EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000079785 (Gene tree)
Gene ID: 1653
Gene Symbol: DDX1
Alias: DBP-RB
Full Name: DEAD-box helicase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 39,934 bases
Position: chr2:15,591,178-15,631,111
Accession: 2734
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000233084	DEAD	PF00270.29	3.4e-79	1	1
ENSP00000370745	DEAD	PF00270.29	3.4e-79	1	1
ENSP00000482416	DEAD	PF00270.29	1.3e-56	1	1
ENSP00000484958	DEAD	PF00270.29	1.3e-56	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30295850	RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation.	Nucleic Acids Res	2018 Dec 14	Li Z	doi: 10.1093/nar/gky867.
18335541	MBNL1 associates with YB-1 in cytoplasmic stress granules.	J Neurosci Res	2008 Jul	Onishi H	doi: 10.1002/jnr.21655.
22902294	An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.	Cell Stem Cell	2012 Oct 5	Vessey JP	doi: 10.1016/j.stem.2012.06.010
12183465	An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.	J Biol Chem	2002 Oct 25	Chen HC	-
21933836	The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.	Hum Mol Genet	2011 Dec 15	Kunde SA	doi: 10.1093/hmg/ddr430
25690890	Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1.	Nucleic Acids Res	2015 Mar 11	Kellner JN	doi: 10.1093/nar/gkv106
25176654	The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.	Cell Rep	2014 Sep 11	Han C	doi: 10.1016/j.celrep.2014.07.058
25496916	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	Retrovirology	2014 Dec 14	Lin MH	doi: 10.1186/s12977-014-0121-9.
15312650	Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.	Neuron	2004 Aug 19	Kanai Y	-
17380053	Identification of DDX1 as a JC virus transcriptional control region-binding protein.	Microbiol Immunol	2007	Sunden Y	-
22051512	DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.	J Mol Biol	2012 Jan 6	Edgcomb SP	doi: 10.1016/j.jmb.2011.10.032
21703541	DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.	Immunity	2011 Jun 24	Zhang Z	doi: 10.1016/j.immuni.2011.03.027.
28153748	A DEAD-Box Helicase Mediates an RNA Structural Transition in the HIV-1 Rev Response Element.	J Mol Biol	2017 Mar 10	Hammond JA	doi: 10.1016/j.jmb.2017.01.018

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000459706	DDX1-204	640	-	-	- (aa)	-	-
ENST00000381341	DDX1-202	2817	-	ENSP00000370745	740 (aa)	-	Q92499
ENST00000434671	DDX1-203	500	-	ENSP00000413767	16 (aa)	-	C9JLP0
ENST00000233084	DDX1-201	2739	-	ENSP00000233084	740 (aa)	-	Q92499
ENST00000478695	DDX1-206	554	-	-	- (aa)	-	-
ENST00000621973	DDX1-208	2183	-	ENSP00000484958	659 (aa)	-	A0A087X2G1
ENST00000617198	DDX1-207	2257	-	ENSP00000482416	659 (aa)	-	F1T0B3
ENST00000470674	DDX1-205	556	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000079785's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000079785	Cholesterol, LDL	7.55799577747581E-5	17903299
ENSG00000079785	Cholesterol, LDL	9.3063306338095E-5	17903299
ENSG00000079785	Hip	1.06980202694672E-6	17903296
