EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000076928 (Gene tree)
Gene ID
9138
Gene Symbol
ARHGEF1
Alias
P115-RHOGEF|SUB1.5|LBCL2
Full Name
Rho guanine nucleotide exchange factor 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
46,990 bases
Position
chr19:41,883,161-41,930,150
Accession
681
RBP type
non-canonical RBP
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000617585ARHGEF1-223737--- (aa)--
ENST00000598587ARHGEF1-216359--- (aa)--
ENST00000599846ARHGEF1-2193393-ENSP00000470715968 (aa)-M0QZR4
ENST00000594258ARHGEF1-207919-ENSP00000470042307 (aa)-M0QYS3
ENST00000347545ARHGEF1-2023091-ENSP00000344429879 (aa)-Q92888
ENST00000598444ARHGEF1-215425--- (aa)--
ENST00000594513ARHGEF1-209325--- (aa)--
ENST00000595897ARHGEF1-2132973--- (aa)--
ENST00000354532ARHGEF1-2033243-ENSP00000346532912 (aa)-Q92888
ENST00000596957ARHGEF1-214570--- (aa)--
ENST00000599589ARHGEF1-2182636-ENSP00000469735702 (aa)-M0QYC1
ENST00000593609ARHGEF1-205576--- (aa)--
ENST00000594044ARHGEF1-206834--- (aa)--
ENST00000600387ARHGEF1-2212272--- (aa)--
ENST00000598812ARHGEF1-217588-ENSP0000047322988 (aa)-M0R3H5
ENST00000378152ARHGEF1-2042986-ENSP00000367394948 (aa)-Q92888
ENST00000594417ARHGEF1-208769-ENSP00000471942128 (aa)-M0R1K8
ENST00000337665ARHGEF1-2013171-ENSP00000337261927 (aa)-Q92888
ENST00000594521ARHGEF1-210826-ENSP00000470557275 (aa)-M0QZH8
ENST00000595723ARHGEF1-211872-ENSP00000472466291 (aa)-M0R2C7
ENST00000595770ARHGEF1-212663NR_135626-- (aa)--
ENST00000600274ARHGEF1-2203439--- (aa)--
ENST00000600517ARHGEF1-222428-ENSP0000046940968 (aa)-M0QXV6
Gene Model
Click here to download ENSG00000076928's gene model file
Pathways
Pathway IDPathway NameSource
hsa04270Vascular smooth muscle contractionKEGG
hsa04611Platelet activationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04928Parathyroid hormone synthesis, secretion and actionKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05205Proteoglycans in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000076928Body Height4.6056322927704E-1017903300
ENSG00000076928Body Height4.92245488132124E-917903300
ENSG00000076928Body Height2.32580733047009E-717903300
ENSG00000076928Body Height4.39096805994889E-917903300
ENSG00000076928Hypertension6.9647986E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000076928's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000076928ARHGEF19989.364ENSMUSG00000040940Arhgef19891.304Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001664G protein-coupled receptor binding-IEAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0005089Rho guanyl-nucleotide exchange factor activity-IEAFunction
GO:0005096GTPase activator activity-IEAFunction
GO:0005515protein binding12681510.20300064.25416956.IPIFunction
GO:0005737cytoplasm10747909.TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0007186G protein-coupled receptor signaling pathway-TASProcess
GO:0007266Rho protein signal transduction10747909.TASProcess
GO:0008283cell proliferation8810315.TASProcess
GO:0035023regulation of Rho protein signal transduction-IEAProcess
GO:0043065positive regulation of apoptotic process-TASProcess
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0051056regulation of small GTPase mediated signal transduction-TASProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26911374Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.Endocr Relat Cancer2016 AprCrois?? Pdoi: 10.1530/ERC-15-0502
12748184Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.J Biol Chem2003 Aug 8Bourguignon LY-
23070684miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.Tumour Biol2012 DecHu Ydoi: 10.1007/s13277-012-0446-8

