EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000079134 (Gene tree)
Gene ID: 9984
Gene Symbol: THOC1
Alias: P84|HPR1
Full Name: THO complex 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 53,540 bases
Position: chr18:214,520-268,059
Accession: 19070
RBP type: canonical RBP
Summary: HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261600	efThoc1	PF11957.8	2.3e-145	1	1
ENSP00000480460	efThoc1	PF11957.8	2.6e-145	1	1
ENSP00000481599	efThoc1	PF11957.8	1e-93	1	1
ENSP00000473276	efThoc1	PF11957.8	9.4e-75	1	1
ENSP00000473499	efThoc1	PF11957.8	3.6e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16738307	Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants.	Mol Cell Biol	2006 Jun	Jimeno S	-
27303905	High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1.	Acta Crystallogr F Struct Biol Commun	2016 Jun	Jacobsen JO	doi: 10.1107/S2053230X16007597

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000584642	THOC1-217	536	-	ENSP00000473499	95 (aa)	-	R4GN58
ENST00000582313	THOC1-214	1811	-	-	- (aa)	-	-
ENST00000578224	THOC1-204	789	-	-	- (aa)	-	-
ENST00000577552	THOC1-203	912	-	-	- (aa)	-	-
ENST00000261600	THOC1-201	2087	XM_011525772	ENSP00000261600	657 (aa)	XP_011524074	Q96FV9
ENST00000577429	THOC1-202	751	-	-	- (aa)	-	-
ENST00000580038	THOC1-208	2033	XM_017026104	ENSP00000462757	251 (aa)	XP_016881593	J3KT14
ENST00000579891	THOC1-207	815	XM_011525774	ENSP00000473276	272 (aa)	XP_011524076	R4GMN4
ENST00000584470	THOC1-216	2255	-	-	- (aa)	-	-
ENST00000583228	THOC1-215	2791	-	-	- (aa)	-	-
ENST00000580544	THOC1-209	496	-	-	- (aa)	-	-
ENST00000579232	THOC1-206	2277	-	-	- (aa)	-	-
ENST00000581576	THOC1-213	577	-	-	- (aa)	-	-
ENST00000581269	THOC1-212	559	-	ENSP00000463965	121 (aa)	-	J3QQZ3
ENST00000580870	THOC1-210	552	-	-	- (aa)	-	-
ENST00000616322	THOC1-219	2078	-	ENSP00000480460	657 (aa)	-	A0A087WWS1
ENST00000581116	THOC1-211	588	-	ENSP00000461943	86 (aa)	-	J3KRD7
ENST00000631280	THOC1-221	2011	-	ENSP00000486359	121 (aa)	-	J3QQZ3
ENST00000621904	THOC1-220	1083	-	ENSP00000481599	360 (aa)	-	A0A087WY84
ENST00000578529	THOC1-205	2681	-	-	- (aa)	-	-
ENST00000585307	THOC1-218	546	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000079134's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000079134	Rotator Cuff	4.7770000E-005	-
ENSG00000079134	Bipolar Disorder	7E-6	18711365
ENSG00000079134	Bipolar Disorder	4E-6	20351715
ENSG00000079134	Depressive Disorder	4E-6	20351715
ENSG00000079134	coenzyme Q10	1E-8	27149984

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000079134	rs59895994	18	248481	?	Lung function (FVC)	30595370			EFO_0004312

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000079134's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000079134	THOC1	89	71.300	ENSAPOG00000015530	-	99	71.300	Acanthochromis_polyacanthus
ENSG00000079134	THOC1	89	71.300	ENSAPOG00000015470	thoc1	99	71.300	Acanthochromis_polyacanthus
ENSG00000079134	THOC1	100	98.630	ENSAMEG00000006645	THOC1	99	98.630	Ailuropoda_melanoleuca
ENSG00000079134	THOC1	99	77.574	ENSACIG00000019392	thoc1	99	68.875	Amphilophus_citrinellus
ENSG00000079134	THOC1	96	77.391	ENSAOCG00000008391	thoc1	99	69.385	Amphiprion_ocellaris
ENSG00000079134	THOC1	99	78.309	ENSAPEG00000001093	thoc1	99	73.006	Amphiprion_percula