ENSG00000079785	Platelet Function Tests	9.3000000E-006	-
ENSG00000079785	Platelet Function Tests	4.6100000E-006	-
ENSG00000079785	Platelet Function Tests	1.3143400E-005	-
ENSG00000079785	Platelet Function Tests	2.5200000E-006	-
ENSG00000079785	Platelet Function Tests	4.9600000E-006	-
ENSG00000079785	Hemoglobins	4.2050000E-006	-
ENSG00000079785	Creatinine	5E-7	26831199
ENSG00000079785	Glomerular Filtration Rate	5E-7	26831199
ENSG00000079785	Wilms Tumor	1E-14	22544364
ENSG00000079785	Asthma	1E-6	24993907
ENSG00000079785	Pulmonary Disease, Chronic Obstructive	1E-6	24993907
ENSG00000079785	Creatinine	7E-12	26831199
ENSG00000079785	Glomerular Filtration Rate	7E-12	26831199
ENSG00000079785	Hair	2E-6	19896111
ENSG00000079785	Renal Insufficiency, Chronic	4E-8	22479191
ENSG00000079785	Bronchodilator Agents	3E-7	26634245
ENSG00000079785	Lung Volume Measurements	3E-7	26634245
ENSG00000079785	Lung Volume Measurements	2E-7	23284291
ENSG00000079785	Lung Volume Measurements	9E-6	21946350
ENSG00000079785	Respiratory Function Tests	9E-6	21946350
ENSG00000079785	Wilms Tumor	1E-14	22544364

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000079785's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000079785	DDX1	54	42.188	ENSG00000125485	DDX31	53	41.935
ENSG00000079785	DDX1	53	40.678	ENSG00000110367	DDX6	63	40.678
ENSG00000079785	DDX1	54	41.538	ENSG00000178105	DDX10	51	41.538
ENSG00000079785	DDX1	53	38.983	ENSG00000123064	DDX54	83	38.983
ENSG00000079785	DDX1	55	35.802	ENSG00000067048	DDX3Y	54	35.802
ENSG00000079785	DDX1	54	46.875	ENSG00000213782	DDX47	75	46.875
ENSG00000079785	DDX1	54	49.180	ENSG00000136271	DDX56	95	49.180
ENSG00000079785	DDX1	54	40.909	ENSG00000105671	DDX49	71	40.909
ENSG00000079785	DDX1	54	41.071	ENSG00000278053	DDX52	58	41.071

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000079785	DDX1	100	84.324	ENSAPOG00000003166	ddx1	100	84.324	Acanthochromis_polyacanthus
ENSG00000079785	DDX1	99	97.835	ENSAMEG00000001071	DDX1	99	97.835	Ailuropoda_melanoleuca
ENSG00000079785	DDX1	100	83.308	ENSACIG00000017422	ddx1	100	82.701	Amphilophus_citrinellus
ENSG00000079785	DDX1	89	82.523	ENSAOCG00000015436	ddx1	94	83.962	Amphiprion_ocellaris
ENSG00000079785	DDX1	100	85.000	ENSAPEG00000007699	ddx1	100	85.000	Amphiprion_percula
ENSG00000079785	DDX1	99	83.537	ENSATEG00000003965	ddx1	98	83.664	Anabas_testudineus
ENSG00000079785	DDX1	100	92.473	ENSAPLG00000011093	DDX1	100	92.473	Anas_platyrhynchos
ENSG00000079785	DDX1	94	90.974	ENSACAG00000011036	DDX1	99	90.974	Anolis_carolinensis
ENSG00000079785	DDX1	100	99.189	ENSANAG00000037912	DDX1	100	99.189	Aotus_nancymaae
ENSG00000079785	DDX1	100	83.612	ENSACLG00000008850	ddx1	100	83.612	Astatotilapia_calliptera
ENSG00000079785	DDX1	100	85.000	ENSAMXG00000002100	ddx1	100	85.000	Astyanax_mexicanus
ENSG00000079785	DDX1	100	97.297	ENSBTAG00000009906	DDX1	100	97.297	Bos_taurus
ENSG00000079785	DDX1	98	47.973	WBGene00021938	Y55F3BR.1	98	47.973	Caenorhabditis_elegans
ENSG00000079785	DDX1	100	99.189	ENSCJAG00000007076	DDX1	100	99.189	Callithrix_jacchus
