EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000078687 (Gene tree)
Gene ID: 57690
Gene Symbol: TNRC6C
Alias: KIAA1582|FLJ20015
Full Name: trinucleotide repeat containing adaptor 6C
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 149,596 bases
Position: chr17:77,959,240-78,108,835
Accession: 29318
RBP type: canonical RBP
Summary: (Trinucleotide Repeat Containing Adaptor 6C) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000336783	Ago_hook	PF10427.9	2.5e-21	1	1
ENSP00000467154	Ago_hook	PF10427.9	2.5e-21	1	1
ENSP00000301624	Ago_hook	PF10427.9	3.1e-21	1	1
ENSP00000468647	Ago_hook	PF10427.9	3.1e-21	1	1
ENSP00000489933	Ago_hook	PF10427.9	3.2e-21	1	1
ENSP00000466277	Ago_hook	PF10427.9	2.9e-18	1	1
ENSP00000301624	RRM_1	PF00076.22	0.00082	1	1
ENSP00000468647	RRM_1	PF00076.22	0.00082	1	1
ENSP00000336783	RRM_1	PF00076.22	0.00085	1	1
ENSP00000467154	RRM_1	PF00076.22	0.00085	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19304925	Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.	RNA	2009 May	Zipprich JT	doi: 10.1261/rna.1448009

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000335749	TNRC6C-202	9740	XM_011525088	ENSP00000336783	1726 (aa)	XP_011523390	Q9HCJ0
ENST00000636222	TNRC6C-211	7093	XM_006721996	ENSP00000489933	1944 (aa)	XP_006722059	A0A1B0GU24
ENST00000585438	TNRC6C-203	682	-	ENSP00000466277	116 (aa)	-	K7ELY5
ENST00000592566	TNRC6C-210	544	-	-	- (aa)	-	-
ENST00000592251	TNRC6C-209	608	-	-	- (aa)	-	-
ENST00000588549	TNRC6C-206	576	-	ENSP00000465707	95 (aa)	-	K7EKN9
ENST00000588847	TNRC6C-207	8527	-	ENSP00000467154	1726 (aa)	-	Q9HCJ0
ENST00000591851	TNRC6C-208	1642	-	-	- (aa)	-	-
ENST00000587990	TNRC6C-204	600	-	-	- (aa)	-	-
ENST00000301624	TNRC6C-201	9632	-	ENSP00000301624	1690 (aa)	-	Q9HCJ0
ENST00000588061	TNRC6C-205	8419	-	ENSP00000468647	1690 (aa)	-	Q9HCJ0

Gene Model

Click here to download ENSG00000078687's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000078687	rs9889827	17	78030590	T	Highest math class taken	30038396	[0.0091-0.0185] unit increase	0.0138	EFO_0004875
ENSG00000078687	rs8074332	17	78004492	T	Educational attainment (MTAG)	30038396	[0.0053-0.0107] unit increase	0.008	EFO_0004784
ENSG00000078687	rs2311441	17	78061661	?	Reaction time	29844566	[0.0048-0.0118] unit increase	0.0083029	EFO_0008393
ENSG00000078687	rs78059684	17	78015605	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000078687's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000078687	TNRC6C	97	41.026	ENSG00000100354	TNRC6B	89	53.012
ENSG00000078687	TNRC6C	98	44.295	ENSG00000090905	TNRC6A	99	65.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000078687	TNRC6C	100	56.897	ENSAPOG00000019749	tnrc6c1	98	48.947	Acanthochromis_polyacanthus
ENSG00000078687	TNRC6C	100	92.632	ENSAMEG00000013756	TNRC6C	99	89.583	Ailuropoda_melanoleuca
ENSG00000078687	TNRC6C	94	50.000	ENSACIG00000008075	tnrc6c1	98	54.130	Amphilophus_citrinellus
ENSG00000078687	TNRC6C	100	56.897	ENSAOCG00000023968	tnrc6c1	99	49.105	Amphiprion_ocellaris
