EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000078070 (Gene tree)
Gene ID: 56922
Gene Symbol: MCCC1
Alias: MCCA
Full Name: methylcrotonoyl-CoA carboxylase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 100,858 bases
Position: chr3:183,015,218-183,116,075
Accession: 6936
RBP type: canonical RBP
Summary: This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000486824	RimK	PF08443.11	2.8e-06	1	1
ENSP00000420433	RimK	PF08443.11	6.6e-06	1	1
ENSP00000419898	RimK	PF08443.11	7e-06	1	1
ENSP00000480435	RimK	PF08443.11	7.8e-06	1	1
ENSP00000265594	RimK	PF08443.11	1e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25274735	Ribosome-controlled transcription termination is essential for the production of antibiotic microcin C.	Nucleic Acids Res	2014 Oct 29	Zukher I	doi: 10.1093/nar/gku880

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497959	MCCC1-213	2874	-	ENSP00000420648	434 (aa)	-	G5E9X5
ENST00000629669	MCCC1-215	2316	-	ENSP00000486824	434 (aa)	-	G5E9X5
ENST00000486226	MCCC1-206	581	-	ENSP00000420223	112 (aa)	-	F8WDI3
ENST00000490284	MCCC1-209	557	-	ENSP00000419328	56 (aa)	-	F8WF46
ENST00000495767	MCCC1-211	1860	-	ENSP00000419658	61 (aa)	-	F2Z2Z7
ENST00000487634	MCCC1-207	559	-	ENSP00000420591	61 (aa)	-	F2Z2Z7
ENST00000492597	MCCC1-210	2774	XM_006713702	ENSP00000419898	616 (aa)	XP_006713765	E9PHF7
ENST00000265594	MCCC1-201	2545	XM_011512992	ENSP00000265594	725 (aa)	XP_011511294	Q96RQ3
ENST00000476176	MCCC1-205	1906	-	ENSP00000420433	598 (aa)	-	E9PG35
ENST00000473955	MCCC1-204	222	-	-	- (aa)	-	-
ENST00000497830	MCCC1-212	2227	-	ENSP00000420088	47 (aa)	-	F2Z3E2
ENST00000489909	MCCC1-208	458	-	-	- (aa)	-	-
ENST00000464601	MCCC1-202	759	-	-	- (aa)	-	-
ENST00000466650	MCCC1-203	567	-	ENSP00000418979	47 (aa)	-	F2Z3E2
ENST00000610757	MCCC1-214	2410	-	ENSP00000480435	575 (aa)	-	F5GYT8

Gene Model

Click here to download ENSG00000078070's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000078070	Parkinson Disease	3E-8	28011712
ENSG00000078070	Parkinson Disease	8E-12	21292315
ENSG00000078070	Parkinson Disease	2E-21	25064009
ENSG00000078070	Metabolism	1E-16	24816252
ENSG00000078070	Parkinson Disease	3E-10	21738487

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000078070	rs12637471	3	183044649	G	Parkinson's disease	25064009	[1.15-1.22]	1.1876	EFO_0002508
ENSG00000078070	rs2270968	3	183037421	G	Parkinson's disease	28011712	NR	1.178	EFO_0002508
ENSG00000078070	rs2270968	3	183037421	T	Blood metabolite levels	24816252	[0.023-0.039] unit increase	0.031	EFO_0005664
ENSG00000078070	rs12637471	3	183044649	G	Parkinson's disease	28892059	[1.15-1.22]	1.1764705	EFO_0002508
ENSG00000078070	rs11711441	3	183103487	G	Parkinson's disease	21292315	[1.13-1.25]	1.19	EFO_0002508
ENSG00000078070	rs10513789	3	183042285	T	Parkinson's disease	21738487	[1.16-1.33]	1.25	EFO_0002508

