EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000078269 (Gene tree)
Gene ID: 8871
Gene Symbol: SYNJ2
Alias: INPP5H
Full Name: synaptojanin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 117,321 bases
Position: chr6:157,981,856-158,099,176
Accession: 11504
RBP type: canonical RBP
Summary: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000492369	Exo_endo_phos	PF03372.23	4.9e-14	1	1
ENSP00000492532	Exo_endo_phos	PF03372.23	5.2e-14	1	1
ENSP00000347792	Exo_endo_phos	PF03372.23	6.6e-14	1	1
ENSP00000356089	DUF1866	PF08952.11	1e-60	1	1
ENSP00000492369	DUF1866	PF08952.11	1.7e-60	1	1
ENSP00000492532	DUF1866	PF08952.11	1.8e-60	1	1
ENSP00000347792	DUF1866	PF08952.11	2.2e-60	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367112	SYNJ2-202	5091	-	-	- (aa)	-	-
ENST00000367122	SYNJ2-204	3029	XM_005267200	ENSP00000356089	839 (aa)	XP_005267257	E7ER60
ENST00000640338	SYNJ2-208	3959	XM_006715592	ENSP00000492532	1288 (aa)	XP_006715655	O15056
ENST00000355585	SYNJ2-201	7378	XM_011536224	ENSP00000347792	1496 (aa)	XP_011534526	O15056
ENST00000367113	SYNJ2-203	939	-	ENSP00000356080	136 (aa)	-	H7BY56
ENST00000449320	SYNJ2-205	680	-	ENSP00000411202	136 (aa)	-	Q5TA15
ENST00000485863	SYNJ2-206	810	-	ENSP00000436657	165 (aa)	-	H0YEV8
ENST00000638626	SYNJ2-207	7332	XM_005267198	ENSP00000492369	1259 (aa)	XP_005267255	A0A1W2PR85
ENST00000640569	SYNJ2-209	2040	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000078269's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000078269	Heart Failure	2.4941602E-004	-
ENSG00000078269	Heart Failure	1.1723354E-004	-
ENSG00000078269	Vascular Diseases	7.1940000E-005	-
ENSG00000078269	Intelligence Tests	1.3558100E-005	-
ENSG00000078269	Child Development Disorders, Pervasive	8.0000000E-005	-
ENSG00000078269	Child Development Disorders, Pervasive	2.7000000E-005	-
ENSG00000078269	Colorectal Neoplasms	4E-6	23300701

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000078269	rs2181190	6	158046957	T	Intraocular pressure	29617998	[0.076-0.146] unit decrease	0.111	EFO_0004695
ENSG00000078269	rs141160611	6	158063872	?	Gamma glutamyl transferase levels	29403010	[0.089-0.135] unit decrease novel	0.1117	EFO_0004532
ENSG00000078269	rs1750034	6	158059112	T	Endometriosis	28881265	[1.521-2.678]	2.018	EFO_0001065

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000078269's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000078269	SYNJ2	94	88.926	ENSAMEG00000009581	SYNJ2	100	81.550	Ailuropoda_melanoleuca
ENSG00000078269	SYNJ2	99	77.612	ENSAPLG00000002563	SYNJ2	99	70.651	Anas_platyrhynchos
ENSG00000078269	SYNJ2	98	74.980	ENSACAG00000004945	SYNJ2	94	71.369	Anolis_carolinensis
ENSG00000078269	SYNJ2	99	97.778	ENSANAG00000026575	SYNJ2	100	96.661	Aotus_nancymaae
ENSG00000078269	SYNJ2	99	92.593	ENSBTAG00000000817	SYNJ2	100	83.201	Bos_taurus
ENSG00000078269	SYNJ2	99	98.519	ENSCJAG00000003570	SYNJ2	100	96.661	Callithrix_jacchus
ENSG00000078269	SYNJ2	94	89.835	ENSCAFG00000000644	SYNJ2	100	85.041	Canis_familiaris
ENSG00000078269	SYNJ2	99	89.630	ENSCAFG00020015809	SYNJ2	100	84.534	Canis_lupus_dingo
ENSG00000078269	SYNJ2	99	93.333	ENSCHIG00000011077	SYNJ2	100	83.101	Capra_hircus
ENSG00000078269	SYNJ2	97	93.253	ENSTSYG00000014342	SYNJ2	97	93.253	Carlito_syrichta
ENSG00000078269	SYNJ2	99	82.049	ENSCAPG00000000287	SYNJ2	100	83.299	Cavia_aperea
ENSG00000078269	SYNJ2	99	91.852	ENSCPOG00000009144	SYNJ2	95	92.766	Cavia_porcellus
ENSG00000078269	SYNJ2	99	98.519	ENSCCAG00000025484	SYNJ2	100	96.351	Cebus_capucinus
ENSG00000078269	SYNJ2	100	97.593	ENSCATG00000042943	SYNJ2	100	97.593	Cercocebus_atys
ENSG00000078269	SYNJ2	99	93.333	ENSCLAG00000004730	SYNJ2	100	86.454	Chinchilla_lanigera