ENSG00000078687	TNRC6C	100	56.897	ENSAPEG00000009020	tnrc6c1	99	49.003	Amphiprion_percula
ENSG00000078687	TNRC6C	100	90.526	ENSAPLG00000005456	TNRC6C	100	86.577	Anas_platyrhynchos
ENSG00000078687	TNRC6C	100	89.474	ENSACAG00000016198	TNRC6C	98	86.778	Anolis_carolinensis
ENSG00000078687	TNRC6C	100	98.947	ENSANAG00000021554	TNRC6C	100	98.354	Aotus_nancymaae
ENSG00000078687	TNRC6C	93	48.314	ENSACLG00000000424	tnrc6c1	98	53.275	Astatotilapia_calliptera
ENSG00000078687	TNRC6C	100	88.069	ENSBTAG00000018658	TNRC6C	100	88.305	Bos_taurus
ENSG00000078687	TNRC6C	100	98.947	ENSCJAG00000019431	TNRC6C	100	98.251	Callithrix_jacchus
ENSG00000078687	TNRC6C	100	91.667	ENSCAFG00000005224	TNRC6C	99	91.264	Canis_familiaris
ENSG00000078687	TNRC6C	100	91.302	ENSCAFG00020006661	TNRC6C	99	91.710	Canis_lupus_dingo
ENSG00000078687	TNRC6C	100	87.581	ENSCHIG00000026004	TNRC6C	100	86.126	Capra_hircus
ENSG00000078687	TNRC6C	100	95.829	ENSTSYG00000005403	TNRC6C	100	95.713	Carlito_syrichta
ENSG00000078687	TNRC6C	100	87.368	ENSCAPG00000007307	TNRC6C	99	84.136	Cavia_aperea
ENSG00000078687	TNRC6C	100	90.355	ENSCPOG00000000467	TNRC6C	100	88.285	Cavia_porcellus
ENSG00000078687	TNRC6C	100	100.000	ENSCCAG00000030524	TNRC6C	100	98.494	Cebus_capucinus
ENSG00000078687	TNRC6C	100	98.957	ENSCATG00000033135	TNRC6C	100	98.957	Cercocebus_atys
ENSG00000078687	TNRC6C	100	93.077	ENSCLAG00000011139	TNRC6C	99	90.370	Chinchilla_lanigera
ENSG00000078687	TNRC6C	100	98.899	ENSCSAG00000005167	TNRC6C	100	98.405	Chlorocebus_sabaeus
ENSG00000078687	TNRC6C	75	92.051	ENSCHOG00000000088	TNRC6C	72	91.172	Choloepus_hoffmanni
ENSG00000078687	TNRC6C	100	90.526	ENSCPBG00000027960	TNRC6C	100	88.017	Chrysemys_picta_bellii
ENSG00000078687	TNRC6C	100	100.000	ENSCANG00000041771	TNRC6C	100	98.611	Colobus_angolensis_palliatus
ENSG00000078687	TNRC6C	100	89.576	ENSCGRG00001022686	Tnrc6c	100	88.398	Cricetulus_griseus_chok1gshd
ENSG00000078687	TNRC6C	100	90.000	ENSCGRG00000018041	Tnrc6c	100	88.398	Cricetulus_griseus_crigri
ENSG00000078687	TNRC6C	92	51.452	ENSCSEG00000012744	tnrc6c1	98	46.036	Cynoglossus_semilaevis
ENSG00000078687	TNRC6C	97	59.292	ENSDARG00000076847	tnrc6c1	99	54.484	Danio_rerio
ENSG00000078687	TNRC6C	100	91.671	ENSDNOG00000003247	TNRC6C	99	89.553	Dasypus_novemcinctus
ENSG00000078687	TNRC6C	100	88.421	ENSDORG00000004558	Tnrc6c	100	85.824	Dipodomys_ordii
ENSG00000078687	TNRC6C	100	81.897	ENSETEG00000005527	TNRC6C	86	83.729	Echinops_telfairi
ENSG00000078687	TNRC6C	100	94.737	ENSEASG00005004799	TNRC6C	100	91.248	Equus_asinus_asinus
ENSG00000078687	TNRC6C	100	94.737	ENSECAG00000012486	TNRC6C	99	90.662	Equus_caballus
ENSG00000078687	TNRC6C	100	91.579	ENSEEUG00000010008	TNRC6C	96	92.217	Erinaceus_europaeus
ENSG00000078687	TNRC6C	100	89.374	ENSFCAG00000028358	TNRC6C	100	89.315	Felis_catus
ENSG00000078687	TNRC6C	100	90.526	ENSFALG00000000848	TNRC6C	100	86.338	Ficedula_albicollis
ENSG00000078687	TNRC6C	100	91.361	ENSFDAG00000010368	TNRC6C	100	89.630	Fukomys_damarensis