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000078070's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000078070	MCCC1	98	92.488	ENSAMEG00000015967	MCCC1	100	88.000	Ailuropoda_melanoleuca
ENSG00000078070	MCCC1	99	80.698	ENSACIG00000023146	mccc1	97	80.698	Amphilophus_citrinellus
ENSG00000078070	MCCC1	99	84.404	ENSAPLG00000008989	MCCC1	100	76.217	Anas_platyrhynchos
ENSG00000078070	MCCC1	100	93.318	ENSANAG00000028235	MCCC1	100	93.318	Aotus_nancymaae
ENSG00000078070	MCCC1	96	80.383	ENSACLG00000026110	mccc1	98	73.065	Astatotilapia_calliptera
ENSG00000078070	MCCC1	96	82.933	ENSAMXG00000001531	mccc1	97	72.727	Astyanax_mexicanus
ENSG00000078070	MCCC1	98	93.882	ENSBTAG00000006548	MCCC1	100	88.414	Bos_taurus
ENSG00000078070	MCCC1	100	94.009	ENSCJAG00000005103	MCCC1	100	94.009	Callithrix_jacchus
ENSG00000078070	MCCC1	98	91.784	ENSCAFG00000011749	MCCC1	100	88.000	Canis_familiaris
ENSG00000078070	MCCC1	98	91.784	ENSCAFG00020001000	MCCC1	100	88.000	Canis_lupus_dingo
ENSG00000078070	MCCC1	98	93.647	ENSCHIG00000025794	MCCC1	99	87.518	Capra_hircus
ENSG00000078070	MCCC1	100	92.857	ENSTSYG00000012606	MCCC1	100	92.857	Carlito_syrichta
ENSG00000078070	MCCC1	97	91.190	ENSCAPG00000012269	MCCC1	99	82.267	Cavia_aperea
ENSG00000078070	MCCC1	98	91.315	ENSCPOG00000010866	MCCC1	100	83.310	Cavia_porcellus
ENSG00000078070	MCCC1	100	97.872	ENSCATG00000037699	MCCC1	100	96.690	Cercocebus_atys
ENSG00000078070	MCCC1	96	83.022	ENSCLAG00000014174	MCCC1	100	82.753	Chinchilla_lanigera
ENSG00000078070	MCCC1	100	97.872	ENSCSAG00000013226	MCCC1	100	97.517	Chlorocebus_sabaeus
ENSG00000078070	MCCC1	97	86.019	ENSCPBG00000000534	MCCC1	96	78.924	Chrysemys_picta_bellii
ENSG00000078070	MCCC1	96	71.223	ENSCING00000019260	-	90	58.912	Ciona_intestinalis
ENSG00000078070	MCCC1	96	70.743	ENSCING00000020099	-	99	57.540	Ciona_intestinalis
ENSG00000078070	MCCC1	95	73.188	ENSCSAVG00000007062	-	99	53.631	Ciona_savignyi
ENSG00000078070	MCCC1	100	96.429	ENSCANG00000037917	MCCC1	100	98.163	Colobus_angolensis_palliatus
ENSG00000078070	MCCC1	98	91.294	ENSCGRG00001012469	Mccc1	99	85.133	Cricetulus_griseus_chok1gshd
ENSG00000078070	MCCC1	98	91.294	ENSCGRG00000002616	Mccc1	99	84.712	Cricetulus_griseus_crigri
ENSG00000078070	MCCC1	96	80.288	ENSCSEG00000019501	mccc1	95	71.637	Cynoglossus_semilaevis
ENSG00000078070	MCCC1	97	81.235	ENSDARG00000102538	mccc1	96	73.110	Danio_rerio
ENSG00000078070	MCCC1	98	92.019	ENSDNOG00000012070	MCCC1	100	88.324	Dasypus_novemcinctus
ENSG00000078070	MCCC1	98	93.412	ENSDORG00000000473	Mccc1	99	87.097	Dipodomys_ordii
ENSG00000078070	MCCC1	97	86.455	ENSETEG00000008384	MCCC1	99	80.166	Echinops_telfairi
ENSG00000078070	MCCC1	87	76.984	ENSEBUG00000016250	-	95	73.383	Eptatretus_burgeri
ENSG00000078070	MCCC1	98	94.118	ENSEASG00005015339	MCCC1	100	93.995	Equus_asinus_asinus
