EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000077348 (Gene tree)
Gene ID: 56915
Gene Symbol: EXOSC5
Alias: hRrp46p|Rrp46p|RRP46|RRP41B|MGC12901|p12B
Full Name: exosome component 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,110 bases
Position: chr19:41,386,370-41,397,479
Accession: 24662
RBP type: canonical RBP
Summary: (Exosome Component 5) is a Protein Coding gene. Diseases associated with EXOSC5 include Cat-Scratch Disease. Among its related pathways are PERK regulates gene expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000221233	RNase_PH	PF01138.21	3.6e-22	1	1
ENSP00000471002	RNase_PH	PF01138.21	3.8e-12	1	1
ENSP00000472396	RNase_PH	PF01138.21	4.7e-08	1	1
ENSP00000471557	RNase_PH	PF01138.21	1.7e-07	1	1
ENSP00000471002	RNase_PH_C	PF03725.15	1.6e-07	1	1
ENSP00000221233	RNase_PH_C	PF03725.15	2.2e-07	1	1

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25879614	Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance.	BMC Genomics	2015 Mar 6	Maekawa S	doi: 10.1186/s12864-015-1358-y.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000593523	EXOSC5-202	716	-	-	- (aa)	-	-
ENST00000596905	EXOSC5-204	826	-	ENSP00000471002	197 (aa)	-	M0R050
ENST00000221233	EXOSC5-201	1118	-	ENSP00000221233	235 (aa)	-	Q9NQT4
ENST00000602129	EXOSC5-205	354	-	ENSP00000472396	62 (aa)	-	M0R289
ENST00000593771	EXOSC5-203	404	-	ENSP00000471557	133 (aa)	-	M0R102

Gene Model

Click here to download ENSG00000077348's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000077348's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000077348	EXOSC5	80	32.512	ENSG00000178896	EXOSC4	69	33.918

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000077348	EXOSC5	95	71.186	ENSAPOG00000012910	exosc5	95	64.904	Acanthochromis_polyacanthus
ENSG00000077348	EXOSC5	67	31.395	ENSAPOG00000000255	exosc4	69	31.395	Acanthochromis_polyacanthus
ENSG00000077348	EXOSC5	100	92.340	ENSAMEG00000011623	EXOSC5	100	92.340	Ailuropoda_melanoleuca
ENSG00000077348	EXOSC5	80	32.512	ENSAMEG00000006093	EXOSC4	69	33.333	Ailuropoda_melanoleuca
ENSG00000077348	EXOSC5	97	76.667	ENSACIG00000024067	exosc5	97	67.925	Amphilophus_citrinellus
ENSG00000077348	EXOSC5	54	33.094	ENSACIG00000017924	exosc4	56	33.094	Amphilophus_citrinellus
ENSG00000077348	EXOSC5	97	73.333	ENSAOCG00000006601	exosc5	95	65.072	Amphiprion_ocellaris
ENSG00000077348	EXOSC5	54	32.374	ENSAOCG00000005105	exosc4	69	31.395	Amphiprion_ocellaris
ENSG00000077348	EXOSC5	97	73.333	ENSAPEG00000014199	exosc5	95	65.072	Amphiprion_percula
ENSG00000077348	EXOSC5	54	32.374	ENSAPEG00000003972	exosc4	69	31.395	Amphiprion_percula
ENSG00000077348	EXOSC5	97	75.000	ENSATEG00000008886	exosc5	95	65.072	Anabas_testudineus
ENSG00000077348	EXOSC5	57	31.944	ENSATEG00000014148	exosc6	65	30.270	Anabas_testudineus
ENSG00000077348	EXOSC5	67	31.395	ENSATEG00000007766	exosc4	69	31.395	Anabas_testudineus
ENSG00000077348	EXOSC5	97	76.667	ENSACAG00000003784	EXOSC5	94	67.464	Anolis_carolinensis
ENSG00000077348	EXOSC5	100	93.548	ENSANAG00000022449	EXOSC5	100	77.021	Aotus_nancymaae
ENSG00000077348	EXOSC5	80	32.512	ENSANAG00000026123	EXOSC4	69	33.918	Aotus_nancymaae
ENSG00000077348	EXOSC5	67	31.395	ENSACLG00000020071	exosc4	69	31.395	Astatotilapia_calliptera
ENSG00000077348	EXOSC5	97	73.333	ENSACLG00000020944	exosc5	90	66.507	Astatotilapia_calliptera
ENSG00000077348	EXOSC5	100	69.355	ENSAMXG00000034946	exosc5	96	66.038	Astyanax_mexicanus
ENSG00000077348	EXOSC5	67	32.749	ENSAMXG00000030867	exosc4	69	32.749	Astyanax_mexicanus
ENSG00000077348	EXOSC5	100	91.489	ENSBTAG00000016034	EXOSC5	100	91.489	Bos_taurus
ENSG00000077348	EXOSC5	86	31.507	ENSBTAG00000014607	EXOSC4	69	33.918	Bos_taurus
ENSG00000077348	EXOSC5	82	41.176	WBGene00000798	crn-5	96	31.429	Caenorhabditis_elegans
