EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000078328 (Gene tree)
Gene ID: 54715
Gene Symbol: RBFOX1
Alias: A2BP1|FOX-1|HRNBP1
Full Name: RNA binding fox-1 homolog 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,473,559 bases
Position: chr16:5,239,782-7,713,340
Accession: 18222
RBP type: canonical RBP
Summary: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447753	Fox-1_C	PF12414.8	2.7e-42	1	1
ENSP00000484837	Fox-1_C	PF12414.8	2.8e-42	1	1
ENSP00000447717	Fox-1_C	PF12414.8	4.2e-42	1	1
ENSP00000450031	Fox-1_C	PF12414.8	4.2e-42	1	1
ENSP00000344196	Fox-1_C	PF12414.8	4.3e-42	1	1
ENSP00000391269	Fox-1_C	PF12414.8	4.7e-42	1	1
ENSP00000402745	Fox-1_C	PF12414.8	4.2e-40	1	1
ENSP00000309117	Fox-1_C	PF12414.8	4.7e-40	1	1
ENSP00000438768	Fox-1_C	PF12414.8	6.8e-40	1	1
ENSP00000448496	Fox-1_C	PF12414.8	7.1e-40	1	1
ENSP00000446842	Fox-1_C	PF12414.8	9.6e-40	1	1
ENSP00000493041	Fox-1_C	PF12414.8	1.4e-39	1	1
ENSP00000347855	Fox-1_C	PF12414.8	8.3e-38	1	1
ENSP00000454250	Fox-1_C	PF12414.8	2.1e-12	1	1
ENSP00000458748	RRM_1	PF00076.22	3.9e-18	1	1
ENSP00000450402	RRM_1	PF00076.22	7e-18	1	1
ENSP00000447281	RRM_1	PF00076.22	7.1e-18	1	1
ENSP00000347855	RRM_1	PF00076.22	1e-17	1	1
ENSP00000402745	RRM_1	PF00076.22	1.1e-17	1	1
ENSP00000447753	RRM_1	PF00076.22	1.1e-17	1	1
ENSP00000484837	RRM_1	PF00076.22	1.1e-17	1	1
ENSP00000309117	RRM_1	PF00076.22	1.2e-17	1	1
ENSP00000447717	RRM_1	PF00076.22	1.2e-17	1	1
ENSP00000450031	RRM_1	PF00076.22	1.2e-17	1	1
ENSP00000344196	RRM_1	PF00076.22	1.2e-17	1	1
ENSP00000391269	RRM_1	PF00076.22	1.3e-17	1	1
ENSP00000446842	RRM_1	PF00076.22	1.5e-17	1	1
ENSP00000493041	RRM_1	PF00076.22	2.1e-17	1	1
ENSP00000448496	RRM_1	PF00076.22	2.1e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29186814	Alternative Splicing of L-type CaV1.2 Calcium Channels: Implications in Cardiovascular Diseases.	Genes (Basel)	2017 Nov 24	Hu Z	doi: 10.3390/genes8120344.
9394616	The chromosomal signal for sex determination in Caenorhabditis elegans.	Bioessays	1997 Nov	Meneely PM	-
9217163	X-chromosome-counting mechanisms that determine nematode sex.	Nature	1997 Jul 10	Nicoll M	-
17530930	Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements.	PLoS Genet	2007 May 25	Yeo GW	-
23236287	Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.	PLoS Genet	2012	Ding D	doi: 10.1371/journal.pgen.1003065
25760045	Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects.	Curr HIV Res	2015	Hahn YK	-
29789616	rbFOX1/MBNL1 competition for CCUG RNA repeats bindingcontributes to myotonic dystrophy type1/type2 differences.	Nat Commun	2018 May 22	Sellier C	doi: 10.1038/s41467-018-04370-x.
11303786	The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.	J Mol Neurosci	2000 Dec	Kiehl TR	-
22678932	Rare inherited A2BP1 deletion in a proband with autism and developmental hemiparesis.	Am J Med Genet A	2012 Jul	Davis LK	doi: 10.1002/ajmg.a.35396
23918370	From the Cover: Neutralization of terminal differentiation in gliomagenesis.	Proc Natl Acad Sci U S A	2013 Sep 3	Hu J	doi: 10.1073/pnas.1308610110
30597088	Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression.	Schizophr Bull	2018 Dec 29	Chapman RM	doi: 10.1093/schbul/sby183
17923701	The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.	Mol Cell Biol	2007 Dec	Kuroyanagi H	-
29170129	Rbfox family proteins make the homo- and hetero-oligomeric complexes.	Biochem Biophys Res Commun	2018 Jan 1	Choi S	doi: 10.1016/j.bbrc.2017.11.128
9927456	Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination.	Genetics	1999 Feb	Skipper M	-
12574126	A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.	EMBO J	2003 Feb 17	Jin Y	-
16362037	Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.	EMBO J	2006 Jan 11	Auweter SD	-
10814712	A novel protein with RNA-binding motifs interacts with ataxin-2.	Hum Mol Genet	2000 May 22	Shibata H	-
20141540	Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cells.	Genes Cells	2010 Mar	Hakim NH	doi: 10.1111/j.1365-2443.2009.01378.x
20042473	Autoregulation of Fox protein expression to produce dominant negative splicing factors.	RNA	2010 Feb	Damianov A	doi: 10.1261/rna.1838210
19688295	Fox-1 family of RNA-binding proteins.	Cell Mol Life Sci	2009 Dec	Kuroyanagi H	doi: 10.1007/s00018-009-0120-5.
23027929	Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.	Proc Natl Acad Sci U S A	2012 Oct 16	Lee AY	doi: 10.1073/pnas.1215406109
17503474	Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism.	Am J Med Genet B Neuropsychiatr Genet	2007 Oct 5	Martin CL	-
17060915	Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.	Nat Methods	2006 Nov	Kuroyanagi H	-
22730494	RBFOX1 regulates both splicing and transcriptional networks in human neuronal development.	Hum Mol Genet	2012 Oct 1	Fogel BL	doi: 10.1093/hmg/dds240
21533652	Definition and testing of the GROMOS force-field versions 54A7 and 54B7.	Eur Biophys J	2011 Jul	Schmid N	doi: 10.1007/s00249-011-0700-9
25571999	Upregulation of RBFOX1 in the malformed cortex of patients with intractable epilepsy and in cultured rat neurons.	Int J Mol Med	2015 Mar	Wen M	doi: 10.3892/ijmm.2015.2061
25575511	The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function.	Hum Mol Genet	2015 Apr 15	Pedrotti S	doi: 10.1093/hmg/ddv003
25069643	NMDA glutamate receptor NR1, NR2A and NR2B expression and NR2B Tyr-1472 phosphorylation in the lens.	Neurochem Res	2014 Sep	Bhattacharyya M	doi: 10.1007/s11064-014-1394-z
24658850	RNA-binding proteins in neurological diseases.	Sci China Life Sci	2014 Apr	Zhou H	-
24613350	HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.	Cell Rep	2014 Mar 27	Weyn-Vanhentenryck SM	doi: 10.1016/j.celrep.2014.02.005
23468662	CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.	PLoS Genet	2013	Kuroyanagi H	doi: 10.1371/journal.pgen.1003337
27164557	Genetic Relationship between Schizophrenia and Nicotine Dependence.	Sci Rep	2016 May 10	Chen J	doi: 10.1038/srep25671.
26687839	Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes.	Neuron	2016 Jan 6	Lee JA	doi: 10.1016/j.neuron.2015.11.025
26430555	Splicing factor SUP-12 and the molecular complexity of apparent cooperativity.	Worm	2015 Jan 30	Mackereth CD	doi: 10.4161/21624054.2014.991240
26222184	Focus on 16p13.3 Locus in Colon Cancer.	PLoS One	2015 Jul 29	Mampaey E	doi: 10.1371/journal.pone.0131421
28487411	A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses.	EMBO J	2017 Jun 14	Rajman M	doi: 10.15252/embj.201695748
29621484	Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.	Neuron	2018 Apr 4	Vuong CK	doi: 10.1016/j.neuron.2018.03.008.
29621488	Protected by a Fox.	Neuron	2018 Apr 4	Lipscombe D	doi: 10.1016/j.neuron.2018.03.026.
29982852	MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.	Acta Neuropathol	2018 Oct	El Fatimy R	doi: 10.1007/s00401-018-1880-5
29997126	The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster.	J Immunol	2018 Aug 15	Nazario-Toole AE	doi: 10.4049/jimmunol.1800496
30159600	RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms.	Ann Hematol	2019 May	Faisal M	doi: 10.1007/s00277-018-3478-3
30596066	Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism.	Ann Transl Med	2018 Nov	Kong LL	doi: 10.21037/atm.2018.07.05.
