EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000076108 (Gene tree)
Gene ID: 11176
Gene Symbol: BAZ2A
Alias: KIAA0314|TIP5|WALp3
Full Name: bromodomain adjacent to zinc finger domain 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 41,221 bases
Position: chr12:56,595,596-56,636,816
Accession: 962
RBP type: canonical RBP
Summary: (Bromodomain Adjacent To Zinc Finger Domain 2A) is a Protein Coding gene. Diseases associated with BAZ2A include Acute Maxillary Sinusitis and Retinitis Pigmentosa 20. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and lysine-acetylated histone binding. An important paralog of this gene is BAZ2B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447941	MBD	PF01429.19	1.5e-19	1	1
ENSP00000446880	MBD	PF01429.19	1.5e-19	1	1
ENSP00000368754	MBD	PF01429.19	1.5e-19	1	1
ENSP00000449473	MBD	PF01429.19	9.6e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16678107	Intergenic transcripts regulate the epigenetic state of rRNA genes.	Mol Cell	2006 May 5	Mayer C	-
19578370	Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.	Nat Cell Biol	2009 Aug	Zhou Y	doi: 10.1038/ncb1914
25916849	A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.	Nucleic Acids Res	2015 May 26	Anosova I	doi: 10.1093/nar/gkv365

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000547650	BAZ2A-205	614	-	ENSP00000449473	205 (aa)	-	H0YII3
ENST00000549763	BAZ2A-209	657	-	-	- (aa)	-	-
ENST00000549787	BAZ2A-210	2773	-	ENSP00000448760	837 (aa)	-	A0A0C4DGI9
ENST00000548578	BAZ2A-206	1002	-	-	- (aa)	-	-
ENST00000547453	BAZ2A-203	484	-	ENSP00000447314	162 (aa)	-	H0YHL2
ENST00000546695	BAZ2A-202	722	-	ENSP00000449496	131 (aa)	-	F8VWQ3
ENST00000549327	BAZ2A-207	421	-	-	- (aa)	-	-
ENST00000551812	BAZ2A-214	8600	XM_011537801	ENSP00000446880	1905 (aa)	XP_011536103	Q9UIF9
ENST00000551996	BAZ2A-216	849	-	ENSP00000447591	277 (aa)	-	H0YHQ7
ENST00000553222	BAZ2A-217	681	-	-	- (aa)	-	-
ENST00000549884	BAZ2A-211	6050	XM_011537803	ENSP00000447941	1903 (aa)	XP_011536105	F8VU39
ENST00000551759	BAZ2A-213	833	-	-	- (aa)	-	-
ENST00000379441	BAZ2A-201	8831	-	ENSP00000368754	1875 (aa)	-	J3KPG5
ENST00000551959	BAZ2A-215	483	-	-	- (aa)	-	-
ENST00000547647	BAZ2A-204	570	-	-	- (aa)	-	-
ENST00000550730	BAZ2A-212	515	-	-	- (aa)	-	-
ENST00000549506	BAZ2A-208	577	-	ENSP00000447248	116 (aa)	-	F8W053

Gene Model

Click here to download ENSG00000076108's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000076108	Blood Pressure	1.8454736E-005	-
ENSG00000076108	Platelet Count	2E-10	22139419

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000076108	rs7973618	12	56625659	C	Mean platelet volume	27863252	[0.071-0.086] unit decrease	0.07865918	EFO_0004584
