EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000077097 (Gene tree)
Gene ID: 7155
Gene Symbol: TOP2B
Alias: N
Full Name: DNA topoisomerase II beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 67,003 bases
Position: chr3:25,597,905-25,664,907
Accession: 11990
RBP type: non-canonical RBP
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20554522	Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).	J Biol Chem	2010 Aug 20	Kawano S	doi: 10.1074/jbc.M110.112979

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435706	TOP2B-204	5389	-	ENSP00000396704	1621 (aa)	-	Q02880
ENST00000413971	TOP2B-202	2049	-	ENSP00000388216	70 (aa)	-	H7BZ82
ENST00000424225	TOP2B-203	3525	-	ENSP00000391112	1150 (aa)	-	E9PCY5
ENST00000475717	TOP2B-206	540	-	-	- (aa)	-	-
ENST00000470132	TOP2B-205	451	-	-	- (aa)	-	-
ENST00000264331	TOP2B-201	5358	XM_011534057	ENSP00000264331	1626 (aa)	XP_011532359	Q02880
ENST00000491510	TOP2B-207	584	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000077097's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01524	Platinum drug resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000077097	Electrocardiography	5.21336706611848E-7	17903306

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000077097	rs6786418	3	25603481	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000077097's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000712	resolution of meiotic recombination intermediates	21873635.	IBA	Process
GO:0000792	heterochromatin	9049244.	IDA	Component
GO:0000819	sister chromatid segregation	21873635.	IBA	Process
GO:0001764	neuron migration	-	IEA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	9049244.	IDA	Function
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	10684600.	IDA	Function
GO:0005080	protein kinase C binding	16611985.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9049244.17567603.	IDA	Component
GO:0005654	nucleoplasm	9049244.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	9049244.	IDA	Component
GO:0005829	cytosol	9049244.	IDA	Component
GO:0006265	DNA topological change	10684600.	IDA	Process
GO:0007409	axonogenesis	-	IEA	Process
GO:0008022	protein C-terminus binding	10666337.	IPI	Function
GO:0019035	viral integration complex	16712776.	IMP	Component
GO:0019899	enzyme binding	17567603.	IPI	Function
GO:0030900	forebrain development	-	IEA	Process
GO:0042826	histone deacetylase binding	11062478.11136718.	IPI	Function
GO:0044774	mitotic DNA integrity checkpoint	21873635.	IBA	Process
GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	16712776.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046982	protein heterodimerization activity	10473615.	IPI	Function
GO:1990904	ribonucleoprotein complex	-	ISS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16969495	Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells.	Oncol Rep	2006 Oct	Tsang WP	-
21793937	The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma.	J Oral Pathol Med	2012 Feb	Zhang B	doi: 10.1111/j.1600-0714.2011.01066.x