30671673	Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data.	Hum Genet	2019 Feb	He KY	doi: 10.1007/s00439-019-01975-0
19713214	Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.	J Biol Chem	2009 Nov 6	Kim KK	doi: 10.1074/jbc.M109.052969
15663938	An integrative approach to gain insights into the cellular function of human ataxin-2.	J Mol Biol	2005 Feb 11	Ralser M	-
28286323	switchSENSE: A new technology to study protein-RNA interactions.	Methods	2017 Apr 15	Clery A	doi: 10.1016/j.ymeth.2017.03.004
29121637	The combinatorial control of alternative splicing in C. elegans.	PLoS Genet	2017 Nov 9	Tan JH	doi: 10.1371/journal.pgen.1007033
30059005	An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.	Elife	2018 Jul 30	Li J	doi: 10.7554/eLife.37184.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000564850	RBFOX1-216	293	-	-	- (aa)	-	-
ENST00000570188	RBFOX1-220	568	-	-	- (aa)	-	-
ENST00000553186	RBFOX1-215	2196	XM_017023338	ENSP00000447753	370 (aa)	XP_016878827	Q9NWB1
ENST00000569889	RBFOX1-218	503	-	-	- (aa)	-	-
ENST00000340209	RBFOX1-202	4099	XM_011522546	ENSP00000344196	402 (aa)	XP_011520848	J3KNW3
ENST00000567470	RBFOX1-217	420	-	ENSP00000454250	74 (aa)	-	H3BM62
ENST00000550418	RBFOX1-212	4775	XM_017023333	ENSP00000450031	397 (aa)	XP_016878822	Q9NWB1
ENST00000535565	RBFOX1-206	1599	XM_017023321	ENSP00000438768	380 (aa)	XP_016878810	F5H0M1
ENST00000436368	RBFOX1-205	1530	-	ENSP00000402745	392 (aa)	-	Q9NWB1
ENST00000570626	RBFOX1-221	725	-	ENSP00000458748	189 (aa)	-	I3L1D4
ENST00000422070	RBFOX1-204	1684	XM_017023324	ENSP00000391269	425 (aa)	XP_016878813	B7Z1U7
ENST00000551752	RBFOX1-213	974	-	ENSP00000447281	263 (aa)	-	F8VZY7
ENST00000547427	RBFOX1-209	557	-	-	- (aa)	-	-
ENST00000641259	RBFOX1-224	3651	XM_017023318	ENSP00000493041	582 (aa)	XP_016878807	A0A286YEU2
ENST00000547605	RBFOX1-210	1811	-	ENSP00000450402	262 (aa)	-	F8VR27
ENST00000355637	RBFOX1-203	3321	XM_005255386	ENSP00000347855	395 (aa)	XP_005255443	Q9NWB1
ENST00000547338	RBFOX1-207	1513	-	ENSP00000447717	397 (aa)	-	Q9NWB1
ENST00000311745	RBFOX1-201	3268	XM_005255394	ENSP00000309117	418 (aa)	XP_005255451	Q9NWB1
ENST00000585867	RBFOX1-222	1580	-	ENSP00000493140	201 (aa)	-	A0A286YFF2
ENST00000548749	RBFOX1-211	538	-	-	- (aa)	-	-
ENST00000569895	RBFOX1-219	829	-	-	- (aa)	-	-
ENST00000620507	RBFOX1-223	4018	XM_011522548	ENSP00000484837	375 (aa)	XP_011520850	A0A087X2B1
ENST00000547372	RBFOX1-208	3524	XM_017023320	ENSP00000446842	466 (aa)	XP_016878809	F8VZG9
ENST00000552089	RBFOX1-214	1430	XM_017023330	ENSP00000448496	391 (aa)	XP_016878819	F8VRS4

Gene Model

Click here to download ENSG00000078328's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000078328	Respiratory Function Tests	9.60497545732297E-7	17903307
ENSG00000078328	Respiratory Function Tests	6.07071609624591E-7	17903307
ENSG00000078328	Body Mass Index	4.9707081993607E-5	17903300
ENSG00000078328	Body Mass Index	2.41071819904284E-5	17903300
ENSG00000078328	Body Weight	2.37881990298074E-5	17903300
ENSG00000078328	Body Weight	8.56552110343686E-5	17903300
ENSG00000078328	Cholesterol, HDL	4.6411424362347E-5	17903299
ENSG00000078328	Cholesterol, LDL	1.61796762560761E-7	17903299
ENSG00000078328	Cholesterol, HDL	7.81511931955414E-5	17903299
ENSG00000078328	Cholesterol, HDL	4.70131377372507E-5	17903299
ENSG00000078328	Cholesterol, LDL	6.63524216522049E-5	17903299
ENSG00000078328	Cholesterol, LDL	5.55400436901277E-5	17903299
ENSG00000078328	Lipoproteins, VLDL	1.939235320682E-6	17903299
ENSG00000078328	Apolipoproteins B	7.24523788024701E-6	17903299
ENSG00000078328	Erythrocytes	1.94598408342905E-5	17903294
ENSG00000078328	Erythrocytes	7.6855409045784E-5	17903294
ENSG00000078328	Calcium-Binding Proteins	3.0812454326985E-9	17903293
ENSG00000078328	Calcium-Binding Proteins	4.28359325123193E-10	17903293
ENSG00000078328	Uric Acid	8.11426262097292E-5	17903292
ENSG00000078328	Neoplasms	6.86545187570505E-6	17903305
ENSG00000078328	Atrial Fibrillation	2.17461237843389E-7	17903304
ENSG00000078328	Atrial Fibrillation	1.97686276381724E-7	17903304
ENSG00000078328	Echocardiography	7.55799577747581E-5	17903301
ENSG00000078328	Inflammatory Bowel Diseases	6.312E-5	17068223
ENSG00000078328	Amyotrophic Lateral Sclerosis	4.6690000E-005	18057069
ENSG00000078328	Bipolar Disorder	3.7E-5	19488044
ENSG00000078328	Bipolar Disorder	7.46E-5	19488044
ENSG00000078328	Bipolar Disorder	9.1E-5	19488044
ENSG00000078328	Myocardial Infarction	3.3445516E-004	-
ENSG00000078328	Alzheimer Disease	2.5425511E-005	17998437
ENSG00000078328	Platelet Count	4.963e-005	-
ENSG00000078328	Creatinine	1.887e-005	-
ENSG00000078328	Alanine Transaminase	8.681e-005	-
ENSG00000078328	Alanine Transaminase	8.914e-005	-
ENSG00000078328	Bilirubin	1.512e-005	-
ENSG00000078328	Neuroticism	6.777e-005	-
ENSG00000078328	Personality	4.974e-005	-
ENSG00000078328	Personality	8.796e-005	-
ENSG00000078328	Personality	4.637e-005	-
ENSG00000078328	Personality	6.38e-005	-
ENSG00000078328	Personality	6.38e-005	-
ENSG00000078328	Body Height	8.6580000E-005	-
ENSG00000078328	Body Height	3.4030000E-005	-
ENSG00000078328	Muscle, Skeletal	2.3350000E-005	-
ENSG00000078328	Arteries	6.7710000E-005	-
ENSG00000078328	Arteries	6.9920000E-005	-
ENSG00000078328	Coronary Disease	7.9020000E-005	-
ENSG00000078328	Social Support	3.0230000E-005	-
ENSG00000078328	Social Support	2.3210000E-005	-
ENSG00000078328	Social Support	7.5830000E-005	-
ENSG00000078328	Social Support	3.0960000E-005	-
ENSG00000078328	Social Support	5.0680000E-005	-
ENSG00000078328	Creatinine	4.3060000E-005	-
ENSG00000078328	Eosinophils	5.0010000E-005	-
ENSG00000078328	Monocytes	5.7900000E-007	-
ENSG00000078328	Leukocyte Count	6.6610000E-005	-
ENSG00000078328	Leukocyte Count	4.2590000E-005	-
ENSG00000078328	Erythrocyte Indices	3.0240000E-005	-
ENSG00000078328	Erythrocyte Indices	9.8060000E-005	-
ENSG00000078328	Erythrocyte Indices	3.6990000E-005	-
ENSG00000078328	Atherosclerosis	7.8036079E-005	-
ENSG00000078328	Blood Pressure	9.8156298E-005	-
ENSG00000078328	Urine	5.2268531E-005	-
ENSG00000078328	Leukoaraiosis	6.9724727E-005	-
ENSG00000078328	Platelet Function Tests	3.0262500E-005	-
ENSG00000078328	Platelet Function Tests	1.2489500E-005	-
ENSG00000078328	Platelet Function Tests	2.3613900E-005	-
ENSG00000078328	Platelet Function Tests	1.3637700E-005	-
ENSG00000078328	Platelet Function Tests	6.1100000E-006	-
ENSG00000078328	Platelet Function Tests	3.5400000E-006	-
ENSG00000078328	Platelet Function Tests	9.6300000E-006	-
ENSG00000078328	Platelet Function Tests	6.6600000E-016	-
ENSG00000078328	Platelet Function Tests	8.8800000E-016	-
ENSG00000078328	Platelet Function Tests	8.9000000E-006	-
ENSG00000078328	Platelet Function Tests	2.1800000E-006	-
ENSG00000078328	Platelet Function Tests	2.4619300E-005	-
ENSG00000078328	Platelet Function Tests	3.4951200E-005	-
ENSG00000078328	Platelet Function Tests	1.3600300E-005	-
ENSG00000078328	Platelet Function Tests	1.6744900E-005	-
ENSG00000078328	Platelet Function Tests	6.2814005E-006	-
ENSG00000078328	Platelet Function Tests	6.2814005E-006	-
ENSG00000078328	Platelet Function Tests	3.8075631E-006	-
ENSG00000078328	Platelet Function Tests	7.3853593E-006	-
ENSG00000078328	Platelet Function Tests	9.1581571E-006	-
ENSG00000078328	Platelet Function Tests	2.0925600E-005	-
ENSG00000078328	Platelet Function Tests	2.2204460E-016	-
ENSG00000078328	Platelet Function Tests	2.2204460E-016	-
ENSG00000078328	Platelet Function Tests	1.7962800E-005	-
ENSG00000078328	Platelet Function Tests	7.9853873E-006	-
ENSG00000078328	Platelet Function Tests	9.5653149E-006	-
ENSG00000078328	Platelet Function Tests	9.5933578E-006	-
ENSG00000078328	Platelet Function Tests	4.7666122E-006	-
ENSG00000078328	Platelet Function Tests	2.2019332E-006	-
ENSG00000078328	Platelet Function Tests	4.4178138E-006	-
ENSG00000078328	Platelet Function Tests	6.2314000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	1.8036500E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	2.8000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	4.1000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	5.3000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	5.8000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	6.1000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	2.5000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	2.6000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	2.0000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	2.0000000E-005	-
ENSG00000078328	Child Development Disorders, Pervasive	5.7000000E-005	-
ENSG00000078328	Triiodothyronine	8.3260000E-006	-
ENSG00000078328	Triiodothyronine	8.0020000E-006	-
ENSG00000078328	Insulin-Like Growth Factor Binding Protein 1	5.0660000E-005	-
ENSG00000078328	Fibrinogen	4.7970000E-005	-
ENSG00000078328	gamma-Glutamyltransferase	2.8960000E-005	-
ENSG00000078328	gamma-Glutamyltransferase	2.2050000E-006	-
ENSG00000078328	monocyte chemoattractant protein 1 (66-77)	9.9100000E-006	-
