EuRBPDB

Description

Ensembl ID: ENSG00000077380 (Gene tree)
Gene ID: 1781
Gene Symbol: DYNC1I2
Alias: DIC74|DNCI2
Full Name: dynein cytoplasmic 1 intermediate chain 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 62,750 bases
Position: chr2:171,687,409-171,750,158
Accession: 2964
RBP type: non-canonical RBP
Summary: This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000470286	DYNC1I2-220	587	-	-	- (aa)	-	-
ENST00000482454	DYNC1I2-224	2590	-	-	- (aa)	-	-
ENST00000443458	DYNC1I2-216	589	-	ENSP00000401005	139 (aa)	-	E7ERR6
ENST00000425485	DYNC1I2-212	622	-	ENSP00000394492	185 (aa)	-	E7EQU2
ENST00000445378	DYNC1I2-217	566	-	ENSP00000415410	121 (aa)	-	E7EU01
ENST00000409317	DYNC1I2-204	2196	XM_006712347	ENSP00000386591	632 (aa)	XP_006712410	Q13409
ENST00000438879	DYNC1I2-215	808	-	ENSP00000392741	214 (aa)	-	E7EMU4
ENST00000435234	DYNC1I2-214	1047	-	ENSP00000410807	305 (aa)	-	E7EQL5
ENST00000409197	DYNC1I2-203	2572	-	ENSP00000386397	612 (aa)	-	Q13409
ENST00000430778	DYNC1I2-213	566	-	ENSP00000409951	110 (aa)	-	E9PGG1
ENST00000422646	DYNC1I2-210	564	-	ENSP00000403089	184 (aa)	-	E7ETL8
ENST00000471482	DYNC1I2-221	581	-	-	- (aa)	-	-
ENST00000479806	DYNC1I2-223	1798	-	-	- (aa)	-	-
ENST00000423910	DYNC1I2-211	585	-	ENSP00000397654	173 (aa)	-	E7ET01
ENST00000412370	DYNC1I2-209	577	-	ENSP00000406104	137 (aa)	-	E7EUM4
ENST00000508530	DYNC1I2-225	2494	-	ENSP00000423339	611 (aa)	-	Q13409
ENST00000397119	DYNC1I2-202	2604	-	ENSP00000380308	638 (aa)	-	Q13409
ENST00000340296	DYNC1I2-201	2589	-	ENSP00000339430	612 (aa)	-	Q13409
ENST00000409453	DYNC1I2-205	2552	-	ENSP00000386886	637 (aa)	-	Q13409
ENST00000452242	DYNC1I2-218	980	-	ENSP00000398765	250 (aa)	-	E7EV09
ENST00000410079	DYNC1I2-207	2159	-	ENSP00000386522	630 (aa)	-	Q13409
ENST00000411953	DYNC1I2-208	582	-	ENSP00000405454	151 (aa)	-	E7ERH4
ENST00000409773	DYNC1I2-206	2583	-	ENSP00000386415	638 (aa)	-	Q13409
ENST00000476551	DYNC1I2-222	474	-	-	- (aa)	-	-
ENST00000456808	DYNC1I2-219	741	-	ENSP00000388699	187 (aa)	-	E7ESD3

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05132	Salmonella infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000077380	Body Height	6.8900000E-005	-
ENSG00000077380	Hippocampus	9E-7	25625606

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000077380	rs950173	2	171713909	A	Hippocampal volume	25625606	[100.56-234.24] unit decrease	167.4	EFO_0005035
ENSG00000077380	rs312924	2	171707511	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000077380	DYNC1I2	100	97.962	ENSMUSG00000027012	Dync1i2	100	97.962	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0003777	microtubule motor activity	8522607.	NAS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005737	cytoplasm	8522607.	NAS	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005868	cytoplasmic dynein complex	21873635.	IBA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007018	microtubule-based movement	8522607.	NAS	Process
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	21873635.	IBA	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030286	dynein complex	21873635.	IBA	Component
GO:0031982	vesicle	20682791.	IDA	Component
GO:0045503	dynein light chain binding	21873635.	IBA	Function
GO:0045504	dynein heavy chain binding	21873635.	IBA	Function
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process