24326092	The association between chemosensitivity and Pgp, GST-?? and Topo II expression in gastric cancer.	Diagn Pathol	2013 Dec 10	Geng M	doi: 10.1186/1746-1596-8-198.
21542140	Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β.	Anat Rec (Hoboken)	2011 Jun	Wang C	doi: 10.1002/ar.21398
28669856	Topoisomerase IIβ and its role in different biological contexts.	Arch Biochem Biophys	2017 Nov 1	Bollimpelli VS	doi: 10.1016/j.abb.2017.06.021

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	25599504	Silent	novel	R1547R	0.18
BLCA	chr3	25598307	Silent	novel	*1627*	0.14
BLCA	chr3	25629058	Missense_Mutation	novel	E593Q	0.33
BLCA	chr3	25598248	3'UTR	novel		0.5
BLCA	chr3	25598456	Missense_Mutation	NA	D1578N	0.55
BLCA	chr3	25624304	Missense_Mutation	novel	M830V	0.05
BLCA	chr3	25645382	Missense_Mutation	NA	R53K	0.28
BLCA	chr3	25615480	Missense_Mutation	novel	S1153C	0.43
BLCA	chr3	25623560	Silent	novel	V894V	0.27
BLCA	chr3	25598470	In_Frame_Ins	novel	K1573delinsTE	0.15
BRCA	chr3	25599509	Frame_Shift_Ins	novel	*K1546Pfs70**	0.03
BRCA	chr3	25627243	Silent	NA	R654R	0.16
BRCA	chr3	25615245	Missense_Mutation	NA	L1184R	0.35
BRCA	chr3	25624346	Missense_Mutation	NA	H816Y	0.17
BRCA	chr3	25629130	Missense_Mutation	NA	H569Y	0.17
BRCA	chr3	25630322	Frame_Shift_Del	NA	*S518Ffs11**	0.17
BRCA	chr3	25632525	Missense_Mutation	NA	S396F	0.15
BRCA	chr3	25609270	Missense_Mutation	NA	S1336P	0.11
BRCA	chr3	25632719	Missense_Mutation	novel	A368T	0.08
BRCA	chr3	25626849	In_Frame_Ins	novel	K677_K678insLFIY	0.06
BRCA	chr3	25626850	Nonsense_Mutation	novel	*K678Ffs3**	0.04
BRCA	chr3	25636141	Nonsense_Mutation	novel	*M216Kfs2**	0.04
CESC	chr3	25636118	Missense_Mutation	novel	E224Q	0.16
CESC	chr3	25598173	3'UTR	novel		0.33
CESC	chr3	25630354	Silent	novel	L507L	0.24
CESC	chr3	25637307	Missense_Mutation	NA	R183C	0.17
CESC	chr3	25642374	Missense_Mutation	NA	D115H	0.36
CESC	chr3	25624763	Missense_Mutation	NA	F755L	0.38
COAD	chr3	25620799	Missense_Mutation	NA	N915K	0.36
COAD	chr3	25606099	Frame_Shift_Ins	novel	*S1441Kfs20**	0.32
COAD	chr3	25604822	Frame_Shift_Ins	NA	*S1476Ffs11**	0.2
COAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.25
COAD	chr3	25630034	Missense_Mutation	novel	D562N	0.05
COAD	chr3	25632575	Missense_Mutation	novel	N379K	0.16
COAD	chr3	25598154	3'UTR	novel		0.78
COAD	chr3	25638296	In_Frame_Del	novel	I137del	0.05
COAD	chr3	25615469	Nonsense_Mutation	NA	E1157*	0.44
COAD	chr3	25607305	In_Frame_Ins	rs746857248	D1388dup	0.32
COAD	chr3	25612528	Missense_Mutation	novel	L1258P	0.37
COAD	chr3	25645437	Frame_Shift_Ins	NA	*E35Rfs10**	0.34
COAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.35
COAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.23
COAD	chr3	25630060	Missense_Mutation	rs748179631	R553H	0.25
COAD	chr3	25618802	Silent	novel	Q1037Q	0.08
COAD	chr3	25643737	Silent	novel	V96V	0.76
COAD	chr3	25620787	Silent	rs375021372	T919T	0.38
COAD	chr3	25623658	Missense_Mutation	novel	Y862H	0.4
COAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.31
