EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000077235 (Gene tree)
Gene ID: 2975
Gene Symbol: GTF3C1
Alias: TFIIIC220
Full Name: general transcription factor IIIC subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 90,376 bases
Position: chr16:27,459,555-27,549,930
Accession: 4664
RBP type: non-canonical RBP
Summary: (General Transcription Factor IIIC Subunit 1) is a Protein Coding gene. Diseases associated with GTF3C1 include Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9418847	Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding.	Mol Cell Biol	1998 Jan	Arrebola R	-
10839822	Acetylation of histones and transcription-related factors.	Microbiol Mol Biol Rev	2000 Jun	Sterner DE	-
3588299	Novobiocin interferes with the binding of transcription factors TFIIIA and TFIIIC to the promoters of class III genes.	Nucleic Acids Res	1987 Jun 11	Van Dyke MW	-
9271407	Domains of the Brf component of RNA polymerase III transcription factor IIIB (TFIIIB): functions in assembly of TFIIIB-DNA complexes and recruitment of RNA polymerase to the promoter.	Mol Cell Biol	1997 Sep	Kassavetis GA	-
10373544	Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III.	Mol Cell Biol	1999 Jul	Hsieh YJ	-
8308884	Encounters of Saccharomyces cerevisiae RNA polymerase III with its transcription factors during RNA chain elongation.	J Mol Biol	1994 Jan 28	Bardeleben C	-
11533232	A novel upstream RNA polymerase III promoter element becomes essential when the chromatin structure of the yeast U6 RNA gene is altered.	Mol Cell Biol	2001 Oct	Martin MP	-
17626045	Zinc fingers 1 and 7 of yeast TFIIIA are essential for assembly of a functional transcription complex on the 5 S RNA gene.	Nucleic Acids Res	2007	Rothfels K	-
3633923	Effects of tRNATyr point mutations on the binding of yeast RNA polymerase III transcription factor C.	J Biol Chem	1986 Apr 25	Baker RE	-
7991561	Directing transcription of an RNA polymerase III gene via GAL4 sites.	Proc Natl Acad Sci U S A	1994 Dec 6	Marsolier MC	-
7518581	Interactions between yeast TFIIIB components.	Nucleic Acids Res	1994 Jun 25	Huet J	-
9917387	The RNA polymerase III-recruiting factor TFIIIB induces a DNA bend between the TATA box and the transcriptional start site.	J Mol Biol	1999 Jan 29	Grove A	-
3601665	Two forms of transcription factor TFIIIC in extracts from HeLa cells.	Nucleic Acids Res	1987 Jul 10	Van Dyke MW	-
2703476	A protein-protein interaction is essential for stable complex formation on a 5 S RNA gene.	J Biol Chem	1989 Apr 15	Hayes J	-
2398887	Additional intragenic promoter elements of the Xenopus 5S RNA genes upstream from the TFIIIA-binding site.	Mol Cell Biol	1990 Oct	Keller HJ	-
2303478	Photoaffinity labeling of RNA polymerase III transcription complexes by nascent RNA.	J Biol Chem	1990 Mar 5	Bartholomew B	-
2052571	Isolation of TFC1, a gene encoding one of two DNA-binding subunits of yeast transcription factor tau (TFIIIC).	Proc Natl Acad Sci U S A	1991 Jun 1	Swanson RN	-
8308883	Analysis of RNA chain elongation and termination by Saccharomyces cerevisiae RNA polymerase III.	J Mol Biol	1994 Jan 28	Matsuzaki H	-
8078782	Interactions between yeast TFIIIB components.	Nucleic Acids Res	1994 Aug 25	Huet J	-
7744776	Lethal mutations in a yeast U6 RNA gene B block promoter element identify essential contacts with transcription factor-IIIC.	J Biol Chem	1995 May 12	Kaiser MW	-
7760828	Coordinate regulation of ribosomal component synthesis in Acanthamoeba castellanii: 5S RNA transcription is down regulated during encystment by alteration of TFIIIA activity.	Mol Cell Biol	1995 Jun	Matthews JL	-
7705660	TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter.	Genes Dev	1995 Apr 1	Roberts S	-
11741971	Intragenic promoter adaptation and facilitated RNA polymerase III recycling in the transcription of SCR1, the 7SL RNA gene of Saccharomyces cerevisiae.	J Biol Chem	2002 Mar 1	Dieci G	-
16407207	Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo.	J Biol Chem	2006 Mar 17	Kassavetis GA	-
11459191	Genetic interactions within TFIIIC, the promoter-binding factor of yeast RNA polymerase III.	Mol Genet Genomics	2001 Jun	Rozenfeld S	-
16880507	Interactions of Brf1 peptides with the tetratricopeptide repeat-containing subunit of TFIIIC inhibit and promote preinitiation complex assembly.	Mol Cell Biol	2006 Aug	Liao Y	-
16822860	A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.	Nucleic Acids Res	2006 Jul 5	Innes F	-
15082757	High-level activation of transcription of the yeast U6 snRNA gene in chromatin by the basal RNA polymerase III transcription factor TFIIIC.	Mol Cell Biol	2004 May	Shivaswamy S	-
17052456	Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly.	Mol Cell	2006 Oct 20	Mylona A	-
16982688	Role of RNA polymerase III transcription factors in the selection of integration sites by the dictyostelium non-long terminal repeat retrotransposon TRE5-A.	Mol Cell Biol	2006 Nov	Siol O	-
21525131	Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome.	Nucleic Acids Res	2011 Aug	Siol O	doi: 10.1093/nar/gkr261
25348158	Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae.	BMC Biol	2014 Oct 28	Wang Q	doi: 10.1186/s12915-014-0089-x.
