EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000079332 (Gene tree)
Gene ID: 56681
Gene Symbol: SAR1A
Alias: SAR1|Sara|SARA1
Full Name: secretion associated Ras related GTPase 1A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 23,241 bases
Position: chr10:70,147,289-70,170,529
Accession: 10534
RBP type: canonical RBP
Summary: SAR1A (Secretion Associated Ras Related GTPase 1A) is a Protein Coding gene. Diseases associated with SAR1A include Cowden Syndrome. Among its related pathways are Protein processing in endoplasmic reticulum and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is SAR1B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362335	MMR_HSR1	PF01926.23	3.4e-05	1	1
ENSP00000362338	MMR_HSR1	PF01926.23	3.4e-05	1	1
ENSP00000362339	MMR_HSR1	PF01926.23	3.4e-05	1	1
ENSP00000399698	MMR_HSR1	PF01926.23	3.4e-05	1	1
ENSP00000362333	MMR_HSR1	PF01926.23	8.6e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477464	SAR1A-208	529	-	-	- (aa)	-	-
ENST00000373242	SAR1A-205	5981	-	ENSP00000362339	198 (aa)	-	Q9NR31
ENST00000373236	SAR1A-201	437	-	ENSP00000362333	121 (aa)	-	Q5SQT8
ENST00000373241	SAR1A-204	2996	-	ENSP00000362338	198 (aa)	-	Q9NR31
ENST00000452767	SAR1A-207	672	-	ENSP00000398165	115 (aa)	-	H0Y5E8
ENST00000373238	SAR1A-202	3227	-	ENSP00000362335	198 (aa)	-	Q9NR31
ENST00000431664	SAR1A-206	2810	-	ENSP00000399698	198 (aa)	-	Q9NR31
ENST00000373239	SAR1A-203	468	-	ENSP00000362336	50 (aa)	-	X1WI22

Gene Model

Click here to download ENSG00000079332's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa05134	Legionellosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000079332	Creatinine	9.2040000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000079332's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000079332	SAR1A	100	100.000	ENSAMEG00000017868	SAR1A	100	98.990	Ailuropoda_melanoleuca
ENSG00000079332	SAR1A	100	100.000	ENSANAG00000030371	SAR1A	100	99.495	Aotus_nancymaae
ENSG00000079332	SAR1A	100	100.000	ENSBTAG00000016858	SAR1A	100	98.990	Bos_taurus
ENSG00000079332	SAR1A	100	100.000	ENSCJAG00000042744	-	100	100.000	Callithrix_jacchus
ENSG00000079332	SAR1A	100	100.000	ENSCAFG00020025897	SAR1A	100	98.990	Canis_lupus_dingo
ENSG00000079332	SAR1A	100	100.000	ENSCHIG00000018882	SAR1A	100	98.990	Capra_hircus
ENSG00000079332	SAR1A	96	89.583	ENSTSYG00000033030	-	100	86.224	Carlito_syrichta
ENSG00000079332	SAR1A	100	100.000	ENSTSYG00000005955	-	100	99.495	Carlito_syrichta
ENSG00000079332	SAR1A	100	100.000	ENSCPOG00000032583	SAR1A	100	98.990	Cavia_porcellus
ENSG00000079332	SAR1A	100	100.000	ENSCCAG00000019722	SAR1A	100	98.485	Cebus_capucinus
ENSG00000079332	SAR1A	100	100.000	ENSCATG00000039017	SAR1A	100	100.000	Cercocebus_atys
ENSG00000079332	SAR1A	100	100.000	ENSCLAG00000012839	SAR1A	100	98.990	Chinchilla_lanigera
ENSG00000079332	SAR1A	100	100.000	ENSCSAG00000008263	SAR1A	100	100.000	Chlorocebus_sabaeus
ENSG00000079332	SAR1A	100	100.000	ENSCHOG00000000472	-	100	98.990	Choloepus_hoffmanni
ENSG00000079332	SAR1A	100	100.000	ENSCPBG00000025882	SAR1A	100	96.970	Chrysemys_picta_bellii
ENSG00000079332	SAR1A	100	100.000	ENSCANG00000038841	SAR1A	100	100.000	Colobus_angolensis_palliatus