COAD	chr3	25626627	Missense_Mutation	NA	F719L	0.36
COAD	chr3	25598219	3'UTR	novel		0.13
COAD	chr3	25606100	Frame_Shift_Del	novel	*S1441Vfs41**	0.14
COAD	chr3	25606100	Frame_Shift_Del	novel	*S1441Vfs41**	0.39
COAD	chr3	25604822	Frame_Shift_Ins	NA	*S1476Ffs11**	0.4
COAD	chr3	25606100	Frame_Shift_Del	novel	*S1441Vfs41**	0.08
COAD	chr3	25632451	Frame_Shift_Ins	NA	K421*	0.35
COAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.32
COAD	chr3	25612582	Missense_Mutation	NA	R1240K	0.38
COAD	chr3	25645437	Frame_Shift_Ins	NA	*E35Rfs10**	0.44
COAD	chr3	25638163	Splice_Site	NA	X181_splice	0.28
COAD	chr3	25645356	Missense_Mutation	novel	E62K	0.3
COAD	chr3	25637238	Nonsense_Mutation	NA	E206*	0.3
COAD	chr3	25623586	Missense_Mutation	NA	P886S	0.36
COAD	chr3	25606100	Frame_Shift_Del	novel	*S1441Vfs41**	0.12
DLBC	chr3	25632727	Frame_Shift_Del	novel	*K365Rfs8**	0.19
ESCA	chr3	25628923	Missense_Mutation	novel	F610L	0.31
ESCA	chr3	25609655	Missense_Mutation	novel	P1282T	0.06
ESCA	chr3	25630888	Missense_Mutation	novel	A440T	0.53
GBM	chr3	25630433	Missense_Mutation	novel	T481R	0.04
GBM	chr3	25609695	Silent	novel	A1268A	0.33
GBM	chr3	25620008	Missense_Mutation	novel	A973S	0.36
GBM	chr3	25618773	Missense_Mutation	novel	R1047Q	0.52
HNSC	chr3	25623655	Frame_Shift_Del	novel	*I863Ffs3**	0.36
HNSC	chr3	25598369	Missense_Mutation	rs764317223	V1607I	0.2
HNSC	chr3	25624708	Missense_Mutation	novel	E774K	0.21
HNSC	chr3	25629104	Silent	rs370638500	F577F	0.46
HNSC	chr3	25598325	Silent	novel	D1621D	0.57
KICH	chr3	25606075	Frame_Shift_Del	novel	*F1448Ifs11**	0.53
KIRP	chr3	25604841	Missense_Mutation	NA	D1470Y	0.36
KIRP	chr3	25609667	Missense_Mutation	NA	F1278V	0.25
LAML	chr3	25623530	Silent	novel	L904L	0.09
LGG	chr3	25624393	Missense_Mutation	rs368712197	N800S	0.44
LGG	chr3	25645360	Silent	novel	Q60Q	0.08
LIHC	chr3	25612538	Missense_Mutation	NA	K1255E	0.6
LIHC	chr3	25626784	Missense_Mutation	NA	H699Q	0.06
LIHC	chr3	25623586	Missense_Mutation	NA	P886S	0.25
LIHC	chr3	25628896	Frame_Shift_Del	novel	W619*	0.13
LIHC	chr3	25629041	Silent	NA	I598I	0.51
LIHC	chr3	25626606	Silent	NA	L726L	0.21
LUAD	chr3	25609191	Missense_Mutation	novel	R1362I	0.31
LUAD	chr3	25599464	Missense_Mutation	novel	G1561C	0.31
LUAD	chr3	25627255	Frame_Shift_Ins	novel	*A650Cfs2**	0.29
LUAD	chr3	25645472	Splice_Site	novel	X24_splice	0.41
LUAD	chr3	25598470	Frame_Shift_Ins	novel	*K1573Rfs37**	0.1
LUAD	chr3	25598478	Splice_Site	novel	X1571_splice	0.2
LUAD	chr3	25627252	Missense_Mutation	novel	D651Y	0.25
LUAD	chr3	25612514	Splice_Site	NA	X1262_splice	0.2
LUAD	chr3	25630865	Missense_Mutation	NA	K447N	0.16
LUAD	chr3	25612616	Frame_Shift_Del	novel	*Q1229Sfs14**	0.1
LUAD	chr3	25609579	Missense_Mutation	novel	K1307R	0.08
LUSC	chr3	25632782	Missense_Mutation	NA	V347L	0.34
LUSC	chr3	25598365	Frame_Shift_Del	novel	*T1600Nfs55**	0.28
LUSC	chr3	25645378	Silent	novel	V54V	0.59
LUSC	chr3	25645363	Silent	NA	T59T	0.3
LUSC	chr3	25619888	Missense_Mutation	novel	Q1013E	0.14
LUSC	chr3	25645318	Silent	NA	S74S	0.22