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1941906751Missense_MutationnovelG902W0.23
BLCAchr19419067913'UTRnovel0.31
BLCAchr1941888758Missense_MutationnovelE40K0.44
BLCAchr1941906492Missense_MutationNAE843K0.37
BLCAchr1941888099Missense_Mutationrs183598386R6P0.14
BLCAchr1941895399Missense_Mutationrs781882065R310W0.35
BLCAchr1941905947Missense_Mutationrs376841668E805K0.24
BLCAchr1941888099Missense_Mutationrs183598386R6Q0.18
BLCAchr1941892206Intronnovel0.22
BLCAchr1941903712SilentnovelL615L0.2
BLCAchr1941902562SilentnovelQ509Q0.09
BLCAchr1941904288Missense_MutationnovelS689C0.13
BLCAchr1941903309Missense_MutationNAE581K0.19
BLCAchr1941898553SilentNAP411P0.3
BRCAchr1941923195Missense_MutationnovelK657M0.13
BRCAchr1941906495Missense_MutationNAD844Y0.39
BRCAchr1941905211SilentNAL762L0.43
BRCAchr1941898375Intronnovel0.46
BRCAchr1941895420Missense_MutationNAP317S0.16
BRCAchr1941884461Intronnovel0.22
BRCAchr1941892052Missense_MutationNAG85C0.39
BRCAchr1941888261Missense_MutationNAE32Q0.16
BRCAchr1941892794Nonsense_MutationNAE187*0.45
BRCAchr1941888273Missense_MutationNAE36Q0.27
BRCAchr1941892122Missense_MutationNAA108V0.13
BRCAchr1941888217Missense_MutationNAG17D0.39
BRCAchr1941906622Splice_SiteNAX885_splice0.24
CESCchr1941928978Missense_MutationnovelY97S0.31
CESCchr1941892487IntronNA0.52
CESCchr1941892848Missense_MutationnovelQ205K0.18
CESCchr1941892849Missense_MutationnovelQ205R0.18
CESCchr1941894503Missense_MutationnovelS266N0.42
CESCchr19419074273'UTRnovel0.45
CESCchr1941895383Silentrs782392629G304G0.07
CESCchr1941903387Missense_MutationnovelR607S0.29
CESCchr19419071893'UTRrs5423637300.71
COADchr1941898529Silentrs200140005P403P0.24
COADchr1941906771SilentNAQ908Q0.25
COADchr1941892022Splice_Regionnovel0.28
COADchr1941902558Missense_MutationnovelF508Y0.35
COADchr1941902627Missense_MutationNAR531H0.35
COADchr1941888804Missense_Mutationrs782343511R55H0.32
COADchr1941896394Missense_MutationnovelE345K0.33
COADchr1941905793Silentrs376174015N790N0.15
COADchr1941906537Frame_Shift_DelNAG859Afs*40.32
COADchr1941896482Missense_MutationnovelS374I0.15
COADchr1941902809Missense_MutationNAR550H0.3
COADchr1941896386Frame_Shift_DelNAL344Wfs*120.31
COADchr1941892644Missense_MutationnovelR137W0.43
COADchr1941894227Missense_MutationnovelI222T0.13
COADchr1941905936Splice_Regionrs3683195320.19
COADchr1941896445Missense_Mutationrs781864535P362S0.58
COADchr1941901995Missense_MutationnovelN459S0.36
COADchr1941894479Missense_MutationnovelP258L0.3
COADchr1941896386Frame_Shift_DelNAL344Wfs*120.32
COADchr19419067943'UTRrs3690264900.25
COADchr1941905946Silentrs144745694T804T0.18
COADchr1941892043Missense_Mutationrs374342194D82N0.31
DLBCchr1941906592Missense_MutationnovelS876N0.17
ESCAchr1941898244Intronnovel0.09
ESCAchr19419071933'UTRnovel0.47
ESCAchr1941904317Missense_MutationnovelD699H0.2
ESCAchr1941896773Intronnovel0.27
ESCAchr1941902342Missense_MutationNAV495M0.56
GBMchr1941905784Missense_MutationnovelS787R0.08
GBMchr1941892816Missense_Mutationrs529943853A194V0.56
GBMchr1941903406Missense_MutationnovelL613Q0.28
GBMchr1941894471Silentrs782763644S255S0.54
HNSCchr1941901886Splice_SitenovelX423_splice0.2
HNSCchr1941904098Missense_MutationnovelD661Y0.15
HNSCchr1941905763SilentnovelT780T0.31
HNSCchr1941902644Frame_Shift_DelnovelA538Rfs*140.43
HNSCchr1941902818Missense_MutationnovelQ553L0.27
HNSCchr1941894453In_Frame_DelnovelM250_E257del0.34
HNSCchr1941893301Missense_MutationnovelK214N0.31
HNSCchr1941902812Missense_MutationnovelR551H0.21