24688796	Evolution of the B-Block Binding Subunit of TFIIIC That Binds to the Internal Promoter for RNA Polymerase III.	Int J Evol Biol	2014	Matsutani S	doi: 10.1155/2014/609865
24336746	Intergenic transcriptional interference is blocked by RNA polymerase III transcription factor TFIIIB in Saccharomyces cerevisiae.	Genetics	2014 Feb	Korde A	doi: 10.1534/genetics.113.160093
25918241	Argonaute 2 Binds Directly to tRNA Genes and Promotes Gene Repression in cis.	Mol Cell Biol	2015 Jul	Woolnough JL	-
25957277	Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe.	G3 (Bethesda)	2015 May 8	Garcia JF	doi: 10.1534/g3.115.018663.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000567843	GTF3C1-208	474	-	-	- (aa)	-	-
ENST00000564664	GTF3C1-204	933	-	ENSP00000457476	139 (aa)	-	H3BU55
ENST00000567806	GTF3C1-207	584	-	-	- (aa)	-	-
ENST00000561623	GTF3C1-202	7015	-	ENSP00000455417	2084 (aa)	-	Q12789
ENST00000566779	GTF3C1-206	645	-	-	- (aa)	-	-
ENST00000570129	GTF3C1-212	505	-	-	- (aa)	-	-
ENST00000568569	GTF3C1-209	540	-	ENSP00000456187	180 (aa)	-	H3BRD0
ENST00000569394	GTF3C1-210	566	-	-	- (aa)	-	-
ENST00000571886	GTF3C1-213	721	-	ENSP00000459231	84 (aa)	-	I3L1Z3
ENST00000569653	GTF3C1-211	897	-	ENSP00000457449	214 (aa)	-	H3BU37
ENST00000564747	GTF3C1-205	2798	-	-	- (aa)	-	-
ENST00000356183	GTF3C1-201	7018	XM_017023188	ENSP00000348510	2109 (aa)	XP_016878677	Q12789
ENST00000562609	GTF3C1-203	2824	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000077235's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000077235	rs61739285	16	27469476	T	Male-pattern baldness	30573740	[0.039-0.073] unit decrease	0.0559936	EFO_0007825

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000077235's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000127	transcription factor TFIIIC complex	21873635.	IBA	Component
GO:0000127	transcription factor TFIIIC complex	17409385.	IDA	Component
GO:0000995	RNA polymerase III general transcription initiation factor activity	21873635.	IBA	Function
GO:0001002	RNA polymerase III type 1 promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0001003	RNA polymerase III type 2 promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	17409385.	IC	Function
GO:0005515	protein binding	18377933.19299493.25416956.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0006383	transcription by RNA polymerase III	17409385.	IC	Process
GO:0006384	transcription initiation from RNA polymerase III promoter	21873635.	IBA	Process
GO:0009303	rRNA transcription	8164661.	TAS	Process
GO:0009304	tRNA transcription	8164661.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0042791	5S class rRNA transcription by RNA polymerase III	21873635.	IBA	Process
GO:0042791	5S class rRNA transcription by RNA polymerase III	17409385.	IC	Process
GO:0042797	tRNA transcription by RNA polymerase III	17409385.	IC	Process
GO:1990904	ribonucleoprotein complex	-	IEA	Component