ENSG00000079785	DDX1	100	97.703	ENSCAFG00000003686	DDX1	100	97.703	Canis_familiaris
ENSG00000079785	DDX1	100	97.703	ENSCAFG00020026083	DDX1	100	97.703	Canis_lupus_dingo
ENSG00000079785	DDX1	100	97.838	ENSCHIG00000011046	DDX1	100	97.838	Capra_hircus
ENSG00000079785	DDX1	100	73.423	ENSTSYG00000037396	-	98	73.525	Carlito_syrichta
ENSG00000079785	DDX1	100	98.243	ENSTSYG00000002477	-	100	98.243	Carlito_syrichta
ENSG00000079785	DDX1	97	77.554	ENSCAPG00000008906	-	93	77.554	Cavia_aperea
ENSG00000079785	DDX1	68	96.414	ENSCPOG00000032467	-	100	96.414	Cavia_porcellus
ENSG00000079785	DDX1	98	94.946	ENSCPOG00000009816	-	96	94.946	Cavia_porcellus
ENSG00000079785	DDX1	100	99.189	ENSCCAG00000030085	DDX1	100	99.189	Cebus_capucinus
ENSG00000079785	DDX1	100	99.595	ENSCATG00000033924	DDX1	100	99.595	Cercocebus_atys
ENSG00000079785	DDX1	100	97.297	ENSCLAG00000005434	DDX1	100	97.297	Chinchilla_lanigera
ENSG00000079785	DDX1	100	99.595	ENSCSAG00000007883	DDX1	100	99.595	Chlorocebus_sabaeus
ENSG00000079785	DDX1	73	97.625	ENSCHOG00000002171	DDX1	74	97.625	Choloepus_hoffmanni
ENSG00000079785	DDX1	99	87.364	ENSCPBG00000013330	DDX1	99	92.271	Chrysemys_picta_bellii
ENSG00000079785	DDX1	100	65.684	ENSCING00000001176	-	100	65.508	Ciona_intestinalis
ENSG00000079785	DDX1	98	60.302	ENSCSAVG00000003028	-	99	60.440	Ciona_savignyi
ENSG00000079785	DDX1	100	99.545	ENSCANG00000031530	DDX1	100	99.545	Colobus_angolensis_palliatus
ENSG00000079785	DDX1	100	97.703	ENSCGRG00001013025	Ddx1	100	97.703	Cricetulus_griseus_chok1gshd
ENSG00000079785	DDX1	100	97.703	ENSCGRG00000000676	Ddx1	100	97.703	Cricetulus_griseus_crigri
ENSG00000079785	DDX1	100	83.915	ENSCSEG00000002630	ddx1	100	84.469	Cynoglossus_semilaevis
ENSG00000079785	DDX1	100	83.612	ENSCVAG00000020927	ddx1	100	84.332	Cyprinodon_variegatus
ENSG00000079785	DDX1	100	84.865	ENSDARG00000032117	ddx1	100	84.877	Danio_rerio
ENSG00000079785	DDX1	100	97.568	ENSDNOG00000006905	DDX1	100	97.568	Dasypus_novemcinctus
ENSG00000079785	DDX1	100	97.973	ENSDORG00000012847	Ddx1	100	97.973	Dipodomys_ordii
ENSG00000079785	DDX1	98	59.234	FBgn0015075	Ddx1	99	59.781	Drosophila_melanogaster
ENSG00000079785	DDX1	99	89.587	ENSETEG00000014259	DDX1	100	86.351	Echinops_telfairi
ENSG00000079785	DDX1	72	77.754	ENSEBUG00000009800	-	99	77.754	Eptatretus_burgeri
ENSG00000079785	DDX1	100	97.297	ENSEASG00005009335	DDX1	92	97.297	Equus_asinus_asinus
ENSG00000079785	DDX1	99	97.099	ENSECAG00000016396	DDX1	100	97.274	Equus_caballus
ENSG00000079785	DDX1	89	93.597	ENSEEUG00000001606	DDX1	89	93.597	Erinaceus_europaeus
ENSG00000079785	DDX1	100	82.591	ENSELUG00000006743	ddx1	100	82.591	Esox_lucius
ENSG00000079785	DDX1	100	98.108	ENSFCAG00000004680	DDX1	100	98.108	Felis_catus
ENSG00000079785	DDX1	100	92.297	ENSFALG00000008696	DDX1	100	92.297	Ficedula_albicollis
ENSG00000079785	DDX1	100	97.162	ENSFDAG00000021305	DDX1	100	97.162	Fukomys_damarensis
ENSG00000079785	DDX1	100	83.378	ENSFHEG00000008444	ddx1	100	83.378	Fundulus_heteroclitus
ENSG00000079785	DDX1	100	81.427	ENSGMOG00000011300	ddx1	100	81.427	Gadus_morhua