ENSG00000078328	beta Carotene	2.6210000E-005	-
ENSG00000078328	Plaque, Atherosclerotic	2.8450000E-005	21909108
ENSG00000078328	Cognition Disorders	5E-9	26252872
ENSG00000078328	Cognitive Dysfunction	5E-9	26252872
ENSG00000078328	Diabetic Retinopathy	6E-7	21441570
ENSG00000078328	Autosomal dominant compelling helio ophthalmic outburst syndrome	3E-21	27182965
ENSG00000078328	Body Weight	2E-6	23251661
ENSG00000078328	Refraction, Ocular	4E-9	23474815
ENSG00000078328	Myopia	2E-6	25233373
ENSG00000078328	Rhinitis, Allergic	5E-7	25085501
ENSG00000078328	Conduct Disorder	3E-6	18846501
ENSG00000078328	Gout	1E-7	22179738
ENSG00000078328	Mental Disorders	5E-6	20889312
ENSG00000078328	Refraction, Ocular	6E-10	23396134
ENSG00000078328	Heart Rate	2E-7	23583979
ENSG00000078328	Intraocular Pressure	4E-6	24002674
ENSG00000078328	Extraversion (Psychology)	2E-6	27918536
ENSG00000078328	Attention Deficit Disorder with Hyperactivity	9E-6	18951430
ENSG00000078328	Conduct Disorder	9E-6	18951430
ENSG00000078328	Body Mass Index	3E-6	25673413
ENSG00000078328	Emotions	2E-7	27089181
ENSG00000078328	Paliperidone Palmitate	3E-7	27846195
ENSG00000078328	Schizophrenia	3E-7	27846195
ENSG00000078328	Periodontitis	5E-6	24024966
ENSG00000078328	S-(3-hydroxypropyl)cysteine N-acetate	6E-6	26053186
ENSG00000078328	Smoking	6E-6	26053186
ENSG00000078328	Body Mass Index	2E-6	23251661
ENSG00000078328	Cognition Disorders	2E-9	26252872
ENSG00000078328	Cognitive Dysfunction	2E-9	26252872
ENSG00000078328	Glaucoma	4E-8	25027321
ENSG00000078328	Glaucoma	1E-8	25027321
ENSG00000078328	Hyperopia	5E-7	25233373
ENSG00000078328	Phospholipids	5E-7	19043545
ENSG00000078328	Subcutaneous Fat	9E-6	22589738
ENSG00000078328	Phospholipids	1E-8	22359512
ENSG00000078328	Antipsychotic Agents	2E-6	19875103
ENSG00000078328	Schizophrenia	7E-7	26198764
ENSG00000078328	Schizophrenia	1E-7	26198764
ENSG00000078328	Alzheimer Disease	4E-10	26830138
ENSG00000078328	Age of Onset	4E-10	26830138
ENSG00000078328	Severe Dengue	2E-7	22001756
ENSG00000078328	Neuroticism	8E-6	27089181
ENSG00000078328	Body Composition	9E-6	23251661
ENSG00000078328	Myopia	2E-63	27182965
ENSG00000078328	Sleep	4E-6	23728906
ENSG00000078328	Age-Related Hearing Impairment 1	4E-9	24939585
ENSG00000078328	Adipose Tissue	2E-7	22589738
ENSG00000078328	Body Mass Index	2E-7	22589738

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000078328	rs112896149	16	7552979	G	Prostate cancer	29356057	[1.43-2.45]	1.87	EFO_0001663
ENSG00000078328	rs476605	16	5379576	?	Colorectal cancer	29228715	[NR]	1.24471	EFO_0005842
ENSG00000078328	rs917543	16	7693745	?	Colorectal cancer	29228715	[NR]	1.2420816	EFO_0005842
ENSG00000078328	rs112153979	16	5735322	T	Cognitive empathy	28584286	[0.22-0.56] unit decrease	0.3899	EFO_0009183
ENSG00000078328	rs3785236	16	7617197	C	Major depressive disorder	27479909	[0.023-0.05] unit increase	0.0365	EFO_0003761
ENSG00000078328	rs12103267	16	7093498	?	Clostridium difficile infection in multiple myeloma	29594489			EFO_0009130\|EFO_0001378
ENSG00000078328	rs6500768	16	6292640	T	Subjective well-being	27089181	[0.0093-0.0205] unit decrease	0.0149	EFO_0007869
ENSG00000078328	rs11640647	16	7612487	T	Neuroticism	27089181	[0.0091-0.0234] unit increase	0.01627837	EFO_0007660
ENSG00000078328	rs192917960	16	5869654	T	Glaucoma	25027321	[1.50-2.33]	1.87	EFO_0000516
ENSG00000078328	rs12597084	16	5769619	?	Allergic rhinitis	25085501	[1.19-1.82]	1.43	EFO_0005854
ENSG00000078328	rs192917960	16	5869654	T	Glaucoma	25027321	[1.65-2.78]	2.14	EFO_0000516
ENSG00000078328	rs12444931	16	7703702	?	Bipolar disorder and schizophrenia	20889312	[NR]	1.2244	EFO_0000677
ENSG00000078328	rs188803409	16	6990147	A	Response to paliperidone in schizophrenia (negative Marder score)	27846195	[NR] unit decrease	7.2424	EFO_0000692\|EFO_0007925\|EFO_0007927
ENSG00000078328	rs2343519	16	6078519	?	Gout	22179738			EFO_0004274
ENSG00000078328	rs75885813	16	7091262	A	Alzheimer disease and age of onset	26830138	unit decrease	6.258	EFO_0000249\|EFO_0004847
ENSG00000078328	rs6500957	16	7412044	C	Spherical equivalent (joint analysis main effects and education interaction)	27020472			EFO_0004784\|EFO_0007814
ENSG00000078328	rs6500957	16	7412044	C	Spherical equivalent (joint analysis main effects and education interaction)	27020472			EFO_0004784\|EFO_0007814
ENSG00000078328	rs4786816	16	6098029	A	Obesity-related traits	23251661	[NR] kg/m2 increase	0.03	EFO_0004340
ENSG00000078328	rs17648524	16	7409682	C	Refractive error	23396134	[0.081-0.155] unit decrease	0.118	HP_0000539
ENSG00000078328	rs10500355	16	7409346	?	Refractive error	23474815	[0.074-0.147] unit decrease	0.111	HP_0000539
ENSG00000078328	rs11645781	16	6846127	G	Heart rate	23583979			EFO_0004326
ENSG00000078328	rs17648524	16	7409682	?	Hyperopia	25233373			HP_0000540
ENSG00000078328	rs4581716	16	7408134	?	Myopia	25233373			HP_0000545
ENSG00000078328	rs75638798	16	6454023	C	Cognitive decline rate in late mild cognitive impairment	26252872	[0.48-0.95] unit decrease	0.7185	HP_0100543\|EFO_0007710
ENSG00000078328	rs75638798	16	6454023	C	Cognitive decline rate in late mild cognitive impairment	26252872	[0.49-0.95] unit decrease	0.7178	HP_0100543\|EFO_0007710
ENSG00000078328	rs191076832	16	5984142	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit increase	1.1977	EFO_0004318\|EFO_0007014
ENSG00000078328	rs12447542	16	7694178	A	Schizophrenia	26198764	[NR]	1.08	EFO_0000692
ENSG00000078328	rs8054347	16	6667756	A	Schizophrenia	26198764	[NR]	1.06	EFO_0000692
ENSG00000078328	rs11643447	16	6649260	T	Visceral adipose tissue adjusted for BMI	22589738			EFO_0004765\|EFO_0004340
ENSG00000078328	rs870288	16	5535851	A	Subcutaneous adipose tissue	22589738			EFO_0004766
ENSG00000078328	rs9302841	16	7177121	?	Response to antipsychotic therapy (extrapyramidal side effects)	19875103			GO_0097332
ENSG00000078328	rs1478693	16	7114218	G	Sleep time	23728906	[5.10-12.54] unit increase	8.82	EFO_0005274
ENSG00000078328	rs1906060	16	6058429	G	Intraocular pressure	24002674	[0.24-0.94] mmHg increase	0.59	EFO_0004695
ENSG00000078328	rs11866781	16	7089172	?	Periodontitis (PAL4Q3)	24024966	[1.16-1.45]	1.3	EFO_0000649
ENSG00000078328	rs7403856	16	6106325	A	Obesity-related traits	23251661	[NR] kg increase	0.03	EFO_0004338
ENSG00000078328	rs7403856	16	6106325	A	Obesity-related traits	23251661	[NR] kg increase	0.03	EFO_0005106
ENSG00000078328	rs4786125	16	6850546	A	Heart rate variability traits (SDNN)	28613276	[0.0088-0.0223] unit decrease	0.015542	EFO_0008003
ENSG00000078328	rs8063603	16	6260644	A	Neuroticism	29255261	z score decrease	4.497	EFO_0007660
ENSG00000078328	rs11077203	16	7616840	A	Neuroticism	29255261	z score increase	6.504	EFO_0007660
ENSG00000078328	rs9302817	16	6113935	G	Body mass index	28892062	[0.01-0.022] kg/m2 decrease	0.016	EFO_0004340
ENSG00000078328	rs6500744	16	6063660	C	Conduct disorder (maternal expressed emotions interaction)	18846501	[NR] unit increase	0.91	EFO_0008342\|EFO_0004216
ENSG00000078328	rs7195044	16	7287939	C	Brain volume in infants (cerebrospinal fluid)	28763065	percent increase	9.54	EFO_0008367
ENSG00000078328	rs3785234	16	7617390	T	Depressive symptoms	29292387	[0.0096-0.019] unit increase	0.0143	EFO_0007006
ENSG00000078328	rs8063603	16	6260644	G	Depressive symptoms	29292387	[0.011-0.021] unit increase	0.0161	EFO_0007006
ENSG00000078328	rs3785234	16	7617390	T	Depressive symptoms (MTAG)	29292387	[0.0084-0.017] unit increase	0.0127	EFO_0007006
ENSG00000078328	rs7193263	16	6265879	G	Depressive symptoms (MTAG)	29292387	[0.011-0.02] unit increase	0.0153	EFO_0007006
ENSG00000078328	rs716508	16	6286911	T	Subjective well-being (MTAG)	29292387	[0.0076-0.0154] unit increase	0.0115	EFO_0007869
ENSG00000078328	rs78165933	16	7063133	?	Rubella	28928442	[0.11-0.3] unit decrease	0.207	EFO_0008418
ENSG00000078328	rs182429520	16	7301002	?	Chronic sinus infection	28928442	[1.01-4.08] unit decrease	2.5453	EFO_0008419
ENSG00000078328	rs192042086	16	7120571	?	Cold sores	28928442	[0.17-0.38] unit increase	0.2749	EFO_0008402
ENSG00000078328	rs142723691	16	5324404	?	Hepatitis A	28928442	[0.83-3.21] unit decrease	2.0241	EFO_0008415
ENSG00000078328	rs11077204	16	7617185	C	Intelligence (MTAG)	29326435	[0.012-0.025] unit decrease	0.018286368	EFO_0004337
ENSG00000078328	rs11077207	16	7618478	C	Intelligence (MTAG)	29326435	[0.013-0.024] unit decrease	0.018427402	EFO_0004337
ENSG00000078328	rs3785238	16	7615555	A	Intelligence (MTAG)	29326435	[0.012-0.024] unit decrease	0.017861888	EFO_0004337
ENSG00000078328	rs4332760	16	7412044	C	Spherical equivalent	29808027	[0.065-0.123] unit increase	0.0938	EFO_0007814
ENSG00000078328	rs4332760	16	7412044	C	Spherical equivalent	29808027	[0.061-0.121] unit increase	0.0912	EFO_0007814
ENSG00000078328	rs17648524	16	7409682	C	Myopia (age of diagnosis)	29808027	[0.084-0.113] unit decrease	0.0986	EFO_0004847\|HP_0000545
