EuRBPDB

Description

Ensembl ID: ENSG00000077549 (Gene tree)
Gene ID: 832
Gene Symbol: CAPZB
Alias: N
Full Name: capping actin protein of muscle Z-line subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 146,869 bases
Position: chr1:19,338,773-19,485,641
Accession: 1491
RBP type: non-canonical RBP
Summary: This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000482808	CAPZB-208	660	-	-	- (aa)	-	-
ENST00000457768	CAPZB-206	432	-	-	- (aa)	-	-
ENST00000264203	CAPZB-202	2068	-	ENSP00000264203	260 (aa)	-	B1AK85
ENST00000264202	CAPZB-201	858	-	ENSP00000264202	272 (aa)	-	P47756
ENST00000433834	CAPZB-205	1462	-	ENSP00000401010	301 (aa)	-	B1AK88
ENST00000375142	CAPZB-203	1686	XM_006710938	ENSP00000364284	277 (aa)	XP_006711001	P47756
ENST00000459967	CAPZB-207	579	-	-	- (aa)	-	-
ENST00000489607	CAPZB-209	488	-	-	- (aa)	-	-
ENST00000375144	CAPZB-204	1568	XM_024450096	ENSP00000364286	260 (aa)	XP_024305864	B1AK87

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000077549	Blood Pressure	6.8020000E-005	-
ENSG00000077549	Insulin Resistance	9.5680000E-006	-
ENSG00000077549	Insulin Resistance	2.4190000E-005	-
ENSG00000077549	Insulin	1.2680000E-005	-
ENSG00000077549	Thyrotropin	1E-8	23408906
ENSG00000077549	Thyrotropin	3E-14	23408906
ENSG00000077549	Thyroid Gland	1E-14	21565293
ENSG00000077549	Thyrotropin	4E-21	23408906
ENSG00000077549	Thyrotropin	3E-7	24852370
ENSG00000077549	Crohn Disease	8E-6	22482804
ENSG00000077549	Psoriasis	8E-6	22482804
ENSG00000077549	Thyroid Hormones	2E-8	22494929
ENSG00000077549	Hypothyroidism	8E-9	27182965
ENSG00000077549	Thyroid Gland	3E-18	21565293
ENSG00000077549	blood	3E-6	25820613
ENSG00000077549	Thyroid Gland	2E-11	21565293
ENSG00000077549	Thyroid Gland	3E-14	21565293

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000077549	rs11456569	1	19423058	CT	Plateletcrit	27863252	[0.018-0.033] unit increase	0.02539743	EFO_0007985
ENSG00000077549	rs7667	1	19392330	?	Crohn's disease and psoriasis	22482804	[NR]	1.11	EFO_0000676\|EFO_0000384
ENSG00000077549	rs12045440	1	19439024	T	Thyroid volume	21565293	[0.05-0.09] unit increase	0.067	EFO_0004865
ENSG00000077549	rs12045440	1	19439024	T	Thyroid volume	21565293	[1.26-1.51]	1.38	EFO_0004865
ENSG00000077549	rs12136530	1	19434935	A	Lead levels in blood	25820613	[0.091-0.229] unit increase	0.16	EFO_0007040
ENSG00000077549	rs34032610	1	19397830	?	Heel bone mineral density	30048462	[0.015-0.023] unit increase	0.0189251	EFO_0009270
ENSG00000077549	rs214321	1	19366634	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000077549	rs4912085	1	19402593	G	Heel bone mineral density	30598549	[0.017-0.024] unit increase	0.0205814	EFO_0009270
ENSG00000077549	rs1472565	1	19428536	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000077549	rs4912090	1	19422908	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000077549	rs72651487	1	19379595	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000077549	CAPZB	100	100.000	ENSMUSG00000028745	Capzb	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000902	cell morphogenesis	21873635.	IBA	Process
GO:0003779	actin binding	28493397.	IDA	Function
GO:0005515	protein binding	28493397.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007010	cytoskeleton organization	21834987.	IMP	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0008290	F-actin capping protein complex	21873635.	IBA	Component
GO:0010591	regulation of lamellipodium assembly	21873635.	IBA	Process
GO:0015629	actin cytoskeleton	7665558.	TAS	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0022604	regulation of cell morphogenesis	21834987.	IMP	Process
GO:0030017	sarcomere	-	IEA	Component
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051016	barbed-end actin filament capping	21873635.	IBA	Process
GO:0051490	negative regulation of filopodium assembly	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0071203	WASH complex	19922875.	IDA	Component