ENSG00000077348	EXOSC5	82	32.039	ENSCJAG00000021458	EXOSC4	69	33.918	Callithrix_jacchus
ENSG00000077348	EXOSC5	100	95.745	ENSCJAG00000020152	EXOSC5	100	95.745	Callithrix_jacchus
ENSG00000077348	EXOSC5	82	31.068	ENSCAFG00000001521	EXOSC4	69	33.333	Canis_familiaris
ENSG00000077348	EXOSC5	100	93.548	ENSCAFG00000032654	EXOSC5	100	93.191	Canis_familiaris
ENSG00000077348	EXOSC5	100	93.548	ENSCAFG00020014770	EXOSC5	100	93.191	Canis_lupus_dingo
ENSG00000077348	EXOSC5	82	31.068	ENSCAFG00020018820	EXOSC4	69	33.333	Canis_lupus_dingo
ENSG00000077348	EXOSC5	86	31.507	ENSCHIG00000021121	EXOSC4	69	33.918	Capra_hircus
ENSG00000077348	EXOSC5	100	90.638	ENSCHIG00000026498	EXOSC5	100	90.638	Capra_hircus
ENSG00000077348	EXOSC5	82	31.553	ENSTSYG00000029697	EXOSC4	69	33.918	Carlito_syrichta
ENSG00000077348	EXOSC5	100	92.340	ENSTSYG00000014183	EXOSC5	100	92.340	Carlito_syrichta
ENSG00000077348	EXOSC5	79	71.351	ENSCAPG00000005778	EXOSC5	100	71.351	Cavia_aperea
ENSG00000077348	EXOSC5	80	30.846	ENSCPOG00000022671	EXOSC4	69	31.953	Cavia_porcellus
ENSG00000077348	EXOSC5	100	91.935	ENSCPOG00000035731	EXOSC5	98	88.983	Cavia_porcellus
ENSG00000077348	EXOSC5	100	96.170	ENSCCAG00000013179	EXOSC5	100	96.170	Cebus_capucinus
ENSG00000077348	EXOSC5	80	32.512	ENSCATG00000029965	EXOSC4	69	33.918	Cercocebus_atys
ENSG00000077348	EXOSC5	100	97.447	ENSCATG00000044084	EXOSC5	100	97.447	Cercocebus_atys
ENSG00000077348	EXOSC5	100	91.935	ENSCLAG00000001186	EXOSC5	100	90.638	Chinchilla_lanigera
ENSG00000077348	EXOSC5	80	32.512	ENSCLAG00000014676	EXOSC4	69	33.918	Chinchilla_lanigera
ENSG00000077348	EXOSC5	100	97.447	ENSCSAG00000003522	EXOSC5	90	97.447	Chlorocebus_sabaeus
ENSG00000077348	EXOSC5	80	32.512	ENSCSAG00000008802	EXOSC4	69	33.918	Chlorocebus_sabaeus
ENSG00000077348	EXOSC5	100	88.710	ENSCHOG00000000047	EXOSC5	100	88.511	Choloepus_hoffmanni
ENSG00000077348	EXOSC5	87	48.148	ENSCING00000005595	-	90	41.038	Ciona_intestinalis
ENSG00000077348	EXOSC5	58	47.222	ENSCING00000009562	-	67	31.928	Ciona_intestinalis
ENSG00000077348	EXOSC5	81	40.000	ENSCSAVG00000008006	-	61	33.553	Ciona_savignyi
ENSG00000077348	EXOSC5	87	46.296	ENSCSAVG00000009006	-	97	38.326	Ciona_savignyi
ENSG00000077348	EXOSC5	100	97.447	ENSCANG00000039325	EXOSC5	100	97.447	Colobus_angolensis_palliatus
ENSG00000077348	EXOSC5	80	32.512	ENSCANG00000035733	EXOSC4	69	33.918	Colobus_angolensis_palliatus
ENSG00000077348	EXOSC5	100	93.548	ENSCGRG00001017207	Exosc5	100	88.936	Cricetulus_griseus_chok1gshd
ENSG00000077348	EXOSC5	86	31.050	ENSCGRG00001020452	Exosc4	69	33.918	Cricetulus_griseus_chok1gshd
ENSG00000077348	EXOSC5	77	84.615	ENSCGRG00000003031	Exosc5	85	90.854	Cricetulus_griseus_crigri
ENSG00000077348	EXOSC5	86	31.050	ENSCGRG00000016505	Exosc4	69	33.918	Cricetulus_griseus_crigri
ENSG00000077348	EXOSC5	54	31.655	ENSCSEG00000010906	exosc4	69	30.814	Cynoglossus_semilaevis
ENSG00000077348	EXOSC5	95	76.271	ENSCSEG00000007190	exosc5	95	67.150	Cynoglossus_semilaevis
ENSG00000077348	EXOSC5	97	76.667	ENSCVAG00000009396	exosc5	95	65.550	Cyprinodon_variegatus
ENSG00000077348	EXOSC5	54	33.094	ENSCVAG00000006625	exosc4	56	33.094	Cyprinodon_variegatus
ENSG00000077348	EXOSC5	64	32.090	ENSCVAG00000021002	EXOSC6	62	32.824	Cyprinodon_variegatus
ENSG00000077348	EXOSC5	64	32.090	ENSCVAG00000021030	exosc6	62	32.824	Cyprinodon_variegatus
ENSG00000077348	EXOSC5	95	67.797	ENSDARG00000040557	exosc5	93	65.217	Danio_rerio
ENSG00000077348	EXOSC5	67	32.164	ENSDARG00000103432	exosc4	70	30.636	Danio_rerio
ENSG00000077348	EXOSC5	100	87.660	ENSDNOG00000017137	EXOSC5	100	87.660	Dasypus_novemcinctus
ENSG00000077348	EXOSC5	78	31.122	ENSDNOG00000009800	EXOSC4	69	33.918	Dasypus_novemcinctus
ENSG00000077348	EXOSC5	82	30.583	ENSDORG00000008461	Exosc4	69	33.333	Dipodomys_ordii
ENSG00000077348	EXOSC5	98	91.803	ENSDORG00000003611	Exosc5	100	86.809	Dipodomys_ordii