ENSG00000078328	rs10500355	16	7409346	A	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score decrease	13.732	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000078328	rs79266634	16	7259046	C	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score decrease	5.932	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000078328	rs12325273	16	7203285	C	Cognitive performance	30038396	[0.011-0.022] unit decrease	0.0166	EFO_0008354
ENSG00000078328	rs1507010	16	7607371	A	Cognitive performance	30038396	[0.012-0.023] unit decrease	0.0173	EFO_0008354
ENSG00000078328	rs7206841	16	6531745	G	Self-reported math ability	30038396	[0.0077-0.0155] unit decrease	0.0116	EFO_0004875
ENSG00000078328	rs8061082	16	6704527	C	Self-reported math ability	30038396	[0.0099-0.0185] unit increase	0.0142	EFO_0004875
ENSG00000078328	rs7189627	16	6040089	?	Albumin-globulin ratio	29403010	[0.027-0.056] unit increase novel	0.04128	EFO_0005128
ENSG00000078328	rs3785234	16	7617390	T	Major depressive disorder	29728651	[NR]	1.035	EFO_0003761
ENSG00000078328	rs11076962	16	5761366	T	Educational attainment (MTAG)	30038396	[0.006-0.0118] unit increase	0.0089	EFO_0004784
ENSG00000078328	rs12709186	16	7199471	A	Educational attainment (MTAG)	30038396	[0.0066-0.012] unit decrease	0.0093	EFO_0004784
ENSG00000078328	rs4787028	16	7483019	T	Educational attainment (MTAG)	30038396	[0.005-0.0104] unit increase	0.0077	EFO_0004784
ENSG00000078328	rs34518736	16	7615168	C	Educational attainment (MTAG)	30038396	[0.0073-0.0123] unit decrease	0.0098	EFO_0004784
ENSG00000078328	rs8044082	16	6553020	T	Self-reported math ability (MTAG)	30038396	[0.007-0.014] unit increase	0.0105	EFO_0004875
ENSG00000078328	rs8061082	16	6704527	T	Self-reported math ability (MTAG)	30038396	[0.009-0.0172] unit decrease	0.0131	EFO_0004875
ENSG00000078328	rs11076962	16	5761366	T	Highest math class taken (MTAG)	30038396	[0.0071-0.0141] unit increase	0.0106	EFO_0004875
ENSG00000078328	rs8044082	16	6553020	T	Highest math class taken (MTAG)	30038396	[0.0072-0.0138] unit increase	0.0105	EFO_0004875
ENSG00000078328	rs8061082	16	6704527	T	Highest math class taken (MTAG)	30038396	[0.0076-0.015] unit decrease	0.0113	EFO_0004875
ENSG00000078328	rs3785229	16	7620997	A	Highest math class taken (MTAG)	30038396	[0.0066-0.0132] unit decrease	0.0099	EFO_0004875
ENSG00000078328	rs11076962	16	5761366	T	Cognitive performance (MTAG)	30038396	[0.012-0.022] unit increase	0.0167	EFO_0008354
ENSG00000078328	rs2346605	16	7201755	C	Cognitive performance (MTAG)	30038396	[0.0091-0.0185] unit decrease	0.0138	EFO_0008354
ENSG00000078328	rs34518736	16	7615168	C	Cognitive performance (MTAG)	30038396	[0.012-0.021] unit decrease	0.0164	EFO_0008354
ENSG00000078328	rs9934817	16	6086218	G	Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event)	29310926		2.663	EFO_0000482\|EFO_0001359\|EFO_0007658\|EFO_0004866
ENSG00000078328	rs55997507	16	7616662	C	Feeling worry	29500382	unit increase	6.437	EFO_0009589
ENSG00000078328	rs4786740	16	5625197	C	Interleukin-1-beta levels	27989323	[0.045-0.124] SD units decrease	0.0845	EFO_0004812
ENSG00000078328	rs62015704	16	7417906	G	Interleukin-1-beta levels	27989323	[0.053-0.164] SD units decrease	0.1082	EFO_0004812
ENSG00000078328	rs12924849	16	6174372	G	Facial morphology (factor 16)	28441456	[0.085-0.205] unit decrease	0.1449	EFO_0007841
ENSG00000078328	rs140227648	16	6147941	G	Interferon gamma-induced protein 10 levels	27989323	[0.34-0.85] SD units increase	0.5926	EFO_0008056
ENSG00000078328	rs9936075	16	7271908	G	Platelet-derived growth factor BB levels	27989323	[0.046-0.11] SD units increase	0.0782	EFO_0008264
ENSG00000078328	rs6500818	16	6767374	?	Dengue shock syndrome	22001756	[NR]	1.31	EFO_0004227
ENSG00000078328	rs870288	16	5535851	?	Phospholipid levels (plasma)	22359512	[NR] % increase	0.8	EFO_0004639
ENSG00000078328	rs12921846	16	6860384	A	Attention deficit hyperactivity disorder and conduct disorder	18951430			EFO_0003888\|EFO_0004216
ENSG00000078328	rs9924951	16	7454852	?	Metabolite levels	19043545			EFO_0004639
ENSG00000078328	rs4787008	16	7365551	G	Diabetic retinopathy	21441570	[NR]	1.47	EFO_0003770
ENSG00000078328	rs11639759	16	5629160	T	Survival in pancreatic cancer	28470677	[1.28-1.89]	1.56	EFO_0000638\|EFO_0002618
ENSG00000078328	rs7202041	16	5621791	A	Survival in pancreatic cancer	28470677	[1.30-1.89]	1.57	EFO_0000638\|EFO_0002618
ENSG00000078328	rs7498702	16	6477347	C	Extraversion	27918536	[0.014-0.038] unit decrease GPC-2 Discovery cohort	0.026	EFO_0004317
ENSG00000078328	rs10500355	16	7409346	?	Myopia	27182965	[1.12-1.15]	1.1350738	HP_0000545
ENSG00000078328	rs17143122	16	7259990	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[796.4-818.7]	807.55	EFO_0004265\|EFO_0007908
ENSG00000078328	rs368977885	16	7040937	?	Photic sneeze reflex	27182965	[1.08-1.13]	1.1074197	EFO_0007887
ENSG00000078328	rs7198928	16	7616400	T	Depression	29700475	[1.02-1.04]	1.03	EFO_0003761
ENSG00000078328	rs8063603	16	6260644	G	Depression	29700475	[1.02-1.04]	1.0309278	EFO_0003761
ENSG00000078328	rs9934041	16	7179578	T	General cognitive ability	29844566	z-score decrease	6.125	EFO_0004337
ENSG00000078328	rs7186834	16	7623253	T	General cognitive ability	29844566	z-score increase	5.859	EFO_0004337
ENSG00000078328	rs11865256	16	7215069	T	General cognitive ability	29844566	z-score decrease	5.678	EFO_0004337
ENSG00000078328	rs12709186	16	7199471	A	General cognitive ability	29844566	z-score decrease	5.47	EFO_0004337
ENSG00000078328	rs11076962	16	5761366	?	General cognitive ability	29844566	z-score increase	4.772	EFO_0004337
ENSG00000078328	rs72778533	16	7711734	?	Reaction time	29844566	[0.0053-0.012] unit increase	0.0086095	EFO_0008393
ENSG00000078328	rs11076962	16	5761366	T	Intelligence	29942086	z-score increase	5.568	EFO_0004337
ENSG00000078328	rs11646221	16	7616086	T	Intelligence	29942086	z-score increase	6.399	EFO_0004337
ENSG00000078328	rs2191130	16	7617795	T	Worry too long after an embarrassing experience	29500382	z score increase	5.95	EFO_0009589
ENSG00000078328	rs2191130	16	7617795	T	Depression	29942085	z score increase	6.099	EFO_0003761
ENSG00000078328	rs7193263	16	6265879	A	Depression	29942085	z score decrease	6.478	EFO_0003761
ENSG00000078328	rs9930139	16	7239569	A	Depressed affect	29942085	[0.0089-0.0182] unit decrease	0.01351	EFO_0003761\|EFO_0004247
ENSG00000078328	rs4602043	16	5538688	C	Rheumatoid arthritis	30423114			EFO_0000685
ENSG00000078328	rs4602043	16	5538688	C	Rheumatoid arthritis	30423114			EFO_0000685
ENSG00000078328	rs3785237	16	7617129	C	Neurociticism	29500382	z score increase	7.18	EFO_0007660
ENSG00000078328	rs3785237	16	7617129	C	Neuroticism	29942085	z score increase	7.574	EFO_0007660
ENSG00000078328	rs3785232	16	7617536	T	Neuroticism	29942085	z score increase	7.763	EFO_0007660
ENSG00000078328	rs8053004	16	7609747	T	Neuroticism	29942085	z score decrease	6.116	EFO_0007660
ENSG00000078328	rs9935836	16	7616969	A	Neuroticism	29942085	z score increase	5.528	EFO_0007660
ENSG00000078328	rs55997507	16	7616662	G	Worry	29942085	[0.011-0.02] unit decrease	0.01558	EFO_0005230
ENSG00000078328	rs12923795	16	7612705	A	Worry	29942085	[0.01-0.019] unit decrease	0.01476	EFO_0005230
ENSG00000078328	rs13337052	16	7323469	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000078328	rs17138199	16	5604140	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000078328	rs8043821	16	7406864	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000078328	rs11076962	16	5761366	T	Educational attainment (years of education)	30038396	[0.0055-0.0117] unit increase	0.0086	EFO_0004784
ENSG00000078328	rs12709186	16	7199471	A	Educational attainment (years of education)	30038396	[0.0062-0.012] unit decrease	0.0091	EFO_0004784
ENSG00000078328	rs4787028	16	7483019	T	Educational attainment (years of education)	30038396	[0.0057-0.0115] unit increase	0.0086	EFO_0004784
ENSG00000078328	rs9929993	16	7614873	T	Educational attainment (years of education)	30038396	[0.0073-0.0131] unit decrease	0.0102	EFO_0004784
ENSG00000078328	rs12444565	16	7357270	?	Brain glucose metabolism (fluorodeoxyglucose uptake)	30596066			EFO_0009367
ENSG00000078328	rs7195278	16	7613288	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000078328	rs4786084	16	6122772	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000078328	rs12933772	16	6510429	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000078328	rs11642387	16	6703238	?	Body mass index	30595370			EFO_0004340
ENSG00000078328	rs7206303	16	7298160	A	Alcohol consumption (drinks per week)	30643258	[0.0096-0.0199] unit increase	0.014760507	EFO_0007878
ENSG00000078328	rs11648210	16	5790634	T	Lumbar spine bone mineral density (integral)	27476799	[0.046-0.104] unit increase	0.075	EFO_0007620
ENSG00000078328	rs7194617	16	7418351	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000078328	rs6500948	16	7321457	A	Adventurousness	30643258	[0.0094-0.0193] unit decrease	0.014369997	EFO_0008579
ENSG00000078328	rs35450617	16	6839674	T	Systolic blood pressure	30224653	[0.11-0.21] mmHg decrease	0.1609	EFO_0006335
