EuRBPDB

Description

Ensembl ID: ENSG00000079313 (Gene tree)
Gene ID: 57455
Gene Symbol: REXO1
Alias: EloA-BP1|KIAA1138|TCEB3BP1
Full Name: RNA exonuclease 1 homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,243 bases
Position: chr19:1,815,246-1,848,488
Accession: 24616
RBP type: canonical RBP
Summary: (RNA Exonuclease 1 Homolog) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is REXO5.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000496305	RNase_T	PF00929.24	0.00015	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000170168	REXO1-201	4591	XM_011528144	ENSP00000170168	1221 (aa)	XP_011526446	Q8N1G1
ENST00000643515	REXO1-208	1894	-	ENSP00000496305	530 (aa)	-	A0A2R8Y7I5
ENST00000588743	REXO1-206	369	-	-	- (aa)	-	-
ENST00000586343	REXO1-203	718	-	ENSP00000481515	64 (aa)	-	A0A087WY50
ENST00000587524	REXO1-205	1390	-	-	- (aa)	-	-
ENST00000590936	REXO1-207	1271	-	ENSP00000468713	161 (aa)	-	K7ESH4
ENST00000586291	REXO1-202	544	-	-	- (aa)	-	-
ENST00000587404	REXO1-204	279	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000079313	rs749109	19	1819737	?	Systolic blood pressure	30595370	EFO_0006335
ENSG00000079313	rs893540	19	1843627	?	Red cell distribution width	30595370	EFO_0005192
ENSG00000079313	rs8102879	19	1832318	?	Cardiovascular disease	30595370	EFO_0000319

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000079313	REXO1	97	69.872	ENSAPLG00000011954	REXO1	100	53.254	Anas_platyrhynchos
ENSG00000079313	REXO1	94	95.000	ENSCGRG00000014248	Rexo1	96	86.192	Cricetulus_griseus_crigri
ENSG00000079313	REXO1	92	67.623	ENSDNOG00000024400	-	97	65.498	Dasypus_novemcinctus
ENSG00000079313	REXO1	97	68.590	ENSGALG00000001043	REXO1	99	52.941	Gallus_gallus
ENSG00000079313	REXO1	97	68.590	ENSGAGG00000022162	REXO1	99	52.299	Gopherus_agassizii
ENSG00000079313	REXO1	97	68.590	ENSMGAG00000002267	REXO1	100	53.361	Meleagris_gallopavo
ENSG00000079313	REXO1	100	99.434	ENSPTRG00000010213	REXO1	100	99.434	Pan_troglodytes
ENSG00000079313	REXO1	94	72.581	ENSTGUG00000000250	REXO1	98	67.727	Taeniopygia_guttata

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004527	exonuclease activity	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process