ENSG00000079785	DDX1	100	93.378	ENSGALG00000016461	DDX1	100	93.378	Gallus_gallus
ENSG00000079785	DDX1	100	83.649	ENSGAFG00000004706	ddx1	100	83.649	Gambusia_affinis
ENSG00000079785	DDX1	100	82.432	ENSGACG00000011162	ddx1	100	82.432	Gasterosteus_aculeatus
ENSG00000079785	DDX1	100	93.378	ENSGAGG00000021020	DDX1	100	93.378	Gopherus_agassizii
ENSG00000079785	DDX1	100	100.000	ENSGGOG00000012482	DDX1	100	100.000	Gorilla_gorilla
ENSG00000079785	DDX1	100	84.459	ENSHBUG00000014069	ddx1	100	84.459	Haplochromis_burtoni
ENSG00000079785	DDX1	100	97.703	ENSHGLG00000000801	DDX1	100	97.703	Heterocephalus_glaber_female
ENSG00000079785	DDX1	99	97.684	ENSHGLG00100000711	DDX1	100	97.684	Heterocephalus_glaber_male
ENSG00000079785	DDX1	100	83.919	ENSHCOG00000011492	ddx1	96	83.919	Hippocampus_comes
ENSG00000079785	DDX1	100	83.108	ENSIPUG00000003494	ddx1	100	83.108	Ictalurus_punctatus
ENSG00000079785	DDX1	99	98.229	ENSSTOG00000003977	DDX1	100	98.229	Ictidomys_tridecemlineatus
ENSG00000079785	DDX1	99	92.824	ENSJJAG00000013315	Ddx1	100	92.824	Jaculus_jaculus
ENSG00000079785	DDX1	100	85.811	ENSKMAG00000011340	ddx1	100	85.811	Kryptolebias_marmoratus
ENSG00000079785	DDX1	100	78.604	ENSLBEG00000008692	ddx1	100	78.604	Labrus_bergylta
ENSG00000079785	DDX1	100	87.568	ENSLACG00000010529	DDX1	100	87.568	Latimeria_chalumnae
ENSG00000079785	DDX1	100	86.863	ENSLOCG00000016473	ddx1	100	86.863	Lepisosteus_oculatus
ENSG00000079785	DDX1	99	96.608	ENSLAFG00000002213	DDX1	99	96.608	Loxodonta_africana
ENSG00000079785	DDX1	100	99.595	ENSMFAG00000033987	DDX1	100	99.595	Macaca_fascicularis
ENSG00000079785	DDX1	100	99.595	ENSMMUG00000023437	DDX1	100	99.595	Macaca_mulatta
ENSG00000079785	DDX1	100	99.595	ENSMNEG00000029189	DDX1	100	99.595	Macaca_nemestrina
ENSG00000079785	DDX1	100	99.459	ENSMLEG00000030787	DDX1	100	99.459	Mandrillus_leucophaeus
ENSG00000079785	DDX1	100	84.865	ENSMAMG00000015916	ddx1	100	84.865	Mastacembelus_armatus
ENSG00000079785	DDX1	100	83.612	ENSMZEG00005015207	ddx1	100	83.612	Maylandia_zebra
ENSG00000079785	DDX1	99	89.160	ENSMGAG00000014025	DDX1	100	89.160	Meleagris_gallopavo
ENSG00000079785	DDX1	64	98.182	ENSMAUG00000016156	Ddx1	100	98.182	Mesocricetus_auratus
ENSG00000079785	DDX1	100	98.514	ENSMICG00000001023	DDX1	100	98.514	Microcebus_murinus
ENSG00000079785	DDX1	100	97.703	ENSMOCG00000000257	Ddx1	100	97.703	Microtus_ochrogaster
ENSG00000079785	DDX1	99	83.053	ENSMMOG00000015397	ddx1	99	83.053	Mola_mola
ENSG00000079785	DDX1	99	95.251	ENSMODG00000010275	DDX1	99	95.251	Monodelphis_domestica
ENSG00000079785	DDX1	100	84.459	ENSMALG00000016409	ddx1	100	84.459	Monopterus_albus
ENSG00000079785	DDX1	100	97.838	MGP_CAROLIEiJ_G0017622	Ddx1	100	97.838	Mus_caroli
ENSG00000079785	DDX1	100	97.568	ENSMUSG00000037149	Ddx1	100	97.568	Mus_musculus
ENSG00000079785	DDX1	100	97.838	MGP_PahariEiJ_G0029378	Ddx1	100	97.838	Mus_pahari
ENSG00000079785	DDX1	100	97.568	MGP_SPRETEiJ_G0018464	Ddx1	100	97.568	Mus_spretus