ENSG00000077348	EXOSC5	89	41.818	FBgn0037815	Rrp46	89	38.462	Drosophila_melanogaster
ENSG00000077348	EXOSC5	100	91.935	ENSETEG00000009358	EXOSC5	98	90.638	Echinops_telfairi
ENSG00000077348	EXOSC5	86	30.000	ENSEBUG00000014277	exosc4	69	33.140	Eptatretus_burgeri
ENSG00000077348	EXOSC5	79	69.388	ENSEBUG00000000312	exosc5	93	57.820	Eptatretus_burgeri
ENSG00000077348	EXOSC5	100	93.548	ENSEASG00005006327	EXOSC5	89	92.766	Equus_asinus_asinus
ENSG00000077348	EXOSC5	82	31.553	ENSEASG00005010166	EXOSC4	69	33.918	Equus_asinus_asinus
ENSG00000077348	EXOSC5	82	31.553	ENSECAG00000013658	EXOSC4	69	33.918	Equus_caballus
ENSG00000077348	EXOSC5	100	93.617	ENSECAG00000024210	EXOSC5	100	93.617	Equus_caballus
ENSG00000077348	EXOSC5	100	90.323	ENSEEUG00000007299	EXOSC5	87	77.561	Erinaceus_europaeus
ENSG00000077348	EXOSC5	97	73.333	ENSELUG00000021719	exosc5	95	65.550	Esox_lucius
ENSG00000077348	EXOSC5	54	33.813	ENSELUG00000021011	exosc4	56	33.813	Esox_lucius
ENSG00000077348	EXOSC5	82	31.553	ENSFCAG00000034465	EXOSC4	69	33.333	Felis_catus
ENSG00000077348	EXOSC5	100	93.548	ENSFCAG00000033818	EXOSC5	100	93.191	Felis_catus
ENSG00000077348	EXOSC5	81	69.474	ENSFALG00000012886	EXOSC5	99	69.474	Ficedula_albicollis
ENSG00000077348	EXOSC5	100	91.935	ENSFDAG00000001207	EXOSC5	100	90.213	Fukomys_damarensis
ENSG00000077348	EXOSC5	80	32.020	ENSFDAG00000006708	EXOSC4	69	33.333	Fukomys_damarensis
ENSG00000077348	EXOSC5	61	33.987	ENSFHEG00000017490	exosc6	55	33.987	Fundulus_heteroclitus
ENSG00000077348	EXOSC5	67	31.395	ENSFHEG00000013533	exosc4	69	31.395	Fundulus_heteroclitus
ENSG00000077348	EXOSC5	95	74.576	ENSFHEG00000021919	exosc5	88	65.865	Fundulus_heteroclitus
ENSG00000077348	EXOSC5	97	71.667	ENSGMOG00000015865	exosc5	99	64.789	Gadus_morhua
ENSG00000077348	EXOSC5	54	33.094	ENSGMOG00000002113	exosc4	55	33.094	Gadus_morhua
ENSG00000077348	EXOSC5	97	75.000	ENSGAFG00000015767	exosc5	96	62.389	Gambusia_affinis
ENSG00000077348	EXOSC5	61	33.987	ENSGAFG00000015179	exosc6	58	33.987	Gambusia_affinis
ENSG00000077348	EXOSC5	54	32.374	ENSGAFG00000021407	exosc4	69	31.395	Gambusia_affinis
ENSG00000077348	EXOSC5	54	33.813	ENSGACG00000017838	exosc4	56	33.793	Gasterosteus_aculeatus
ENSG00000077348	EXOSC5	97	71.667	ENSGACG00000012986	exosc5	99	63.981	Gasterosteus_aculeatus
ENSG00000077348	EXOSC5	75	70.946	ENSGAGG00000003166	EXOSC5	84	69.481	Gopherus_agassizii
ENSG00000077348	EXOSC5	80	32.512	ENSGGOG00000040193	-	69	33.918	Gorilla_gorilla
ENSG00000077348	EXOSC5	80	32.512	ENSGGOG00000044212	-	69	33.918	Gorilla_gorilla
ENSG00000077348	EXOSC5	100	97.872	ENSGGOG00000008428	EXOSC5	100	97.872	Gorilla_gorilla
ENSG00000077348	EXOSC5	97	73.333	ENSHBUG00000010082	exosc5	90	66.507	Haplochromis_burtoni
ENSG00000077348	EXOSC5	67	31.395	ENSHBUG00000006605	exosc4	69	31.395	Haplochromis_burtoni
ENSG00000077348	EXOSC5	100	90.638	ENSHGLG00000008975	EXOSC5	100	90.638	Heterocephalus_glaber_female
ENSG00000077348	EXOSC5	80	32.512	ENSHGLG00000016299	EXOSC4	69	33.918	Heterocephalus_glaber_female
ENSG00000077348	EXOSC5	100	90.323	ENSHGLG00100016097	EXOSC5	100	90.213	Heterocephalus_glaber_male
ENSG00000077348	EXOSC5	80	32.512	ENSHGLG00100018786	EXOSC4	69	33.918	Heterocephalus_glaber_male
ENSG00000077348	EXOSC5	97	75.000	ENSHCOG00000017818	exosc5	88	63.636	Hippocampus_comes
ENSG00000077348	EXOSC5	64	30.147	ENSHCOG00000012112	exosc6	54	31.544	Hippocampus_comes
ENSG00000077348	EXOSC5	54	31.655	ENSHCOG00000018875	exosc4	53	31.655	Hippocampus_comes
ENSG00000077348	EXOSC5	67	32.749	ENSIPUG00000011922	Exosc4	69	32.749	Ictalurus_punctatus
ENSG00000077348	EXOSC5	89	72.727	ENSIPUG00000011820	Exosc5	95	63.768	Ictalurus_punctatus
ENSG00000077348	EXOSC5	59	30.872	ENSIPUG00000004761	exosc6	54	30.872	Ictalurus_punctatus