ENSG00000078269	SYNJ2	100	96.925	ENSCSAG00000013130	SYNJ2	100	96.925	Chlorocebus_sabaeus
ENSG00000078269	SYNJ2	75	98.113	ENSCHOG00000000343	-	52	97.273	Choloepus_hoffmanni
ENSG00000078269	SYNJ2	99	79.851	ENSCPBG00000016273	SYNJ2	98	72.853	Chrysemys_picta_bellii
ENSG00000078269	SYNJ2	100	96.186	ENSCANG00000040349	SYNJ2	100	97.842	Colobus_angolensis_palliatus
ENSG00000078269	SYNJ2	99	88.889	ENSCGRG00001004257	Synj2	99	85.450	Cricetulus_griseus_chok1gshd
ENSG00000078269	SYNJ2	94	89.556	ENSCGRG00000001656	Synj2	97	87.410	Cricetulus_griseus_crigri
ENSG00000078269	SYNJ2	99	79.269	ENSDNOG00000015900	SYNJ2	100	84.615	Dasypus_novemcinctus
ENSG00000078269	SYNJ2	94	87.997	ENSDORG00000014128	Synj2	97	83.253	Dipodomys_ordii
ENSG00000078269	SYNJ2	80	92.029	ENSETEG00000017418	SYNJ2	82	92.029	Echinops_telfairi
ENSG00000078269	SYNJ2	99	91.852	ENSEASG00005018902	SYNJ2	100	86.000	Equus_asinus_asinus
ENSG00000078269	SYNJ2	99	91.852	ENSECAG00000012646	SYNJ2	94	85.933	Equus_caballus
ENSG00000078269	SYNJ2	54	81.250	ENSEEUG00000015796	-	58	77.193	Erinaceus_europaeus
ENSG00000078269	SYNJ2	100	88.898	ENSFCAG00000010854	SYNJ2	100	88.742	Felis_catus
ENSG00000078269	SYNJ2	87	85.417	ENSFALG00000012593	SYNJ2	98	70.111	Ficedula_albicollis
ENSG00000078269	SYNJ2	96	90.840	ENSFDAG00000016352	SYNJ2	100	85.024	Fukomys_damarensis
ENSG00000078269	SYNJ2	97	78.480	ENSGALG00000013727	SYNJ2	98	71.343	Gallus_gallus
ENSG00000078269	SYNJ2	99	79.104	ENSGAGG00000009857	SYNJ2	98	72.769	Gopherus_agassizii
ENSG00000078269	SYNJ2	100	99.379	ENSGGOG00000012210	SYNJ2	100	99.379	Gorilla_gorilla
ENSG00000078269	SYNJ2	99	93.333	ENSHGLG00000007534	SYNJ2	100	85.648	Heterocephalus_glaber_female
ENSG00000078269	SYNJ2	99	93.333	ENSHGLG00100009973	SYNJ2	98	87.782	Heterocephalus_glaber_male
ENSG00000078269	SYNJ2	94	91.542	ENSSTOG00000016474	SYNJ2	99	87.090	Ictidomys_tridecemlineatus
ENSG00000078269	SYNJ2	94	88.474	ENSJJAG00000014436	Synj2	100	90.090	Jaculus_jaculus
ENSG00000078269	SYNJ2	87	76.389	ENSLACG00000007316	SYNJ2	99	70.197	Latimeria_chalumnae
ENSG00000078269	SYNJ2	99	82.626	ENSLAFG00000011979	SYNJ2	100	83.515	Loxodonta_africana
ENSG00000078269	SYNJ2	99	98.519	ENSMFAG00000040552	SYNJ2	100	96.944	Macaca_fascicularis
ENSG00000078269	SYNJ2	100	96.305	ENSMMUG00000007153	SYNJ2	100	97.901	Macaca_mulatta
ENSG00000078269	SYNJ2	100	97.593	ENSMNEG00000017211	SYNJ2	100	97.593	Macaca_nemestrina
ENSG00000078269	SYNJ2	99	98.519	ENSMLEG00000024911	SYNJ2	100	93.516	Mandrillus_leucophaeus
ENSG00000078269	SYNJ2	87	86.897	ENSMGAG00000012839	SYNJ2	100	74.215	Meleagris_gallopavo
ENSG00000078269	SYNJ2	98	88.810	ENSMAUG00000022212	Synj2	97	89.307	Mesocricetus_auratus
ENSG00000078269	SYNJ2	100	90.217	ENSMICG00000015804	SYNJ2	100	90.217	Microcebus_murinus
ENSG00000078269	SYNJ2	99	88.148	ENSMOCG00000020054	Synj2	97	89.673	Microtus_ochrogaster
ENSG00000078269	SYNJ2	97	86.950	ENSMODG00000007783	SYNJ2	100	80.744	Monodelphis_domestica
ENSG00000078269	SYNJ2	99	86.854	MGP_CAROLIEiJ_G0021026	Synj2	100	93.182	Mus_caroli
ENSG00000078269	SYNJ2	98	87.619	ENSMUSG00000023805	Synj2	100	93.182	Mus_musculus
ENSG00000078269	SYNJ2	99	87.407	MGP_PahariEiJ_G0023344	Synj2	100	93.030	Mus_pahari
ENSG00000078269	SYNJ2	98	87.302	MGP_SPRETEiJ_G0021931	Synj2	100	92.576	Mus_spretus
ENSG00000078269	SYNJ2	99	88.148	ENSMPUG00000005323	SYNJ2	98	85.866	Mustela_putorius_furo
ENSG00000078269	SYNJ2	99	82.460	ENSMLUG00000000324	SYNJ2	100	83.111	Myotis_lucifugus
ENSG00000078269	SYNJ2	99	89.630	ENSNGAG00000014859	Synj2	92	94.894	Nannospalax_galili
ENSG00000078269	SYNJ2	100	93.673	ENSNLEG00000010750	SYNJ2	100	93.673	Nomascus_leucogenys
ENSG00000078269	SYNJ2	91	94.444	ENSMEUG00000003493	SYNJ2	95	83.867	Notamacropus_eugenii