LUSC	chr3	25645311	Missense_Mutation	novel	P77T	0.22
LUSC	chr3	25628903	Missense_Mutation	novel	D617V	0.15
LUSC	chr3	25615577	Missense_Mutation	NA	E1121Q	0.33
OV	chr3	25623657	Missense_Mutation	NA	Y862C	0.27
OV	chr3	25623717	Missense_Mutation	novel	V842G	0.13
OV	chr3	25633939	Missense_Mutation	novel	I310F	0.05
OV	chr3	25645413	Missense_Mutation	novel	N43Y	0.05
OV	chr3	25645403	Missense_Mutation	novel	S46L	0.3
PAAD	chr3	25599515	Missense_Mutation	novel	A1544S	0.19
PAAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.43
PAAD	chr3	25618752	Missense_Mutation	rs745953350	R1054H	0.24
PAAD	chr3	25626795	Missense_Mutation	novel	R696C	0.14
PAAD	chr3	25630830	Missense_Mutation	novel	I459T	0.22
PRAD	chr3	25632576	Frame_Shift_Del	NA	*N379Tfs24**	0.39
PRAD	chr3	25612639	Frame_Shift_Del	novel	*G1221Afs5**	0.26
READ	chr3	25619901	Missense_Mutation	NA	K1008N	0.24
READ	chr3	25643703	Nonsense_Mutation	NA	E108*	0.32
READ	chr3	25598392	Missense_Mutation	rs184041688	R1599Q	0.41
READ	chr3	25604841	Missense_Mutation	NA	D1470Y	0.43
READ	chr3	25609578	Missense_Mutation	NA	K1307N	0.5
READ	chr3	25629109	Missense_Mutation	NA	N576H	0.42
READ	chr3	25601143	Silent	rs767046447	S1524S	0.46
READ	chr3	25609300	Missense_Mutation	NA	A1326T	0.28
SARC	chr3	25643754	Missense_Mutation	novel	M91V	0.35
SARC	chr3	25626672	Splice_Region	novel	Q704Q	0.31
SKCM	chr3	25629104	Silent	rs370638500	F577F	0.37
SKCM	chr3	25623724	Missense_Mutation	NA	P840S	0.24
SKCM	chr3	25632575	Silent	rs749899522	N379N	0.25
SKCM	chr3	25609214	Silent	novel	I1354I	0.24
SKCM	chr3	25645341	Missense_Mutation	NA	R67C	0.39
SKCM	chr3	25623623	Silent	NA	G873G	0.34
SKCM	chr3	25623643	Missense_Mutation	NA	P867S	0.21
SKCM	chr3	25645341	Missense_Mutation	NA	R67C	0.11
SKCM	chr3	25632700	Missense_Mutation	NA	P374L	0.28
SKCM	chr3	25615270	Missense_Mutation	NA	L1176F	0.3
SKCM	chr3	25599451	Missense_Mutation	NA	S1565F	0.54
SKCM	chr3	25628927	Missense_Mutation	NA	S609F	0.25
SKCM	chr3	25612616	Nonsense_Mutation	novel	Q1229*	0.25
SKCM	chr3	25620004	Nonsense_Mutation	NA	L974*	0.25
STAD	chr3	25612685	Missense_Mutation	novel	D1206N	0.24
STAD	chr3	25645438	Frame_Shift_Del	novel	*E35Kfs44**	0.28
STAD	chr3	25632524	Silent	NA	S396S	0.5
STAD	chr3	25633841	Missense_Mutation	novel	K342N	0.15
STAD	chr3	25609339	Missense_Mutation	NA	R1313G	0.16
STAD	chr3	25627274	Missense_Mutation	NA	K643N	0.21
STAD	chr3	25632779	Missense_Mutation	novel	D348N	0.34
STAD	chr3	25628942	Frame_Shift_Del	novel	*N604Ifs20**	0.54
STAD	chr3	25598286	3'UTR	novel		0.38
STAD	chr3	25615514	Missense_Mutation	novel	D1142Y	0.29
STAD	chr3	25599521	Nonsense_Mutation	NA	R1542*	0.12
STAD	chr3	25598188	3'UTR	novel		0.33
STAD	chr3	25624330	Missense_Mutation	NA	A821V	0.18
STAD	chr3	25624386	Silent	NA	I802I	0.08
STAD	chr3	25636059	Missense_Mutation	NA	D243E	0.14
STAD	chr3	25629130	Missense_Mutation	novel	H569N	0.23
STAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.14
STAD	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.48
THCA	chr3	25598478	Splice_Site	novel	X1571_splice	0.13