ENSG00000078328	rs17139246	16	6056259	C	Insomnia symptoms (never/rarely vs. usually)	30804566	[1.00-1.03]	1.02	EFO_0007876
ENSG00000078328	rs12447665	16	5487597	?	Proliferative diabetic retinopathy (vs no DR)	30487263	[NR]	1.83	EFO_0009322
ENSG00000078328	rs7198928	16	7616400	T	Depression	30718901	[1.018-1.027]	1.022	EFO_0003761
ENSG00000078328	rs7193263	16	6265879	G	Depression	30718901	[1.02-1.03]	1.0204082	EFO_0003761
ENSG00000078328	rs4479249	16	7310131	T	General risk tolerance (MTAG)	30643258	[0.0078-0.0136] unit increase	0.0107	EFO_0008579
ENSG00000078328	rs12051285	16	7410114	G	Refractive astigmatism	30306274	[1.034-1.081]	1.057	HP_0000483
ENSG00000078328	rs716508	16	6286911	T	Neuroticism	30643256	[0.0094-0.0156] unit decrease	0.0125026	EFO_0007660
ENSG00000078328	rs7191427	16	6350354	T	Neuroticism	30643256	[0.0067-0.0133] unit increase	0.009988291	EFO_0007660
ENSG00000078328	rs2191130	16	7617795	T	Neuroticism	30643256	[0.0085-0.0148] unit increase	0.011671352	EFO_0007660
ENSG00000078328	rs716508	16	6286911	T	Depressive symptoms	30643256	[0.006-0.01] unit decrease	0.007992385	EFO_0007006
ENSG00000078328	rs7191427	16	6350354	T	Depressive symptoms	30643256	[0.0043-0.0085] unit increase	0.006378761	EFO_0007006
ENSG00000078328	rs2191130	16	7617795	T	Depressive symptoms	30643256	[0.0054-0.0094] unit increase	0.007441718	EFO_0007006
ENSG00000078328	rs716508	16	6286911	?	Neuroticism	30595370			EFO_0007660
ENSG00000078328	rs3785232	16	7617536	?	Neuroticism	30595370			EFO_0007660
ENSG00000078328	rs716508	16	6286911	T	Well-being spectrum (multivariate analysis)	30643256	[0.0059-0.0098] unit decrease	0.007879294	EFO_0007869
ENSG00000078328	rs7191427	16	6350354	T	Well-being spectrum (multivariate analysis)	30643256	[0.0042-0.0083] unit increase	0.006227955	EFO_0007869
ENSG00000078328	rs3785234	16	7617390	T	Well-being spectrum (multivariate analysis)	30643256	[0.0054-0.0091] unit increase	0.00722901	EFO_0007869
ENSG00000078328	rs7191427	16	6350354	T	Life satisfaction	30643256	[0.0053-0.011] unit increase	0.008168689	EFO_0007869
ENSG00000078328	rs716508	16	6286911	T	Life satisfaction	30643256	[0.0075-0.013] unit decrease	0.010252982	EFO_0007869
ENSG00000078328	rs2191130	16	7617795	T	Life satisfaction	30643256	[0.0063-0.0124] unit increase	0.009343457	EFO_0007869
ENSG00000078328	rs716508	16	6286911	T	Positive affect	30643256	[0.0072-0.0121] unit decrease	0.009630196	EFO_0007869
ENSG00000078328	rs7191427	16	6350354	T	Positive affect	30643256	[0.0051-0.0102] unit increase	0.00766451	EFO_0007869
ENSG00000078328	rs8053004	16	7609747	T	Positive affect	30643256	[0.0051-0.0102] unit decrease	0.007626521	EFO_0007869
ENSG00000078328	rs7189389	16	5758519	G	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0062-0.0109] unit increase	0.0085805	EFO_0006527
ENSG00000078328	rs8044687	16	6054822	G	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0041-0.0087] unit decrease	0.00636904	EFO_0006527
ENSG00000078328	rs813913	16	6504252	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0044-0.0086] unit decrease	0.0065105	EFO_0006527
ENSG00000078328	rs11076962	16	5761366	C	Smoking initiation (ever regular vs never regular)	30643251	[0.013-0.024] unit increase	0.018299866	EFO_0006527
ENSG00000078328	rs13332522	16	5779203	C	Attention deficit hyperactivity disorder or intracranial volume (pleiotropy)	30818988	NR z score increase	5.784743	EFO_0003888\|EFO_0004886
ENSG00000078328	rs8063603	16	6260644	A	Autism and major depressive disorder (MTAG)	30804558	[0.023-0.059] unit decrease	0.041	EFO_0003761\|EFO_0003756
ENSG00000078328	rs3095508	16	6500399	C	Sleep duration	30846698	unit increase	0.702	EFO_0005271

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000078328's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000078328	RBFOX1	62	35.135	ENSG00000090621	PABPC4	97	31.356
ENSG00000078328	RBFOX1	80	78.333	ENSG00000167281	RBFOX3	100	77.143
ENSG00000078328	RBFOX1	100	69.634	ENSG00000100320	RBFOX2	100	66.667

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000078328	RBFOX1	100	81.186	ENSAPOG00000003197	rbfox1	100	81.701	Acanthochromis_polyacanthus
ENSG00000078328	RBFOX1	95	97.207	ENSAMEG00000008605	RBFOX1	100	96.000	Ailuropoda_melanoleuca
ENSG00000078328	RBFOX1	65	71.375	ENSACIG00000005478	rbfox1	68	71.375	Amphilophus_citrinellus
ENSG00000078328	RBFOX1	100	69.565	ENSAOCG00000008283	rbfox1	96	77.857	Amphiprion_ocellaris
ENSG00000078328	RBFOX1	95	71.390	ENSAPEG00000010636	rbfox1	100	71.274	Amphiprion_percula
ENSG00000078328	RBFOX1	100	68.421	ENSATEG00000007513	rbfox1	97	75.704	Anabas_testudineus
ENSG00000078328	RBFOX1	98	94.602	ENSAPLG00000013263	RBFOX1	98	94.629	Anas_platyrhynchos
ENSG00000078328	RBFOX1	95	91.620	ENSACAG00000004013	RBFOX1	100	86.717	Anolis_carolinensis
ENSG00000078328	RBFOX1	100	99.744	ENSANAG00000029527	RBFOX1	100	99.744	Aotus_nancymaae
ENSG00000078328	RBFOX1	96	87.845	ENSAMXG00000002431	rbfox1	64	89.498	Astyanax_mexicanus
ENSG00000078328	RBFOX1	100	97.884	ENSBTAG00000007210	RBFOX1	98	98.462	Bos_taurus
ENSG00000078328	RBFOX1	100	99.488	ENSCJAG00000017351	RBFOX1	100	99.488	Callithrix_jacchus
ENSG00000078328	RBFOX1	100	99.241	ENSCAFG00000019082	RBFOX1	100	99.241	Canis_familiaris
ENSG00000078328	RBFOX1	97	98.828	ENSCAFG00020024881	RBFOX1	99	85.823	Canis_lupus_dingo
ENSG00000078328	RBFOX1	100	98.481	ENSCHIG00000023549	RBFOX1	100	98.481	Capra_hircus
ENSG00000078328	RBFOX1	98	99.169	ENSTSYG00000005334	RBFOX1	100	99.229	Carlito_syrichta
ENSG00000078328	RBFOX1	100	97.368	ENSCAPG00000017669	RBFOX1	100	98.196	Cavia_aperea
ENSG00000078328	RBFOX1	100	98.237	ENSCPOG00000011314	RBFOX1	100	98.237	Cavia_porcellus
ENSG00000078328	RBFOX1	100	99.620	ENSCCAG00000023031	RBFOX1	100	99.766	Cebus_capucinus
ENSG00000078328	RBFOX1	100	100.000	ENSCATG00000033816	RBFOX1	100	100.000	Cercocebus_atys
ENSG00000078328	RBFOX1	100	98.489	ENSCLAG00000012761	RBFOX1	100	98.489	Chinchilla_lanigera
ENSG00000078328	RBFOX1	100	100.000	ENSCSAG00000008739	RBFOX1	98	98.919	Chlorocebus_sabaeus
ENSG00000078328	RBFOX1	96	96.685	ENSCHOG00000012843	RBFOX1	100	76.316	Choloepus_hoffmanni
ENSG00000078328	RBFOX1	100	93.651	ENSCPBG00000026626	RBFOX1	98	94.615	Chrysemys_picta_bellii
ENSG00000078328	RBFOX1	100	100.000	ENSCANG00000033125	RBFOX1	100	100.000	Colobus_angolensis_palliatus
ENSG00000078328	RBFOX1	100	98.237	ENSCGRG00001013729	Rbfox1	100	98.237	Cricetulus_griseus_chok1gshd
ENSG00000078328	RBFOX1	100	98.237	ENSCGRG00000003272	Rbfox1	100	98.237	Cricetulus_griseus_crigri
ENSG00000078328	RBFOX1	95	76.216	ENSCSEG00000008840	rbfox1	100	76.216	Cynoglossus_semilaevis
ENSG00000078328	RBFOX1	100	87.601	ENSDARG00000014746	rbfox1	100	87.871	Danio_rerio
ENSG00000078328	RBFOX1	98	98.205	ENSDNOG00000043612	RBFOX1	94	98.205	Dasypus_novemcinctus
ENSG00000078328	RBFOX1	100	93.564	ENSDORG00000010024	Rbfox1	100	93.564	Dipodomys_ordii
ENSG00000078328	RBFOX1	100	78.947	ENSETEG00000003771	RBFOX1	100	78.947	Echinops_telfairi
ENSG00000078328	RBFOX1	100	98.987	ENSEASG00005011599	RBFOX1	100	98.987	Equus_asinus_asinus
ENSG00000078328	RBFOX1	100	98.942	ENSECAG00000012667	RBFOX1	100	98.734	Equus_caballus
ENSG00000078328	RBFOX1	83	73.832	ENSELUG00000013096	rbfox1	100	53.495	Esox_lucius
ENSG00000078328	RBFOX1	100	99.240	ENSFCAG00000025322	RBFOX1	100	99.233	Felis_catus
ENSG00000078328	RBFOX1	98	91.571	ENSFALG00000004027	RBFOX1	100	92.793	Ficedula_albicollis
ENSG00000078328	RBFOX1	100	98.859	ENSFDAG00000007388	RBFOX1	100	98.741	Fukomys_damarensis
ENSG00000078328	RBFOX1	100	93.301	ENSGALG00000034325	RBFOX1	100	93.301	Gallus_gallus
ENSG00000078328	RBFOX1	100	92.911	ENSGAGG00000023681	RBFOX1	100	94.960	Gopherus_agassizii
ENSG00000078328	RBFOX1	100	100.000	ENSGGOG00000016871	-	100	100.000	Gorilla_gorilla
ENSG00000078328	RBFOX1	100	98.489	ENSHGLG00000016944	RBFOX1	100	98.489	Heterocephalus_glaber_female
ENSG00000078328	RBFOX1	100	98.489	ENSHGLG00100003272	RBFOX1	100	98.489	Heterocephalus_glaber_male
ENSG00000078328	RBFOX1	88	73.988	ENSHCOG00000016419	rbfox1	91	76.562	Hippocampus_comes
ENSG00000078328	RBFOX1	95	90.857	ENSIPUG00000015215	rbfox1	100	90.857	Ictalurus_punctatus
ENSG00000078328	RBFOX1	100	97.985	ENSSTOG00000000322	RBFOX1	100	97.985	Ictidomys_tridecemlineatus
ENSG00000078328	RBFOX1	100	94.710	ENSJJAG00000002575	Rbfox1	100	94.710	Jaculus_jaculus
ENSG00000078328	RBFOX1	95	78.261	ENSLBEG00000014659	rbfox1	97	78.533	Labrus_bergylta
ENSG00000078328	RBFOX1	95	92.179	ENSLOCG00000006675	rbfox1	99	87.277	Lepisosteus_oculatus
ENSG00000078328	RBFOX1	77	99.026	ENSLAFG00000011480	RBFOX1	100	99.351	Loxodonta_africana
ENSG00000078328	RBFOX1	100	99.785	ENSMFAG00000036447	RBFOX1	100	99.785	Macaca_fascicularis
ENSG00000078328	RBFOX1	100	99.785	ENSMMUG00000003458	RBFOX1	100	99.785	Macaca_mulatta
ENSG00000078328	RBFOX1	100	99.785	ENSMNEG00000032034	RBFOX1	100	99.785	Macaca_nemestrina
ENSG00000078328	RBFOX1	100	100.000	ENSMLEG00000015382	RBFOX1	100	100.000	Mandrillus_leucophaeus
ENSG00000078328	RBFOX1	95	80.548	ENSMAMG00000003142	rbfox1	100	81.096	Mastacembelus_armatus