ENSG00000078269	SYNJ2	99	83.704	ENSOPRG00000009648	SYNJ2	93	80.351	Ochotona_princeps
ENSG00000078269	SYNJ2	99	91.111	ENSODEG00000007709	SYNJ2	94	92.979	Octodon_degus
ENSG00000078269	SYNJ2	77	62.048	ENSOANG00000029828	-	99	62.162	Ornithorhynchus_anatinus
ENSG00000078269	SYNJ2	99	84.664	ENSOCUG00000004762	SYNJ2	100	84.805	Oryctolagus_cuniculus
ENSG00000078269	SYNJ2	96	88.550	ENSOGAG00000000488	SYNJ2	100	90.406	Otolemur_garnettii
ENSG00000078269	SYNJ2	94	88.439	ENSOARG00000004304	SYNJ2	100	82.209	Ovis_aries
ENSG00000078269	SYNJ2	100	99.049	ENSPPAG00000028831	SYNJ2	99	99.064	Pan_paniscus
ENSG00000078269	SYNJ2	100	89.053	ENSPPRG00000009068	SYNJ2	100	88.898	Panthera_pardus
ENSG00000078269	SYNJ2	97	89.076	ENSPTIG00000018780	SYNJ2	97	88.916	Panthera_tigris_altaica
ENSG00000078269	SYNJ2	100	99.457	ENSPTRG00000018739	SYNJ2	100	99.457	Pan_troglodytes
ENSG00000078269	SYNJ2	100	97.748	ENSPANG00000010755	SYNJ2	100	97.748	Papio_anubis
ENSG00000078269	SYNJ2	87	85.417	ENSPSIG00000014659	SYNJ2	97	73.154	Pelodiscus_sinensis
ENSG00000078269	SYNJ2	94	90.041	ENSPEMG00000006247	Synj2	97	88.484	Peromyscus_maniculatus_bairdii
ENSG00000078269	SYNJ2	97	86.950	ENSPCIG00000010179	SYNJ2	100	81.462	Phascolarctos_cinereus
ENSG00000078269	SYNJ2	100	97.660	ENSPPYG00000017130	SYNJ2	100	97.660	Pongo_abelii
ENSG00000078269	SYNJ2	87	88.136	ENSPCAG00000009217	SYNJ2	95	70.106	Procavia_capensis
ENSG00000078269	SYNJ2	99	94.074	ENSPCOG00000026910	SYNJ2	100	92.469	Propithecus_coquereli
ENSG00000078269	SYNJ2	99	89.630	ENSPVAG00000006131	SYNJ2	100	81.254	Pteropus_vampyrus
ENSG00000078269	SYNJ2	98	86.374	ENSRNOG00000017114	Synj2	100	85.020	Rattus_norvegicus
ENSG00000078269	SYNJ2	99	98.519	ENSRBIG00000044126	SYNJ2	100	93.826	Rhinopithecus_bieti
ENSG00000078269	SYNJ2	100	97.904	ENSRROG00000027755	SYNJ2	100	97.904	Rhinopithecus_roxellana
ENSG00000078269	SYNJ2	99	98.519	ENSSBOG00000034876	SYNJ2	100	96.351	Saimiri_boliviensis_boliviensis
ENSG00000078269	SYNJ2	94	86.831	ENSSHAG00000018881	SYNJ2	100	80.855	Sarcophilus_harrisii
ENSG00000078269	SYNJ2	99	78.358	ENSSPUG00000000491	SYNJ2	99	70.308	Sphenodon_punctatus
ENSG00000078269	SYNJ2	99	91.852	ENSSSCG00000012315	SYNJ2	100	89.441	Sus_scrofa
ENSG00000078269	SYNJ2	99	79.104	ENSTGUG00000011082	SYNJ2	100	73.987	Taeniopygia_guttata
ENSG00000078269	SYNJ2	100	76.429	ENSTBEG00000015827	SYNJ2	85	80.781	Tupaia_belangeri
ENSG00000078269	SYNJ2	99	92.593	ENSTTRG00000009677	SYNJ2	100	80.200	Tursiops_truncatus
ENSG00000078269	SYNJ2	94	77.889	ENSUAMG00000021958	-	98	78.310	Ursus_americanus
ENSG00000078269	SYNJ2	80	82.639	ENSUMAG00000012826	SYNJ2	96	82.341	Ursus_maritimus
ENSG00000078269	SYNJ2	92	89.500	ENSVVUG00000007407	SYNJ2	100	89.500	Vulpes_vulpes
ENSG00000078269	SYNJ2	99	73.333	ENSXETG00000034066	synj2	81	69.737	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	21873635.	IBA	Function
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	-	TAS	Function
GO:0005515	protein binding	15090612.17474147.20936779.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0007420	brain development	21873635.	IBA	Process
GO:0017124	SH3 domain binding	21873635.	IBA	Function
GO:0030165	PDZ domain binding	21873635.	IBA	Function
GO:0030424	axon	-	IEA	Component
GO:0045121	membrane raft	-	IEA	Component
GO:0046855	inositol phosphate dephosphorylation	21873635.	IBA	Process
GO:0046856	phosphatidylinositol dephosphorylation	21873635.	IBA	Process
GO:0048471	perinuclear region of cytoplasm	21873635.	IBA	Component
GO:0061024	membrane organization	-	TAS	Process
GO:0098793	presynapse	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25605973	Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.	Sci Signal	2015 Jan 20	Ben-Chetrit N	doi: 10.1126/scisignal.2005537.