UCEC	chr3	25620787	Silent	rs375021372	T919T	0.03
UCEC	chr3	25598110	3'UTR	novel		0.46
UCEC	chr3	25607347	Missense_Mutation	NA	F1374L	0.33
UCEC	chr3	25615226	Silent	rs754406807	A1190A	0.38
UCEC	chr3	25632460	Missense_Mutation	NA	K418Q	0.37
UCEC	chr3	25624743	Missense_Mutation	novel	E762G	0.39
UCEC	chr3	25636055	Missense_Mutation	novel	S245P	0.14
UCEC	chr3	25627195	Missense_Mutation	NA	I670V	0.28
UCEC	chr3	25636128	Missense_Mutation	novel	M220I	0.08
UCEC	chr3	25609232	Missense_Mutation	novel	E1348D	0.33
UCEC	chr3	25632444	Splice_Site	novel	X422_splice	0.39
UCEC	chr3	25607327	Missense_Mutation	novel	D1381G	0.38
UCEC	chr3	25598310	Missense_Mutation	NA	N1626K	0.41
UCEC	chr3	25607369	Missense_Mutation	NA	R1367I	0.46
UCEC	chr3	25626815	Missense_Mutation	novel	F689C	0.05
UCEC	chr3	25598288	3'UTR	novel		0.41
UCEC	chr3	25642361	Missense_Mutation	novel	R119M	0.43
UCEC	chr3	25629094	Missense_Mutation	novel	N581D	0.17
UCEC	chr3	25618789	Nonsense_Mutation	NA	E1042*	0.25
UCEC	chr3	25620695	Missense_Mutation	novel	R950I	0.15
UCEC	chr3	25623592	Missense_Mutation	novel	K884Q	0.4
UCEC	chr3	25599510	In_Frame_Ins	novel	A1544_K1545insNKS	0.05
UCEC	chr3	25615458	Missense_Mutation	NA	E1160D	0.19
UCEC	chr3	25620787	Silent	rs375021372	T919T	0.22
UCEC	chr3	25626632	Missense_Mutation	novel	D718Y	0.34
UCEC	chr3	25612623	Missense_Mutation	NA	K1226N	0.4
UCEC	chr3	25601154	Missense_Mutation	novel	N1521H	0.47
UCEC	chr3	25637238	Nonsense_Mutation	NA	E206*	0.14
UCEC	chr3	25598461	Missense_Mutation	novel	S1576Y	0.38
UCEC	chr3	25627197	Missense_Mutation	novel	A669V	0.42
UCEC	chr3	25635980	Missense_Mutation	novel	S270P	0.38
UCEC	chr3	25618753	Missense_Mutation	NA	R1054C	0.29
UCEC	chr3	25624791	Missense_Mutation	novel	G746D	0.36
UCEC	chr3	25624313	Missense_Mutation	novel	I827L	0.09
UCEC	chr3	25612544	Missense_Mutation	NA	A1253T	0.35
UCEC	chr3	25597917	3'UTR	novel		0.43
UCEC	chr3	25601219	Missense_Mutation	rs375477555	P1499L	0.43
UCEC	chr3	25627198	Missense_Mutation	rs532925587	A669T	0.4
UCEC	chr3	25629101	Silent	novel	I578I	0.49
UCEC	chr3	25634001	Missense_Mutation	rs768311598	R289H	0.48
UCEC	chr3	25598295	3'UTR	novel		0.51
UCEC	chr3	25598392	Missense_Mutation	novel	R1599L	0.46
UCEC	chr3	25612679	Missense_Mutation	novel	L1208M	0.41
UCEC	chr3	25615469	Nonsense_Mutation	NA	E1157*	0.45
UCEC	chr3	25630050	Silent	novel	K556K	0.56
UCEC	chr3	25642321	Splice_Site	novel	X132_splice	0.49
UCEC	chr3	25645437	Frame_Shift_Ins	NA	*E35Rfs10**	0.37
UCEC	chr3	25599509	Frame_Shift_Ins	novel	*K1546Lfs63**	0.07
UCEC	chr3	25599510	In_Frame_Ins	novel	A1544_K1545insNKS	0.06
UCEC	chr3	25633924	Missense_Mutation	novel	N315H	0.43
UCEC	chr3	25624732	Missense_Mutation	NA	A766T	0.32
UCEC	chr3	25632512	Missense_Mutation	NA	E400D	0.3
UCEC	chr3	25645299	Splice_Site	NA	X80_splice	0.39
UCEC	chr3	25630395	Silent	novel	L494L	0.41
UCEC	chr3	25632767	Missense_Mutation	novel	D352N	0.34
UCEC	chr3	25638264	Missense_Mutation	novel	V148I	0.33
UCEC	chr3	25645357	Silent	novel	L61L	0.27
UCEC	chr3	25626810	Missense_Mutation	NA	E691K	0.36