ENSG00000077348	EXOSC5	80	31.707	ENSSTOG00000002632	EXOSC4	69	32.370	Ictidomys_tridecemlineatus
ENSG00000077348	EXOSC5	100	93.548	ENSSTOG00000019738	EXOSC5	100	92.766	Ictidomys_tridecemlineatus
ENSG00000077348	EXOSC5	94	96.552	ENSJJAG00000013914	Exosc5	97	93.519	Jaculus_jaculus
ENSG00000077348	EXOSC5	80	33.005	ENSJJAG00000009655	Exosc4	69	33.918	Jaculus_jaculus
ENSG00000077348	EXOSC5	59	31.544	ENSKMAG00000009821	exosc6	55	31.544	Kryptolebias_marmoratus
ENSG00000077348	EXOSC5	54	31.655	ENSKMAG00000015373	exosc4	69	30.814	Kryptolebias_marmoratus
ENSG00000077348	EXOSC5	97	76.667	ENSKMAG00000009517	exosc5	95	66.507	Kryptolebias_marmoratus
ENSG00000077348	EXOSC5	87	63.158	ENSLBEG00000018216	exosc5	94	63.158	Labrus_bergylta
ENSG00000077348	EXOSC5	67	31.977	ENSLBEG00000012754	exosc4	69	31.977	Labrus_bergylta
ENSG00000077348	EXOSC5	83	54.082	ENSLACG00000018233	EXOSC5	97	54.359	Latimeria_chalumnae
ENSG00000077348	EXOSC5	97	76.667	ENSLOCG00000014220	exosc5	91	58.605	Lepisosteus_oculatus
ENSG00000077348	EXOSC5	100	87.234	ENSLAFG00000013753	EXOSC5	100	87.234	Loxodonta_africana
ENSG00000077348	EXOSC5	82	31.068	ENSLAFG00000030187	EXOSC4	69	33.918	Loxodonta_africana
ENSG00000077348	EXOSC5	100	97.872	ENSMFAG00000045851	EXOSC5	100	97.462	Macaca_fascicularis
ENSG00000077348	EXOSC5	80	32.512	ENSMFAG00000000161	EXOSC4	69	33.918	Macaca_fascicularis
ENSG00000077348	EXOSC5	80	32.512	ENSMMUG00000007160	EXOSC4	69	33.918	Macaca_mulatta
ENSG00000077348	EXOSC5	100	97.872	ENSMMUG00000014345	EXOSC5	100	97.872	Macaca_mulatta
ENSG00000077348	EXOSC5	80	32.512	ENSMNEG00000033938	EXOSC4	69	33.918	Macaca_nemestrina
ENSG00000077348	EXOSC5	100	97.872	ENSMNEG00000044403	EXOSC5	100	97.462	Macaca_nemestrina
ENSG00000077348	EXOSC5	100	97.872	ENSMLEG00000042915	EXOSC5	100	97.872	Mandrillus_leucophaeus
ENSG00000077348	EXOSC5	80	32.512	ENSMLEG00000041197	EXOSC4	69	33.918	Mandrillus_leucophaeus
ENSG00000077348	EXOSC5	95	77.966	ENSMAMG00000014323	exosc5	88	66.346	Mastacembelus_armatus
ENSG00000077348	EXOSC5	54	32.374	ENSMAMG00000014749	exosc4	56	32.374	Mastacembelus_armatus
ENSG00000077348	EXOSC5	67	31.395	ENSMZEG00005025086	exosc4	69	31.395	Maylandia_zebra
ENSG00000077348	EXOSC5	97	73.333	ENSMZEG00005024196	exosc5	99	62.128	Maylandia_zebra
ENSG00000077348	EXOSC5	86	31.050	ENSMAUG00000007911	Exosc4	69	33.918	Mesocricetus_auratus
ENSG00000077348	EXOSC5	91	86.512	ENSMAUG00000010419	Exosc5	93	86.512	Mesocricetus_auratus
ENSG00000077348	EXOSC5	100	91.489	ENSMICG00000002016	EXOSC5	100	91.489	Microcebus_murinus
ENSG00000077348	EXOSC5	86	31.050	ENSMOCG00000020295	Exosc4	69	33.918	Microtus_ochrogaster
ENSG00000077348	EXOSC5	98	93.443	ENSMOCG00000002379	Exosc5	100	89.362	Microtus_ochrogaster
ENSG00000077348	EXOSC5	56	31.724	ENSMMOG00000016779	exosc4	58	31.724	Mola_mola
ENSG00000077348	EXOSC5	97	71.667	ENSMMOG00000004799	exosc5	89	65.550	Mola_mola
ENSG00000077348	EXOSC5	77	30.928	ENSMODG00000010435	EXOSC4	79	32.749	Monodelphis_domestica
ENSG00000077348	EXOSC5	100	91.935	ENSMODG00000008642	EXOSC5	100	84.388	Monodelphis_domestica
ENSG00000077348	EXOSC5	54	32.374	ENSMALG00000020564	exosc4	58	32.414	Monopterus_albus
ENSG00000077348	EXOSC5	97	76.667	ENSMALG00000009453	exosc5	95	66.986	Monopterus_albus
ENSG00000077348	EXOSC5	80	33.005	MGP_CAROLIEiJ_G0019919	Exosc4	69	33.918	Mus_caroli
ENSG00000077348	EXOSC5	98	93.443	MGP_CAROLIEiJ_G0029376	Exosc5	100	88.936	Mus_caroli
ENSG00000077348	EXOSC5	98	93.443	ENSMUSG00000061286	Exosc5	100	89.362	Mus_musculus
ENSG00000077348	EXOSC5	80	33.005	ENSMUSG00000034259	Exosc4	69	33.918	Mus_musculus
ENSG00000077348	EXOSC5	98	93.443	MGP_PahariEiJ_G0021229	Exosc5	100	90.213	Mus_pahari
ENSG00000077348	EXOSC5	86	31.050	MGP_PahariEiJ_G0019929	Exosc4	69	33.918	Mus_pahari
ENSG00000077348	EXOSC5	98	93.443	MGP_SPRETEiJ_G0030472	Exosc5	100	89.362	Mus_spretus