ENSG00000079134	THOC1	99	77.941	ENSATEG00000004783	thoc1	99	72.811	Anabas_testudineus
ENSG00000079134	THOC1	99	92.620	ENSAPLG00000016149	THOC1	98	89.043	Anas_platyrhynchos
ENSG00000079134	THOC1	99	89.706	ENSACAG00000008307	THOC1	98	86.798	Anolis_carolinensis
ENSG00000079134	THOC1	100	98.193	ENSANAG00000033200	THOC1	100	98.193	Aotus_nancymaae
ENSG00000079134	THOC1	89	89.427	ENSANAG00000020363	-	97	89.427	Aotus_nancymaae
ENSG00000079134	THOC1	99	77.941	ENSACLG00000016836	thoc1	99	72.546	Astatotilapia_calliptera
ENSG00000079134	THOC1	99	82.418	ENSAMXG00000014708	thoc1	97	71.474	Astyanax_mexicanus
ENSG00000079134	THOC1	100	97.565	ENSBTAG00000019215	THOC1	100	97.565	Bos_taurus
ENSG00000079134	THOC1	97	31.313	WBGene00020172	thoc-1	69	35.745	Caenorhabditis_elegans
ENSG00000079134	THOC1	100	99.239	ENSCJAG00000020450	THOC1	100	99.239	Callithrix_jacchus
ENSG00000079134	THOC1	100	98.478	ENSCAFG00000018324	THOC1	100	98.478	Canis_familiaris
ENSG00000079134	THOC1	100	98.478	ENSCAFG00020017894	THOC1	100	98.478	Canis_lupus_dingo
ENSG00000079134	THOC1	100	97.565	ENSCHIG00000015399	THOC1	100	97.565	Capra_hircus
ENSG00000079134	THOC1	100	98.326	ENSTSYG00000010585	THOC1	99	98.326	Carlito_syrichta
ENSG00000079134	THOC1	99	96.809	ENSCAPG00000016270	THOC1	98	72.755	Cavia_aperea
ENSG00000079134	THOC1	99	96.809	ENSCPOG00000000959	THOC1	100	95.738	Cavia_porcellus
ENSG00000079134	THOC1	100	99.391	ENSCCAG00000025766	THOC1	100	99.391	Cebus_capucinus
ENSG00000079134	THOC1	100	99.722	ENSCATG00000028180	THOC1	100	99.722	Cercocebus_atys
ENSG00000079134	THOC1	99	97.872	ENSCLAG00000009117	THOC1	100	96.870	Chinchilla_lanigera
ENSG00000079134	THOC1	100	99.543	ENSCSAG00000017631	THOC1	100	99.543	Chlorocebus_sabaeus
ENSG00000079134	THOC1	98	91.398	ENSCHOG00000010609	THOC1	89	86.691	Choloepus_hoffmanni
ENSG00000079134	THOC1	99	93.727	ENSCPBG00000027558	THOC1	99	92.366	Chrysemys_picta_bellii
ENSG00000079134	THOC1	95	50.857	ENSCING00000007663	-	99	48.988	Ciona_intestinalis
ENSG00000079134	THOC1	99	49.281	ENSCSAVG00000010649	-	99	46.815	Ciona_savignyi
ENSG00000079134	THOC1	100	99.391	ENSCANG00000034265	THOC1	100	99.391	Colobus_angolensis_palliatus
ENSG00000079134	THOC1	99	97.872	ENSCGRG00001016464	Thoc1	99	95.586	Cricetulus_griseus_chok1gshd
ENSG00000079134	THOC1	99	82.657	ENSCGRG00000003390	-	99	78.885	Cricetulus_griseus_crigri
ENSG00000079134	THOC1	99	97.872	ENSCGRG00000010269	-	100	95.618	Cricetulus_griseus_crigri
ENSG00000079134	THOC1	99	77.206	ENSCSEG00000012486	thoc1	99	73.151	Cynoglossus_semilaevis
ENSG00000079134	THOC1	99	77.206	ENSCVAG00000020600	thoc1	99	71.933	Cyprinodon_variegatus
ENSG00000079134	THOC1	99	81.985	ENSDARG00000088246	thoc1	99	74.809	Danio_rerio
ENSG00000079134	THOC1	100	97.717	ENSDNOG00000019217	THOC1	100	97.717	Dasypus_novemcinctus
ENSG00000079134	THOC1	99	94.834	ENSDORG00000008060	Thoc1	99	91.862	Dipodomys_ordii
ENSG00000079134	THOC1	96	41.484	FBgn0037382	Hpr1	74	41.682	Drosophila_melanogaster
ENSG00000079134	THOC1	98	95.699	ENSETEG00000004165	THOC1	100	75.168	Echinops_telfairi
ENSG00000079134	THOC1	99	70.370	ENSEBUG00000005998	thoc1	98	65.449	Eptatretus_burgeri
ENSG00000079134	THOC1	100	98.174	ENSEASG00005002549	THOC1	96	98.174	Equus_asinus_asinus
ENSG00000079134	THOC1	100	98.630	ENSECAG00000009267	THOC1	90	98.630	Equus_caballus