16102578	Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.	Cancer Genet Cytogenet	2005 Sep	Rossi MR	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	158028860	Missense_Mutation	rs778353772	L107F	0.61
BLCA	chr6	158071725	Silent	rs756320625	A688A	0.4
BLCA	chr6	158083516	Missense_Mutation	rs750424606	M985V	0.09	Exo_endo_phos
BLCA	chr6	158095740	Silent	NA	P1289P	0.15
BLCA	chr6	158096257	Missense_Mutation	novel	E1462K	0.42
BLCA	chr6	158063838	Missense_Mutation	rs138792733	R392Q	0.46
BLCA	chr6	158081238	Silent	rs149130768	P899P	0.44
BLCA	chr6	158064699	Missense_Mutation	novel	H436Q	0.56
BLCA	chr6	158083476	Silent	novel	L971L	0.14
BLCA	chr6	158066603	Missense_Mutation	rs751616283	S562L	0.38
BLCA	chr6	158078196	Missense_Mutation	NA	D828H	0.17
BLCA	chr6	158028753	Splice_Region	novel		0.35
BLCA	chr6	158095855	Missense_Mutation	novel	L1328V	0.5
BRCA	chr6	158076691	Silent	novel	S786S	0.11
BRCA	chr6	158083489	Nonsense_Mutation	novel	E976*	0.08	Exo_endo_phos
BRCA	chr6	158063789	Splice_Site	NA	X376_splice	0.55
BRCA	chr6	158095694	Frame_Shift_Del	NA	*P1275Lfs4**	0.4
BRCA	chr6	158076651	Missense_Mutation	novel	A773D	0.17
BRCA	chr6	158084026	Silent	NA	D1020D	0.16
BRCA	chr6	158064660	Silent	novel	F423F	0.12
BRCA	chr6	158074596	Missense_Mutation	novel	S717F	0.22
BRCA	chr6	158096148	Missense_Mutation	NA	L1425F	0.33
BRCA	chr6	158069610	Missense_Mutation	NA	S626L	0.3
BRCA	chr6	158095806	Silent	NA	A1311A	0.15
BRCA	chr6	158074588	Frame_Shift_Del	novel	*V715Ffs3**	0.04
CESC	chr6	158033608	Silent	novel	R213R	0.3
CESC	chr6	158076648	Missense_Mutation	novel	G772E	0.19
CESC	chr6	158081238	Silent	rs149130768	P899P	0.07
CESC	chr6	158071629	Silent	rs758367538	T656T	0.12
CESC	chr6	158061998	Missense_Mutation	novel	L321F	0.4
CESC	chr6	158088706	Silent	rs765919885	S1130S	0.33
CESC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.4
CESC	chr6	158066587	Missense_Mutation	NA	D557H	0.46
COAD	chr6	158066485	Missense_Mutation	rs767505170	E523K	0.44
COAD	chr6	158089891	Missense_Mutation	rs762615484	T1170I	0.37
COAD	chr6	158062144	Frame_Shift_Del	novel	*E371Rfs14**	0.13
COAD	chr6	158033594	Missense_Mutation	rs759832201	V209I	0.44
COAD	chr6	158092965	Missense_Mutation	novel	D1202G	0.27
COAD	chr6	158028843	Missense_Mutation	novel	A101G	0.25
COAD	chr6	158071688	Missense_Mutation	NA	S676I	0.32
COAD	chr6	158062129	Silent	rs376745407	F364F	0.42
COAD	chr6	158028918	Missense_Mutation	rs373812551	S126L	0.3
COAD	chr6	158066598	Silent	NA	L560L	0.36
COAD	chr6	158033545	Silent	NA	R192R	0.35
COAD	chr6	158083541	Missense_Mutation	novel	N993T	0.18	Exo_endo_phos
COAD	chr6	158028888	Missense_Mutation	rs376223674	R116H	0.27
COAD	chr6	158081112	Silent	novel	P857P	0.6
COAD	chr6	158086908	Missense_Mutation	NA	R1088C	0.4
COAD	chr6	158086976	Frame_Shift_Ins	rs531633531	*P1114Sfs48**	0.41
COAD	chr6	158064862	Nonsense_Mutation	rs766003401	R466*	0.33
COAD	chr6	158084157	Missense_Mutation	novel	Q1064R	0.13
COAD	chr6	158093029	Frame_Shift_Ins	rs761465339	*L1226Tfs32**	0.22
COAD	chr6	158084167	Silent	rs149771444	T1067T	0.32
COAD	chr6	158081290	Nonsense_Mutation	rs752714124	Q917*	0.13	Exo_endo_phos
COAD	chr6	158069611	Silent	rs148150317	S626S	0.33
COAD	chr6	158093030	Frame_Shift_Del	novel	*P1225Hfs19**	0.23
COAD	chr6	158064686	Missense_Mutation	NA	S432F	0.14
COAD	chr6	158028912	Missense_Mutation	novel	L124H	0.06
COAD	chr6	158066508	Silent	NA	I530I	0.35
COAD	chr6	158074586	Missense_Mutation	novel	N714H	0.03
COAD	chr6	158017676	Intron	novel		0.3
COAD	chr6	158062144	Frame_Shift_Del	novel	*E371Rfs14**	0.43
COAD	chr6	158095830	Silent	novel	V1319V	0.11
DLBC	chr6	158083518	Missense_Mutation	novel	M985I	0.32	Exo_endo_phos
ESCA	chr6	158084021	Nonsense_Mutation	novel	E1019*	0.3
ESCA	chr6	158017250	Silent	rs530198926	T58T	0.2
ESCA	chr6	158095831	Frame_Shift_Ins	novel	*L1323Hfs81**	0.46
GBM	chr6	158033470	Silent	rs745847436	H167H	0.77
GBM	chr6	158062017	Missense_Mutation	rs202038099	A327V	0.73
GBM	chr6	158081476	Missense_Mutation	rs758373037	S944L	0.05	Exo_endo_phos