ENSG00000077348	EXOSC5	80	33.005	MGP_SPRETEiJ_G0020822	Exosc4	69	33.918	Mus_spretus
ENSG00000077348	EXOSC5	100	91.915	ENSMPUG00000017649	EXOSC5	100	91.915	Mustela_putorius_furo
ENSG00000077348	EXOSC5	100	93.548	ENSMLUG00000013104	EXOSC5	99	89.744	Myotis_lucifugus
ENSG00000077348	EXOSC5	100	93.548	ENSNGAG00000005929	Exosc5	100	91.489	Nannospalax_galili
ENSG00000077348	EXOSC5	80	33.005	ENSNGAG00000022428	Exosc4	69	33.918	Nannospalax_galili
ENSG00000077348	EXOSC5	67	31.395	ENSNBRG00000012326	exosc4	69	31.395	Neolamprologus_brichardi
ENSG00000077348	EXOSC5	97	75.000	ENSNBRG00000004340	exosc5	95	66.986	Neolamprologus_brichardi
ENSG00000077348	EXOSC5	80	32.512	ENSNLEG00000010449	EXOSC4	69	33.918	Nomascus_leucogenys
ENSG00000077348	EXOSC5	100	97.462	ENSNLEG00000013696	EXOSC5	100	97.462	Nomascus_leucogenys
ENSG00000077348	EXOSC5	82	31.553	ENSMEUG00000011002	EXOSC4	69	32.749	Notamacropus_eugenii
ENSG00000077348	EXOSC5	100	91.935	ENSMEUG00000010485	EXOSC5	93	69.907	Notamacropus_eugenii
ENSG00000077348	EXOSC5	100	75.845	ENSODEG00000000427	EXOSC5	100	75.845	Octodon_degus
ENSG00000077348	EXOSC5	80	32.512	ENSODEG00000013951	EXOSC4	69	33.918	Octodon_degus
ENSG00000077348	EXOSC5	54	32.374	ENSONIG00000009617	exosc4	69	31.395	Oreochromis_niloticus
ENSG00000077348	EXOSC5	97	76.667	ENSONIG00000004023	exosc5	90	66.986	Oreochromis_niloticus
ENSG00000077348	EXOSC5	80	33.005	ENSOCUG00000021243	EXOSC4	69	33.918	Oryctolagus_cuniculus
ENSG00000077348	EXOSC5	100	93.548	ENSOCUG00000011497	EXOSC5	100	88.936	Oryctolagus_cuniculus
ENSG00000077348	EXOSC5	97	76.667	ENSORLG00000023035	exosc5	95	67.943	Oryzias_latipes
ENSG00000077348	EXOSC5	57	31.724	ENSORLG00000013325	exosc6	65	30.435	Oryzias_latipes
ENSG00000077348	EXOSC5	67	31.395	ENSORLG00000017295	exosc4	69	31.395	Oryzias_latipes
ENSG00000077348	EXOSC5	97	75.000	ENSORLG00020017279	exosc5	95	67.943	Oryzias_latipes_hni
ENSG00000077348	EXOSC5	57	31.724	ENSORLG00020017597	exosc6	65	30.435	Oryzias_latipes_hni
ENSG00000077348	EXOSC5	67	31.395	ENSORLG00020009788	exosc4	69	31.395	Oryzias_latipes_hni
ENSG00000077348	EXOSC5	97	76.667	ENSORLG00015001719	exosc5	99	64.889	Oryzias_latipes_hsok
ENSG00000077348	EXOSC5	67	31.395	ENSORLG00015009754	exosc4	69	31.395	Oryzias_latipes_hsok
ENSG00000077348	EXOSC5	67	31.977	ENSOMEG00000005800	exosc4	69	31.977	Oryzias_melastigma
ENSG00000077348	EXOSC5	97	75.000	ENSOMEG00000021763	exosc5	95	66.986	Oryzias_melastigma
ENSG00000077348	EXOSC5	100	93.617	ENSOGAG00000016075	EXOSC5	100	93.617	Otolemur_garnettii
ENSG00000077348	EXOSC5	80	32.512	ENSOGAG00000007411	EXOSC4	69	33.918	Otolemur_garnettii
ENSG00000077348	EXOSC5	86	30.769	ENSOARG00000015188	EXOSC4	69	32.948	Ovis_aries
ENSG00000077348	EXOSC5	100	90.638	ENSOARG00000007412	EXOSC5	100	90.638	Ovis_aries
ENSG00000077348	EXOSC5	100	98.723	ENSPPAG00000024210	EXOSC5	100	98.723	Pan_paniscus
ENSG00000077348	EXOSC5	80	32.512	ENSPPAG00000035746	EXOSC4	69	33.918	Pan_paniscus
ENSG00000077348	EXOSC5	100	93.548	ENSPPRG00000003713	EXOSC5	100	92.766	Panthera_pardus
ENSG00000077348	EXOSC5	82	31.553	ENSPPRG00000019782	EXOSC4	69	33.333	Panthera_pardus
ENSG00000077348	EXOSC5	100	93.548	ENSPTIG00000015884	EXOSC5	100	92.340	Panthera_tigris_altaica
ENSG00000077348	EXOSC5	80	32.512	ENSPTRG00000020677	EXOSC4	69	33.918	Pan_troglodytes
ENSG00000077348	EXOSC5	100	98.723	ENSPTRG00000011024	EXOSC5	100	98.723	Pan_troglodytes
ENSG00000077348	EXOSC5	100	97.872	ENSPANG00000004945	EXOSC5	100	97.872	Papio_anubis
ENSG00000077348	EXOSC5	80	32.512	ENSPANG00000023276	EXOSC4	69	33.918	Papio_anubis
ENSG00000077348	EXOSC5	97	73.333	ENSPKIG00000013092	exosc5	92	64.623	Paramormyrops_kingsleyae
ENSG00000077348	EXOSC5	67	31.579	ENSPKIG00000018362	exosc4	69	31.579	Paramormyrops_kingsleyae
ENSG00000077348	EXOSC5	97	78.333	ENSPMGG00000015323	exosc5	94	67.464	Periophthalmus_magnuspinnatus