ENSG00000079134	THOC1	77	97.403	ENSEEUG00000012214	-	82	79.000	Erinaceus_europaeus
ENSG00000079134	THOC1	99	80.412	ENSELUG00000023277	thoc1	100	73.112	Esox_lucius
ENSG00000079134	THOC1	100	98.326	ENSFCAG00000022454	THOC1	87	98.326	Felis_catus
ENSG00000079134	THOC1	99	94.681	ENSFALG00000006205	THOC1	99	90.980	Ficedula_albicollis
ENSG00000079134	THOC1	99	97.872	ENSFDAG00000006842	THOC1	100	97.063	Fukomys_damarensis
ENSG00000079134	THOC1	99	77.206	ENSFHEG00000008841	thoc1	99	71.472	Fundulus_heteroclitus
ENSG00000079134	THOC1	99	77.574	ENSGMOG00000011486	thoc1	99	72.061	Gadus_morhua
ENSG00000079134	THOC1	99	94.681	ENSGALG00000014915	THOC1	98	90.229	Gallus_gallus
ENSG00000079134	THOC1	99	79.044	ENSGAFG00000021464	thoc1	99	71.933	Gambusia_affinis
ENSG00000079134	THOC1	99	77.941	ENSGACG00000017361	thoc1	99	72.881	Gasterosteus_aculeatus
ENSG00000079134	THOC1	100	66.008	ENSGAGG00000014067	-	96	66.008	Gopherus_agassizii
ENSG00000079134	THOC1	99	93.727	ENSGAGG00000021230	-	98	92.061	Gopherus_agassizii
ENSG00000079134	THOC1	100	99.543	ENSGGOG00000003013	THOC1	99	99.543	Gorilla_gorilla
ENSG00000079134	THOC1	99	77.941	ENSHBUG00000009096	thoc1	99	72.546	Haplochromis_burtoni
ENSG00000079134	THOC1	99	94.681	ENSHGLG00000009264	-	99	90.674	Heterocephalus_glaber_female
ENSG00000079134	THOC1	99	97.872	ENSHGLG00000003712	-	100	95.890	Heterocephalus_glaber_female
ENSG00000079134	THOC1	99	93.617	ENSHGLG00100002225	-	99	89.119	Heterocephalus_glaber_male
ENSG00000079134	THOC1	99	97.872	ENSHGLG00100003570	THOC1	100	96.195	Heterocephalus_glaber_male
ENSG00000079134	THOC1	91	81.609	ENSHCOG00000017981	thoc1	97	74.837	Hippocampus_comes
ENSG00000079134	THOC1	99	80.000	ENSIPUG00000005306	thoc1	99	74.194	Ictalurus_punctatus
ENSG00000079134	THOC1	100	97.869	ENSSTOG00000006484	THOC1	100	97.869	Ictidomys_tridecemlineatus
ENSG00000079134	THOC1	99	97.872	ENSJJAG00000014893	-	99	94.068	Jaculus_jaculus
ENSG00000079134	THOC1	99	77.574	ENSKMAG00000003904	thoc1	99	71.689	Kryptolebias_marmoratus
ENSG00000079134	THOC1	99	77.895	ENSLBEG00000020372	thoc1	98	72.824	Labrus_bergylta
ENSG00000079134	THOC1	99	83.456	ENSLACG00000014869	THOC1	99	78.473	Latimeria_chalumnae
ENSG00000079134	THOC1	99	82.353	ENSLOCG00000002097	thoc1	99	76.380	Lepisosteus_oculatus
ENSG00000079134	THOC1	100	97.869	ENSLAFG00000009585	THOC1	100	97.869	Loxodonta_africana
ENSG00000079134	THOC1	100	99.543	ENSMFAG00000041520	THOC1	99	99.543	Macaca_fascicularis
ENSG00000079134	THOC1	100	99.543	ENSMMUG00000004662	THOC1	100	99.543	Macaca_mulatta
ENSG00000079134	THOC1	100	99.543	ENSMNEG00000040177	THOC1	99	99.543	Macaca_nemestrina
ENSG00000079134	THOC1	100	99.543	ENSMLEG00000034201	THOC1	99	99.543	Mandrillus_leucophaeus
ENSG00000079134	THOC1	99	76.557	ENSMAMG00000016747	thoc1	99	73.312	Mastacembelus_armatus
ENSG00000079134	THOC1	99	77.941	ENSMZEG00005024609	thoc1	99	72.546	Maylandia_zebra
ENSG00000079134	THOC1	99	94.681	ENSMGAG00000009811	THOC1	100	90.031	Meleagris_gallopavo
ENSG00000079134	THOC1	99	97.872	ENSMAUG00000010272	Thoc1	99	95.586	Mesocricetus_auratus
ENSG00000079134	THOC1	100	98.326	ENSMICG00000027200	THOC1	100	98.326	Microcebus_murinus
ENSG00000079134	THOC1	99	97.872	ENSMOCG00000014536	-	86	94.512	Microtus_ochrogaster
