EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000076003 (Gene tree)
Gene ID: 4175
Gene Symbol: MCM6
Alias: Mis5
Full Name: minichromosome maintenance complex component 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 36,852 bases
Position: chr2:135,839,626-135,876,477
Accession: 6949
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000264156	MCM6-201	3736	-	ENSP00000264156	821 (aa)	-	Q14566
ENST00000483902	MCM6-202	577	-	-	- (aa)	-	-
ENST00000492091	MCM6-203	712	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000076003's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa04110	Cell cycle	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000076003	alpha-Linolenic Acid	2.4780000E-005	21829377
ENSG00000076003	Body Mass Index	2E-6	25673413
ENSG00000076003	Body Mass Index	5E-6	25673413
ENSG00000076003	Hip	2E-8	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000076003	rs4988235	2	135851076	A	Hip circumference	25673412	[0.014-0.029] unit increase	0.0217	EFO_0005093
ENSG00000076003	rs4988198	2	135861240	?	Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes	28736931	unit increase	0.058	GO_1903491\|EFO_0001360\|EFO_0007806\|GO_1901557
ENSG00000076003	rs4988235	2	135851076	A	Blood protein levels	29875488	[0.74-0.82] unit increase	0.78	EFO_0007937
ENSG00000076003	rs4988235	2	135851076	A	Body mass index	26426971	unit increase	0.0183999	EFO_0004340
ENSG00000076003	rs4988235	2	135851076	G	Body mass index	30108127	[NR] unit decrease	0.016	EFO_0004340
ENSG00000076003	rs4988235	2	135851076	G	Blood protein levels	30072576	[0.91-1.02] unit decrease	0.963	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000076003's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000076003	MCM6	78	30.647	WBGene00003157	mcm-5	85	30.647	Caenorhabditis_elegans
ENSG00000076003	MCM6	65	36.890	FBgn0017577	Mcm5	71	36.890	Drosophila_melanogaster
ENSG00000076003	MCM6	68	37.213	FBgn0020633	Mcm7	72	37.743	Drosophila_melanogaster
ENSG00000076003	MCM6	67	35.842	ENSG00000166508	MCM7	85	35.882	Homo_sapiens
ENSG00000076003	MCM6	67	33.333	ENSG00000100297	MCM5	73	33.824	Homo_sapiens
ENSG00000076003	MCM6	79	30.835	ENSG00000112118	MCM3	79	31.060	Homo_sapiens
ENSG00000076003	MCM6	65	34.944	ENSMUSG00000029730	Mcm7	85	30.579	Mus_musculus
ENSG00000076003	MCM6	77	31.259	ENSMUSG00000041859	Mcm3	79	31.259	Mus_musculus
ENSG00000076003	MCM6	83	48.257	YGL201C		73	47.383	Saccharomyces_cerevisiae
ENSG00000076003	MCM6	66	34.021	YLR274W	MCM5	71	33.849	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0003697	single-stranded DNA binding	-	IEA	Function
GO:0004003	ATP-dependent DNA helicase activity	9305914.	IDA	Function
GO:0005515	protein binding	11095689.15232106.16189514.16438930.16899510.16902406.17296731.17955473.20202939.22190034.22540012.23764002.24299456.25036637.25416956.26167883.26496610.29290612.29426014.	IPI	Function
GO:0005524	ATP binding	9286856.	NAS	Function
GO:0005634	nucleus	16899510.	IDA	Component
GO:0005634	nucleus	9286856.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006260	DNA replication	9286856.	NAS	Process
GO:0006260	DNA replication	-	TAS	Process
GO:0006268	DNA unwinding involved in DNA replication	-	IEA	Process
GO:0006270	DNA replication initiation	-	IEA	Process
GO:0042555	MCM complex	17296731.	IDA	Component
GO:0042802	identical protein binding	15232106.16189514.	IPI	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17410335	Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.	J Neurooncol	2007 Jun	Xu J	-