UCEC	chr3	25636081	In_Frame_Ins	novel	T236delinsKA	0.09
UCEC	chr3	25604792	Missense_Mutation	novel	K1486T	0.37
UCEC	chr3	25618821	Missense_Mutation	novel	K1031T	0.38
UCEC	chr3	25619984	Missense_Mutation	novel	Y981D	0.3
UCEC	chr3	25630842	Missense_Mutation	novel	K455T	0.41
UCEC	chr3	25599476	Missense_Mutation	rs764860175	D1557N	0.32
UCEC	chr3	25609275	Missense_Mutation	novel	P1334L	0.26
UCEC	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.3
UCEC	chr3	25599509	Frame_Shift_Ins	novel	*K1546Lfs63**	0.13
UCEC	chr3	25618747	Missense_Mutation	novel	E1056K	0.45
UCEC	chr3	25633967	Missense_Mutation	novel	L300F	0.29
UCEC	chr3	25619860	Splice_Site	novel	X1021_splice	0.19
UCEC	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.37
UCEC	chr3	25604852	Missense_Mutation	novel	S1466N	0.52
UCEC	chr3	25629121	Frame_Shift_Ins	novel	*G572Rfs5**	0.05
UCEC	chr3	25637247	Missense_Mutation	novel	A203S	0.29
UCEC	chr3	25615224	Missense_Mutation	rs760982587	A1191V	0.26
UCEC	chr3	25598424	Silent	NA	S1588S	0.25
UCEC	chr3	25643747	Missense_Mutation	rs763948503	C93Y	0.12
UCEC	chr3	25627236	Missense_Mutation	rs757502615	R656H	0.2
UCEC	chr3	25618787	Missense_Mutation	novel	E1042D	0.37
UCEC	chr3	25618789	Nonsense_Mutation	NA	E1042*	0.36
UCEC	chr3	25638236	Missense_Mutation	novel	Y157S	0.53
UCEC	chr3	25599508	Missense_Mutation	NA	K1546T	0.35
UCEC	chr3	25607354	Nonsense_Mutation	novel	F1372*	0.05
UCEC	chr3	25607355	Frame_Shift_Ins	novel	*F1372Ifs3**	0.05
UCEC	chr3	25624324	Missense_Mutation	NA	S823N	0.27
UCEC	chr3	25638188	Missense_Mutation	NA	D173G	0.4
UCEC	chr3	25642348	Missense_Mutation	NA	M123I	0.3
UCEC	chr3	25618784	Missense_Mutation	NA	F1043L	0.38
UCEC	chr3	25619902	Missense_Mutation	novel	K1008T	0.05
UCEC	chr3	25629058	Nonsense_Mutation	novel	E593*	0.05
UCEC	chr3	25638294	Missense_Mutation	novel	S138R	0.26
UCEC	chr3	25615284	Missense_Mutation	rs200043349	R1171Q	0.17
UCEC	chr3	25629035	Missense_Mutation	novel	K600N	0.28
UCEC	chr3	25630904	Silent	novel	N434N	0.18
UCEC	chr3	25635971	Frame_Shift_Ins	novel	*G273Wfs7**	0.24
UCEC	chr3	25607369	Missense_Mutation	NA	R1367I	0.46
UCEC	chr3	25632567	Nonsense_Mutation	novel	W382*	0.33
UCEC	chr3	25620786	Missense_Mutation	NA	I920L	0.28
UCEC	chr3	25627265	Missense_Mutation	NA	K646N	0.26
UCEC	chr3	25632452	Frame_Shift_Del	novel	*F420Lfs10**	0.27
UCEC	chr3	25623675	Missense_Mutation	novel	R856H	0.52
UCEC	chr3	25635945	Missense_Mutation	novel	K281N	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7222	0.02241
LUAD	DEL	0.3178	0.068154
SKCM	DEL	0.1499	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0976	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0061	Kaplan-Meier Survival Analysis
KIRC	0.00068	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.036	Kaplan-Meier Survival Analysis
SKCM	0.0026	Kaplan-Meier Survival Analysis
READ	0.0031	Kaplan-Meier Survival Analysis
LAML	0.00035	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0061	Kaplan-Meier Survival Analysis
UVM	0.0033	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742