ENSG00000079134	THOC1	99	83.053	ENSMOCG00000014924	-	96	83.053	Microtus_ochrogaster
ENSG00000079134	THOC1	99	77.895	ENSMMOG00000011772	thoc1	100	72.712	Mola_mola
ENSG00000079134	THOC1	100	93.835	ENSMODG00000021482	THOC1	100	93.835	Monodelphis_domestica
ENSG00000079134	THOC1	99	79.044	ENSMALG00000021872	thoc1	99	72.965	Monopterus_albus
ENSG00000079134	THOC1	99	97.872	MGP_CAROLIEiJ_G0021989	Thoc1	100	96.043	Mus_caroli
ENSG00000079134	THOC1	99	97.872	ENSMUSG00000024287	Thoc1	100	97.163	Mus_musculus
ENSG00000079134	THOC1	99	97.872	MGP_PahariEiJ_G0018726	Thoc1	100	96.195	Mus_pahari
ENSG00000079134	THOC1	99	97.872	MGP_SPRETEiJ_G0022905	Thoc1	100	96.195	Mus_spretus
ENSG00000079134	THOC1	100	98.478	ENSMPUG00000005448	THOC1	100	98.478	Mustela_putorius_furo
ENSG00000079134	THOC1	100	86.047	ENSMLUG00000024912	-	100	84.131	Myotis_lucifugus
ENSG00000079134	THOC1	99	89.362	ENSMLUG00000027965	-	99	84.148	Myotis_lucifugus
ENSG00000079134	THOC1	100	97.416	ENSMLUG00000004090	-	100	97.416	Myotis_lucifugus
ENSG00000079134	THOC1	100	97.412	ENSNGAG00000001401	-	100	97.412	Nannospalax_galili
ENSG00000079134	THOC1	99	76.384	ENSNGAG00000008061	-	99	76.043	Nannospalax_galili
ENSG00000079134	THOC1	99	77.941	ENSNBRG00000005991	thoc1	98	72.613	Neolamprologus_brichardi
ENSG00000079134	THOC1	100	99.543	ENSNLEG00000006835	THOC1	100	99.543	Nomascus_leucogenys
ENSG00000079134	THOC1	99	92.958	ENSMEUG00000009756	THOC1	99	81.847	Notamacropus_eugenii
ENSG00000079134	THOC1	85	97.531	ENSOPRG00000001108	THOC1	100	78.539	Ochotona_princeps
ENSG00000079134	THOC1	99	95.203	ENSODEG00000006623	THOC1	100	90.563	Octodon_degus
ENSG00000079134	THOC1	99	77.941	ENSONIG00000009440	thoc1	99	72.231	Oreochromis_niloticus
ENSG00000079134	THOC1	60	90.741	ENSOANG00000020006	-	93	94.545	Ornithorhynchus_anatinus
ENSG00000079134	THOC1	87	86.161	ENSOANG00000008228	-	98	87.405	Ornithorhynchus_anatinus
ENSG00000079134	THOC1	100	98.174	ENSOCUG00000011601	THOC1	100	98.174	Oryctolagus_cuniculus
ENSG00000079134	THOC1	99	77.574	ENSORLG00000017629	thoc1	99	72.239	Oryzias_latipes
ENSG00000079134	THOC1	99	77.574	ENSORLG00020007567	thoc1	99	72.239	Oryzias_latipes_hni
ENSG00000079134	THOC1	99	77.574	ENSORLG00015007356	thoc1	99	72.393	Oryzias_latipes_hsok
ENSG00000079134	THOC1	99	76.838	ENSOMEG00000008200	thoc1	99	71.626	Oryzias_melastigma
ENSG00000079134	THOC1	99	97.872	ENSOGAG00000000470	THOC1	99	94.977	Otolemur_garnettii
ENSG00000079134	THOC1	99	97.872	ENSOARG00000009238	THOC1	99	95.884	Ovis_aries
ENSG00000079134	THOC1	100	99.543	ENSPPAG00000031812	THOC1	99	99.543	Pan_paniscus
ENSG00000079134	THOC1	100	98.021	ENSPPRG00000023794	THOC1	100	98.329	Panthera_pardus
ENSG00000079134	THOC1	100	98.021	ENSPTIG00000007469	THOC1	100	98.329	Panthera_tigris_altaica
ENSG00000079134	THOC1	100	98.837	ENSPTRG00000009816	THOC1	100	98.645	Pan_troglodytes
ENSG00000079134	THOC1	100	98.487	ENSPANG00000008665	THOC1	100	98.487	Papio_anubis
ENSG00000079134	THOC1	99	79.044	ENSPKIG00000005906	thoc1	99	73.242	Paramormyrops_kingsleyae
ENSG00000079134	THOC1	99	93.727	ENSPSIG00000007691	THOC1	98	93.809	Pelodiscus_sinensis
ENSG00000079134	THOC1	99	76.838	ENSPMGG00000008279	thoc1	95	73.096	Periophthalmus_magnuspinnatus
ENSG00000079134	THOC1	99	97.872	ENSPEMG00000021789	Thoc1	100	96.043	Peromyscus_maniculatus_bairdii
