense_Mutation	novel	R426K	0.45
UCEC	chr3	172344191	Missense_Mutation	rs777849570	C728Y	0.38
UCEC	chr3	172400039	3'UTR	novel		0.52
UCEC	chr3	172295487	Missense_Mutation	novel	R325L	0.32
UCEC	chr3	172251355	Missense_Mutation	rs190147254	R202C	0.25
UCEC	chr3	172347231	Missense_Mutation	NA	A795V	0.09
UCEC	chr3	172337336	Missense_Mutation	novel	P596L	0.05
UCEC	chr3	172112539	Silent	rs146058540	N20N	0.23
UCEC	chr3	172251496	Nonsense_Mutation	novel	R249*	0.35
UCEC	chr3	172330614	Nonsense_Mutation	NA	R485*	0.46
UCEC	chr3	172337450	Intron	novel		0.05
UCEC	chr3	172251356	Missense_Mutation	NA	R202L	0.39
UCEC	chr3	172344098	Missense_Mutation	rs755249189	S697L	0.11
UCEC	chr3	172398920	3'UTR	novel		0.45
UCEC	chr3	172330614	Nonsense_Mutation	NA	R485*	0.35
UCEC	chr3	172399451	3'UTR	novel		0.37
UCEC	chr3	172251297	Silent	novel	T182T	0.08
UCEC	chr3	172397377	Missense_Mutation	novel	M1173V	0.15
UCEC	chr3	172307450	Frame_Shift_Del	novel	*P385Lfs11**	0.24
UCEC	chr3	172251496	Nonsense_Mutation	novel	R249*	0.5
UCEC	chr3	172307402	Silent	rs145255541	S367S	0.46
UCEC	chr3	172352829	Silent	rs147677058	P847P	0.32
UCEC	chr3	172397240	Missense_Mutation	rs749504946	A1127V	0.43
UCEC	chr3	172399424	3'UTR	rs779771121		0.49
UCEC	chr3	172399394	3'UTR	novel		0.39
UCEC	chr3	172397298	Silent	rs572571045	A1146A	0.27
UCEC	chr3	172298756	Missense_Mutation	novel	D344Y	0.29
UCEC	chr3	172341113	Missense_Mutation	rs139658890	A618V	0.46
UCEC	chr3	172399489	3'UTR	novel		0.33
UCEC	chr3	172362779	Missense_Mutation	novel	S981I	0.38
UCEC	chr3	172378437	Splice_Site	novel	X1059_splice	0.45
UCEC	chr3	172399287	3'UTR	novel		0.35
UCEC	chr3	172399405	3'UTR	novel		0.39
UCEC	chr3	172186961	Intron	novel		0.63
UCEC	chr3	172398410	3'UTR	novel		0.44
UCEC	chr3	172337344	Missense_Mutation	NA	N599D	0.06
UCEC	chr3	172112529	Missense_Mutation	NA	P17L	0.26
UCEC	chr3	172330627	Missense_Mutation	novel	T489I	0.44
UCEC	chr3	172399394	3'UTR	novel		0.59
UCEC	chr3	172334970	Missense_Mutation	novel	K556N	0.53
UCEC	chr3	172399105	3'UTR	novel		0.06
UCEC	chr3	172398868	3'UTR	novel		0.3
UCEC	chr3	172399215	3'UTR	novel		0.43
UCEC	chr3	172378419	Frame_Shift_Ins	rs769012096	*T1056Hfs16**	0.33
UCEC	chr3	172397674	3'UTR	rs572453554		0.4
UCEC	chr3	172186950	Intron	novel		0.3
UCEC	chr3	172247655	Missense_Mutation	novel	H129Q	0.31
UCEC	chr3	172295429	Missense_Mutation	novel	P306T	0.44
UCEC	chr3	172334952	Silent	novel	A550A	0.36
UCEC	chr3	172399394	3'UTR	novel		0.41
UCEC	chr3	172186824	Intron	novel		0.38
UCEC	chr3	172346403	Missense_Mutation	novel	S776F	0.32
UCEC	chr3	172398902	3'UTR	novel		0.33
UCEC	chr3	172399434	3'UTR	novel		0.19
UCEC	chr3	172400025	3'UTR	novel		0.36
UCEC	chr3	172398801	3'UTR	novel		0.17
UCEC	chr3	172397277	Silent	rs147667100	S1139S	0.5
UCEC	chr3	172341113	Missense_Mutation	rs139658890	A618V	0.26
UCEC	chr3	172399394	3'UTR	novel		0.29
UCEC	chr3	172310855	Missense_Mutation	novel	T410A	0.31
UCEC	chr3	172399321	3'UTR	novel		0.16
UCEC	chr3	172397600	3'UTR	rs535706239		0.4
UCEC	chr3	172330637	Silent	rs566667380	T492T	0.33
UCEC	chr3	172352939	Missense_Mutation	rs201267676	A884V	0.12
UCEC	chr3	172397297	Missense_Mutation	NA	A1146V	0.04
UCEC	chr3	172397211	Silent	novel	T1117T	0.48
UCEC	chr3	172295486	Silent	NA	R325R	0.08
UCEC	chr3	172251502	Missense_Mutation	novel	A251S	0.09
UCEC	chr3	172251299	Missense_Mutation	rs780386473	R183Q	0.42
UCEC	chr3	172353075	Frame_Shift_Ins	novel	T930*	0.05
UCEC	chr3	172353076	In_Frame_Ins	novel	T930_Y931insASPVVS	0.05
UCEC	chr3	172247772	Silent	novel	E168E	0.52
UCEC	chr3	172352843	Missense_Mutation	novel	V852A	0.21
UCEC	chr3	172295457	Missense_Mutation	novel	S315N	0.49
UCEC	chr3	172400690	3'UTR	novel		0.22
UCEC	chr3	172285954	Missense_Mutation	NA	Q273H	0.29
UCEC	chr3	172381005	Frame_Shift_Del	novel	*L1073Yfs8**	0.07
UCEC	chr3	172343038	Missense_Mutation	NA	L667V	0.24
UCEC	chr3	172186833	Intron	novel		0.33
UCEC	chr3	172330670	Silent	rs143644974	P503P	0.38
UCEC	chr3	172400484	3'UTR	novel		0.35
UCS	chr3	172112504	Missense_Mutation	rs780399563	D9N	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4461	0.0018563
CESC	AMP	0.739	2.3522e-34
KIRC	AMP	0.1212	2.0306e-05
KIRP	AMP	0.3299	0.15981
PAAD	AMP	0.1141	0.16151
SARC	DEL	0.179	0.0086757
TGCT	AMP	0.2467	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
STAD	0.023	Kaplan-Meier Survival Analysis
SARC	0.032	Kaplan-Meier Survival Analysis
MESO	0.0031	Kaplan-Meier Survival Analysis
ACC	0.0033	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
KIRP	0.0012	Kaplan-Meier Survival Analysis
PAAD	0.00018	Kaplan-Meier Survival Analysis
BLCA	0.043	Kaplan-Meier Survival Analysis
CESC	0.00015	Kaplan-Meier Survival Analysis
READ	0.045	Kaplan-Meier Survival Analysis
LAML	0.00011	Kaplan-Meier Survival Analysis
KICH	0.0068	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
GBM	0.00024	Kaplan-Meier Survival Analysis
LIHC	0.0018	Kaplan-Meier Survival Analysis
LUAD	0.0017	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742