17294730	[Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis].	Sichuan Da Xue Xue Bao Yi Xue Ban	2007 Jan	Xu JG	-
29243125	Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma.	Virchows Arch	2018 Apr	Hotton J	doi: 10.1007/s00428-017-2278-9

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	135846367	Silent	NA	V693V	0.51
BLCA	chr2	135846275	Missense_Mutation	NA	S724C	0.58
BLCA	chr2	135859342	Missense_Mutation	novel	E441Q	0.16
BLCA	chr2	135868757	Silent	NA	L157L	0.29
BLCA	chr2	135862702	Silent	rs767725842	G375G	0.41
BLCA	chr2	135852869	Missense_Mutation	NA	R558K	0.1
BLCA	chr2	135856819	Missense_Mutation	novel	R512T	0.16
BLCA	chr2	135870327	Missense_Mutation	rs779470520	F97L	0.25
BLCA	chr2	135844662	Missense_Mutation	novel	K744N	0.39
BRCA	chr2	135848095	Missense_Mutation	NA	E671Q	0.2
BRCA	chr2	135844676	Missense_Mutation	rs377298657	E740K	0.39
BRCA	chr2	135870257	Missense_Mutation	novel	R120K	0.23
BRCA	chr2	135851564	Splice_Site	novel	X586_splice	0.18
BRCA	chr2	135848148	Missense_Mutation	novel	N653I	0.13
BRCA	chr2	135840836	Nonstop_Mutation	NA	822Sext6	0.17
CESC	chr2	135865098	Silent	novel	V331V	0.18
CESC	chr2	135840899	Missense_Mutation	NA	G801E	0.16
CESC	chr2	135868646	Missense_Mutation	NA	D194N	0.19
COAD	chr2	135870315	Missense_Mutation	rs767037709	R101C	0.47
COAD	chr2	135848157	Missense_Mutation	novel	R650Q	0.25
COAD	chr2	135865043	Missense_Mutation	novel	L350I	0.29
COAD	chr2	135866215	Nonsense_Mutation	NA	R282*	0.1
COAD	chr2	135844583	Frame_Shift_Del	NA	*R771Efs3**	0.33
COAD	chr2	135840651	3'UTR	novel		0.41
COAD	chr2	135856847	Missense_Mutation	novel	A503T	0.07
COAD	chr2	135862701	Missense_Mutation	rs759630336	V376I	0.36
COAD	chr2	135862732	Frame_Shift_Del	novel	*K365Nfs6**	0.23
COAD	chr2	135856863	Silent	novel	T497T	0.33
COAD	chr2	135840822	3'UTR	novel		0.35
COAD	chr2	135844592	Missense_Mutation	NA	N768H	0.19
COAD	chr2	135865014	Splice_Region	novel	H359H	0.2
COAD	chr2	135851464	Nonsense_Mutation	NA	R619*	0.36
COAD	chr2	135859424	Silent	rs760232150	S413S	0.14
COAD	chr2	135868669	Missense_Mutation	NA	A186V	0.23
COAD	chr2	135844619	Missense_Mutation	NA	E759Q	0.23
GBM	chr2	135862702	Silent	rs767725842	G375G	0.06
GBM	chr2	135866273	Silent	novel	A262A	0.11
GBM	chr2	135866274	Missense_Mutation	novel	A262V	0.09
GBM	chr2	135870362	Splice_Site	NA	X85_splice	0.27
GBM	chr2	135876378	5'UTR	novel		0.14
GBM	chr2	135857927	Silent	novel	Q480Q	0.14
GBM	chr2	135872824	Missense_Mutation	novel	E43K	0.32
GBM	chr2	135872767	Missense_Mutation	NA	V62L	0.07
GBM	chr2	135859330	Missense_Mutation	novel	E445K	0.1
HNSC	chr2	135856852	Missense_Mutation	novel	A501E	0.34
HNSC	chr2	135866148	Missense_Mutation	rs150278316	A304V	0.12
HNSC	chr2	135857925	Missense_Mutation	novel	T481I	0.12
HNSC	chr2	135866169	Missense_Mutation	novel	V297A	0.05
HNSC	chr2	135862740	Missense_Mutation	novel	E363K	0.33
HNSC	chr2	135852870	Missense_Mutation	novel	R558G	0.37
KIRC	chr2	135876278	Missense_Mutation	novel	F30I	0.15
KIRP	chr2	135862631	Missense_Mutation	NA	S399I	0.44
KIRP	chr2	135862632	Missense_Mutation	NA	S399R	0.44
KIRP	chr2	135846277	Silent	novel	I723I	0.35
KIRP	chr2	135856868	Missense_Mutation	novel	R496W	0.29
LAML	chr2	135844666	Nonsense_Mutation	novel	L743*	0.03
LGG	chr2	135865012	Splice_Site	novel	X360_splice	0.37
LGG	chr2	135868646	Missense_Mutation	NA	D194Y	0.04
LGG	chr2	135868640	Missense_Mutation	novel	N196D	0.12