ENSG00000078070	MCCC1	98	93.662	ENSECAG00000008214	MCCC1	100	89.241	Equus_caballus
ENSG00000078070	MCCC1	100	76.461	ENSEEUG00000011233	MCCC1	99	71.326	Erinaceus_europaeus
ENSG00000078070	MCCC1	98	79.108	ENSELUG00000010299	mccc1	99	73.778	Esox_lucius
ENSG00000078070	MCCC1	100	92.396	ENSFCAG00000000940	MCCC1	100	92.396	Felis_catus
ENSG00000078070	MCCC1	97	87.441	ENSFALG00000008252	MCCC1	97	78.818	Ficedula_albicollis
ENSG00000078070	MCCC1	98	90.353	ENSFDAG00000009183	MCCC1	100	79.917	Fukomys_damarensis
ENSG00000078070	MCCC1	98	77.700	ENSGMOG00000008521	mccc1	99	69.320	Gadus_morhua
ENSG00000078070	MCCC1	97	87.678	ENSGALG00000008785	MCCC1	94	76.751	Gallus_gallus
ENSG00000078070	MCCC1	98	79.343	ENSGAFG00000010643	mccc1	97	71.884	Gambusia_affinis
ENSG00000078070	MCCC1	92	87.218	ENSGAGG00000000770	MCCC1	99	79.817	Gopherus_agassizii
ENSG00000078070	MCCC1	100	98.848	ENSGGOG00000002784	MCCC1	100	98.848	Gorilla_gorilla
ENSG00000078070	MCCC1	96	80.383	ENSHBUG00000000956	mccc1	96	72.117	Haplochromis_burtoni
ENSG00000078070	MCCC1	98	91.765	ENSHGLG00000014650	MCCC1	99	85.892	Heterocephalus_glaber_female
ENSG00000078070	MCCC1	98	91.765	ENSHGLG00100015295	MCCC1	99	85.892	Heterocephalus_glaber_male
ENSG00000078070	MCCC1	96	80.000	ENSHCOG00000010503	mccc1	98	71.450	Hippocampus_comes
ENSG00000078070	MCCC1	97	83.135	ENSIPUG00000024615	mccc1	97	72.832	Ictalurus_punctatus
ENSG00000078070	MCCC1	98	92.235	ENSSTOG00000010361	MCCC1	99	89.365	Ictidomys_tridecemlineatus
ENSG00000078070	MCCC1	99	84.539	ENSJJAG00000003543	Mccc1	99	83.520	Jaculus_jaculus
ENSG00000078070	MCCC1	96	80.048	ENSLBEG00000001741	mccc1	93	71.994	Labrus_bergylta
ENSG00000078070	MCCC1	98	83.294	ENSLACG00000018119	MCCC1	96	76.633	Latimeria_chalumnae
ENSG00000078070	MCCC1	98	80.471	ENSLOCG00000000778	mccc1	97	66.097	Lepisosteus_oculatus
ENSG00000078070	MCCC1	98	90.118	ENSLAFG00000018018	MCCC1	100	86.750	Loxodonta_africana
ENSG00000078070	MCCC1	100	97.872	ENSMFAG00000000043	MCCC1	100	97.696	Macaca_fascicularis
ENSG00000078070	MCCC1	100	97.465	ENSMMUG00000010553	MCCC1	100	97.465	Macaca_mulatta
ENSG00000078070	MCCC1	100	97.403	ENSMNEG00000017163	MCCC1	100	97.403	Macaca_nemestrina
ENSG00000078070	MCCC1	100	97.235	ENSMLEG00000039351	MCCC1	100	97.235	Mandrillus_leucophaeus
ENSG00000078070	MCCC1	96	80.383	ENSMZEG00005015532	mccc1	96	72.117	Maylandia_zebra
ENSG00000078070	MCCC1	98	87.028	ENSMGAG00000009494	MCCC1	98	79.148	Meleagris_gallopavo
ENSG00000078070	MCCC1	100	92.396	ENSMICG00000048884	MCCC1	100	92.396	Microcebus_murinus
ENSG00000078070	MCCC1	98	89.882	ENSMOCG00000003671	Mccc1	99	82.238	Microtus_ochrogaster
ENSG00000078070	MCCC1	97	89.835	ENSMODG00000021288	MCCC1	98	81.678	Monodelphis_domestica
ENSG00000078070	MCCC1	98	92.000	MGP_CAROLIEiJ_G0024932	Mccc1	99	84.637	Mus_caroli
ENSG00000078070	MCCC1	98	91.765	ENSMUSG00000027709	Mccc1	99	84.637	Mus_musculus