ENSG00000078328	RBFOX1	100	93.651	ENSMGAG00000008606	RBFOX1	96	88.571	Meleagris_gallopavo
ENSG00000078328	RBFOX1	99	64.615	ENSMAUG00000020570	Rbfox1	99	56.818	Mesocricetus_auratus
ENSG00000078328	RBFOX1	100	99.240	ENSMICG00000034286	RBFOX1	100	99.233	Microcebus_murinus
ENSG00000078328	RBFOX1	100	98.237	ENSMOCG00000020932	Rbfox1	100	98.237	Microtus_ochrogaster
ENSG00000078328	RBFOX1	88	76.331	ENSMMOG00000009716	rbfox1	86	77.885	Mola_mola
ENSG00000078328	RBFOX1	92	97.531	ENSMODG00000005826	RBFOX1	100	97.740	Monodelphis_domestica
ENSG00000078328	RBFOX1	100	81.414	ENSMALG00000003337	rbfox1	100	81.414	Monopterus_albus
ENSG00000078328	RBFOX1	100	98.489	MGP_CAROLIEiJ_G0020427	Rbfox1	100	98.489	Mus_caroli
ENSG00000078328	RBFOX1	100	98.237	ENSMUSG00000008658	Rbfox1	100	99.248	Mus_musculus
ENSG00000078328	RBFOX1	100	98.489	MGP_PahariEiJ_G0016135	Rbfox1	100	98.489	Mus_pahari
ENSG00000078328	RBFOX1	100	97.985	MGP_SPRETEiJ_G0021321	Rbfox1	100	97.985	Mus_spretus
ENSG00000078328	RBFOX1	100	96.709	ENSMPUG00000014822	RBFOX1	100	96.709	Mustela_putorius_furo
ENSG00000078328	RBFOX1	77	99.674	ENSMLUG00000015896	RBFOX1	100	99.674	Myotis_lucifugus
ENSG00000078328	RBFOX1	100	98.086	ENSNGAG00000023276	Rbfox1	100	98.711	Nannospalax_galili
ENSG00000078328	RBFOX1	100	61.429	ENSNBRG00000011084	rbfox1	98	61.429	Neolamprologus_brichardi
ENSG00000078328	RBFOX1	100	99.761	ENSNLEG00000010017	-	100	99.761	Nomascus_leucogenys
ENSG00000078328	RBFOX1	94	97.191	ENSMEUG00000012525	RBFOX1	100	80.622	Notamacropus_eugenii
ENSG00000078328	RBFOX1	95	97.765	ENSOPRG00000006199	-	100	80.383	Ochotona_princeps
ENSG00000078328	RBFOX1	100	97.985	ENSODEG00000013166	RBFOX1	100	97.985	Octodon_degus
ENSG00000078328	RBFOX1	100	95.767	ENSOANG00000002379	RBFOX1	98	95.676	Ornithorhynchus_anatinus
ENSG00000078328	RBFOX1	95	96.089	ENSOCUG00000001205	-	100	94.222	Oryctolagus_cuniculus
ENSG00000078328	RBFOX1	100	97.985	ENSOGAG00000025535	RBFOX1	100	97.985	Otolemur_garnettii
ENSG00000078328	RBFOX1	95	86.345	ENSOARG00000005135	RBFOX1	99	93.074	Ovis_aries
ENSG00000078328	RBFOX1	100	100.000	ENSPPAG00000036238	-	100	100.000	Pan_paniscus
ENSG00000078328	RBFOX1	100	99.240	ENSPPRG00000006546	RBFOX1	100	99.233	Panthera_pardus
ENSG00000078328	RBFOX1	96	94.841	ENSPTIG00000021154	RBFOX1	99	86.632	Panthera_tigris_altaica
ENSG00000078328	RBFOX1	100	100.000	ENSPTRG00000007744	RBFOX1	100	100.000	Pan_troglodytes
ENSG00000078328	RBFOX1	100	100.000	ENSPANG00000026500	RBFOX1	100	100.000	Papio_anubis
ENSG00000078328	RBFOX1	100	88.441	ENSPKIG00000009667	-	95	90.616	Paramormyrops_kingsleyae
ENSG00000078328	RBFOX1	100	89.947	ENSPKIG00000019353	rbfox1	86	92.830	Paramormyrops_kingsleyae
ENSG00000078328	RBFOX1	100	94.180	ENSPSIG00000006523	RBFOX1	98	93.893	Pelodiscus_sinensis
ENSG00000078328	RBFOX1	100	98.489	ENSPEMG00000017607	Rbfox1	100	98.489	Peromyscus_maniculatus_bairdii
ENSG00000078328	RBFOX1	73	92.759	ENSPCIG00000026887	RBFOX1	100	92.759	Phascolarctos_cinereus
ENSG00000078328	RBFOX1	100	97.975	ENSPPYG00000007079	-	100	97.975	Pongo_abelii
ENSG00000078328	RBFOX1	96	89.418	ENSPCAG00000002630	RBFOX1	100	89.418	Procavia_capensis
ENSG00000078328	RBFOX1	100	99.240	ENSPCOG00000025687	RBFOX1	100	99.043	Propithecus_coquereli
ENSG00000078328	RBFOX1	100	94.019	ENSPVAG00000013467	RBFOX1	100	94.019	Pteropus_vampyrus
ENSG00000078328	RBFOX1	95	87.838	ENSPNAG00000023109	rbfox1	100	87.838	Pygocentrus_nattereri
ENSG00000078328	RBFOX1	100	97.264	ENSRNOG00000002827	Rbfox1	100	95.215	Rattus_norvegicus
ENSG00000078328	RBFOX1	100	100.000	ENSRBIG00000044478	RBFOX1	100	100.000	Rhinopithecus_bieti
ENSG00000078328	RBFOX1	100	100.000	ENSRROG00000044411	RBFOX1	100	100.000	Rhinopithecus_roxellana
ENSG00000078328	RBFOX1	100	99.747	ENSSBOG00000033726	RBFOX1	100	99.747	Saimiri_boliviensis_boliviensis
ENSG00000078328	RBFOX1	100	92.443	ENSSHAG00000009257	RBFOX1	100	92.443	Sarcophilus_harrisii
ENSG00000078328	RBFOX1	96	68.421	ENSSFOG00015009955	-	87	73.761	Scleropages_formosus
ENSG00000078328	RBFOX1	100	90.476	ENSSFOG00015023675	rbfox1	97	86.667	Scleropages_formosus
ENSG00000078328	RBFOX1	98	82.322	ENSSMAG00000015505	rbfox1	93	82.152	Scophthalmus_maximus
ENSG00000078328	RBFOX1	98	80.000	ENSSDUG00000016413	rbfox1	99	79.726	Seriola_dumerili
ENSG00000078328	RBFOX1	96	71.859	ENSSLDG00000009353	rbfox1	97	78.641	Seriola_lalandi_dorsalis
ENSG00000078328	RBFOX1	88	92.941	ENSSPUG00000009732	RBFOX1	87	89.776	Sphenodon_punctatus
ENSG00000078328	RBFOX1	98	81.266	ENSSPAG00000009723	rbfox1	100	81.003	Stegastes_partitus
ENSG00000078328	RBFOX1	100	98.481	ENSSSCG00000007917	RBFOX1	100	98.870	Sus_scrofa
ENSG00000078328	RBFOX1	98	94.602	ENSTGUG00000004562	RBFOX1	100	94.859	Taeniopygia_guttata
ENSG00000078328	RBFOX1	98	80.739	ENSTRUG00000020940	rbfox1	99	81.003	Takifugu_rubripes
ENSG00000078328	RBFOX1	65	62.718	ENSTNIG00000002567	rbfox1	100	64.460	Tetraodon_nigroviridis
ENSG00000078328	RBFOX1	81	89.655	ENSTBEG00000009169	-	81	89.655	Tupaia_belangeri
ENSG00000078328	RBFOX1	100	98.086	ENSTTRG00000005700	RBFOX1	100	98.086	Tursiops_truncatus
ENSG00000078328	RBFOX1	97	99.608	ENSUAMG00000024633	RBFOX1	99	94.430	Ursus_americanus
ENSG00000078328	RBFOX1	95	99.441	ENSUMAG00000003579	RBFOX1	99	85.570	Ursus_maritimus
ENSG00000078328	RBFOX1	81	99.351	ENSVPAG00000001284	RBFOX1	81	99.351	Vicugna_pacos
ENSG00000078328	RBFOX1	100	98.413	ENSVVUG00000017311	RBFOX1	98	98.378	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003723	RNA binding	10814712.	NAS	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	16713569.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	10814712.	IDA	Component
GO:0005802	trans-Golgi network	10814712.	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0007399	nervous system development	21873635.	IBA	Process
GO:0008022	protein C-terminus binding	10814712.	IPI	Function
GO:0008380	RNA splicing	-	IEA	Process
GO:0050658	RNA transport	10814712.	NAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23286373	Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.	Mol Cancer	2013 Jan 3	Sengupta N	doi: 10.1186/1476-4598-12-1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr16	7518218	Silent	NA	P33P	0.21
BLCA	chr16	7710719	Nonsense_Mutation	novel	G390*	0.43
BLCA	chr16	7595611	Silent	NA	H177H	0.2
BLCA	chr16	7653921	Silent	novel	P288P	0.25
BLCA	chr16	7518296	Silent	NA	P59P	0.25
BLCA	chr16	7595613	Frame_Shift_Ins	novel	*V180Pfs3**	0.06	Fox-1_C
BLCA	chr16	7709104	Silent	novel	P348P	0.09
BLCA	chr16	7710714	Missense_Mutation	rs747612014	R388Q	0.11
BLCA	chr16	7595639	Missense_Mutation	novel	E187Q	0.13	Fox-1_C
BLCA	chr16	7693325	Intron	novel		0.18
BRCA	chr16	7595615	Missense_Mutation	novel	T179A	0.32	Fox-1_C
BRCA	chr16	7332994	Intron	rs753642368		0.19
BRCA	chr16	7333010	Intron	rs771567004		0.13
BRCA	chr16	7597419	Missense_Mutation	NA	P204S	0.06
BRCA	chr16	7518186	Missense_Mutation	NA	Q23K	0.29
BRCA	chr16	7518359	Silent	NA	T80T	0.52
BRCA	chr16	7332919	Intron	novel		0.27
BRCA	chr16	7579858	Missense_Mutation	rs772938189	R118W	0.17
BRCA	chr16	7711118	3'Flank	novel		0.3
BRCA	chr16	7710714	Missense_Mutation	rs747612014	R388Q	0.07
BRCA	chr16	7595561	Missense_Mutation	NA	V161I	0.09
BRCA	chr16	7710840	3'UTR	novel		0.16
BRCA	chr16	7587290	Missense_Mutation	novel	R153Q	0.05
BRCA	chr16	7052098	Missense_Mutation	rs758592429	R9S	0.2
BRCA	chr16	7676797	Silent	rs182244522	Y318Y	0.23
BRCA	chr16	7709112	Frame_Shift_Ins	novel	*Y352Efs19**	0.08
BRCA	chr16	7712449	3'Flank	rs149490928		0.16
BRCA	chr16	7712047	3'Flank	novel		0.38
CESC	chr16	7595612	Missense_Mutation	NA	G178S	0.36	Fox-1_C
CESC	chr16	7607295	Missense_Mutation	NA	L211F	0.33
CESC	chr16	7579834	Missense_Mutation	NA	T110A	0.26
CESC	chr16	7711458	3'Flank	novel		0.2
CESC	chr16	7595561	Missense_Mutation	NA	V161I	0.47
CESC	chr16	7597413	Missense_Mutation	rs774774269	V202I	0.3	Fox-1_C
CESC	chr16	7712484	3'Flank	novel		0.12
CESC	chr16	7710711	Missense_Mutation	NA	Y387C	0.29
CESC	chr16	7653875	Missense_Mutation	NA	R273Q	1
CESC	chr16	7711656	3'Flank	rs563450623		0.45
CESC	chr16	7710728	Missense_Mutation	rs755043919	R393C	0.31
CESC	chr16	7518352	Missense_Mutation	NA	A78V	0.39
CESC	chr16	7579799	Missense_Mutation	rs373077021	T98M	0.48
CHOL	chr16	7518218	Silent	NA	P33P	0.11
COAD	chr16	7332863	Intron	novel		0.31
COAD	chr16	7607326	Missense_Mutation	NA	E222K	0.25
COAD	chr16	7653843	Silent	rs755253534	T262T	0.2
COAD	chr16	7518236	Silent	rs771957716	A39A	0.47
COAD	chr16	7518325	Missense_Mutation	novel	A69V	0.33
COAD	chr16	7518264	Missense_Mutation	rs755458164	A49T	0.4
COAD	chr16	7333009	Intron	rs753427339		0.26
COAD	chr16	7518266	Silent	rs752770034	A49A	0.41
COAD	chr16	7333010	Intron	rs771567004		0.27
COAD	chr16	7676805	Missense_Mutation	NA	P321L	0.31
COAD	chr16	7693331	Intron	rs550037838		0.39
COAD	chr16	7676798	Missense_Mutation	rs199644500	A319T	0.11
COAD	chr16	7709106	Frame_Shift_Del	NA	*T351Pfs7**	0.34
COAD	chr16	7587290	Missense_Mutation	novel	R153Q	0.36
COAD	chr16	7518253	Missense_Mutation	NA	H45R	0.38
COAD	chr16	7710737	Missense_Mutation	NA	P396S	0.3
COAD	chr16	7693330	Intron	NA		0.73