HNSCchr1941895373Missense_Mutationrs200700112R301Q0.19
KIRCchr1941904347Missense_MutationNAR709W0.4
KIRCchr1941892073Missense_MutationnovelA92P0.22
LGGchr1941892108Silentrs782384716F103F0.5
LGGchr1941892817Silentrs781919682A194A0.33
LIHCchr1941904962SilentnovelF725F0.27
LIHCchr1941892801In_Frame_InsnovelH192_R196dup0.35
LUADchr1941892206Intronnovel0.07
LUADchr1941894629Missense_MutationNAP282L0.69
LUADchr1941906578Missense_MutationnovelQ871H0.24
LUADchr1941888232Missense_MutationNAS22I0.26
LUADchr1941884451Intronrs5454989950.17
LUADchr1941892144Intronrs7828028360.25
LUADchr1941892814SilentNAV193V0.45
LUADchr1941884437Intronnovel0.07
LUADchr1941903772SilentNAL635L0.36
LUADchr19418880825'UTRnovel0.41
LUADchr1941895414Missense_MutationnovelG315R0.08
LUADchr1941906542SilentNAG859G0.26
LUSCchr1941895473SilentNAP334P0.2
LUSCchr1941892329Splice_SiteNAX109_splice0.16
LUSCchr1941892739Missense_MutationnovelW168C0.08
LUSCchr1941892731Missense_MutationnovelT166A0.47
LUSCchr1941888279Splice_SitenovelX37_splice0.26
LUSCchr1941901885Splice_SitenovelX423_splice0.11
LUSCchr1941892228Intronnovel0.08
LUSCchr1941906499Missense_Mutationrs782293753N845S0.42
LUSCchr1941892343Missense_MutationNAP113S0.23
OVchr1941892605Missense_MutationNAR124G0.28
OVchr1941884474IntronNA0.33
OVchr1941888821Missense_MutationNAA61T0.39
OVchr1941892790Missense_MutationnovelS185R0.67
OVchr1941905814Silentrs149372116T797T0.13
OVchr1941894257Missense_MutationNAR232Q0.2
OVchr1941905191Missense_MutationNAT756P0.31
OVchr1941905177Missense_MutationnovelW751S0.31
OVchr1941896674IntronNA0.38
PAADchr1941892805Missense_MutationnovelE190D0.22
PAADchr1941902342Missense_MutationNAV495M0.16
PRADchr1941906786Nonstop_MutationNA*913Cext*190.37
PRADchr1941888800Missense_Mutationrs782110668R54W0.41
PRADchr1941905219Missense_MutationnovelP765L0.47
READchr1941892671Nonsense_MutationnovelQ146*0.33
SARCchr1941892166Intronnovel0.35
SARCchr1941892167Intronnovel0.38
SKCMchr1941892232Intronnovel0.31
SKCMchr1941888097SilentnovelA5A0.43
SKCMchr19419067923'UTRnovel0.52
SKCMchr1941895445Missense_MutationNAS325F0.29
SKCMchr1941895461SilentnovelS330S0.22
SKCMchr1941902573Missense_Mutationrs781854393S513F0.3
SKCMchr1941892333Splice_RegionNAV109V0.37
SKCMchr1941894297SilentNAF245F0.45
SKCMchr1941892649Silentrs782354288F138F0.5
SKCMchr1941892649Silentrs782354288F138F0.4
SKCMchr1941892720Missense_MutationNAL162P0.25
SKCMchr1941905967SilentnovelL811L0.16
STADchr1941894481Missense_MutationNAA259S0.29
STADchr1941901912Silentrs377396950H431H0.31
STADchr1941902653Missense_MutationNAV540M0.35
STADchr1941906487Missense_Mutationrs375950739A841V0.27
STADchr1941898564Missense_MutationNAV415A0.62
STADchr1941892336Silentrs782791739L110L0.08
STADchr1941892049SilentNAL84L0.36
STADchr1941892289Intronnovel0.07
STADchr1941903318Missense_MutationNAE584K0.14
STADchr1941893293Missense_MutationNAE212K0.17
STADchr1941902800Missense_MutationNAP547L0.19
STADchr1941902348SilentNAL497L0.37
STADchr1941895424Missense_MutationnovelG318V0.29
STADchr1941895396Missense_MutationNAS309P0.35
STADchr1941905234Missense_Mutationrs781883859R770H0.42
UCECchr1941888266Silentrs41306984N33N0.45
UCECchr1941904271Silentrs782266591E683E0.19
UCECchr1941923142SilentnovelA639A0.43
UCECchr1941905256SilentNAP777P0.5
UCECchr1941892661SilentNAV142V0.22
UCECchr1941902289Missense_Mutationrs782431103R477H0.52
UCECchr19419074403'UTRnovel0.48
UCECchr1941892733SilentNAT166T0.32
UCECchr1941898515Missense_MutationNAR399W0.28
UCECchr1941902024Missense_MutationNAE469K0.21