ENSG00000078070	MCCC1	98	92.000	MGP_SPRETEiJ_G0025866	Mccc1	99	84.637	Mus_spretus
ENSG00000078070	MCCC1	98	92.254	ENSMPUG00000002371	MCCC1	87	88.075	Mustela_putorius_furo
ENSG00000078070	MCCC1	98	92.254	ENSMLUG00000012257	MCCC1	99	87.293	Myotis_lucifugus
ENSG00000078070	MCCC1	98	93.647	ENSNGAG00000001216	Mccc1	99	86.130	Nannospalax_galili
ENSG00000078070	MCCC1	100	97.872	ENSNLEG00000005989	MCCC1	100	97.465	Nomascus_leucogenys
ENSG00000078070	MCCC1	98	91.803	ENSOPRG00000007258	MCCC1	100	82.231	Ochotona_princeps
ENSG00000078070	MCCC1	98	92.254	ENSODEG00000012286	MCCC1	100	83.518	Octodon_degus
ENSG00000078070	MCCC1	96	80.622	ENSONIG00000008395	mccc1	96	72.263	Oreochromis_niloticus
ENSG00000078070	MCCC1	99	82.573	ENSOANG00000011253	MCCC1	100	82.701	Ornithorhynchus_anatinus
ENSG00000078070	MCCC1	100	83.724	ENSOCUG00000012393	MCCC1	100	83.724	Oryctolagus_cuniculus
ENSG00000078070	MCCC1	96	80.529	ENSORLG00000011678	mccc1	99	70.274	Oryzias_latipes
ENSG00000078070	MCCC1	96	80.529	ENSORLG00020005680	mccc1	99	70.376	Oryzias_latipes_hni
ENSG00000078070	MCCC1	96	80.529	ENSORLG00015003526	mccc1	97	71.598	Oryzias_latipes_hsok
ENSG00000078070	MCCC1	96	80.288	ENSOMEG00000011470	mccc1	98	69.516	Oryzias_melastigma
ENSG00000078070	MCCC1	99	90.701	ENSOGAG00000000659	MCCC1	100	88.685	Otolemur_garnettii
ENSG00000078070	MCCC1	98	93.412	ENSOARG00000020660	MCCC1	100	88.793	Ovis_aries
ENSG00000078070	MCCC1	100	99.188	ENSPPAG00000036167	MCCC1	100	99.172	Pan_paniscus
ENSG00000078070	MCCC1	100	92.166	ENSPPRG00000000127	MCCC1	100	92.166	Panthera_pardus
ENSG00000078070	MCCC1	100	91.475	ENSPTIG00000018514	MCCC1	100	91.475	Panthera_tigris_altaica
ENSG00000078070	MCCC1	100	99.309	ENSPTRG00000015662	MCCC1	100	99.309	Pan_troglodytes
ENSG00000078070	MCCC1	100	97.872	ENSPANG00000006870	MCCC1	100	97.517	Papio_anubis
ENSG00000078070	MCCC1	97	86.019	ENSPSIG00000017510	MCCC1	99	78.135	Pelodiscus_sinensis
ENSG00000078070	MCCC1	95	74.334	ENSPMGG00000000155	mccc1	97	68.554	Periophthalmus_magnuspinnatus
ENSG00000078070	MCCC1	98	90.588	ENSPEMG00000014164	Mccc1	99	85.070	Peromyscus_maniculatus_bairdii
ENSG00000078070	MCCC1	98	86.385	ENSPCIG00000013027	MCCC1	84	81.575	Phascolarctos_cinereus
ENSG00000078070	MCCC1	98	79.108	ENSPFOG00000019171	mccc1	98	70.940	Poecilia_formosa
ENSG00000078070	MCCC1	98	78.873	ENSPLAG00000022735	mccc1	98	70.798	Poecilia_latipinna
ENSG00000078070	MCCC1	98	78.873	ENSPMEG00000000664	mccc1	98	70.798	Poecilia_mexicana
ENSG00000078070	MCCC1	100	97.241	ENSPPYG00000014331	MCCC1	100	97.241	Pongo_abelii
ENSG00000078070	MCCC1	98	85.211	ENSPCAG00000003195	MCCC1	99	76.078	Procavia_capensis
ENSG00000078070	MCCC1	100	92.166	ENSPCOG00000020095	MCCC1	100	92.166	Propithecus_coquereli
ENSG00000078070	MCCC1	98	88.498	ENSPVAG00000013436	MCCC1	99	84.561	Pteropus_vampyrus