ENSG00000076108	rs941207	12	56629500	G	Platelet count	22139419	[1.91-3.6] 10^9/l increase	2.751	EFO_0004309

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000076108's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000076108	BAZ2A	84	39.362	ENSG00000123636	BAZ2B	100	46.927

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000076108	BAZ2A	100	98.276	ENSAMEG00000004115	BAZ2A	99	91.155	Ailuropoda_melanoleuca
ENSG00000076108	BAZ2A	100	44.521	ENSAOCG00000005016	baz2a	50	46.805	Amphiprion_ocellaris
ENSG00000076108	BAZ2A	98	43.559	ENSATEG00000016605	baz2a	52	46.066	Anabas_testudineus
ENSG00000076108	BAZ2A	98	70.175	ENSACAG00000016700	BAZ2A	95	57.283	Anolis_carolinensis
ENSG00000076108	BAZ2A	100	99.138	ENSANAG00000019057	BAZ2A	100	96.535	Aotus_nancymaae
ENSG00000076108	BAZ2A	97	44.700	ENSAMXG00000001995	baz2a	52	45.955	Astyanax_mexicanus
ENSG00000076108	BAZ2A	100	99.237	ENSBTAG00000017840	BAZ2A	100	90.933	Bos_taurus
ENSG00000076108	BAZ2A	100	99.138	ENSCJAG00000010774	BAZ2A	100	94.704	Callithrix_jacchus
ENSG00000076108	BAZ2A	100	100.000	ENSCAFG00000000135	BAZ2A	100	91.061	Canis_familiaris
ENSG00000076108	BAZ2A	100	100.000	ENSCAFG00020024281	BAZ2A	100	90.063	Canis_lupus_dingo
ENSG00000076108	BAZ2A	100	98.473	ENSCHIG00000025797	BAZ2A	100	87.832	Capra_hircus
ENSG00000076108	BAZ2A	100	99.237	ENSTSYG00000008784	BAZ2A	100	90.446	Carlito_syrichta
ENSG00000076108	BAZ2A	100	96.947	ENSCPOG00000006404	BAZ2A	99	87.489	Cavia_porcellus
ENSG00000076108	BAZ2A	100	97.265	ENSCCAG00000033508	BAZ2A	100	96.931	Cebus_capucinus
ENSG00000076108	BAZ2A	100	99.237	ENSCATG00000042491	BAZ2A	100	97.957	Cercocebus_atys
ENSG00000076108	BAZ2A	100	96.183	ENSCLAG00000010711	BAZ2A	100	88.172	Chinchilla_lanigera
ENSG00000076108	BAZ2A	100	99.237	ENSCSAG00000005062	BAZ2A	99	98.008	Chlorocebus_sabaeus
ENSG00000076108	BAZ2A	100	99.237	ENSCHOG00000007335	BAZ2A	90	90.688	Choloepus_hoffmanni
ENSG00000076108	BAZ2A	100	99.237	ENSCANG00000000275	BAZ2A	100	98.324	Colobus_angolensis_palliatus
ENSG00000076108	BAZ2A	100	93.966	ENSCGRG00001005683	Baz2a	100	84.313	Cricetulus_griseus_chok1gshd
ENSG00000076108	BAZ2A	100	93.966	ENSCGRG00000007771	Baz2a	100	84.313	Cricetulus_griseus_crigri
ENSG00000076108	BAZ2A	99	44.138	ENSCVAG00000015916	baz2a	50	45.850	Cyprinodon_variegatus
ENSG00000076108	BAZ2A	97	44.521	ENSDARG00000102974	baz2a	53	46.299	Danio_rerio
ENSG00000076108	BAZ2A	100	98.473	ENSDNOG00000011221	BAZ2A	100	89.479	Dasypus_novemcinctus
ENSG00000076108	BAZ2A	95	96.800	ENSDORG00000009234	Baz2a	100	89.211	Dipodomys_ordii
ENSG00000076108	BAZ2A	100	95.420	ENSETEG00000010203	BAZ2A	91	87.084	Echinops_telfairi
ENSG00000076108	BAZ2A	100	98.473	ENSEASG00005006215	BAZ2A	100	90.795	Equus_asinus_asinus