GBM	chr6	158066647	Intron	novel		0.73
GBM	chr6	158066554	Missense_Mutation	rs367889806	R546W	0.18
GBM	chr6	158076767	Missense_Mutation	novel	P812S	0.15
GBM	chr6	158081257	Missense_Mutation	novel	E906K	0.22	Exo_endo_phos
GBM	chr6	158096239	Missense_Mutation	rs763080057	A1456T	0.67
GBM	chr6	158096461	3'UTR	novel		0.22
GBM	chr6	158062021	Silent	rs142499089	G328G	0.84
GBM	chr6	158078218	Missense_Mutation	novel	H835P	0.07
GBM	chr6	158062164	Missense_Mutation	NA	R376H	0.21
GBM	chr6	158096098	Missense_Mutation	novel	G1409S	0.04
GBM	chr6	158096257	Nonsense_Mutation	novel	E1462*	0.09
GBM	chr6	158093903	Intron	rs370329778		0.25
HNSC	chr6	158071680	Silent	novel	Q673Q	0.31
HNSC	chr6	158095959	Silent	novel	N1362N	0.19
HNSC	chr6	158096318	Frame_Shift_Del	novel	*K1483Rfs16**	0.32
HNSC	chr6	158095884	Silent	novel	K1337K	0.21
HNSC	chr6	158088764	Nonsense_Mutation	novel	Q1150*	0.22
HNSC	chr6	158089911	Nonsense_Mutation	novel	E1177*	0.29
HNSC	chr6	158028913	Silent	novel	L124L	0.28
HNSC	chr6	158062027	Silent	rs750486579	T330T	0.12
HNSC	chr6	158033585	Missense_Mutation	novel	V206F	0.41
HNSC	chr6	158029003	Silent	novel	S154S	0.2
HNSC	chr6	158095810	Missense_Mutation	novel	P1313S	0.11
HNSC	chr6	158064629	Missense_Mutation	novel	G413E	0.07
HNSC	chr6	158095709	Missense_Mutation	novel	T1279I	0.13
HNSC	chr6	158028947	Missense_Mutation	rs147584404	D136N	0.22
HNSC	chr6	158028845	Missense_Mutation	NA	T102A	0.34
KIRC	chr6	158043344	Missense_Mutation	novel	S247Y	0.34
KIRC	chr6	158074682	Missense_Mutation	NA	D746Y	0.26
KIRC	chr6	158076763	Silent	NA	K810K	0.11
KIRC	chr6	158096192	Missense_Mutation	NA	G1440E	0.35
KIRC	chr6	158062011	Missense_Mutation	NA	C325F	0.06
KIRP	chr6	158028937	Silent	novel	S132S	0.32
KIRP	chr6	158028973	Silent	rs372960799	V144V	0.39
KIRP	chr6	158068705	Silent	rs756648873	S592S	0.08
KIRP	chr6	158083503	Silent	novel	R980R	0.36
LAML	chr6	158064626	Frame_Shift_Ins	novel	*L414Afs8**	0.11
LGG	chr6	158086915	Missense_Mutation	rs141300011	R1090H	0.21
LGG	chr6	158096425	3'UTR	novel		0.41
LGG	chr6	158028888	Missense_Mutation	rs376223674	R116H	0.47
LGG	chr6	158033630	Missense_Mutation	rs538435329	R221C	0.37
LGG	chr6	158043324	Silent	novel	Y240Y	0.11
LGG	chr6	158069649	Missense_Mutation	rs772055760	R639H	0.46
LGG	chr6	158093904	Intron	rs768860844		0.36
LGG	chr6	158094012	Intron	novel		0.39
LGG	chr6	158095658	Missense_Mutation	novel	H1262R	0.45
LGG	chr6	158095875	Silent	rs3749847	P1334P	0.41
LGG	chr6	158095931	Missense_Mutation	NA	S1353N	0.47
LGG	chr6	158083593	In_Frame_Del	novel	E1011del	0.21
LIHC	chr6	158069545	Missense_Mutation	novel	K604N	0.57
LIHC	chr6	158089866	Missense_Mutation	novel	P1162S	0.23
LIHC	chr6	158066643	Splice_Region	novel		0.1
LUAD	chr6	158081300	Missense_Mutation	NA	G920V	0.19	Exo_endo_phos
LUAD	chr6	158062022	Missense_Mutation	novel	D329H	0.6
LUAD	chr6	158066505	Silent	novel	R529R	0.62
LUAD	chr6	158093904	Intron	novel		0.22
LUAD	chr6	158086904	Missense_Mutation	NA	E1086D	0.33
LUAD	chr6	158028801	Missense_Mutation	NA	S87F	0.07
LUAD	chr6	158086945	Missense_Mutation	novel	N1100S	0.2
LUAD	chr6	158028979	Silent	novel	T146T	0.17
LUAD	chr6	158033619	Missense_Mutation	rs778616482	R217H	0.55
LUAD	chr6	158076761	Missense_Mutation	novel	K810E	0.6
LUAD	chr6	158071626	Missense_Mutation	NA	K655N	0.1
LUAD	chr6	158084156	Missense_Mutation	novel	Q1064K	0.09
LUAD	chr6	158066508	Silent	NA	I530I	0.08
LUAD	chr6	158071638	Silent	NA	G659G	0.09
LUAD	chr6	158066453	Missense_Mutation	novel	R512K	0.43
LUSC	chr6	158081284	Missense_Mutation	novel	L915I	0.21	Exo_endo_phos
LUSC	chr6	158017247	Silent	novel	L57L	0.21
LUSC	chr6	158074617	Missense_Mutation	NA	C724F	0.16
LUSC	chr6	158088737	Missense_Mutation	novel	T1141S	0.52
LUSC	chr6	158096251	Missense_Mutation	novel	K1460E	0.13
LUSC	chr6	158028920	Missense_Mutation	novel	G127W	0.29
LUSC	chr6	158083526	Missense_Mutation	rs779341189	V988G	0.36	Exo_endo_phos
LUSC	chr6	158066521	Missense_Mutation	NA	G535W	0.33
LUSC	chr6	158028821	Missense_Mutation	novel	A94S	0.3