ENSG00000079332	SAR1A	100	100.000	ENSCGRG00001016695	Sar1a	100	98.990	Cricetulus_griseus_chok1gshd
ENSG00000079332	SAR1A	100	100.000	ENSCGRG00000014890	Sar1a	100	98.990	Cricetulus_griseus_crigri
ENSG00000079332	SAR1A	100	100.000	ENSDNOG00000035765	-	100	99.495	Dasypus_novemcinctus
ENSG00000079332	SAR1A	86	88.235	ENSDORG00000029471	-	94	88.235	Dipodomys_ordii
ENSG00000079332	SAR1A	100	100.000	ENSDORG00000023465	-	100	98.990	Dipodomys_ordii
ENSG00000079332	SAR1A	100	100.000	ENSEASG00005016046	SAR1A	100	98.990	Equus_asinus_asinus
ENSG00000079332	SAR1A	100	100.000	ENSECAG00000009730	SAR1A	100	98.990	Equus_caballus
ENSG00000079332	SAR1A	100	100.000	ENSFCAG00000043085	SAR1A	100	98.990	Felis_catus
ENSG00000079332	SAR1A	100	98.000	ENSFALG00000012661	SAR1A	100	96.970	Ficedula_albicollis
ENSG00000079332	SAR1A	100	100.000	ENSFDAG00000010673	SAR1A	100	98.990	Fukomys_damarensis
ENSG00000079332	SAR1A	100	100.000	ENSGALG00000004431	SAR1A	100	97.475	Gallus_gallus
ENSG00000079332	SAR1A	100	100.000	ENSGAGG00000013705	SAR1A	100	96.465	Gopherus_agassizii
ENSG00000079332	SAR1A	100	100.000	ENSGGOG00000024879	SAR1A	100	100.000	Gorilla_gorilla
ENSG00000079332	SAR1A	100	100.000	ENSHGLG00000016765	SAR1A	100	98.990	Heterocephalus_glaber_female
ENSG00000079332	SAR1A	100	100.000	ENSHGLG00100017379	SAR1A	100	98.990	Heterocephalus_glaber_male
ENSG00000079332	SAR1A	100	100.000	ENSSTOG00000012780	SAR1A	100	99.495	Ictidomys_tridecemlineatus
ENSG00000079332	SAR1A	100	100.000	ENSJJAG00000016603	-	100	97.980	Jaculus_jaculus
ENSG00000079332	SAR1A	100	100.000	ENSLAFG00000004046	SAR1A	100	98.990	Loxodonta_africana
ENSG00000079332	SAR1A	100	100.000	ENSMFAG00000039894	SAR1A	100	100.000	Macaca_fascicularis
ENSG00000079332	SAR1A	100	100.000	ENSMMUG00000006398	SAR1A	100	100.000	Macaca_mulatta
ENSG00000079332	SAR1A	100	100.000	ENSMNEG00000030362	SAR1A	100	100.000	Macaca_nemestrina
ENSG00000079332	SAR1A	100	100.000	ENSMLEG00000037528	SAR1A	100	100.000	Mandrillus_leucophaeus
ENSG00000079332	SAR1A	100	100.000	ENSMAUG00000005624	Sar1a	100	98.990	Mesocricetus_auratus
ENSG00000079332	SAR1A	100	100.000	ENSMICG00000001638	-	100	99.495	Microcebus_murinus
ENSG00000079332	SAR1A	100	94.000	ENSMICG00000035294	-	95	82.383	Microcebus_murinus
ENSG00000079332	SAR1A	100	100.000	ENSMOCG00000018004	Sar1a	100	98.485	Microtus_ochrogaster
ENSG00000079332	SAR1A	100	100.000	MGP_CAROLIEiJ_G0015372	Sar1a	100	99.495	Mus_caroli
ENSG00000079332	SAR1A	100	100.000	ENSMUSG00000020088	Sar1a	100	99.495	Mus_musculus
ENSG00000079332	SAR1A	100	100.000	MGP_PahariEiJ_G0030788	Sar1a	100	99.495	Mus_pahari
ENSG00000079332	SAR1A	100	100.000	MGP_SPRETEiJ_G0016183	Sar1a	100	99.495	Mus_spretus
ENSG00000079332	SAR1A	100	100.000	ENSMPUG00000004338	SAR1A	100	98.990	Mustela_putorius_furo
ENSG00000079332	SAR1A	100	100.000	ENSMLUG00000006626	SAR1A	100	98.485	Myotis_lucifugus
ENSG00000079332	SAR1A	100	100.000	ENSNGAG00000010545	Sar1a	100	98.485	Nannospalax_galili
ENSG00000079332	SAR1A	100	100.000	ENSNLEG00000011243	SAR1A	100	100.000	Nomascus_leucogenys
ENSG00000079332	SAR1A	100	100.000	ENSODEG00000014517	SAR1A	100	98.953	Octodon_degus
