EuRBPDB

Description

Ensembl ID: ENSG00000076924 (Gene tree)
Gene ID: 56949
Gene Symbol: XAB2
Alias: HCNP|HCRN|SYF1|NTC90
Full Name: XPA binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 10,041 bases
Position: chr19:7,619,525-7,629,565
Accession: 14089
RBP type: non-canonical RBP
Summary: (XPA Binding Protein 2) is a Protein Coding gene. Diseases associated with XAB2 include Cockayne Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is CRNKL1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28919079	Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae.	Cell	2017 Sep 21	Wan R	doi: 10.1016/j.cell.2017.08.029
26228655	XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.	BMC Cancer	2015 Jul 31	Pei N	doi: 10.1186/s12885-015-1567-4.
17283134	Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.	Cancer Res	2007 Feb 1	Ohnuma-Ishikawa K	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000358368	XAB2-201	2667	-	ENSP00000351137	855 (aa)	-	Q9HCS7
ENST00000596134	XAB2-203	543	-	-	- (aa)	-	-
ENST00000595288	XAB2-202	4555	-	-	- (aa)	-	-
ENST00000600230	XAB2-204	749	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000076924	XAB2	100	98.830	ENSMUSG00000019470	Xab2	100	98.830	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000349	generation of catalytic spliceosome for first transesterification step	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	21873635.	IBA	Component
GO:0001824	blastocyst development	-	IEA	Process
GO:0005515	protein binding	10944529.16189514.22365833.25416956.25599396.	IPI	Function
GO:0005634	nucleus	10944529.	IC	Component
GO:0005634	nucleus	28076346.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	10944529.	IDA	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	10944529.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0021987	cerebral cortex development	-	IEA	Process
GO:0071007	U2-type catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071014	post-mRNA release spliceosomal complex	21873635.	IBA	Component