LUSC	chr6	158033532	Missense_Mutation	novel	V188G	0.27
LUSC	chr6	158095896	Silent	rs141704208	P1341P	0.13
LUSC	chr6	158069626	Silent	novel	G631G	0.22
LUSC	chr6	158069555	Missense_Mutation	novel	G608C	0.41
LUSC	chr6	158095905	Silent	novel	F1344F	0.29
LUSC	chr6	158096095	Missense_Mutation	novel	L1408V	0.27
OV	chr6	158095860	Silent	novel	V1329V	0.3
OV	chr6	158069537	Missense_Mutation	novel	T602S	0.07
OV	chr6	158062148	Missense_Mutation	novel	E371K	0.17
OV	chr6	158071708	Missense_Mutation	novel	C683G	0.14
OV	chr6	158096085	Silent	novel	A1404A	0.03
OV	chr6	158093994	Intron	novel		0.21
OV	chr6	158088713	Missense_Mutation	novel	H1133Y	0.09
OV	chr6	158078277	Missense_Mutation	novel	H855Y	0.05
OV	chr6	158081211	Silent	NA	A890A	0.77
OV	chr6	158084069	Missense_Mutation	novel	E1035Q	0.17
PAAD	chr6	158069586	Missense_Mutation	novel	S618C	0.46
PAAD	chr6	158074660	Silent	novel	V738V	0.24
PAAD	chr6	158095694	Missense_Mutation	novel	A1274V	0.19
PCPG	chr6	158096405	3'UTR	novel		0.45
PRAD	chr6	158062027	Silent	rs750486579	T330T	0.14
PRAD	chr6	158093037	Missense_Mutation	NA	L1226H	0.12
PRAD	chr6	158089906	Missense_Mutation	NA	E1175V	0.18
READ	chr6	158066485	Missense_Mutation	rs767505170	E523K	0.27
READ	chr6	158093017	Missense_Mutation	novel	E1219D	0.36
READ	chr6	158074690	Silent	NA	K748K	0.11
READ	chr6	158095901	Missense_Mutation	novel	A1343D	0.13
SARC	chr6	158093973	Intron	novel		0.32
SARC	chr6	158096367	3'UTR	novel		0.18
SARC	chr6	158033559	Missense_Mutation	novel	S197F	0.14
SARC	chr6	158069610	Missense_Mutation	NA	S626L	0.32
SARC	chr6	158064840	Silent	novel	K458K	0.39
SKCM	chr6	158088705	Missense_Mutation	NA	S1130F	0.4
SKCM	chr6	158088719	Missense_Mutation	NA	Q1135E	0.36
SKCM	chr6	158084118	Missense_Mutation	novel	A1051V	0.41
SKCM	chr6	158088679	Silent	NA	K1121K	0.27
SKCM	chr6	158093066	Missense_Mutation	NA	P1236S	0.21
SKCM	chr6	158064750	Splice_Region	novel	K453K	0.39
SKCM	chr6	158063815	Missense_Mutation	NA	M384I	0.86
SKCM	chr6	158028909	Missense_Mutation	novel	I123N	0.39
SKCM	chr6	158096109	Silent	novel	Q1412Q	0.34
SKCM	chr6	158066701	Intron	novel		0.41
SKCM	chr6	158069588	Missense_Mutation	NA	H619Y	0.49
SKCM	chr6	158084074	Silent	rs759564713	L1036L	0.41
SKCM	chr6	158095928	Missense_Mutation	NA	N1352S	0.35
SKCM	chr6	158092988	Missense_Mutation	NA	E1210K	0.18
SKCM	chr6	158064741	Silent	NA	G450G	0.27
SKCM	chr6	158084018	Missense_Mutation	rs771454251	D1018N	0.51
SKCM	chr6	158081250	Silent	novel	E903E	0.25
SKCM	chr6	158076644	Missense_Mutation	NA	E771K	0.69
SKCM	chr6	158084124	Missense_Mutation	NA	P1053L	0.26
SKCM	chr6	158062064	Missense_Mutation	NA	G343S	0.29
SKCM	chr6	158084141	Missense_Mutation	NA	L1059F	0.37
SKCM	chr6	158095996	Missense_Mutation	NA	G1375S	0.36
SKCM	chr6	158086937	Silent	novel	S1097S	0.14
SKCM	chr6	158076644	Missense_Mutation	NA	E771K	0.53
SKCM	chr6	158063795	Nonsense_Mutation	NA	Q378*	0.07
SKCM	chr6	158029009	Nonsense_Mutation	rs759833654	W156*	0.31
SKCM	chr6	158062069	Silent	novel	G344G	0.11
SKCM	chr6	158096000	Missense_Mutation	novel	T1376I	0.64
SKCM	chr6	158074635	Missense_Mutation	NA	R730H	0.1
SKCM	chr6	158076623	Splice_Region	rs186036801		0.25
SKCM	chr6	158064960	Silent	NA	G498G	0.39
SKCM	chr6	158076625	Splice_Site	NA	X765_splice	0.24
SKCM	chr6	158081193	Silent	NA	F884F	0.15
SKCM	chr6	158062000	Silent	NA	L321L	0.8
SKCM	chr6	158071683	Silent	NA	F674F	0.08
SKCM	chr6	158088681	Missense_Mutation	NA	S1122L	0.16
SKCM	chr6	158028922	Silent	rs747591822	G127G	0.42
SKCM	chr6	158084160	Missense_Mutation	NA	H1065R	0.23
SKCM	chr6	158062085	Missense_Mutation	NA	E350K	0.22
SKCM	chr6	158096112	Silent	NA	D1413D	0.34
SKCM	chr6	158096272	Missense_Mutation	NA	H1467Y	0.53
SKCM	chr6	158093038	Silent	NA	L1226L	0.16
SKCM	chr6	158084014	Silent	novel	E1016E	0.76
SKCM	chr6	158033665	Silent	rs778933903	F232F	0.2
SKCM	chr6	158081189	Missense_Mutation	novel	S883F	0.23	Exo_endo_phos
SKCM	chr6	158089855	Missense_Mutation	rs748652406	G1158E	0.27
SKCM	chr6	158028909	Frame_Shift_Del	novel	*I123Tfs20**	0.13