ENSG00000079134	THOC1	95	40.244	ENSPMAG00000003689	-	99	64.943	Petromyzon_marinus
ENSG00000079134	THOC1	99	95.203	ENSPCIG00000026942	THOC1	98	93.522	Phascolarctos_cinereus
ENSG00000079134	THOC1	99	78.676	ENSPFOG00000011673	thoc1	99	72.197	Poecilia_formosa
ENSG00000079134	THOC1	99	78.676	ENSPLAG00000019648	thoc1	99	72.086	Poecilia_latipinna
ENSG00000079134	THOC1	99	78.676	ENSPMEG00000007083	thoc1	99	72.197	Poecilia_mexicana
ENSG00000079134	THOC1	99	78.676	ENSPREG00000006719	thoc1	99	71.933	Poecilia_reticulata
ENSG00000079134	THOC1	99	98.936	ENSPPYG00000009049	-	99	99.384	Pongo_abelii
ENSG00000079134	THOC1	100	94.186	ENSPCAG00000005320	THOC1	100	87.823	Procavia_capensis
ENSG00000079134	THOC1	100	98.021	ENSPCOG00000009234	THOC1	100	98.021	Propithecus_coquereli
ENSG00000079134	THOC1	100	96.195	ENSPVAG00000004007	THOC1	100	96.195	Pteropus_vampyrus
ENSG00000079134	THOC1	99	77.941	ENSPNYG00000019152	thoc1	99	72.546	Pundamilia_nyererei
ENSG00000079134	THOC1	99	83.158	ENSPNAG00000023390	thoc1	99	74.615	Pygocentrus_nattereri
ENSG00000079134	THOC1	99	97.872	ENSRNOG00000015332	Thoc1	100	85.882	Rattus_norvegicus
ENSG00000079134	THOC1	50	79.412	ENSRNOG00000032739	Da2-19	76	82.625	Rattus_norvegicus
ENSG00000079134	THOC1	100	98.494	ENSRBIG00000033738	THOC1	100	98.494	Rhinopithecus_bieti
ENSG00000079134	THOC1	100	99.543	ENSRROG00000044988	THOC1	100	99.543	Rhinopithecus_roxellana
ENSG00000079134	THOC1	98	80.309	ENSSBOG00000028733	-	99	80.309	Saimiri_boliviensis_boliviensis
ENSG00000079134	THOC1	100	99.087	ENSSBOG00000016556	THOC1	99	99.087	Saimiri_boliviensis_boliviensis
ENSG00000079134	THOC1	100	94.681	ENSSHAG00000014829	THOC1	100	94.681	Sarcophilus_harrisii
ENSG00000079134	THOC1	99	81.250	ENSSFOG00015021527	thoc1	99	74.847	Scleropages_formosus
ENSG00000079134	THOC1	99	77.206	ENSSMAG00000018465	thoc1	99	70.814	Scophthalmus_maximus
ENSG00000079134	THOC1	99	77.941	ENSSDUG00000016810	thoc1	99	73.272	Seriola_dumerili
ENSG00000079134	THOC1	99	77.574	ENSSLDG00000015555	thoc1	99	72.965	Seriola_lalandi_dorsalis
ENSG00000079134	THOC1	100	95.349	ENSSARG00000006910	THOC1	88	96.552	Sorex_araneus
ENSG00000079134	THOC1	99	92.251	ENSSPUG00000007238	THOC1	99	89.466	Sphenodon_punctatus
ENSG00000079134	THOC1	99	73.897	ENSSPAG00000018847	thoc1	99	70.031	Stegastes_partitus
ENSG00000079134	THOC1	100	98.326	ENSSSCG00000025653	THOC1	94	98.326	Sus_scrofa
ENSG00000079134	THOC1	99	94.681	ENSTGUG00000010204	THOC1	99	90.992	Taeniopygia_guttata
ENSG00000079134	THOC1	99	76.103	ENSTRUG00000013518	thoc1	99	72.086	Takifugu_rubripes
ENSG00000079134	THOC1	99	76.838	ENSTNIG00000008473	thoc1	99	72.239	Tetraodon_nigroviridis
ENSG00000079134	THOC1	99	96.809	ENSTBEG00000016920	THOC1	100	90.107	Tupaia_belangeri
ENSG00000079134	THOC1	99	97.872	ENSTTRG00000016664	THOC1	100	91.020	Tursiops_truncatus
ENSG00000079134	THOC1	100	98.478	ENSUAMG00000002527	THOC1	100	98.478	Ursus_americanus
ENSG00000079134	THOC1	100	98.478	ENSUMAG00000019693	THOC1	100	98.478	Ursus_maritimus
ENSG00000079134	THOC1	77	97.000	ENSVPAG00000003726	-	77	97.000	Vicugna_pacos
ENSG00000079134	THOC1	100	98.478	ENSVVUG00000004384	THOC1	100	98.478	Vulpes_vulpes
ENSG00000079134	THOC1	99	84.043	ENSXETG00000003155	thoc1	98	78.939	Xenopus_tropicalis
ENSG00000079134	THOC1	99	70.221	ENSXCOG00000016085	thoc1	89	70.213	Xiphophorus_couchianus