ENSG00000077348	EXOSC5	67	31.395	ENSPMGG00000019307	exosc4	69	31.395	Periophthalmus_magnuspinnatus
ENSG00000077348	EXOSC5	60	31.126	ENSPMGG00000016974	exosc6	62	31.126	Periophthalmus_magnuspinnatus
ENSG00000077348	EXOSC5	98	93.443	ENSPEMG00000018589	Exosc5	100	88.511	Peromyscus_maniculatus_bairdii
ENSG00000077348	EXOSC5	86	31.050	ENSPEMG00000017031	Exosc4	69	33.918	Peromyscus_maniculatus_bairdii
ENSG00000077348	EXOSC5	88	31.111	ENSPMAG00000001175	exosc4	61	32.237	Petromyzon_marinus
ENSG00000077348	EXOSC5	100	91.935	ENSPCIG00000016745	EXOSC5	99	88.235	Phascolarctos_cinereus
ENSG00000077348	EXOSC5	82	31.068	ENSPCIG00000009102	EXOSC4	69	32.164	Phascolarctos_cinereus
ENSG00000077348	EXOSC5	73	32.447	ENSPFOG00000015869	exosc6	66	32.620	Poecilia_formosa
ENSG00000077348	EXOSC5	54	32.374	ENSPFOG00000015214	exosc4	56	32.374	Poecilia_formosa
ENSG00000077348	EXOSC5	97	75.000	ENSPFOG00000014158	exosc5	95	63.810	Poecilia_formosa
ENSG00000077348	EXOSC5	97	75.000	ENSPLAG00000005701	exosc5	81	65.550	Poecilia_latipinna
ENSG00000077348	EXOSC5	54	32.374	ENSPLAG00000018751	exosc4	56	32.374	Poecilia_latipinna
ENSG00000077348	EXOSC5	73	32.447	ENSPLAG00000014150	exosc6	66	32.620	Poecilia_latipinna
ENSG00000077348	EXOSC5	97	75.000	ENSPMEG00000020815	exosc5	91	65.566	Poecilia_mexicana
ENSG00000077348	EXOSC5	73	32.447	ENSPMEG00000019665	exosc6	66	32.620	Poecilia_mexicana
ENSG00000077348	EXOSC5	54	32.374	ENSPMEG00000023116	exosc4	56	32.374	Poecilia_mexicana
ENSG00000077348	EXOSC5	97	75.000	ENSPREG00000017723	exosc5	89	64.593	Poecilia_reticulata
ENSG00000077348	EXOSC5	74	31.579	ENSPREG00000019548	exosc6	55	33.117	Poecilia_reticulata
ENSG00000077348	EXOSC5	54	33.094	ENSPREG00000009632	exosc4	56	33.094	Poecilia_reticulata
ENSG00000077348	EXOSC5	80	30.846	ENSPPYG00000018959	EXOSC4	70	31.953	Pongo_abelii
ENSG00000077348	EXOSC5	79	98.387	ENSPPYG00000010016	-	99	98.387	Pongo_abelii
ENSG00000077348	EXOSC5	94	94.828	ENSPCAG00000005946	EXOSC5	100	79.574	Procavia_capensis
ENSG00000077348	EXOSC5	86	30.137	ENSPCAG00000014920	EXOSC4	69	33.333	Procavia_capensis
ENSG00000077348	EXOSC5	80	33.005	ENSPCOG00000020992	EXOSC4	69	33.918	Propithecus_coquereli
ENSG00000077348	EXOSC5	100	91.489	ENSPCOG00000020582	EXOSC5	100	91.489	Propithecus_coquereli
ENSG00000077348	EXOSC5	98	90.164	ENSPVAG00000013083	EXOSC5	100	72.340	Pteropus_vampyrus
ENSG00000077348	EXOSC5	82	30.583	ENSPVAG00000007100	EXOSC4	69	33.333	Pteropus_vampyrus
ENSG00000077348	EXOSC5	67	31.395	ENSPNYG00000014429	exosc4	69	31.395	Pundamilia_nyererei
ENSG00000077348	EXOSC5	97	73.333	ENSPNYG00000007712	exosc5	90	66.507	Pundamilia_nyererei
ENSG00000077348	EXOSC5	100	70.968	ENSPNAG00000030099	exosc5	98	64.151	Pygocentrus_nattereri
ENSG00000077348	EXOSC5	98	93.443	ENSRNOG00000020635	Exosc5	100	89.362	Rattus_norvegicus
ENSG00000077348	EXOSC5	86	31.050	ENSRNOG00000012348	Exosc4	69	33.918	Rattus_norvegicus
ENSG00000077348	EXOSC5	80	32.512	ENSRBIG00000038476	EXOSC4	69	33.918	Rhinopithecus_bieti
ENSG00000077348	EXOSC5	100	97.447	ENSRBIG00000040585	EXOSC5	100	96.954	Rhinopithecus_bieti
ENSG00000077348	EXOSC5	80	32.512	ENSRROG00000038556	EXOSC4	69	33.918	Rhinopithecus_roxellana
ENSG00000077348	EXOSC5	100	97.872	ENSRROG00000044020	EXOSC5	90	97.872	Rhinopithecus_roxellana
ENSG00000077348	EXOSC5	100	93.548	ENSSBOG00000031753	EXOSC5	100	81.702	Saimiri_boliviensis_boliviensis
ENSG00000077348	EXOSC5	82	31.553	ENSSHAG00000005397	EXOSC4	69	32.749	Sarcophilus_harrisii
ENSG00000077348	EXOSC5	98	72.131	ENSSFOG00015022999	exosc5	93	65.714	Scleropages_formosus
ENSG00000077348	EXOSC5	59	32.237	ENSSFOG00015004133	exosc4	61	32.237	Scleropages_formosus
ENSG00000077348	EXOSC5	97	76.667	ENSSMAG00000020240	exosc5	87	66.986	Scophthalmus_maximus