SKCM	chr6	158066603	Missense_Mutation	rs751616283	S562L	0.76
SKCM	chr6	158066508	Silent	NA	I530I	0.5
SKCM	chr6	158092972	Silent	NA	E1204E	0.38
SKCM	chr6	158081193	Silent	NA	F884F	0.4
STAD	chr6	158069627	Missense_Mutation	rs144180367	V632I	0.25
STAD	chr6	158055030	Splice_Site	novel	X286_splice	0.24
STAD	chr6	158086976	Frame_Shift_Ins	rs531633531	*P1114Sfs48**	0.47
STAD	chr6	158071743	Missense_Mutation	novel	K694N	0.11
STAD	chr6	158086936	Missense_Mutation	NA	S1097L	0.4
STAD	chr6	158095677	Silent	rs138770799	P1268P	0.18
STAD	chr6	158095875	Silent	rs3749847	P1334P	0.23
STAD	chr6	158062027	Silent	rs750486579	T330T	0.33
STAD	chr6	158076644	Missense_Mutation	NA	E771K	0.06
STAD	chr6	158078281	Missense_Mutation	NA	R856I	0.22
STAD	chr6	158088738	Missense_Mutation	rs752212604	T1141M	0.2
STAD	chr6	158083474	Silent	novel	L971L	0.79
STAD	chr6	158028887	Missense_Mutation	rs781667368	R116C	0.42
STAD	chr6	158071688	Missense_Mutation	NA	S676I	0.33
STAD	chr6	158017752	Intron	novel		0.3
STAD	chr6	158028888	Missense_Mutation	rs376223674	R116H	0.14
STAD	chr6	158071666	Missense_Mutation	novel	G669S	0.39
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.38
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.41
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.4
STAD	chr6	158084074	Silent	rs759564713	L1036L	0.22
STAD	chr6	158063789	Splice_Site	novel	X376_splice	0.5
STAD	chr6	158093972	Intron	novel		0.06
STAD	chr6	158076723	Frame_Shift_Del	novel	*A799Pfs25**	0.23
STAD	chr6	158066445	Splice_Region	NA	V509V	0.13
STAD	chr6	158095931	Missense_Mutation	NA	S1353N	0.13
STAD	chr6	158033606	Missense_Mutation	rs200442289	R213C	0.34
STAD	chr6	158095640	Missense_Mutation	NA	F1256C	0.09
STAD	chr6	158028937	Silent	rs140060886	S132S	0.08
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.48
STAD	chr6	158066651	Intron	rs776486873		0.29
STAD	chr6	158071660	Missense_Mutation	rs368394869	A667T	0.31
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.41
STAD	chr6	158076723	Frame_Shift_Del	novel	*A799Pfs25**	0.23
STAD	chr6	158062147	Silent	rs374031897	G370G	0.23
STAD	chr6	158062083	Missense_Mutation	NA	L349S	0.2
STAD	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.51
STAD	chr6	158066564	Missense_Mutation	NA	V549A	0.21
STAD	chr6	158096238	Silent	rs752770656	G1455G	0.2
TGCT	chr6	158096176	Missense_Mutation	novel	D1435N	0.09
TGCT	chr6	158028798	Missense_Mutation	novel	T86I	0.11
THYM	chr6	158066803	Intron	novel		0.1
UCEC	chr6	158076700	Silent	rs751052578	Y789Y	0.6
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.4
UCEC	chr6	158069610	Missense_Mutation	NA	S626L	0.33
UCEC	chr6	158074584	Missense_Mutation	NA	R713I	0.27
UCEC	chr6	158043331	Missense_Mutation	rs763854356	D243N	0.19
UCEC	chr6	158086954	Missense_Mutation	rs765829961	R1103Q	0.43
UCEC	chr6	158059303	Missense_Mutation	NA	N302H	0.43
UCEC	chr6	158017668	Intron	novel		0.29
UCEC	chr6	158059323	Silent	novel	G308G	0.41
UCEC	chr6	158069611	Silent	rs148150317	S626S	0.45
UCEC	chr6	158071737	Missense_Mutation	novel	Q692H	0.45
UCEC	chr6	158076700	Silent	rs751052578	Y789Y	0.41
UCEC	chr6	158095686	Silent	rs753365797	S1271S	0.45
UCEC	chr6	158066599	Missense_Mutation	rs183272327	D561N	0.15
UCEC	chr6	158033650	Silent	NA	G227G	0.31
UCEC	chr6	158062062	Missense_Mutation	NA	K342R	0.25
UCEC	chr6	158017261	Missense_Mutation	novel	G62D	0.18
UCEC	chr6	158066716	Intron	novel		0.07
UCEC	chr6	158071608	Silent	NA	V649V	0.43
UCEC	chr6	158076746	Silent	NA	L805L	0.44
UCEC	chr6	158071721	Missense_Mutation	rs767395214	T687M	0.33
UCEC	chr6	158093048	Missense_Mutation	rs570177970	R1230W	0.52
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.82
UCEC	chr6	158028888	Missense_Mutation	rs376223674	R116H	0.28
UCEC	chr6	158043345	Silent	novel	S247S	0.35
UCEC	chr6	158064701	Missense_Mutation	novel	S437N	0.32
UCEC	chr6	158071674	Silent	novel	R671R	0.44
UCEC	chr6	158089840	Missense_Mutation	novel	P1153L	0.29
UCEC	chr6	158096069	Missense_Mutation	rs780434246	A1399V	0.32
UCEC	chr6	158096954	3'UTR	novel		0.28