UCECchr1941894272Missense_MutationnovelD237V0.22
UCECchr1941895480Nonsense_MutationnovelE337*0.14
UCECchr1941892777Missense_Mutationrs782691132R181Q0.15
UCECchr1941902652SilentnovelF539F0.05
UCECchr1941902803Missense_MutationnovelR548Q0.48
UCECchr1941894281Missense_Mutationrs368940793S240L0.43
UCECchr1941895477Missense_Mutationrs782364939R336W0.4
UCECchr1941906572Missense_MutationnovelE869D0.49
UCECchr1941896726Intronnovel0.24
UCECchr1941902797Missense_Mutationrs781793791R546H0.54
UCECchr1941894475Missense_Mutationrs782629121E257K0.33
UCECchr1941896462Silentrs199929341D367D0.45
UCECchr1941902289Missense_Mutationrs782431103R477H0.47
UCECchr1941902886Missense_Mutationrs782335508G576R0.37
UCECchr1941898515Missense_MutationNAR399W0.14
UCECchr1941892606Missense_MutationNAR124H0.22
UCECchr19419074273'UTRnovel0.13
UCECchr1941892649Silentrs782354288F138F0.27
UCECchr1941888211Missense_Mutationrs781793490R15Q0.53
UCECchr1941903316Missense_MutationnovelT583K0.5
UCECchr1941892361Missense_Mutationrs371771035A119T0.37
UCECchr1941895384Missense_Mutationrs201550936V305M0.39
UCECchr1941884475Intronnovel0.24
UCECchr1941896386Frame_Shift_DelNAL344Wfs*120.34
UCECchr1941898324Intronnovel0.33
UCECchr1941896386Frame_Shift_DelNAL344Wfs*120.7
UCECchr1941902335SilentnovelI492I0.14
UCECchr1941923135Missense_MutationnovelM637T0.32
UCECchr1941888266Silentrs41306984N33N0.36
UCECchr1941903398Missense_MutationnovelE610D0.09
UCECchr1941892316Intronnovel0.5
UCECchr1941894281Missense_Mutationrs368940793S240L0.44
UCECchr1941896526Intronnovel0.53
UCECchr1941904964Missense_MutationNAY726C0.54
UCECchr1941893278Missense_MutationnovelT207A0.4
UCECchr1941898334Intronnovel0.29
UCECchr1941895405Missense_Mutationrs782161306R312W0.15
UCECchr1941894464Missense_MutationnovelR253L0.38
UCECchr1941905178Missense_MutationNAW751C0.31
UCECchr1941902800Missense_MutationNAP547L0.44
UCECchr1941892802SilentnovelR189R0.53
UCECchr1941888277Missense_MutationnovelT37I0.15
UCECchr1941894449Splice_SitenovelX249_splice0.1
UCECchr1941898422Intronnovel0.4
UCECchr1941892776Missense_Mutationrs782100845R181W0.36
UCECchr1941892308Intronnovel0.36
UCECchr1941888094SilentNAF4F0.2
UCECchr1941894276Missense_MutationnovelK238N0.17
UCECchr1941901952Missense_MutationnovelP445S0.43
UCECchr1941902617Missense_MutationnovelA528T0.5
UCECchr1941906541Missense_Mutationrs782700907G859D0.42
UCECchr1941892605Missense_Mutationrs369826806R124C0.26
UCECchr1941892605Missense_Mutationrs369826806R124C0.38
UCECchr1941906020Missense_Mutationrs782226783R829Q0.47
UCECchr1941928950Missense_MutationnovelG702E0.3
UCECchr19419073943'UTRnovel0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.04510.054726
READDEL0.06060.23023
UCSDEL0.21430.12448

Survival Analysis
CancerP-value Q-value
THYM0.0038

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.047

Kaplan-Meier Survival Analysis

ACC0.00069

Kaplan-Meier Survival Analysis

UCS0.0046

Kaplan-Meier Survival Analysis

HNSC0.041

Kaplan-Meier Survival Analysis

LUSC0.021

Kaplan-Meier Survival Analysis

BRCA0.0016

Kaplan-Meier Survival Analysis

ESCA0.044

Kaplan-Meier Survival Analysis

KIRP0.0087

Kaplan-Meier Survival Analysis

COAD0.0065

Kaplan-Meier Survival Analysis

PAAD0.015

Kaplan-Meier Survival Analysis

LAML0.00098

Kaplan-Meier Survival Analysis

KICH0.049

Kaplan-Meier Survival Analysis

UCEC0.013

Kaplan-Meier Survival Analysis

OV0.027

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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