ENSG00000079134	THOC1	99	79.044	ENSXMAG00000002353	thoc1	99	71.933	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000018	regulation of DNA recombination	22144908.	IMP	Process
GO:0000346	transcription export complex	15833825.15998806.	IDA	Component
GO:0000347	THO complex	21873635.	IBA	Component
GO:0000347	THO complex	15998806.	IDA	Component
GO:0000445	THO complex part of transcription export complex	21873635.	IBA	Component
GO:0000445	THO complex part of transcription export complex	15998806.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	15870275.19059247.19165146.22365833.23299939.25416956.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15358532.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	15358532.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006396	RNA processing	7525595.	TAS	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	17190602.	IDA	Process
GO:0006406	mRNA export from nucleus	22144908.	IMP	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006915	apoptotic process	10512864.	IDA	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016363	nuclear matrix	-	IEA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0031297	replication fork processing	22144908.	IMP	Process
GO:0032784	regulation of DNA-templated transcription, elongation	21873635.	IBA	Process
GO:0032784	regulation of DNA-templated transcription, elongation	15870275.	IDA	Process
GO:0032786	positive regulation of DNA-templated transcription, elongation	22144908.	IMP	Process
GO:0045171	intercellular bridge	-	IDA	Component
GO:0046784	viral mRNA export from host cell nucleus	18974867.	IDA	Process
GO:0048297	negative regulation of isotype switching to IgA isotypes	-	ISS	Process
GO:2000002	negative regulation of DNA damage checkpoint	22144908.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24682263	Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.	Mol Med Rep	2014 Jun	Wan J	doi: 10.3892/mmr.2014.2088
26545775	Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer.	Biochem Biophys Res Commun	2015 Dec 4-11	Liu C	doi: 10.1016/j.bbrc.2015.10.166
22952718	Transcriptional regulation of hTREX84 in human cancer cells.	PLoS One	2012	Guo S	doi: 10.1371/journal.pone.0043610
25296641	The Thoc1 ribonucleoprotein and prostate cancer progression.	J Natl Cancer Inst	2014 Oct 8	Chinnam M	doi: 10.1093/jnci/dju306

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr18	265325	Missense_Mutation	novel	R56K	0.23	efThoc1
BLCA	chr18	225208	Intron	novel		0.44
BLCA	chr18	265362	Missense_Mutation	novel	E44K	0.53	efThoc1
BLCA	chr18	226868	Missense_Mutation	rs757641974	R318C	0.61
BRCA	chr18	247878	Missense_Mutation	NA	E253K	0.15
BRCA	chr18	259187	Missense_Mutation	novel	E171D	0.13
BRCA	chr18	225119	Frame_Shift_Del	novel	*D370Mfs9**	0.12
BRCA	chr18	226824	Silent	NA	L332L	0.36
BRCA	chr18	259687	Missense_Mutation	novel	C140Y	0.75
BRCA	chr18	225259	Intron	novel		0.07
BRCA	chr18	216572	Missense_Mutation	NA	H506Y	0.33
BRCA	chr18	224148	Missense_Mutation	NA	R414W	0.1
BRCA	chr18	225557	Intron	novel		0.06
BRCA	chr18	225409	Splice_Region	novel		0.21
CESC	chr18	246446	Missense_Mutation	NA	E266Q	0.21
CESC	chr18	268040	5'Flank	novel		0.45
CESC	chr18	247950	Missense_Mutation	novel	P229T	0.33