LGG	chr2	135876403	5'UTR	novel		0.63
LIHC	chr2	135865123	Missense_Mutation	novel	E323V	0.35
LIHC	chr2	135851523	Missense_Mutation	novel	K599I	0.24
LIHC	chr2	135868810	Missense_Mutation	novel	G139E	0.05
LUAD	chr2	135844574	Missense_Mutation	novel	E774Q	0.1
LUAD	chr2	135868799	Missense_Mutation	rs750353136	R143W	0.21
LUAD	chr2	135876308	Missense_Mutation	novel	D20Y	0.25
LUAD	chr2	135872705	Silent	novel	E82E	0.5
LUAD	chr2	135848071	Missense_Mutation	NA	G679C	0.16
LUAD	chr2	135876314	Missense_Mutation	NA	V18I	0.11
LUAD	chr2	135868710	Missense_Mutation	NA	F172L	0.11
LUAD	chr2	135862671	Missense_Mutation	novel	L386I	0.1
LUAD	chr2	135848156	Silent	NA	R650R	0.13
LUAD	chr2	135840934	Missense_Mutation	novel	E789D	0.44
LUAD	chr2	135851433	Missense_Mutation	NA	E629V	0.33
LUAD	chr2	135851465	Silent	NA	V618V	0.65
LUAD	chr2	135866205	Missense_Mutation	NA	R285L	0.45
LUAD	chr2	135840899	Missense_Mutation	NA	G801E	0.16
LUAD	chr2	135872755	Missense_Mutation	NA	V66M	0.16
LUAD	chr2	135868728	Missense_Mutation	novel	R166S	0.12
LUSC	chr2	135846326	Missense_Mutation	novel	S707C	0.4
LUSC	chr2	135840803	3'UTR	novel		0.16
LUSC	chr2	135846331	Silent	novel	Q705Q	0.19
LUSC	chr2	135876305	Missense_Mutation	NA	E21K	0.37
LUSC	chr2	135868757	Silent	NA	L157L	0.34
LUSC	chr2	135859443	Splice_Site	NA	X407_splice	0.15
LUSC	chr2	135872697	Missense_Mutation	novel	R85K	0.11
LUSC	chr2	135856871	Missense_Mutation	rs759786957	A495S	0.21
LUSC	chr2	135862717	Silent	NA	L370L	0.38
LUSC	chr2	135872780	Silent	novel	E57E	0.1
LUSC	chr2	135868805	Missense_Mutation	NA	V141L	0.62
OV	chr2	135859371	Missense_Mutation	NA	A431V	0.19
OV	chr2	135870340	Silent	NA	R92R	0.12
OV	chr2	135840952	Splice_Site	novel	X784_splice	0.41
OV	chr2	135866266	Missense_Mutation	novel	E265K	0.09
PAAD	chr2	135844562	Missense_Mutation	novel	H778Y	0.29
PAAD	chr2	135844638	Nonsense_Mutation	novel	Y752*	0.08
PAAD	chr2	135852891	Missense_Mutation	rs564036914	R551C	0.26
PAAD	chr2	135852899	Missense_Mutation	novel	I548T	0.25
PAAD	chr2	135856764	Silent	rs372757156	F530F	0.31
PAAD	chr2	135870360	Missense_Mutation	novel	V86I	0.29
PAAD	chr2	135848134	Missense_Mutation	rs142938887	R658C	0.51
PRAD	chr2	135852890	Missense_Mutation	rs200697022	R551H	0.16
PRAD	chr2	135866214	Missense_Mutation	rs780556954	R282Q	0.14
PRAD	chr2	135848138	Silent	rs773560866	I656I	0.17
READ	chr2	135844645	Missense_Mutation	rs754663697	N750S	0.3
READ	chr2	135868856	Nonsense_Mutation	NA	R124*	0.34
READ	chr2	135862702	Silent	rs767725842	G375G	0.37
READ	chr2	135856763	Missense_Mutation	novel	D531N	0.41
READ	chr2	135862611	Missense_Mutation	novel	L406I	0.38
SARC	chr2	135856783	Missense_Mutation	novel	A524D	0.09
SKCM	chr2	135856768	Missense_Mutation	NA	R529Q	0.4
SKCM	chr2	135852849	Missense_Mutation	NA	R565C	0.29
SKCM	chr2	135862675	Silent	NA	T384T	0.31
SKCM	chr2	135870316	Silent	NA	D100D	0.59
SKCM	chr2	135851475	Missense_Mutation	NA	R615K	0.17
SKCM	chr2	135866682	Missense_Mutation	NA	P221L	0.35
SKCM	chr2	135866725	Missense_Mutation	rs201824504	R207C	0.15
SKCM	chr2	135851443	Missense_Mutation	novel	R626C	0.44
SKCM	chr2	135872704	Missense_Mutation	NA	F83L	0.22
SKCM	chr2	135856748	Missense_Mutation	novel	L536F	0.43
SKCM	chr2	135846320	Missense_Mutation	novel	P709L	0.27
STAD	chr2	135859321	Missense_Mutation	NA	A448P	0.35
STAD	chr2	135859390	Missense_Mutation	NA	S425G	0.22
STAD	chr2	135866679	Missense_Mutation	rs773959284	R222H	0.17
STAD	chr2	135866156	Nonsense_Mutation	novel	C301*	0.14