ENSG00000076108	BAZ2A	100	99.237	ENSECAG00000018243	BAZ2A	100	91.481	Equus_caballus
ENSG00000076108	BAZ2A	100	100.000	ENSFCAG00000012029	BAZ2A	100	92.461	Felis_catus
ENSG00000076108	BAZ2A	100	98.473	ENSFDAG00000010784	BAZ2A	98	88.799	Fukomys_damarensis
ENSG00000076108	BAZ2A	61	58.647	ENSFHEG00000017715	baz2a	51	46.694	Fundulus_heteroclitus
ENSG00000076108	BAZ2A	100	44.898	ENSGMOG00000001100	baz2a	87	54.032	Gadus_morhua
ENSG00000076108	BAZ2A	100	42.568	ENSGAFG00000012444	baz2a	52	46.384	Gambusia_affinis
ENSG00000076108	BAZ2A	99	43.448	ENSGACG00000015232	baz2a	99	42.337	Gasterosteus_aculeatus
ENSG00000076108	BAZ2A	99	53.349	ENSGAGG00000000428	-	98	58.030	Gopherus_agassizii
ENSG00000076108	BAZ2A	100	100.000	ENSGGOG00000011580	BAZ2A	100	99.580	Gorilla_gorilla
ENSG00000076108	BAZ2A	99	42.282	ENSHBUG00000011999	baz2a	59	49.430	Haplochromis_burtoni
ENSG00000076108	BAZ2A	100	99.237	ENSHGLG00000009114	-	100	88.177	Heterocephalus_glaber_female
ENSG00000076108	BAZ2A	96	86.935	ENSHGLG00000003725	-	99	75.518	Heterocephalus_glaber_female
ENSG00000076108	BAZ2A	96	86.935	ENSHGLG00100000993	-	99	74.946	Heterocephalus_glaber_male
ENSG00000076108	BAZ2A	100	99.237	ENSHGLG00100011609	-	100	87.448	Heterocephalus_glaber_male
ENSG00000076108	BAZ2A	99	44.492	ENSHCOG00000019107	baz2a	55	47.859	Hippocampus_comes
ENSG00000076108	BAZ2A	100	99.237	ENSSTOG00000013452	BAZ2A	100	91.832	Ictidomys_tridecemlineatus
ENSG00000076108	BAZ2A	99	96.522	ENSJJAG00000009782	Baz2a	100	86.464	Jaculus_jaculus
ENSG00000076108	BAZ2A	100	42.000	ENSKMAG00000012331	baz2a	50	46.052	Kryptolebias_marmoratus
ENSG00000076108	BAZ2A	98	64.035	ENSLACG00000018672	BAZ2A	100	51.842	Latimeria_chalumnae
ENSG00000076108	BAZ2A	99	48.260	ENSLOCG00000007281	baz2a	85	51.768	Lepisosteus_oculatus
ENSG00000076108	BAZ2A	100	99.138	ENSLAFG00000008255	BAZ2A	100	89.659	Loxodonta_africana
ENSG00000076108	BAZ2A	100	99.237	ENSMFAG00000029840	BAZ2A	100	98.271	Macaca_fascicularis
ENSG00000076108	BAZ2A	100	99.237	ENSMMUG00000019332	BAZ2A	99	98.322	Macaca_mulatta
ENSG00000076108	BAZ2A	100	99.237	ENSMNEG00000034555	BAZ2A	100	98.219	Macaca_nemestrina
ENSG00000076108	BAZ2A	100	99.237	ENSMLEG00000042063	BAZ2A	100	98.271	Mandrillus_leucophaeus
ENSG00000076108	BAZ2A	99	42.282	ENSMZEG00005026049	baz2a	57	53.947	Maylandia_zebra
ENSG00000076108	BAZ2A	100	93.162	ENSMAUG00000020341	Baz2a	100	80.593	Mesocricetus_auratus
ENSG00000076108	BAZ2A	100	95.420	ENSMOCG00000012655	Baz2a	100	84.603	Microtus_ochrogaster
ENSG00000076108	BAZ2A	100	97.414	ENSMUSG00000040054	Baz2a	99	85.976	Mus_musculus
ENSG00000076108	BAZ2A	100	97.414	MGP_SPRETEiJ_G0016745	Baz2a	100	84.130	Mus_spretus
ENSG00000076108	BAZ2A	100	99.237	ENSMPUG00000001495	BAZ2A	100	90.127	Mustela_putorius_furo