CESC	chr18	265514	Missense_Mutation	novel	A24V	0.23	efThoc1
COAD	chr18	225119	Frame_Shift_Del	novel	*D370Mfs9**	0.31
COAD	chr18	214889	Missense_Mutation	NA	G571R	0.23
COAD	chr18	265347	Frame_Shift_Ins	rs746975641	*C49Mfs4**	0.37	efThoc1
COAD	chr18	260208	Missense_Mutation	NA	K118T	0.14
COAD	chr18	216583	Missense_Mutation	rs775547853	R502Q	0.3
COAD	chr18	224096	Frame_Shift_Ins	novel	*I431Nfs6**	0.23
COAD	chr18	246322	Splice_Site	NA	X306_splice	0.31
COAD	chr18	246401	Missense_Mutation	NA	A281T	0.17
COAD	chr18	215424	Splice_Site	novel	X560_splice	0.42
COAD	chr18	214782	Silent	NA	S606S	0.46
COAD	chr18	225292	Intron	novel		0.2
COAD	chr18	247949	Missense_Mutation	novel	P229Q	0.22
COAD	chr18	260241	Missense_Mutation	novel	D107G	0.12
COAD	chr18	260205	Frame_Shift_Del	NA	*N119Mfs26**	0.36
COAD	chr18	224148	Missense_Mutation	NA	R414W	0.24
COAD	chr18	265499	Frame_Shift_Del	novel	*N29Tfs6**	0.37	efThoc1
COAD	chr18	214900	Missense_Mutation	novel	K567T	0.07
COAD	chr18	252570	Missense_Mutation	novel	E216K	0.24
DLBC	chr18	216549	Silent	novel	Q513Q	0.78
GBM	chr18	225100	Missense_Mutation	NA	K376E	0.71
GBM	chr18	225170	Intron	novel		0.52
HNSC	chr18	214778	Missense_Mutation	novel	D608Y	0.18
KICH	chr18	216576	Silent	novel	S504S	0.09
KIRC	chr18	226879	Frame_Shift_Del	novel	*S313Tfs32**	0.19
KIRP	chr18	214669	Missense_Mutation	novel	D644G	0.29
KIRP	chr18	267995	Frame_Shift_Del	novel	*S9Vfs17**	0.3	efThoc1
LAML	chr18	214730	Nonsense_Mutation	novel	E624*	0.08
LGG	chr18	265475	Missense_Mutation	novel	F37C	0.69	efThoc1
LIHC	chr18	224989	Missense_Mutation	novel	I381M	0.79
LUAD	chr18	214838	Missense_Mutation	novel	L588M	0.38
LUSC	chr18	247935	Missense_Mutation	novel	L234V	0.14
LUSC	chr18	259238	Silent	novel	V154V	0.69
LUSC	chr18	215489	Missense_Mutation	NA	I540V	0.81
LUSC	chr18	224971	Frame_Shift_Ins	novel	*N387Kfs15**	0.1
LUSC	chr18	225376	Silent	novel	Q349Q	0.12
OV	chr18	223447	Missense_Mutation	NA	E455Q	0.44
PAAD	chr18	265360	Missense_Mutation	novel	E44D	0.22	efThoc1
PAAD	chr18	265516	Missense_Mutation	novel	E23D	0.08	efThoc1
PAAD	chr18	225229	Intron	novel		0.15
PCPG	chr18	246364	Missense_Mutation	novel	G293E	0.15
PRAD	chr18	260304	Splice_Region	novel	G86delinsALPIC	0.25
READ	chr18	218892	Missense_Mutation	novel	E483G	0.05
READ	chr18	265480	Silent	novel	S35S	0.67
READ	chr18	224148	Missense_Mutation	NA	R414W	0.83
READ	chr18	247929	Nonsense_Mutation	NA	R236*	0.42
READ	chr18	225541	Intron	novel		0.89
READ	chr18	224148	Missense_Mutation	NA	R414W	0.26
SARC	chr18	215471	Missense_Mutation	novel	E546K	0.26
SARC	chr18	225202	Intron	novel		0.11
SKCM	chr18	225463	Intron	novel		0.31
SKCM	chr18	215447	Silent	rs768361205	L554L	0.23
SKCM	chr18	259250	Silent	novel	S150S	0.19
STAD	chr18	215507	Splice_Region	novel		0.26
STAD	chr18	224097	Frame_Shift_Del	novel	*I431Ffs2**	0.3
STAD	chr18	224097	Frame_Shift_Del	novel	*I431Ffs2**	0.24
STAD	chr18	265348	Frame_Shift_Del	rs779903682	*K48Nfs12**	0.42	efThoc1
STAD	chr18	265348	Frame_Shift_Del	rs779903682	*K48Nfs12**	0.5	efThoc1
STAD	chr18	265478	Missense_Mutation	NA	T36I	0.37	efThoc1
STAD	chr18	216529	Missense_Mutation	NA	E520G	0.35
STAD	chr18	224147	Missense_Mutation	rs377169666	R414Q	0.33
STAD	chr18	225467	Intron	novel		0.23
STAD	chr18	246429	Frame_Shift_Del	novel	*F271Lfs6**	0.49