STAD	chr2	135866575	Missense_Mutation	rs769922696	L257F	0.11
STAD	chr2	135868685	Nonsense_Mutation	novel	R181*	0.16
STAD	chr2	135872707	Missense_Mutation	novel	E82K	0.28
STAD	chr2	135844677	Silent	rs774404951	D739D	0.28
STAD	chr2	135866661	Frame_Shift_Del	novel	L228*	0.18
STAD	chr2	135868679	Missense_Mutation	NA	P183S	0.32
STAD	chr2	135866143	Missense_Mutation	NA	T306P	0.1
STAD	chr2	135856826	Missense_Mutation	NA	Y510H	0.19
STAD	chr2	135852892	Frame_Shift_Del	novel	*R550Sfs3**	0.22
STAD	chr2	135862667	Missense_Mutation	NA	R387Q	0.28
STAD	chr2	135856872	Silent	rs554092858	N494N	0.21
TGCT	chr2	135876260	Missense_Mutation	rs769402048	E36K	0.32
UCEC	chr2	135866705	Silent	NA	A213A	0.38
UCEC	chr2	135872702	Missense_Mutation	NA	F83L	0.24
UCEC	chr2	135870290	Missense_Mutation	NA	D109A	0.13
UCEC	chr2	135851464	Nonsense_Mutation	NA	R619*	0.1
UCEC	chr2	135866713	Missense_Mutation	novel	T211P	0.08
UCEC	chr2	135856850	Missense_Mutation	novel	A502T	0.43
UCEC	chr2	135851464	Nonsense_Mutation	NA	R619*	0.4
UCEC	chr2	135866584	Missense_Mutation	rs762490656	V254I	0.51
UCEC	chr2	135851453	Missense_Mutation	NA	E622D	0.33
UCEC	chr2	135862609	Splice_Region	NA	L406L	0.41
UCEC	chr2	135840774	3'UTR	novel		0.37
UCEC	chr2	135859335	Missense_Mutation	novel	V443A	0.11
UCEC	chr2	135859395	Missense_Mutation	rs771453730	A423V	0.31
UCEC	chr2	135844583	Frame_Shift_Del	NA	*R771Efs3**	0.44
UCEC	chr2	135868657	Missense_Mutation	novel	R190I	0.53
UCEC	chr2	135872710	Missense_Mutation	novel	E81K	0.31
UCEC	chr2	135846314	Missense_Mutation	novel	A711V	0.33
UCEC	chr2	135856784	Missense_Mutation	novel	A524T	0.35
UCEC	chr2	135851533	Nonsense_Mutation	novel	E596*	0.29
UCEC	chr2	135859442	Splice_Region	novel	K407K	0.28
UCEC	chr2	135865074	Silent	NA	E339E	0.16
UCEC	chr2	135844617	Missense_Mutation	novel	E759D	0.33
UCEC	chr2	135872773	Missense_Mutation	novel	T60A	0.41
UCEC	chr2	135844563	Missense_Mutation	novel	I777M	0.42
UCEC	chr2	135856819	Missense_Mutation	novel	R512I	0.44
UCEC	chr2	135856768	Missense_Mutation	NA	R529Q	0.27
UCEC	chr2	135851499	Missense_Mutation	novel	S607Y	0.14
UCEC	chr2	135851514	Missense_Mutation	rs184578188	R602H	0.52
UCEC	chr2	135840945	In_Frame_Ins	novel	H785_V786insTT	0.06
UCEC	chr2	135846282	Nonsense_Mutation	novel	R722*	0.25
UCEC	chr2	135852877	Silent	novel	L555L	0.16
UCEC	chr2	135859328	Missense_Mutation	novel	E445D	0.2
UCEC	chr2	135868856	Nonsense_Mutation	NA	R124*	0.17
UCEC	chr2	135866591	Silent	NA	V251V	0.33
UCEC	chr2	135840901	Silent	novel	E800E	0.4
UCS	chr2	135840947	Missense_Mutation	novel	H785R	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1889	0.15279
COAD	DEL	0.0266	0.13394
DLBC	DEL	0.125	0.01124
PAAD	DEL	0.0435	0.2014
PRAD	DEL	0.1545	4.4558e-21

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0021	Kaplan-Meier Survival Analysis
KIRC	0.016	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
PRAD	0.046	Kaplan-Meier Survival Analysis
LUSC	0.0081	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
COAD	0.015	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
CESC	0.0061	Kaplan-Meier Survival Analysis
READ	0.017	Kaplan-Meier Survival Analysis
KICH	0.0055	Kaplan-Meier Survival Analysis
UCEC	0.005	Kaplan-Meier Survival Analysis
GBM	0.043	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00091	Kaplan-Meier Survival Analysis
UVM	0.0011	Kaplan-Meier Survival Analysis
OV	0.034	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742