ENSG00000076108	BAZ2A	100	98.473	ENSMLUG00000000546	-	96	90.201	Myotis_lucifugus
ENSG00000076108	BAZ2A	100	99.237	ENSNGAG00000021737	Baz2a	100	88.714	Nannospalax_galili
ENSG00000076108	BAZ2A	100	100.000	ENSNLEG00000017462	BAZ2A	100	98.481	Nomascus_leucogenys
ENSG00000076108	BAZ2A	100	92.241	ENSMEUG00000002868	BAZ2A	91	96.078	Notamacropus_eugenii
ENSG00000076108	BAZ2A	100	98.276	ENSOPRG00000001687	BAZ2A	98	84.208	Ochotona_princeps
ENSG00000076108	BAZ2A	100	96.947	ENSODEG00000005990	BAZ2A	99	87.435	Octodon_degus
ENSG00000076108	BAZ2A	99	46.324	ENSONIG00000017063	baz2a	99	48.656	Oreochromis_niloticus
ENSG00000076108	BAZ2A	100	98.473	ENSOCUG00000006079	BAZ2A	99	85.767	Oryctolagus_cuniculus
ENSG00000076108	BAZ2A	100	41.549	ENSORLG00000012214	baz2a	50	46.066	Oryzias_latipes
ENSG00000076108	BAZ2A	100	41.549	ENSORLG00020017841	baz2a	50	46.066	Oryzias_latipes_hni
ENSG00000076108	BAZ2A	100	41.549	ENSORLG00015012543	baz2a	50	45.871	Oryzias_latipes_hsok
ENSG00000076108	BAZ2A	99	42.797	ENSOMEG00000006706	baz2a	51	46.097	Oryzias_melastigma
ENSG00000076108	BAZ2A	100	96.183	ENSOGAG00000003537	BAZ2A	100	91.960	Otolemur_garnettii
ENSG00000076108	BAZ2A	100	98.473	ENSOARG00000008407	BAZ2A	100	90.509	Ovis_aries
ENSG00000076108	BAZ2A	100	100.000	ENSPPAG00000003707	BAZ2A	100	99.685	Pan_paniscus
ENSG00000076108	BAZ2A	100	100.000	ENSPPRG00000006678	BAZ2A	100	92.670	Panthera_pardus
ENSG00000076108	BAZ2A	100	100.000	ENSPTIG00000018184	BAZ2A	100	92.461	Panthera_tigris_altaica
ENSG00000076108	BAZ2A	100	100.000	ENSPTRG00000005106	BAZ2A	100	99.580	Pan_troglodytes
ENSG00000076108	BAZ2A	100	99.237	ENSPANG00000021120	BAZ2A	100	98.114	Papio_anubis
ENSG00000076108	BAZ2A	98	50.058	ENSPKIG00000023937	baz2a	79	47.883	Paramormyrops_kingsleyae
ENSG00000076108	BAZ2A	100	81.851	ENSPEMG00000018987	Baz2a	99	81.554	Peromyscus_maniculatus_bairdii
ENSG00000076108	BAZ2A	100	92.241	ENSPCIG00000018044	BAZ2A	100	82.324	Phascolarctos_cinereus
ENSG00000076108	BAZ2A	99	46.207	ENSPFOG00000011764	baz2a	100	41.840	Poecilia_formosa
ENSG00000076108	BAZ2A	100	41.892	ENSPLAG00000005140	baz2a	51	45.574	Poecilia_latipinna
ENSG00000076108	BAZ2A	66	42.958	ENSPMEG00000016580	-	50	33.226	Poecilia_mexicana
ENSG00000076108	BAZ2A	100	42.568	ENSPMEG00000015610	baz2a	52	46.028	Poecilia_mexicana
ENSG00000076108	BAZ2A	100	100.000	ENSPPYG00000004667	BAZ2A	100	98.951	Pongo_abelii
ENSG00000076108	BAZ2A	100	93.130	ENSPCAG00000010434	BAZ2A	77	91.507	Procavia_capensis
ENSG00000076108	BAZ2A	100	97.710	ENSPCOG00000017805	BAZ2A	100	93.766	Propithecus_coquereli
ENSG00000076108	BAZ2A	100	98.473	ENSPVAG00000007618	BAZ2A	91	93.820	Pteropus_vampyrus
ENSG00000076108	BAZ2A	100	46.452	ENSPNAG00000010685	baz2a	53	47.770	Pygocentrus_nattereri