COAD	chr16	7709064	Missense_Mutation	rs763620262	R335Q	0.29
COAD	chr16	7710760	3'UTR	novel		0.06
COAD	chr16	7518370	Missense_Mutation	novel	T84S	0.3
COAD	chr16	7630653	Missense_Mutation	NA	A243T	0.17
DLBC	chr16	7332974	Intron	novel		0.42
DLBC	chr16	7709116	Silent	rs372365163	Y352Y	0.49
ESCA	chr16	7711450	3'Flank	novel		0.43
ESCA	chr16	7712027	3'Flank	novel		0.18
ESCA	chr16	7712400	3'Flank	novel		0.38
ESCA	chr16	7711754	3'Flank	novel		0.14
ESCA	chr16	7676798	Missense_Mutation	rs199644500	A319T	0.13
ESCA	chr16	7710803	3'UTR	novel		0.8
ESCA	chr16	7711146	3'Flank	novel		0.2
ESCA	chr16	7676797	Silent	rs182244522	Y318Y	0.27
ESCA	chr16	7332814	Intron	novel		0.45
ESCA	chr16	7332995	Intron	rs535330462		0.45
ESCA	chr16	7711909	3'Flank	novel		0.63
ESCA	chr16	7711598	3'Flank	novel		0.2
ESCA	chr16	7710881	3'Flank	novel		0.38
ESCA	chr16	7710905	3'Flank	novel		0.44
GBM	chr16	7710755	3'UTR	novel		0.32
GBM	chr16	7579854	Silent	novel	P116P	0.05
GBM	chr16	7676793	Missense_Mutation	rs776698363	R317H	0.42
GBM	chr16	7333062	Intron	NA		0.3
HNSC	chr16	7653880	Missense_Mutation	rs768320837	R275C	0.38
HNSC	chr16	7333040	Intron	rs757066841		0.27
HNSC	chr16	7518264	Missense_Mutation	rs755458164	A49T	0.27
HNSC	chr16	7518327	Missense_Mutation	novel	Q70K	0.26
HNSC	chr16	7518362	Silent	NA	S81S	0.19
HNSC	chr16	7579797	Silent	novel	P97P	0.31
HNSC	chr16	7595620	Silent	novel	V180V	0.29
HNSC	chr16	7333038	Intron	novel		0.36
HNSC	chr16	7595627	Missense_Mutation	novel	G183R	0.09	Fox-1_C
HNSC	chr16	7653826	Missense_Mutation	novel	P257T	0.22
HNSC	chr16	7052087	Missense_Mutation	novel	E6K	0.31
HNSC	chr16	7676774	Missense_Mutation	novel	G311R	0.13
KICH	chr16	7333010	Intron	rs771567004		0.45
KIRC	chr16	7518335	Missense_Mutation	NA	H72Q	0.16
KIRC	chr16	7518248	Silent	NA	A43A	0.12
KIRC	chr16	7595618	Missense_Mutation	rs372761949	V180M	0.09	Fox-1_C
KIRP	chr16	7653909	Silent	novel	R284R	0.45
LGG	chr16	7595560	Silent	NA	F160F	0.17
LGG	chr16	7518362	Silent	NA	S81S	0.39
LGG	chr16	7518364	Missense_Mutation	novel	A82V	0.39
LGG	chr16	7518265	Missense_Mutation	rs767917479	A49V	0.41
LGG	chr16	7333040	Intron	rs757066841		0.05
LGG	chr16	7579892	Missense_Mutation	NA	R129L	0.34
LIHC	chr16	7579891	Missense_Mutation	NA	R129W	0.47
LIHC	chr16	7710683	Missense_Mutation	NA	V378F	0.23
LIHC	chr16	7676802	Missense_Mutation	novel	Q320L	0.5
LIHC	chr16	7607282	Splice_Region	rs767289951		0.19
LIHC	chr16	7710802	3'UTR	novel		0.5
LIHC	chr16	7710816	3'UTR	novel		0.25
LIHC	chr16	7518312	Silent	NA	L65L	0.44
LUAD	chr16	7607323	Missense_Mutation	NA	P221T	0.41
LUAD	chr16	7333078	Intron	novel		0.41
LUAD	chr16	7653941	Missense_Mutation	NA	Y295C	0.38
LUAD	chr16	7595561	Missense_Mutation	NA	V161I	0.16
LUAD	chr16	7332945	Intron	novel		0.28
LUAD	chr16	7587292	Missense_Mutation	NA	G154S	0.09
LUAD	chr16	7518323	Silent	NA	P68P	0.32
LUAD	chr16	7710748	3'UTR	novel		0.2
LUAD	chr16	7709116	Silent	rs372365163	Y352Y	0.14
LUAD	chr16	7579813	Missense_Mutation	novel	Q103K	0.22
LUAD	chr16	7333026	Intron	novel		0.06
LUAD	chr16	7333000	Intron	rs745333470		0.23
LUAD	chr16	7595631	Missense_Mutation	novel	R184L	0.36	Fox-1_C
LUAD	chr16	7333018	Intron	rs200160011		0.1
LUAD	chr16	7671567	Intron	novel		0.21
LUAD	chr16	7333004	Intron	novel		0.07
LUAD	chr16	7579895	Missense_Mutation	novel	D130V	0.22
LUAD	chr16	7693331	Intron	novel		0.08
LUAD	chr16	7587284	Missense_Mutation	NA	N151S	0.11
LUAD	chr16	7671573	Intron	novel		0.11
LUAD	chr16	7671575	Intron	novel		0.11
LUAD	chr16	7579796	Missense_Mutation	rs139251660	P97L	0.19
LUAD	chr16	7653847	Missense_Mutation	NA	A264S	0.26
LUAD	chr16	7518294	Missense_Mutation	NA	P59T	0.2
LUAD	chr16	7579918	Missense_Mutation	NA	G138C	0.26
LUAD	chr16	7518295	Missense_Mutation	novel	P59H	0.24
LUAD	chr16	7710686	Missense_Mutation	NA	L379I	0.26
LUAD	chr16	7332930	Intron	novel		0.31
LUAD	chr16	7710700	Missense_Mutation	NA	Q383H	0.35
LUAD	chr16	7653843	Silent	NA	T262T	0.33
LUAD	chr16	7518264	Missense_Mutation	rs755458164	A49T	0.19
LUAD	chr16	7709063	Silent	novel	R335R	0.13
LUAD	chr16	7710647	Missense_Mutation	NA	A366T	0.38
LUAD	chr16	7710775	3'UTR	novel		0.31
LUAD	chr16	7710714	Missense_Mutation	NA	R388L	0.05
LUAD	chr16	7709092	Missense_Mutation	NA	H344Q	0.18
LUAD	chr16	7518185	Silent	novel	A22A	0.09
LUAD	chr16	7693369	Intron	novel		0.12
LUAD	chr16	7710705	Missense_Mutation	NA	S385I	0.18
LUAD	chr16	7518277	Missense_Mutation	novel	T53K	0.35
LUAD	chr16	7710746	3'UTR	novel		0.07
LUAD	chr16	7333080	Intron	novel		0.13
LUAD	chr16	7595555	Missense_Mutation	novel	G159C	0.17
LUAD	chr16	7710793	3'UTR	novel		0.26
LUAD	chr16	7332961	Intron	rs548917553		0.41
LUAD	chr16	7333059	Intron	novel		0.18
LUAD	chr16	7595587	Silent	NA	A169A	0.37
LUSC	chr16	7676821	Silent	rs146803665	A326A	0.12
LUSC	chr16	7518313	Missense_Mutation	NA	L65P	0.17
LUSC	chr16	7518178	Missense_Mutation	novel	T20I	0.35
LUSC	chr16	7671575	Intron	novel		0.28
LUSC	chr16	7333001	Intron	novel		0.19
LUSC	chr16	7709102	Missense_Mutation	novel	P348T	0.42
LUSC	chr16	7518383	Silent	NA	T88T	0.2
LUSC	chr16	7518161	Silent	NA	A14A	0.25
LUSC	chr16	7579900	Missense_Mutation	NA	D132N	0.17
LUSC	chr16	7630643	Silent	rs201549920	S239S	0.18
LUSC	chr16	7579857	Silent	novel	K117K	0.2
LUSC	chr16	7710683	Missense_Mutation	rs369122393	V378I	0.23
MESO	chr16	7518362	Silent	NA	S81S	0.27
OV	chr16	7333020	Intron	NA		0.39
OV	chr16	7630666	Missense_Mutation	NA	L247P	0.2
OV	chr16	7710890	3'Flank	novel		0.24
OV	chr16	7518224	Missense_Mutation	novel	N35K	0.05
PAAD	chr16	7518352	Missense_Mutation	NA	A78V	0.22
PAAD	chr16	7332943	Intron	novel		0.27
PAAD	chr16	7332862	Intron	novel		0.16
PAAD	chr16	7664955	Missense_Mutation	novel	G306A	0.03
PRAD	chr16	7518324	Missense_Mutation	rs754708372	A69T	0.25
PRAD	chr16	7607340	Splice_Site	NA	X226_splice	0.16
PRAD	chr16	7653828	Silent	NA	P257P	0.09
PRAD	chr16	7595569	Silent	NA	F163F	0.38
PRAD	chr16	7709093	Missense_Mutation	rs150941982	A345T	0.34
READ	chr16	7693324	Intron	NA		0.09
READ	chr16	7676792	Missense_Mutation	novel	R317C	0.36
READ	chr16	7693324	Intron	NA		0.41
READ	chr16	7332918	Intron	rs191528660		0.33
READ	chr16	7710729	Missense_Mutation	NA	R393H	0.33
READ	chr16	7710794	3'UTR	rs376748559		0.5
READ	chr16	7518372	Missense_Mutation	NA	V85I	0.33
SARC	chr16	7710640	Missense_Mutation	novel	L363F	0.16
SARC	chr16	7518224	Missense_Mutation	novel	N35K	0.59
SARC	chr16	7052074	Translation_Start_Site	novel	M1?	0.19
SARC	chr16	7711869	3'Flank	novel		0.18
SARC	chr16	7518216	Missense_Mutation	novel	P33S	0.36
SARC	chr16	7518331	Missense_Mutation	NA	T71M	0.73
SARC	chr16	7711657	3'Flank	novel		0.1
SARC	chr16	7587261	Silent	novel	I143I	0.17
SKCM	chr16	7518262	Missense_Mutation	NA	P48L	0.44
SKCM	chr16	7607326	Missense_Mutation	NA	E222K	0.61
SKCM	chr16	7664945	Missense_Mutation	NA	G303R	0.23
SKCM	chr16	7052092	Silent	novel	Q7Q	0.41
SKCM	chr16	7579879	Missense_Mutation	NA	P125S	0.32
SKCM	chr16	7332883	Intron	novel		0.41
SKCM	chr16	7607326	Missense_Mutation	NA	E222K	0.31
SKCM	chr16	7518233	Silent	rs376877653	P38P	0.57
SKCM	chr16	7664946	Missense_Mutation	NA	G303E	0.31
SKCM	chr16	7518236	Silent	rs771957716	A39A	0.24
SKCM	chr16	7653906	Silent	novel	F283F	0.32
SKCM	chr16	7518346	Missense_Mutation	NA	S76N	0.11
SKCM	chr16	7710717	Missense_Mutation	NA	G389E	0.32
SKCM	chr16	7664946	Missense_Mutation	NA	G303E	0.29
SKCM	chr16	7693324	Intron	NA		0.19
SKCM	chr16	7653867	Silent	novel	A270A	0.54
SKCM	chr16	7518213	Missense_Mutation	NA	P32S	0.34
SKCM	chr16	7518144	Splice_Region	novel		0.45
SKCM	chr16	7595639	Missense_Mutation	NA	E187K	0.3	Fox-1_C
SKCM	chr16	7579890	Silent	rs536057811	F128F	0.32
SKCM	chr16	7595570	Missense_Mutation	NA	E164K	0.32
SKCM	chr16	7653875	Missense_Mutation	NA	R273Q	0.46
SKCM	chr16	7693343	Intron	NA		0.33
SKCM	chr16	7332979	Intron	novel		0.47
SKCM	chr16	7653886	Missense_Mutation	NA	R277C	0.1
SKCM	chr16	7518156	Missense_Mutation	NA	E13K	0.47
SKCM	chr16	7332853	Intron	novel		0.27
SKCM	chr16	7579881	Silent	novel	P125P	0.44
SKCM	chr16	7332923	Intron	novel		0.39
SKCM	chr16	7332901	Intron	novel		0.4
SKCM	chr16	7518265	Missense_Mutation	rs767917479	A49V	0.26
SKCM	chr16	7709078	Missense_Mutation	NA	D340N	0.07
SKCM	chr16	7595560	Silent	NA	F160F	0.2
SKCM	chr16	7332943	Intron	novel		0.48
SKCM	chr16	7052074	Translation_Start_Site	novel	M1?	0.36
SKCM	chr16	7595593	Silent	NA	R171R	0.22
SKCM	chr16	7595560	Silent	NA	F160F	0.17
SKCM	chr16	7332980	Intron	NA		0.22
SKCM	chr16	7333010	Intron	rs771567004		0.46
SKCM	chr16	7579797	Silent	rs770163669	P97P	0.23
SKCM	chr16	7518202	Missense_Mutation	NA	A28V	0.23
SKCM	chr16	7579801	Missense_Mutation	rs774467606	D99N	0.31
SKCM	chr16	7693343	Intron	NA		0.47
SKCM	chr16	7332978	Intron	novel		0.85
SKCM	chr16	7518211	Missense_Mutation	NA	A31V	0.05
SKCM	chr16	7710682	Silent	NA	L377L	0.21
SKCM	chr16	7518297	Missense_Mutation	NA	E60K	0.1
SKCM	chr16	7332956	Intron	novel		0.13
SKCM	chr16	7333049	Intron	novel		0.26
SKCM	chr16	7333049	Intron	rs768357955		0.45
SKCM	chr16	7671556	Intron	novel		0.28
SKCM	chr16	7710714	Missense_Mutation	rs747612014	R388Q	0.26
SKCM	chr16	7518280	Missense_Mutation	novel	G54A	0.41