ENSG00000079332	SAR1A	100	100.000	ENSOANG00000012148	SAR1A	100	96.465	Ornithorhynchus_anatinus
ENSG00000079332	SAR1A	100	100.000	ENSOCUG00000004547	SAR1A	100	99.495	Oryctolagus_cuniculus
ENSG00000079332	SAR1A	100	100.000	ENSOGAG00000005040	SAR1A	100	99.495	Otolemur_garnettii
ENSG00000079332	SAR1A	100	100.000	ENSOARG00000005884	SAR1A	100	98.485	Ovis_aries
ENSG00000079332	SAR1A	100	100.000	ENSPPAG00000031193	SAR1A	100	100.000	Pan_paniscus
ENSG00000079332	SAR1A	100	100.000	ENSPPRG00000023919	-	100	98.990	Panthera_pardus
ENSG00000079332	SAR1A	100	100.000	ENSPTIG00000015795	SAR1A	100	98.990	Panthera_tigris_altaica
ENSG00000079332	SAR1A	100	100.000	ENSPTRG00000002584	SAR1A	100	100.000	Pan_troglodytes
ENSG00000079332	SAR1A	100	100.000	ENSPANG00000022249	SAR1A	100	100.000	Papio_anubis
ENSG00000079332	SAR1A	100	98.000	ENSPSIG00000014285	SAR1A	100	96.465	Pelodiscus_sinensis
ENSG00000079332	SAR1A	100	100.000	ENSPCIG00000015309	-	100	96.970	Phascolarctos_cinereus
ENSG00000079332	SAR1A	100	100.000	ENSPPYG00000002374	SAR1A	100	100.000	Pongo_abelii
ENSG00000079332	SAR1A	100	100.000	ENSPCOG00000021042	SAR1A	100	99.495	Propithecus_coquereli
ENSG00000079332	SAR1A	100	100.000	ENSPVAG00000000098	SAR1A	100	99.495	Pteropus_vampyrus
ENSG00000079332	SAR1A	100	100.000	ENSRBIG00000031590	SAR1A	100	100.000	Rhinopithecus_bieti
ENSG00000079332	SAR1A	100	100.000	ENSRROG00000044164	SAR1A	100	100.000	Rhinopithecus_roxellana
ENSG00000079332	SAR1A	100	100.000	ENSSBOG00000036189	SAR1A	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000079332	SAR1A	100	100.000	ENSSHAG00000008596	SAR1A	100	96.970	Sarcophilus_harrisii
ENSG00000079332	SAR1A	100	100.000	ENSSARG00000000951	SAR1A	100	97.980	Sorex_araneus
ENSG00000079332	SAR1A	100	100.000	ENSSSCG00000010260	SAR1A	100	98.990	Sus_scrofa
ENSG00000079332	SAR1A	100	98.000	ENSTGUG00000004523	SAR1A	100	96.970	Taeniopygia_guttata
ENSG00000079332	SAR1A	100	100.000	ENSTBEG00000008657	SAR1A	100	99.495	Tupaia_belangeri
ENSG00000079332	SAR1A	100	98.485	ENSTTRG00000006648	SAR1A	100	98.485	Tursiops_truncatus
ENSG00000079332	SAR1A	100	100.000	ENSUAMG00000003779	SAR1A	100	98.990	Ursus_americanus
ENSG00000079332	SAR1A	100	100.000	ENSUMAG00000007921	SAR1A	100	98.990	Ursus_maritimus
ENSG00000079332	SAR1A	100	100.000	ENSVPAG00000002631	SAR1A	100	98.990	Vicugna_pacos
ENSG00000079332	SAR1A	100	100.000	ENSVVUG00000021609	SAR1A	100	98.990	Vulpes_vulpes
ENSG00000079332	SAR1A	100	100.000	ENSXETG00000026979	sar1a	100	96.465	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0003400	regulation of COPII vesicle coating	21873635.	IBA	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	19181664.19822759.26522472.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0016050	vesicle organization	21873635.	IBA	Process
GO:0030127	COPII vesicle coat	21873635.	IBA	Component
GO:0030127	COPII vesicle coat	17499046.	IDA	Component
GO:0061024	membrane organization	21873635.	IBA	Process
GO:0070863	positive regulation of protein exit from endoplasmic reticulum	21873635.	IBA	Process
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component
GO:0090110	cargo loading into COPII-coated vesicle	17499046.18843296.	IDA	Process