ENSG00000077348	EXOSC5	54	32.374	ENSSMAG00000020020	exosc4	69	31.395	Scophthalmus_maximus
ENSG00000077348	EXOSC5	54	32.374	ENSSDUG00000018966	exosc4	69	31.395	Seriola_dumerili
ENSG00000077348	EXOSC5	97	76.667	ENSSDUG00000000339	exosc5	81	66.986	Seriola_dumerili
ENSG00000077348	EXOSC5	97	76.667	ENSSLDG00000005218	exosc5	81	66.986	Seriola_lalandi_dorsalis
ENSG00000077348	EXOSC5	54	32.374	ENSSLDG00000008003	exosc4	69	31.395	Seriola_lalandi_dorsalis
ENSG00000077348	EXOSC5	99	71.552	ENSSARG00000010083	-	99	71.552	Sorex_araneus
ENSG00000077348	EXOSC5	97	75.000	ENSSPAG00000018306	exosc5	95	65.550	Stegastes_partitus
ENSG00000077348	EXOSC5	67	31.395	ENSSPAG00000016707	exosc4	64	31.395	Stegastes_partitus
ENSG00000077348	EXOSC5	98	90.164	ENSSSCG00000003015	EXOSC5	100	92.784	Sus_scrofa
ENSG00000077348	EXOSC5	86	30.137	ENSSSCG00000005925	EXOSC4	69	32.749	Sus_scrofa
ENSG00000077348	EXOSC5	83	67.010	ENSTGUG00000014136	EXOSC5	99	67.010	Taeniopygia_guttata
ENSG00000077348	EXOSC5	54	33.094	ENSTRUG00000025054	exosc4	56	33.094	Takifugu_rubripes
ENSG00000077348	EXOSC5	97	75.000	ENSTRUG00000009689	exosc5	95	66.029	Takifugu_rubripes
ENSG00000077348	EXOSC5	74	30.055	ENSTNIG00000004018	exosc6	59	31.544	Tetraodon_nigroviridis
ENSG00000077348	EXOSC5	97	74.194	ENSTNIG00000000238	exosc5	96	59.813	Tetraodon_nigroviridis
ENSG00000077348	EXOSC5	54	32.374	ENSTNIG00000008519	exosc4	56	32.374	Tetraodon_nigroviridis
ENSG00000077348	EXOSC5	87	92.683	ENSTBEG00000007203	EXOSC5	100	92.683	Tupaia_belangeri
ENSG00000077348	EXOSC5	100	92.340	ENSTTRG00000012863	EXOSC5	100	92.340	Tursiops_truncatus
ENSG00000077348	EXOSC5	100	91.371	ENSUAMG00000010104	EXOSC5	100	91.371	Ursus_americanus
ENSG00000077348	EXOSC5	82	31.068	ENSUAMG00000020173	EXOSC4	69	33.333	Ursus_americanus
ENSG00000077348	EXOSC5	62	32.520	ENSUMAG00000020831	EXOSC4	59	37.500	Ursus_maritimus
ENSG00000077348	EXOSC5	98	93.443	ENSUMAG00000005660	EXOSC5	93	91.707	Ursus_maritimus
ENSG00000077348	EXOSC5	82	31.068	ENSVVUG00000009675	EXOSC4	69	33.333	Vulpes_vulpes
ENSG00000077348	EXOSC5	100	93.548	ENSVVUG00000005320	EXOSC5	100	92.766	Vulpes_vulpes
ENSG00000077348	EXOSC5	69	30.508	ENSXETG00000007667	exosc6	65	30.508	Xenopus_tropicalis
ENSG00000077348	EXOSC5	100	75.806	ENSXETG00000018752	exosc5	93	72.512	Xenopus_tropicalis
ENSG00000077348	EXOSC5	97	75.000	ENSXCOG00000012487	exosc5	89	66.507	Xiphophorus_couchianus
ENSG00000077348	EXOSC5	67	31.395	ENSXCOG00000015017	exosc4	69	31.395	Xiphophorus_couchianus
ENSG00000077348	EXOSC5	61	33.766	ENSXCOG00000013623	exosc6	55	33.766	Xiphophorus_couchianus
ENSG00000077348	EXOSC5	97	71.667	ENSXMAG00000004786	exosc5	70	65.550	Xiphophorus_maculatus
ENSG00000077348	EXOSC5	61	33.117	ENSXMAG00000006280	exosc6	55	33.117	Xiphophorus_maculatus
ENSG00000077348	EXOSC5	67	31.395	ENSXMAG00000016287	exosc4	69	31.395	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	11110791.	NAS	Function
GO:0000176	nuclear exosome (RNase complex)	21873635.	IBA	Component
GO:0000177	cytoplasmic exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	20531389.	IDA	Component
GO:0003723	RNA binding	-	IEA	Function
GO:0004532	exoribonuclease activity	17174896.	IDA	Function
GO:0005515	protein binding	11812149.12419256.15231747.17185417.18334637.19060904.20531389.21255825.21876179.22407013.25043052.25416956.26496610.27107012.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005730	nucleolus	11110791.	NAS	Component
GO:0005737	cytoplasm	11110791.	NAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	11110791.	NAS	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0016075	rRNA catabolic process	21873635.	IBA	Process
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	21873635.	IBA	Process
GO:0034475	U4 snRNA 3'-end processing	21873635.	IBA	Process
GO:0035327	transcriptionally active chromatin	20699273.	IMP	Component