SKCM	chr16	7709053	Splice_Region	rs748515640		0.18
SKCM	chr16	7579801	Missense_Mutation	rs774467606	D99N	0.14
SKCM	chr16	7332910	Intron	novel		0.28
SKCM	chr16	7653886	Missense_Mutation	NA	R277C	0.17
SKCM	chr16	7653914	Missense_Mutation	novel	A286V	0.33
SKCM	chr16	7332945	Intron	novel		0.47
SKCM	chr16	7653827	Missense_Mutation	rs765695547	P257L	0.38
SKCM	chr16	7710622	Splice_Site	NA	X358_splice	0.36
SKCM	chr16	7518257	Silent	NA	P46P	0.25
SKCM	chr16	7332971	Intron	novel		0.24
SKCM	chr16	7630639	Missense_Mutation	novel	S238F	0.61
SKCM	chr16	7710868	3'Flank	novel		0.44
SKCM	chr16	7595600	Missense_Mutation	novel	E174K	0.37	Fox-1_C
SKCM	chr16	7693362	Intron	NA		0.33
SKCM	chr16	7710759	3'UTR	novel		0.34
SKCM	chr16	7332980	Intron	NA		0.59
SKCM	chr16	7595588	Missense_Mutation	novel	D170N	0.21
STAD	chr16	7332922	Intron	novel		0.35
STAD	chr16	7332922	Intron	novel		0.38
STAD	chr16	7710724	Silent	novel	Y391Y	0.13
STAD	chr16	7709120	Missense_Mutation	rs138704494	V354I	0.38
STAD	chr16	7518264	Missense_Mutation	rs755458164	A49T	0.16
STAD	chr16	7664946	Missense_Mutation	NA	G303E	0.27
STAD	chr16	7709062	Silent	NA	G334G	0.28
STAD	chr16	7518331	Missense_Mutation	NA	T71M	0.2
STAD	chr16	7518165	Missense_Mutation	rs779321097	A16T	0.27
STAD	chr16	7587257	Missense_Mutation	NA	K142T	0.45
STAD	chr16	7333074	Intron	novel		0.28
STAD	chr16	7653892	Missense_Mutation	rs766300841	V279M	0.28
STAD	chr16	7518165	Missense_Mutation	rs779321097	A16T	0.06
STAD	chr16	7518388	Missense_Mutation	NA	T90R	0.2
STAD	chr16	7595630	Missense_Mutation	NA	R184C	0.37	Fox-1_C
STAD	chr16	7595560	Silent	NA	F160F	0.57
STAD	chr16	7333010	Intron	rs771567004		0.1
STAD	chr16	7333067	Intron	novel		0.23
STAD	chr16	7630606	Missense_Mutation	rs145006582	T227M	0.22
STAD	chr16	7597400	Frame_Shift_Del	novel	*N198Kfs13**	0.05	Fox-1_C
STAD	chr16	7630606	Missense_Mutation	rs145006582	T227M	0.21
STAD	chr16	7333010	Intron	rs771567004		0.08
STAD	chr16	7333040	Intron	rs757066841		0.25
STAD	chr16	7710729	Frame_Shift_Ins	novel	*A395Cfs35**	0.2
STAD	chr16	7595561	Missense_Mutation	NA	V161I	0.32
STAD	chr16	7332925	Intron	NA		0.22
STAD	chr16	7630637	Silent	novel	G237G	0.32
THYM	chr16	7710861	3'Flank	novel		0.12
UCEC	chr16	7712197	3'Flank	rs562628788		0.74
UCEC	chr16	7671589	Intron	NA		0.33
UCEC	chr16	7595638	Silent	NA	I186I	0.26
UCEC	chr16	7518264	Missense_Mutation	rs755458164	A49T	0.41
UCEC	chr16	7579912	Missense_Mutation	novel	M136V	0.39
UCEC	chr16	7595555	Missense_Mutation	novel	G159C	0.38
UCEC	chr16	7518289	Missense_Mutation	rs748167936	T57M	0.44
UCEC	chr16	7333010	Intron	rs771567004		0.37
UCEC	chr16	7579847	Missense_Mutation	NA	S114Y	0.34
UCEC	chr16	7607334	Silent	novel	Y224Y	0.45
UCEC	chr16	7676784	Missense_Mutation	novel	A314V	0.39
UCEC	chr16	7711574	3'Flank	novel		0.24
UCEC	chr16	7712400	3'Flank	novel		0.36
UCEC	chr16	7710686	Missense_Mutation	NA	L379F	0.36
UCEC	chr16	7710916	3'Flank	novel		0.43
UCEC	chr16	7607299	Missense_Mutation	novel	P213S	0.37
UCEC	chr16	7693319	Intron	novel		0.34
UCEC	chr16	7711657	3'Flank	novel		0.44
UCEC	chr16	7332918	Intron	rs191528660		0.38
UCEC	chr16	7587261	Silent	NA	I143I	0.42
UCEC	chr16	7693337	Intron	NA		0.44
UCEC	chr16	7710939	3'Flank	novel		0.42
UCEC	chr16	7710887	3'Flank	novel		0.36
UCEC	chr16	7595596	Silent	rs751982525	A172A	0.45
UCEC	chr16	7693325	Intron	novel		0.37
UCEC	chr16	7712302	3'Flank	novel		0.4
UCEC	chr16	7518339	Missense_Mutation	novel	E74K	0.21
UCEC	chr16	7332863	Intron	novel		0.12
UCEC	chr16	7587257	Missense_Mutation	NA	K142T	0.22
UCEC	chr16	7709116	Silent	rs372365163	Y352Y	0.23
UCEC	chr16	7332995	Intron	rs535330462		0.42
UCEC	chr16	7579780	Missense_Mutation	NA	T92A	0.44
UCEC	chr16	7712400	3'Flank	novel		0.45
UCEC	chr16	7518265	Missense_Mutation	rs767917479	A49V	0.08
UCEC	chr16	7595561	Missense_Mutation	NA	V161I	0.21
UCEC	chr16	7693324	Intron	NA		0.39
UCEC	chr16	7333029	Intron	novel		0.46
UCEC	chr16	7710697	Silent	rs756984329	L382L	0.53
UCEC	chr16	7711451	3'Flank	rs576642943		0.25
UCEC	chr16	7712400	3'Flank	novel		0.46
UCEC	chr16	7333059	Intron	novel		0.39
UCEC	chr16	7595634	Missense_Mutation	novel	K185R	0.34	Fox-1_C
UCEC	chr16	7712067	3'Flank	novel		0.5
UCEC	chr16	7712518	3'Flank	rs185649958		0.24
UCEC	chr16	7712076	3'Flank	novel		0.43
UCEC	chr16	7712300	3'Flank	novel		0.38
UCEC	chr16	7332892	Intron	novel		0.24
UCEC	chr16	7712400	3'Flank	novel		0.54
UCEC	chr16	7711451	3'Flank	rs576642943		0.3
UCEC	chr16	7711597	3'Flank	novel		0.47
UCEC	chr16	7597412	Silent	rs772611871	T201T	0.34
UCEC	chr16	7712400	3'Flank	novel		0.36
UCEC	chr16	7710881	3'Flank	novel		0.41
UCEC	chr16	7710856	3'Flank	novel		0.06
UCEC	chr16	7671574	Intron	novel		0.43
UCEC	chr16	7676792	Missense_Mutation	novel	R317C	0.11
UCEC	chr16	7333058	Intron	rs147261087		0.31
UCEC	chr16	7709077	Silent	rs148909710	A339A	0.33
UCEC	chr16	7710749	3'UTR	novel		0.47
UCEC	chr16	7711094	3'Flank	novel		0.11
UCEC	chr16	7711808	3'Flank	novel		0.61
UCEC	chr16	7333056	Intron	rs773668882		0.28
UCEC	chr16	7052089	Silent	NA	E6E	0.45
UCEC	chr16	7597383	Missense_Mutation	NA	T192A	0.39	Fox-1_C
UCEC	chr16	7676822	Missense_Mutation	rs139929599	A327T	0.42
UCEC	chr16	7711451	3'Flank	rs576642943		0.37
UCEC	chr16	7711657	3'Flank	novel		0.41
UCEC	chr16	7333023	Intron	novel		0.63
UCEC	chr16	7597405	Missense_Mutation	novel	K199T	0.4	Fox-1_C
UCEC	chr16	7711035	3'Flank	novel		0.41
UCEC	chr16	7712491	3'Flank	novel		0.34
UCEC	chr16	7710723	Missense_Mutation	novel	Y391C	0.27
UCEC	chr16	7710789	3'UTR	novel		0.26
UCEC	chr16	7518263	Silent	rs61742359	P48P	0.12
UCEC	chr16	7710868	3'Flank	novel		0.37
UCEC	chr16	7711651	3'Flank	novel		0.42
UCEC	chr16	7712067	3'Flank	novel		0.27
UCEC	chr16	7711409	3'Flank	novel		0.46
UCEC	chr16	7712249	3'Flank	novel		0.31
UCEC	chr16	7711451	3'Flank	rs576642943		0.44
UCEC	chr16	7712400	3'Flank	novel		0.45
UCEC	chr16	7595570	Missense_Mutation	NA	E164K	0.28
UCEC	chr16	7710761	3'UTR	novel		0.3
UCEC	chr16	7607325	Silent	rs780509888	P221P	0.39
UCEC	chr16	7693324	Intron	NA		0.28
UCEC	chr16	7711854	3'Flank	novel		0.36
UCEC	chr16	7711367	3'Flank	novel		0.41
UCEC	chr16	7712400	3'Flank	novel		0.31
UCEC	chr16	7333000	Intron	rs745333470		0.31
UCEC	chr16	7579847	Missense_Mutation	NA	S114F	0.42
UCEC	chr16	7711451	3'Flank	rs576642943		0.36
UCEC	chr16	7711657	3'Flank	novel		0.42
UCEC	chr16	7712662	3'Flank	novel		0.8
UCEC	chr16	7587290	Missense_Mutation	novel	R153Q	0.34
UCEC	chr16	7711644	3'Flank	novel		0.54
UCEC	chr16	7607331	Missense_Mutation	novel	F223L	0.32
UCEC	chr16	7518374	Silent	novel	V85V	0.15
UCEC	chr16	7711707	3'Flank	novel		0.17
UCEC	chr16	7518164	Silent	NA	A15A	0.44
UCEC	chr16	7630646	Missense_Mutation	rs765149103	M240I	0.12
UCEC	chr16	7709058	Missense_Mutation	novel	Y333C	0.2
UCEC	chr16	7712281	3'Flank	novel		0.21
UCEC	chr16	7711451	3'Flank	rs576642943		0.36
UCEC	chr16	7579892	Missense_Mutation	rs757718956	R129Q	0.29
UCEC	chr16	7712400	3'Flank	novel		0.47
UCEC	chr16	7711552	3'Flank	novel		0.41
UCEC	chr16	7587289	Nonsense_Mutation	NA	R153*	0.36
UCEC	chr16	7710694	In_Frame_Ins	novel	S381_L382insVTFF	0.04
UCEC	chr16	7711575	3'Flank	novel		0.39
UCEC	chr16	7518199	Missense_Mutation	rs527782263	S27L	0.3
UCEC	chr16	7711451	3'Flank	rs576642943		0.48
UCEC	chr16	7710694	Frame_Shift_Ins	novel	*L382Vfs8**	0.06
UCEC	chr16	7333033	Intron	rs145351963		0.42
UCEC	chr16	7711657	3'Flank	novel		0.43
UCEC	chr16	7587249	Missense_Mutation	novel	Q139H	0.3
UCEC	chr16	7671556	Intron	novel		0.32
UCEC	chr16	7693325	Intron	novel		0.39
UCEC	chr16	7710723	Missense_Mutation	novel	Y391C	0.37
UCEC	chr16	7712067	3'Flank	novel		0.33
UCEC	chr16	7595561	Missense_Mutation	NA	V161I	0.53
UCEC	chr16	7710825	3'UTR	novel		0.16
UCEC	chr16	7518194	Silent	novel	Y25Y	0.27
UCEC	chr16	7595582	Missense_Mutation	NA	D168N	0.4
UCEC	chr16	7711657	3'Flank	novel		0.22
UCEC	chr16	7332799	Intron	rs182615482		0.3
UCEC	chr16	7518176	Silent	rs748401124	D19D	0.34
UCEC	chr16	7579847	Missense_Mutation	NA	S114F	0.32
UCEC	chr16	7711657	3'Flank	novel		0.4
UCEC	chr16	7712400	3'Flank	novel		0.28
UCEC	chr16	7333074	Intron	novel		0.5
UCEC	chr16	7579799	Missense_Mutation	rs373077021	T98M	0.51
UCEC	chr16	7595617	Silent	rs756360831	T179T	0.42
UCEC	chr16	7597393	Missense_Mutation	novel	V195A	0.52	Fox-1_C
UCEC	chr16	7711202	3'Flank	novel		0.5
UCEC	chr16	7711499	3'Flank	novel		0.3
UCEC	chr16	7711646	3'Flank	novel		0.41
UCEC	chr16	7712400	3'Flank	novel		0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.011293
CHOL	DEL	0.1111	0.23475
COAD	DEL	0.3592	2.8781e-123
MESO	DEL	0.2759	3.1518e-12
READ	DEL	0.3576	2.5201e-36
SKCM	DEL	0.1608	0.00017967
STAD	DEL	0.1882	2.4826e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00086	Kaplan-Meier Survival Analysis
MESO	0.0069	Kaplan-Meier Survival Analysis
UCS	0.035	Kaplan-Meier Survival Analysis
HNSC	0.01	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
BRCA	0.0077	Kaplan-Meier Survival Analysis
LGG	0.0078	Kaplan-Meier Survival Analysis
CHOL	0.0067	Kaplan-Meier Survival Analysis
LUAD	0.0038	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742