EuRBPDB

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  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000078618 (Gene tree)
Gene ID
4898
Gene Symbol
NRDC
Alias
hNRD1|hNRD2|NRD1
Full Name
nardilysin convertase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
89,747 bases
Position
chr1:51,789,191-51,878,937
Accession
7995
RBP type
non-canonical RBP
Summary
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23770370Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.Biochem Biophys Res Commun2013 Jul 19Kobayashi Adoi: 10.1016/j.bbrc.2013.06.008
9618475Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association.Proc Natl Acad Sci U S A1998 Jun 9Steinmetz EJ-
21084293Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein.J Biol Chem2011 Feb 4Hobor Fdoi: 10.1074/jbc.M110.158774
28973465The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition.Nucleic Acids Res2017 Sep 29Franco-Echevarria Edoi: 10.1093/nar/gkx685.
11565036RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts.Nature2001 Sep 20Steinmetz EJ-
19279143Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.Mol Biol Cell2009 MaySatoh Rdoi: 10.1091/mbc.E08-09-0893
17237360Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements.RNA2007 MarCarroll KL-
22276125Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast.PLoS One2012Satoh Rdoi: 10.1371/journal.pone.0029683
21949810A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.PLoS One2011Lepore Ndoi: 10.1371/journal.pone.0024962
21954178Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing.RNA2011 NovJamonnak Ndoi: 10.1261/rna.2840711
24860164Structure and semi-sequence-specific RNA binding of Nrd1.Nucleic Acids Res2014 JulBacikova Vdoi: 10.1093/nar/gku446
24097444Human snRNA genes use polyadenylation factors to promote efficient transcription termination.Nucleic Acids Res2014 JanO'Reilly Ddoi: 10.1093/nar/gkt892
16427013Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts.Mol Cell2006 Jan 20Vasiljeva L-
18007593Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control.EMBO J2007 Dec 12Houseley J-
22564898A genetic screen for terminator function in yeast identifies a role for a new functional domain in termination factor Nab3.Nucleic Acids Res2012 AugLoya TJdoi: 10.1093/nar/gks377
27492286Backmasking in the yeast genome: encoding overlapping information for protein-coding and RNA degradation.Nucleic Acids Res2016 Sep 30Cakiroglu SAdoi: 10.1093/nar/gkw683
10207106Isolation of a mammalian homologue of a fission yeast differentiation regulator.Mol Cell Biol1999 MayYamamoto H-
9671458An RNA binding protein negatively controlling differentiation in fission yeast.Mol Cell Biol1998 AugTsukahara K-
12907709Rpb7 subunit of RNA polymerase II interacts with an RNA-binding protein involved in processing of transcripts.Nucleic Acids Res2003 Aug 15Mitsuzawa H-
16537912cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II.Mol Cell Biol2006 AprSteinmetz EJ-
15226427Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts.Mol Cell Biol2004 JulCarroll KL-
23109428Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.Mol Cell Biol2013 JanTomson BNdoi: 10.1128/MCB.01233-12
16973436Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3.Mol Cell2006 Sep 15Arigo JT-
22028667Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1.PLoS Genet2011 OctCreamer TJdoi: 10.1371/journal.pgen.1002329
25611193Amyloid-like assembly of the low complexity domain of yeast Nab3.Prion2015O'Rourke TWdoi: 10.1080/19336896.2014.997618
24393166PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast.Genome Biol2014 Jan 7Webb Sdoi: 10.1186/gb-2014-15-1-r8.
24210918Transcriptome surveillance by selective termination of noncoding RNA synthesis.Cell2013 Nov 21Schulz Ddoi: 10.1016/j.cell.2013.10.024
24013500A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism.Genes Dev2013 Sep 1Marina DBdoi: 10.1101/gad.226019.113.
27166441TRAMP Stimulation of Exosome.Enzymes2012Holub Pdoi: 10.1016/B978-0-12-404740-2.00004-5
28284018Chemical shift assignments of the first and second RRMs of Nrd1, a fission yeast MAPK-target RNA binding protein.Biomol NMR Assign2017 OctKobayashi Adoi: 10.1007/s12104-017-9731-1
25775092Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1.PLoS Genet2015 Mar 16Fasken MBdoi: 10.1371/journal.pgen.1005044
26612606Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination.Wiley Interdiscip Rev RNA2016 Jan-FebFox MJdoi: 10.1002/wrna.1317
21460797The nuclear RNA polymerase II surveillance system targets polymerase III transcripts.EMBO J2011 May 4Wlotzka Wdoi: 10.1038/emboj.2011.97
25437538The evolutionarily conserved Pol II flap loop contributes to proper transcription termination on short yeast genes.Cell Rep2014 Nov 6Pearson Edoi: 10.1016/j.celrep.2014.10.007
24196955The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.J Biol Chem2013 Dec 20Heo DHdoi: 10.1074/jbc.M113.508267
24100036A network of interdependent molecular interactions describes a higher order Nrd1-Nab3 complex involved in yeast transcription termination.J Biol Chem2013 Nov 22Loya TJdoi: 10.1074/jbc.M113.516765
29093577Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression.Sci Rep2017 Nov 1Morita Ydoi: 10.1038/s41598-017-14942-4.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000473805NRDC-2061013--- (aa)--
ENST00000483007NRDC-209810--- (aa)--
ENST00000491410NRDC-2111020--- (aa)--
ENST00000354831NRDC-2023895-ENSP000003468901219 (aa)-B1AKJ5
ENST00000468722NRDC-205754--- (aa)--
ENST00000544028NRDC-2143819-ENSP00000442262949 (aa)-F5H7V1
ENST00000497358NRDC-212700--- (aa)--
ENST00000485608NRDC-2103149--- (aa)--
ENST00000539524NRDC-2133417XM_011541522ENSP000004444161087 (aa)XP_011539824G3V1R5
ENST00000440943NRDC-2031660-ENSP00000398464538 (aa)-H0Y5G9
ENST00000475715NRDC-208583--- (aa)--
ENST00000475310NRDC-2071025--- (aa)--
ENST00000352171NRDC-2013691XM_011541523ENSP000002626791151 (aa)XP_011539825O43847
ENST00000464385NRDC-204472--- (aa)--
Gene Model
Click here to download ENSG00000078618's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000078618Prostatic Neoplasms5.4160000E-00518264096
ENSG00000078618Alcoholism1.64402e-00522978509
ENSG00000078618Alcoholism2.03417e-00522978509
ENSG00000078618Alcoholism4.22957e-00522978509
ENSG00000078618Alcoholism6.0709e-00622978509
ENSG00000078618Alcoholism5.82491e-00522978509
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000078618rs1890946151876755CDepression30718901[1.02-1.02]1.0193679EFO_0003761
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000078618's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004222metalloendopeptidase activity9581555.NASFunction
GO:0005515protein binding18355445.22653443.IPIFunction
GO:0005739mitochondrion28017472.IDAComponent
GO:0005829cytosol12463163.TASComponent
GO:0006508proteolysis9581555.NASProcess
GO:0007528neuromuscular junction development9479496.TASProcess
GO:0008283cell proliferation12463163.TASProcess
GO:0009986cell surface12463163.TASComponent
GO:0016477cell migration15544571.TASProcess
GO:0046872metal ion binding-IEAFunction
GO:0048408epidermal growth factor binding12463163.TASFunction
GO:0051044positive regulation of membrane protein ectodomain proteolysis18355445.IDAProcess
GO:0052548regulation of endopeptidase activity18355445.IDAProcess
GO:0120163negative regulation of cold-induced thermogenesis24492630.ISSProcess

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