ENSG00000076108	BAZ2A	100	96.552	ENSRNOG00000053881	Baz2a	99	80.201	Rattus_norvegicus
ENSG00000076108	BAZ2A	100	99.237	ENSRBIG00000040119	BAZ2A	100	97.483	Rhinopithecus_bieti
ENSG00000076108	BAZ2A	100	99.237	ENSRROG00000041655	BAZ2A	100	98.324	Rhinopithecus_roxellana
ENSG00000076108	BAZ2A	100	98.276	ENSSBOG00000032610	BAZ2A	100	96.434	Saimiri_boliviensis_boliviensis
ENSG00000076108	BAZ2A	100	93.103	ENSSHAG00000000118	BAZ2A	99	72.349	Sarcophilus_harrisii
ENSG00000076108	BAZ2A	99	48.318	ENSSFOG00015013413	baz2a	74	47.670	Scleropages_formosus
ENSG00000076108	BAZ2A	100	97.710	ENSSARG00000009404	-	54	100.000	Sorex_araneus
ENSG00000076108	BAZ2A	98	66.957	ENSSPUG00000004790	BAZ2A	99	56.950	Sphenodon_punctatus
ENSG00000076108	BAZ2A	100	45.205	ENSSPAG00000016257	baz2a	50	46.535	Stegastes_partitus
ENSG00000076108	BAZ2A	100	100.000	ENSSSCG00000000403	BAZ2A	100	92.098	Sus_scrofa
ENSG00000076108	BAZ2A	99	42.759	ENSTRUG00000003058	baz2a	53	45.695	Takifugu_rubripes
ENSG00000076108	BAZ2A	98	47.904	ENSTNIG00000012597	baz2a	99	42.901	Tetraodon_nigroviridis
ENSG00000076108	BAZ2A	99	88.968	ENSTBEG00000001463	BAZ2A	80	88.678	Tupaia_belangeri
ENSG00000076108	BAZ2A	90	90.878	ENSTTRG00000002130	BAZ2A	89	90.878	Tursiops_truncatus
ENSG00000076108	BAZ2A	100	99.237	ENSUAMG00000021587	BAZ2A	100	89.245	Ursus_americanus
ENSG00000076108	BAZ2A	100	99.237	ENSUMAG00000017488	BAZ2A	100	89.193	Ursus_maritimus
ENSG00000076108	BAZ2A	100	99.237	ENSVPAG00000004023	BAZ2A	83	94.608	Vicugna_pacos
ENSG00000076108	BAZ2A	100	100.000	ENSVVUG00000020881	BAZ2A	100	89.487	Vulpes_vulpes
ENSG00000076108	BAZ2A	98	47.619	ENSXETG00000021782	baz2a	97	51.143	Xenopus_tropicalis
ENSG00000076108	BAZ2A	100	43.243	ENSXMAG00000017451	baz2a	51	45.827	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	ISS	Process
GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding	22368283.	IDA	Function
GO:0001188	RNA polymerase I preinitiation complex assembly	-	IEA	Process
GO:0003723	RNA binding	-	ISS	Function
GO:0005515	protein binding	11532953.17474147.26100909.	IPI	Function
GO:0005677	chromatin silencing complex	-	ISS	Component
GO:0005730	nucleolus	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006306	DNA methylation	-	ISS	Process
GO:0006338	chromatin remodeling	11532953.	NAS	Process
GO:0006351	transcription, DNA-templated	10662543.	NAS	Process
GO:0006355	regulation of transcription, DNA-templated	10662543.	NAS	Process
GO:0016575	histone deacetylation	-	ISS	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0016922	nuclear receptor binding	10662543.	NAS	Function
GO:0033553	rDNA heterochromatin	-	ISS	Component
GO:0042393	histone binding	22368283.	IPI	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0070577	lysine-acetylated histone binding	-	ISS	Function