ENSG00000078070	MCCC1	98	80.941	ENSPNAG00000025069	mccc1	98	67.435	Pygocentrus_nattereri
ENSG00000078070	MCCC1	98	90.824	ENSRNOG00000013293	Mccc1	99	84.432	Rattus_norvegicus
ENSG00000078070	MCCC1	100	97.872	ENSRBIG00000038726	MCCC1	100	97.696	Rhinopithecus_bieti
ENSG00000078070	MCCC1	100	97.872	ENSRROG00000041247	MCCC1	100	97.465	Rhinopithecus_roxellana
ENSG00000078070	MCCC1	100	93.182	ENSSBOG00000026219	MCCC1	100	94.836	Saimiri_boliviensis_boliviensis
ENSG00000078070	MCCC1	98	87.442	ENSSHAG00000016104	MCCC1	99	82.828	Sarcophilus_harrisii
ENSG00000078070	MCCC1	98	81.412	ENSSFOG00015007784	mccc1	99	72.355	Scleropages_formosus
ENSG00000078070	MCCC1	96	80.622	ENSSMAG00000019667	mccc1	95	71.784	Scophthalmus_maximus
ENSG00000078070	MCCC1	92	86.500	ENSSPUG00000014366	MCCC1	99	78.387	Sphenodon_punctatus
ENSG00000078070	MCCC1	96	79.808	ENSSPAG00000011206	mccc1	98	70.230	Stegastes_partitus
ENSG00000078070	MCCC1	98	90.845	ENSSSCG00000025942	MCCC1	100	86.949	Sus_scrofa
ENSG00000078070	MCCC1	96	87.560	ENSTGUG00000010506	MCCC1	100	79.616	Taeniopygia_guttata
ENSG00000078070	MCCC1	96	90.191	ENSTBEG00000007988	MCCC1	99	81.073	Tupaia_belangeri
ENSG00000078070	MCCC1	98	93.662	ENSTTRG00000016518	MCCC1	100	89.379	Tursiops_truncatus
ENSG00000078070	MCCC1	99	91.841	ENSUAMG00000008378	MCCC1	100	91.204	Ursus_americanus
ENSG00000078070	MCCC1	98	92.723	ENSUMAG00000006927	MCCC1	100	88.552	Ursus_maritimus
ENSG00000078070	MCCC1	98	91.549	ENSVVUG00000006835	MCCC1	100	87.724	Vulpes_vulpes
ENSG00000078070	MCCC1	98	84.272	ENSXETG00000016826	mccc1	97	75.575	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002169	3-methylcrotonyl-CoA carboxylase complex, mitochondrial	11170888.11181649.11401427.	NAS	Component
GO:0002169	3-methylcrotonyl-CoA carboxylase complex, mitochondrial	22869039.	TAS	Component
GO:0004075	biotin carboxylase activity	22869039.	NAS	Function
GO:0004485	methylcrotonoyl-CoA carboxylase activity	17360195.	IDA	Function
GO:0004485	methylcrotonoyl-CoA carboxylase activity	11170888.11181649.11401427.	NAS	Function
GO:0005515	protein binding	17360195.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	16023992.	IDA	Component
GO:0005759	mitochondrial matrix	11170888.	NAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006552	leucine catabolic process	-	IEA	Process
GO:0006552	leucine catabolic process	11170888.	ISS	Process
GO:0006552	leucine catabolic process	11170888.	NAS	Process
GO:0006768	biotin metabolic process	11401427.22869039.	NAS	Process
GO:0006768	biotin metabolic process	-	TAS	Process
GO:0009083	branched-chain amino acid catabolic process	-	TAS	Process
GO:0009374	biotin binding	11401427.	NAS	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051291	protein heterooligomerization	11170888.	NAS	Process
GO:1905202	methylcrotonoyl-CoA carboxylase complex	17360195.	IDA	Component