ENSG00000078687	TNRC6C	89	71.005	ENSFHEG00000002936	tnrc6c1	99	45.760	Fundulus_heteroclitus
ENSG00000078687	TNRC6C	100	90.526	ENSGALG00000001725	TNRC6C	100	88.527	Gallus_gallus
ENSG00000078687	TNRC6C	100	48.840	ENSGAFG00000019019	tnrc6c1	100	48.923	Gambusia_affinis
ENSG00000078687	TNRC6C	97	51.786	ENSGACG00000012320	tnrc6c1	97	48.156	Gasterosteus_aculeatus
ENSG00000078687	TNRC6C	100	89.474	ENSGAGG00000022043	TNRC6C	99	87.438	Gopherus_agassizii
ENSG00000078687	TNRC6C	100	100.000	ENSGGOG00000011304	TNRC6C	100	99.126	Gorilla_gorilla
ENSG00000078687	TNRC6C	100	47.566	ENSHBUG00000010846	tnrc6c1	98	53.474	Haplochromis_burtoni
ENSG00000078687	TNRC6C	100	92.485	ENSHGLG00000004809	TNRC6C	99	89.698	Heterocephalus_glaber_female
ENSG00000078687	TNRC6C	100	91.461	ENSHGLG00100012597	TNRC6C	99	89.854	Heterocephalus_glaber_male
ENSG00000078687	TNRC6C	100	65.517	ENSIPUG00000000818	tnrc6c1	98	51.555	Ictalurus_punctatus
ENSG00000078687	TNRC6C	100	91.194	ENSSTOG00000009101	TNRC6C	100	88.802	Ictidomys_tridecemlineatus
ENSG00000078687	TNRC6C	100	88.869	ENSJJAG00000017055	Tnrc6c	99	86.947	Jaculus_jaculus
ENSG00000078687	TNRC6C	100	49.138	ENSKMAG00000021023	tnrc6c1	100	50.489	Kryptolebias_marmoratus
ENSG00000078687	TNRC6C	100	80.000	ENSLACG00000015283	TNRC6C	100	74.263	Latimeria_chalumnae
ENSG00000078687	TNRC6C	100	64.655	ENSLOCG00000013377	tnrc6c1	99	55.604	Lepisosteus_oculatus
ENSG00000078687	TNRC6C	100	90.813	ENSLAFG00000011122	TNRC6C	99	89.224	Loxodonta_africana
ENSG00000078687	TNRC6C	100	99.073	ENSMFAG00000043943	TNRC6C	100	99.073	Macaca_fascicularis
ENSG00000078687	TNRC6C	100	99.073	ENSMMUG00000011924	TNRC6C	100	98.994	Macaca_mulatta
ENSG00000078687	TNRC6C	100	98.971	ENSMNEG00000030405	TNRC6C	100	98.971	Macaca_nemestrina
ENSG00000078687	TNRC6C	100	99.015	ENSMLEG00000033436	TNRC6C	100	99.015	Mandrillus_leucophaeus
ENSG00000078687	TNRC6C	100	56.034	ENSMAMG00000023613	tnrc6c1	100	51.397	Mastacembelus_armatus
ENSG00000078687	TNRC6C	97	50.099	ENSMZEG00005010920	tnrc6c1	98	53.275	Maylandia_zebra
ENSG00000078687	TNRC6C	100	90.526	ENSMGAG00000003906	TNRC6C	100	80.775	Meleagris_gallopavo
ENSG00000078687	TNRC6C	100	89.517	ENSMAUG00000021618	Tnrc6c	100	89.340	Mesocricetus_auratus
ENSG00000078687	TNRC6C	100	94.737	ENSMICG00000003952	TNRC6C	100	94.322	Microcebus_murinus
ENSG00000078687	TNRC6C	100	91.657	ENSMOCG00000015879	Tnrc6c	100	89.070	Microtus_ochrogaster
ENSG00000078687	TNRC6C	100	56.034	ENSMMOG00000005203	tnrc6c1	100	50.678	Mola_mola
ENSG00000078687	TNRC6C	100	87.243	ENSMODG00000001785	TNRC6C	99	85.395	Monodelphis_domestica
ENSG00000078687	TNRC6C	100	91.243	MGP_CAROLIEiJ_G0017465	Tnrc6c	100	88.733	Mus_caroli
ENSG00000078687	TNRC6C	100	91.006	ENSMUSG00000025571	Tnrc6c	100	88.509	Mus_musculus
ENSG00000078687	TNRC6C	100	91.065	MGP_PahariEiJ_G0018593	Tnrc6c	100	88.565	Mus_pahari
ENSG00000078687	TNRC6C	100	91.065	MGP_SPRETEiJ_G0018309	Tnrc6c	100	88.565	Mus_spretus
ENSG00000078687	TNRC6C	100	89.062	ENSMPUG00000013348	TNRC6C	98	88.768	Mustela_putorius_furo