THCA	chr18	265318	Missense_Mutation	rs760373126	I58M	0.36	efThoc1
UCEC	chr18	225562	Intron	novel		0.28
UCEC	chr18	214788	Silent	NA	C604C	0.34
UCEC	chr18	216591	Silent	NA	L499L	0.43
UCEC	chr18	259686	Silent	novel	C140C	0.45
UCEC	chr18	225564	Intron	novel		0.46
UCEC	chr18	224136	Missense_Mutation	novel	A418S	0.4
UCEC	chr18	225557	Intron	novel		0.17
UCEC	chr18	214668	Silent	NA	D644D	0.17
UCEC	chr18	252570	Missense_Mutation	novel	E216K	0.36
UCEC	chr18	214856	Missense_Mutation	novel	G582C	0.31
UCEC	chr18	224138	Missense_Mutation	novel	T417I	0.06
UCEC	chr18	225262	Intron	novel		0.32
UCEC	chr18	264039	Silent	novel	G81G	0.2
UCEC	chr18	225301	Intron	novel		0.07
UCEC	chr18	224148	Missense_Mutation	NA	R414W	0.35
UCEC	chr18	216524	Missense_Mutation	novel	L522I	0.24
UCEC	chr18	224148	Missense_Mutation	NA	R414W	0.69
UCEC	chr18	254353	Missense_Mutation	novel	L175I	0.33
UCEC	chr18	259191	Missense_Mutation	NA	S170F	0.27
UCEC	chr18	224945	Missense_Mutation	novel	C396Y	0.1
UCEC	chr18	225557	Intron	novel		0.35
UCEC	chr18	226821	Missense_Mutation	novel	K333N	0.06
UCEC	chr18	265302	Splice_Site	novel	X63_splice	0.39
UCEC	chr18	216486	Splice_Region	rs755407022	P534P	0.4
UCEC	chr18	225557	Intron	novel		0.22
UCEC	chr18	214866	Silent	novel	A578A	0.12
UCEC	chr18	218942	Missense_Mutation	NA	F466L	0.16
UCEC	chr18	247928	Missense_Mutation	rs775390511	R236Q	0.15
UCEC	chr18	216524	Missense_Mutation	novel	L522I	0.34
UCEC	chr18	223475	Nonsense_Mutation	novel	C445*	0.3
UCEC	chr18	224098	Missense_Mutation	novel	K430N	0.39
UCEC	chr18	252542	Missense_Mutation	novel	T225M	0.3
UCEC	chr18	214870	Missense_Mutation	novel	F577C	0.48
UCEC	chr18	224148	Missense_Mutation	NA	R414W	0.26
UCEC	chr18	225323	Intron	novel		0.25
UCEC	chr18	265325	Missense_Mutation	novel	R56I	0.16	efThoc1
UCEC	chr18	225557	Intron	novel		0.21
UCEC	chr18	225557	Intron	novel		0.2
UCEC	chr18	225282	Intron	novel		0.26
UCEC	chr18	225557	Intron	novel		0.12
UCEC	chr18	214894	Missense_Mutation	NA	V569A	0.39
UCEC	chr18	224158	Silent	rs747161472	T410T	0.24
UCEC	chr18	226886	Missense_Mutation	novel	L312M	0.52
UCEC	chr18	224101	Missense_Mutation	novel	K429N	0.06
UCEC	chr18	226865	Nonsense_Mutation	NA	R319*	0.37
UCEC	chr18	246440	Missense_Mutation	novel	L268V	0.4
UCEC	chr18	254309	Missense_Mutation	novel	F189L	0.24
UCEC	chr18	224148	Missense_Mutation	NA	R414W	0.49
UCEC	chr18	218969	Missense_Mutation	novel	R457S	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUSC	AMP	0.2695	0.19322
PAAD	DEL	0.1413	0.12313
SARC	DEL	0.2179	0.24876
TGCT	DEL	0.6867	0.00046313

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0032	Kaplan-Meier Survival Analysis
KIRC	0.00031	Kaplan-Meier Survival Analysis
MESO	0.0043	Kaplan-Meier Survival Analysis
ACC	0.012	Kaplan-Meier Survival Analysis
SKCM	0.023	Kaplan-Meier Survival Analysis
PRAD	0.011	Kaplan-Meier Survival Analysis
LUSC	0.017	Kaplan-Meier Survival Analysis
BRCA	0.0048	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
BLCA	0.0023	Kaplan-Meier Survival Analysis
CESC	0.038	Kaplan-Meier Survival Analysis
LAML	0.0013	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.012	Kaplan-Meier Survival Analysis
LUAD	0.034	Kaplan-Meier Survival Analysis
UVM	0.043	Kaplan-Meier Survival Analysis
OV	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742