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	11782436.	IMP	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045006	DNA deamination	21255825.	IDA	Process
GO:0051607	defense response to virus	21791617.	IMP	Process
GO:0071028	nuclear mRNA surveillance	21873635.	IBA	Process
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	21873635.	IBA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	41397229	Missense_Mutation	novel	E34K	0.23
BLCA	chr19	41386691	Missense_Mutation	NA	S217W	0.31
BLCA	chr19	41389806	Missense_Mutation	novel	D162N	0.23	RNase_PH
BLCA	chr19	41397307	Missense_Mutation	novel	D8Y	0.39
BRCA	chr19	41397345	5'UTR	novel		0.41
BRCA	chr19	41391942	Missense_Mutation	NA	E95K	0.12
CESC	chr19	41386691	Missense_Mutation	rs754247072	S217L	0.57
CESC	chr19	41386614	3'UTR	novel		0.34
CESC	chr19	41397213	Missense_Mutation	rs771048778	S39L	0.23
COAD	chr19	41389794	Missense_Mutation	rs377108451	V166M	0.29	RNase_PH
COAD	chr19	41387561	Missense_Mutation	rs377456809	R190W	0.17	RNase_PH
COAD	chr19	41391888	Missense_Mutation	rs367849322	R113C	0.47
COAD	chr19	41389774	Missense_Mutation	NA	K172N	0.08	RNase_PH
COAD	chr19	41389857	Missense_Mutation	NA	G145S	0.1
COAD	chr19	41387561	Missense_Mutation	rs377456809	R190W	0.06	RNase_PH
GBM	chr19	41392952	Silent	rs148206160	Y59Y	0.38
HNSC	chr19	41389764	Splice_Site	novel	X175_splice	0.23
HNSC	chr19	41392883	Silent	rs766392972	P82P	0.19
HNSC	chr19	41389806	Missense_Mutation	novel	D162H	0.4	RNase_PH
KIRC	chr19	41389802	Missense_Mutation	NA	G163V	0.35	RNase_PH
LGG	chr19	41386660	Silent	novel	S227S	0.2
LIHC	chr19	41386724	Missense_Mutation	NA	L206P	0.17	RNase_PH
LUAD	chr19	41397330	5'UTR	novel		0.3
LUAD	chr19	41389899	Missense_Mutation	novel	A131T	0.17
LUSC	chr19	41392960	Missense_Mutation	novel	G57R	0.18
LUSC	chr19	41391934	Silent	rs759499806	L97L	0.12
LUSC	chr19	41391857	Missense_Mutation	rs201243873	V123A	0.12
LUSC	chr19	41397205	Missense_Mutation	novel	D42H	0.06
LUSC	chr19	41397205	Missense_Mutation	NA	D42N	0.19
OV	chr19	41392869	Missense_Mutation	novel	P87H	0.04
OV	chr19	41389851	Missense_Mutation	novel	P147A	0.05
PAAD	chr19	41386703	Missense_Mutation	novel	A213V	0.08	RNase_PH
PRAD	chr19	41391849	Missense_Mutation	novel	A126T	0.35
PRAD	chr19	41397235	Missense_Mutation	novel	A32T	0.42
SKCM	chr19	41397244	Missense_Mutation	rs762295191	R29W	0.35
SKCM	chr19	41392916	Silent	rs750069576	F71F	0.12
SKCM	chr19	41392942	Missense_Mutation	rs183362480	E63K	0.16
SKCM	chr19	41387561	Missense_Mutation	rs377456809	R190W	0.35	RNase_PH
SKCM	chr19	41397291	Missense_Mutation	rs772326120	A13V	0.28
SKCM	chr19	41392884	Missense_Mutation	novel	P82L	0.4
SKCM	chr19	41392885	Missense_Mutation	rs774465263	P82S	0.37
STAD	chr19	41387560	Missense_Mutation	rs770640185	R190Q	0.31	RNase_PH
STAD	chr19	41386690	Silent	rs540292584	S217S	0.56
UCEC	chr19	41389851	Missense_Mutation	NA	P147S	0.28
UCEC	chr19	41392880	Missense_Mutation	novel	K83N	0.12
UCEC	chr19	41392901	Silent	NA	L76L	0.18
UCEC	chr19	41391866	Missense_Mutation	NA	L120P	0.43
UCEC	chr19	41386546	3'UTR	novel		0.32
UCEC	chr19	41391891	Missense_Mutation	novel	P112S	0.25
UCEC	chr19	41392899	Missense_Mutation	novel	E77A	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
READ	DEL	0.0606	0.23023
UCS	DEL	0.2143	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0032	Kaplan-Meier Survival Analysis
ACC	0.037	Kaplan-Meier Survival Analysis
PRAD	0.032	Kaplan-Meier Survival Analysis
LUSC	0.025	Kaplan-Meier Survival Analysis
KIRP	0.00094	Kaplan-Meier Survival Analysis
CESC	0.05	Kaplan-Meier Survival Analysis
LAML	0.0059	Kaplan-Meier Survival Analysis
UCEC	0.013	Kaplan-Meier Survival Analysis
GBM	0.012	Kaplan-Meier Survival Analysis
LIHC	0.0028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742