ENSG00000078687	TNRC6C	100	82.541	ENSMLUG00000014431	TNRC6C	98	82.108	Myotis_lucifugus
ENSG00000078687	TNRC6C	100	90.754	ENSNGAG00000012203	Tnrc6c	99	89.172	Nannospalax_galili
ENSG00000078687	TNRC6C	92	53.082	ENSNBRG00000005344	tnrc6c1	98	54.025	Neolamprologus_brichardi
ENSG00000078687	TNRC6C	100	99.138	ENSNLEG00000000047	TNRC6C	99	95.668	Nomascus_leucogenys
ENSG00000078687	TNRC6C	100	84.211	ENSMEUG00000005104	TNRC6C	99	89.583	Notamacropus_eugenii
ENSG00000078687	TNRC6C	100	92.632	ENSODEG00000012499	TNRC6C	100	92.071	Octodon_degus
ENSG00000078687	TNRC6C	94	51.185	ENSONIG00000002210	tnrc6c1	100	50.938	Oreochromis_niloticus
ENSG00000078687	TNRC6C	100	78.333	ENSOANG00000009758	-	100	61.111	Ornithorhynchus_anatinus
ENSG00000078687	TNRC6C	92	83.908	ENSOCUG00000006122	TNRC6C	95	79.452	Oryctolagus_cuniculus
ENSG00000078687	TNRC6C	97	50.442	ENSORLG00000009837	tnrc6c1	100	66.914	Oryzias_latipes
ENSG00000078687	TNRC6C	95	51.351	ENSORLG00020016510	tnrc6c1	100	49.140	Oryzias_latipes_hni
ENSG00000078687	TNRC6C	95	52.252	ENSORLG00015000171	tnrc6c1	98	44.606	Oryzias_latipes_hsok
ENSG00000078687	TNRC6C	94	54.128	ENSOMEG00000000357	tnrc6c1	99	47.969	Oryzias_melastigma
ENSG00000078687	TNRC6C	100	94.737	ENSOGAG00000007197	TNRC6C	100	92.642	Otolemur_garnettii
ENSG00000078687	TNRC6C	100	83.621	ENSOARG00000006041	TNRC6C	97	85.060	Ovis_aries
ENSG00000078687	TNRC6C	100	100.000	ENSPPAG00000027160	TNRC6C	100	99.710	Pan_paniscus
ENSG00000078687	TNRC6C	100	89.374	ENSPPRG00000018881	TNRC6C	100	89.315	Panthera_pardus
ENSG00000078687	TNRC6C	100	85.345	ENSPTIG00000008791	TNRC6C	81	96.429	Panthera_tigris_altaica
ENSG00000078687	TNRC6C	100	100.000	ENSPTRG00000009699	TNRC6C	100	99.743	Pan_troglodytes
ENSG00000078687	TNRC6C	100	98.971	ENSPANG00000019994	TNRC6C	100	98.971	Papio_anubis
ENSG00000078687	TNRC6C	97	58.407	ENSPKIG00000005428	tnrc6c1	100	51.577	Paramormyrops_kingsleyae
ENSG00000078687	TNRC6C	100	86.407	ENSPSIG00000018069	TNRC6C	100	84.069	Pelodiscus_sinensis
ENSG00000078687	TNRC6C	100	53.448	ENSPMGG00000022911	tnrc6c1	97	63.265	Periophthalmus_magnuspinnatus
ENSG00000078687	TNRC6C	100	90.872	ENSPEMG00000009785	Tnrc6c	100	88.398	Peromyscus_maniculatus_bairdii
ENSG00000078687	TNRC6C	100	83.158	ENSPCIG00000017421	-	99	85.509	Phascolarctos_cinereus
ENSG00000078687	TNRC6C	100	51.724	ENSPFOG00000012560	tnrc6c1	97	57.143	Poecilia_formosa
ENSG00000078687	TNRC6C	100	52.586	ENSPLAG00000021055	tnrc6c1	100	49.777	Poecilia_latipinna
ENSG00000078687	TNRC6C	100	99.479	ENSPPYG00000008679	TNRC6C	99	99.126	Pongo_abelii
ENSG00000078687	TNRC6C	93	92.654	ENSPCAG00000012510	TNRC6C	91	92.654	Procavia_capensis
ENSG00000078687	TNRC6C	100	94.844	ENSPCOG00000021451	TNRC6C	100	94.844	Propithecus_coquereli
ENSG00000078687	TNRC6C	100	87.931	ENSPVAG00000002008	TNRC6C	95	88.983	Pteropus_vampyrus
ENSG00000078687	TNRC6C	100	47.406	ENSPNYG00000014477	tnrc6c1	98	52.977	Pundamilia_nyererei
ENSG00000078687	TNRC6C	100	90.426	ENSRNOG00000022395	Tnrc6c	100	90.366	Rattus_norvegicus