UCEC	chr6	158096750	3'UTR	novel		0.3
UCEC	chr6	158066485	Missense_Mutation	rs767505170	E523K	0.41
UCEC	chr6	158028791	Missense_Mutation	novel	G84C	0.46
UCEC	chr6	158097003	3'UTR	rs539570042		0.45
UCEC	chr6	158092950	Missense_Mutation	novel	A1197V	0.12
UCEC	chr6	158062129	Silent	rs376745407	F364F	0.25
UCEC	chr6	158063822	Missense_Mutation	novel	L387I	0.63
UCEC	chr6	158074660	Silent	novel	V738V	0.47
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.43
UCEC	chr6	158089877	Frame_Shift_Ins	novel	*A1179Dfs37**	0.09
UCEC	chr6	158066626	Missense_Mutation	rs148023347	D570N	0.46
UCEC	chr6	158028918	Missense_Mutation	rs373812551	S126L	0.06
UCEC	chr6	158095711	Frame_Shift_Del	novel	*A1280Pfs121**	0.26
UCEC	chr6	158095712	Missense_Mutation	novel	A1280D	0.25
UCEC	chr6	158081276	Missense_Mutation	rs151268691	R912H	0.14	Exo_endo_phos
UCEC	chr6	158066641	Splice_Region	novel		0.41
UCEC	chr6	158076727	Silent	rs773447167	P798P	0.17
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.5
UCEC	chr6	158028947	Missense_Mutation	rs147584404	D136N	0.41
UCEC	chr6	158033636	Missense_Mutation	rs143215663	V223M	0.45
UCEC	chr6	158068716	Missense_Mutation	novel	I596T	0.35
UCEC	chr6	158094005	Intron	rs188000207		0.22
UCEC	chr6	158033581	Silent	NA	C204C	0.13
UCEC	chr6	158074731	Missense_Mutation	novel	S762I	0.06
UCEC	chr6	158096358	Missense_Mutation	NA	K1495N	0.26
UCEC	chr6	158063838	Missense_Mutation	rs138792733	R392Q	0.27
UCEC	chr6	158062129	Silent	rs376745407	F364F	0.23
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.42
UCEC	chr6	158033585	Missense_Mutation	rs535069011	V206I	0.3
UCEC	chr6	158062027	Silent	rs750486579	T330T	0.18
UCEC	chr6	158066715	Intron	novel		0.47
UCEC	chr6	158076682	Silent	rs138927100	D783D	0.34
UCEC	chr6	158062017	Missense_Mutation	rs202038099	A327V	0.39
UCEC	chr6	158029005	Missense_Mutation	novel	E155G	0.23
UCEC	chr6	158033681	Splice_Site	novel	X237_splice	0.34
UCEC	chr6	158086925	Silent	NA	S1093S	0.24
UCEC	chr6	158083581	Missense_Mutation	NA	L1006F	0.43	Exo_endo_phos
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.37
UCEC	chr6	158086977	Frame_Shift_Del	rs752817404	*P1113Lfs5**	0.35
UCEC	chr6	158033665	Silent	rs778933903	F232F	0.47
UCEC	chr6	158066553	Silent	NA	F545F	0.35
UCEC	chr6	158086976	Frame_Shift_Ins	rs531633531	*P1114Sfs48**	0.49
UCEC	chr6	158028888	Missense_Mutation	rs376223674	R116H	0.29
UCEC	chr6	158095744	Missense_Mutation	novel	T1291A	0.36
UCEC	chr6	158043371	Missense_Mutation	rs200593132	P256L	0.36
UCEC	chr6	158084139	Missense_Mutation	novel	A1058D	0.08
UCEC	chr6	158088744	Missense_Mutation	NA	R1143I	0.38
UCEC	chr6	158071629	Silent	rs758367538	T656T	0.15
UCEC	chr6	158043371	Missense_Mutation	rs200593132	P256L	0.51
UCEC	chr6	158062027	Silent	rs750486579	T330T	0.4
UCEC	chr6	158066589	Silent	novel	D557D	0.45
UCEC	chr6	158095718	Missense_Mutation	rs763382477	R1282Q	0.34
UCEC	chr6	158097084	3'UTR	novel		0.29
UCEC	chr6	158086932	Missense_Mutation	novel	L1096M	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3676	0.00027473
CESC	DEL	0.2847	9.8477e-05
KIRC	DEL	0.2481	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0054594
MESO	DEL	0.3908	0.05642
PAAD	DEL	0.3804	0.11274
SKCM	DEL	0.5531	1.5442e-06
TGCT	DEL	0.0933	0.0031874
THYM	DEL	0.1382	0.10691
UVM	DEL	0.275	0.0054289

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0063	Kaplan-Meier Survival Analysis
STAD	0.0065	Kaplan-Meier Survival Analysis
MESO	0.00017	Kaplan-Meier Survival Analysis
LUSC	0.05	Kaplan-Meier Survival Analysis
BRCA	0.00028	Kaplan-Meier Survival Analysis
KIRP	0.0017	Kaplan-Meier Survival Analysis
CESC	0.04	Kaplan-Meier Survival Analysis
READ	0.017	Kaplan-Meier Survival Analysis
KICH	0.0095	Kaplan-Meier Survival Analysis
UCEC	0.0097	Kaplan-Meier Survival Analysis
GBM	0.0073	Kaplan-Meier Survival Analysis
LGG	0.0014	Kaplan-Meier Survival Analysis
LUAD	0.035	Kaplan-Meier Survival Analysis
UVM	0.0032	Kaplan-Meier Survival Analysis
OV	0.0068	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742