ENSG00000078687	TNRC6C	100	100.000	ENSRBIG00000027777	TNRC6C	100	98.957	Rhinopithecus_bieti
ENSG00000078687	TNRC6C	100	100.000	ENSRROG00000042912	TNRC6C	100	99.015	Rhinopithecus_roxellana
ENSG00000078687	TNRC6C	100	97.895	ENSSBOG00000023981	TNRC6C	100	97.891	Saimiri_boliviensis_boliviensis
ENSG00000078687	TNRC6C	100	80.172	ENSSHAG00000018330	-	100	89.730	Sarcophilus_harrisii
ENSG00000078687	TNRC6C	100	57.759	ENSSFOG00015006475	tnrc6c1	99	51.952	Scleropages_formosus
ENSG00000078687	TNRC6C	99	52.174	ENSSFOG00015004735	-	99	61.257	Scleropages_formosus
ENSG00000078687	TNRC6C	91	58.095	ENSSMAG00000012761	tnrc6c1	99	50.517	Scophthalmus_maximus
ENSG00000078687	TNRC6C	100	56.897	ENSSDUG00000002366	tnrc6c1	99	49.605	Seriola_dumerili
ENSG00000078687	TNRC6C	100	56.034	ENSSLDG00000025613	tnrc6c1	100	50.083	Seriola_lalandi_dorsalis
ENSG00000078687	TNRC6C	100	83.158	ENSSARG00000006816	TNRC6C	91	88.235	Sorex_araneus
ENSG00000078687	TNRC6C	100	79.487	ENSSPUG00000007341	TNRC6C	98	86.815	Sphenodon_punctatus
ENSG00000078687	TNRC6C	100	56.897	ENSSPAG00000014977	tnrc6c1	97	48.911	Stegastes_partitus
ENSG00000078687	TNRC6C	97	90.951	ENSSSCG00000034373	TNRC6C	100	87.987	Sus_scrofa
ENSG00000078687	TNRC6C	100	90.526	ENSTGUG00000007733	TNRC6C	100	86.082	Taeniopygia_guttata
ENSG00000078687	TNRC6C	100	55.172	ENSTRUG00000011685	tnrc6c1	100	49.558	Takifugu_rubripes
ENSG00000078687	TNRC6C	100	55.172	ENSTNIG00000005273	tnrc6c1	100	60.784	Tetraodon_nigroviridis
ENSG00000078687	TNRC6C	100	85.345	ENSTBEG00000005046	TNRC6C	100	82.410	Tupaia_belangeri
ENSG00000078687	TNRC6C	100	93.684	ENSTTRG00000010828	TNRC6C	97	91.425	Tursiops_truncatus
ENSG00000078687	TNRC6C	100	92.632	ENSUMAG00000013614	TNRC6C	99	89.917	Ursus_maritimus
ENSG00000078687	TNRC6C	100	83.621	ENSVPAG00000006765	-	99	80.892	Vicugna_pacos
ENSG00000078687	TNRC6C	100	91.962	ENSVVUG00000015268	TNRC6C	100	91.962	Vulpes_vulpes
ENSG00000078687	TNRC6C	100	80.000	ENSXETG00000019470	tnrc6c	100	74.794	Xenopus_tropicalis
ENSG00000078687	TNRC6C	100	55.172	ENSXMAG00000025971	tnrc6c1	100	48.840	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	21873635.	IBA	Component
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	19383768.19716330.19838187.20098421.20181956.21063388.21981923.21984185.23340509.23463101.24768540.	IPI	Function
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	Process
GO:0010628	positive regulation of gene expression	-	TAS	Process
GO:0010629	negative regulation of gene expression	-	TAS	Process
GO:0035068	micro-ribonucleoprotein complex	21873635.	IBA	Component
GO:0035194	posttranscriptional gene silencing by RNA	-	TAS	Process
GO:0035195	gene silencing by miRNA	21873635.	IBA	Process
GO:0035195	gene silencing by miRNA	23172285.	IGI	Process
GO:0035278	miRNA mediated inhibition of translation	21984184.	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21873635.	IBA	Process
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21984185.	IDA	Process
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21984185.	IDA	Process