ENSG00000079785	DDX1	100	97.973	ENSMPUG00000013606	DDX1	100	97.973	Mustela_putorius_furo
ENSG00000079785	DDX1	99	97.147	ENSMLUG00000003027	DDX1	98	97.147	Myotis_lucifugus
ENSG00000079785	DDX1	99	98.093	ENSNGAG00000015783	Ddx1	100	98.093	Nannospalax_galili
ENSG00000079785	DDX1	88	80.274	ENSNBRG00000020677	ddx1	95	80.274	Neolamprologus_brichardi
ENSG00000079785	DDX1	100	99.865	ENSNLEG00000014417	DDX1	100	99.865	Nomascus_leucogenys
ENSG00000079785	DDX1	99	93.712	ENSMEUG00000008254	DDX1	99	92.886	Notamacropus_eugenii
ENSG00000079785	DDX1	92	83.616	ENSOPRG00000004290	DDX1	100	70.135	Ochotona_princeps
ENSG00000079785	DDX1	100	97.432	ENSODEG00000000569	DDX1	100	97.432	Octodon_degus
ENSG00000079785	DDX1	100	85.155	ENSONIG00000000513	ddx1	100	85.155	Oreochromis_niloticus
ENSG00000079785	DDX1	85	92.652	ENSOANG00000005450	DDX1	99	92.652	Ornithorhynchus_anatinus
ENSG00000079785	DDX1	100	97.973	ENSOCUG00000007010	DDX1	100	97.973	Oryctolagus_cuniculus
ENSG00000079785	DDX1	100	84.865	ENSORLG00000016709	ddx1	100	84.865	Oryzias_latipes
ENSG00000079785	DDX1	99	84.605	ENSORLG00020003290	ddx1	100	84.605	Oryzias_latipes_hni
ENSG00000079785	DDX1	100	84.459	ENSORLG00015022438	ddx1	100	84.459	Oryzias_latipes_hsok
ENSG00000079785	DDX1	100	80.000	ENSOMEG00000017620	ddx1	100	78.514	Oryzias_melastigma
ENSG00000079785	DDX1	99	98.098	ENSOGAG00000008730	DDX1	100	98.098	Otolemur_garnettii
ENSG00000079785	DDX1	99	97.554	ENSOARG00000016369	DDX1	100	97.554	Ovis_aries
ENSG00000079785	DDX1	100	99.865	ENSPPAG00000027432	DDX1	100	99.865	Pan_paniscus
ENSG00000079785	DDX1	100	98.108	ENSPPRG00000020556	DDX1	100	98.108	Panthera_pardus
ENSG00000079785	DDX1	100	98.243	ENSPTIG00000008267	DDX1	100	98.243	Panthera_tigris_altaica
ENSG00000079785	DDX1	100	99.865	ENSPTRG00000011670	DDX1	100	99.865	Pan_troglodytes
ENSG00000079785	DDX1	100	99.459	ENSPANG00000025185	DDX1	100	99.459	Papio_anubis
ENSG00000079785	DDX1	100	83.919	ENSPKIG00000012466	ddx1	100	84.060	Paramormyrops_kingsleyae
ENSG00000079785	DDX1	54	91.067	ENSPSIG00000012292	DDX1	100	91.067	Pelodiscus_sinensis
ENSG00000079785	DDX1	100	82.162	ENSPMGG00000000782	ddx1	100	80.676	Periophthalmus_magnuspinnatus
ENSG00000079785	DDX1	100	97.432	ENSPEMG00000016389	Ddx1	100	97.432	Peromyscus_maniculatus_bairdii
ENSG00000079785	DDX1	99	79.620	ENSPMAG00000009118	-	100	79.620	Petromyzon_marinus
ENSG00000079785	DDX1	100	95.676	ENSPCIG00000010941	DDX1	100	95.676	Phascolarctos_cinereus
ENSG00000079785	DDX1	97	82.271	ENSPFOG00000006873	-	100	82.271	Poecilia_formosa
ENSG00000079785	DDX1	100	83.784	ENSPFOG00000011921	ddx1	100	83.784	Poecilia_formosa
ENSG00000079785	DDX1	100	83.514	ENSPLAG00000005939	ddx1	100	83.514	Poecilia_latipinna
ENSG00000079785	DDX1	100	84.054	ENSPMEG00000011140	ddx1	100	84.054	Poecilia_mexicana
ENSG00000079785	DDX1	100	83.649	ENSPREG00000011751	ddx1	100	83.649	Poecilia_reticulata
ENSG00000079785	DDX1	100	100.000	ENSPPYG00000012638	DDX1	100	100.000	Pongo_abelii
ENSG00000079785	DDX1	97	87.127	ENSPCAG00000001491	DDX1	100	83.784	Procavia_capensis
ENSG00000079785	DDX1	99	96.185	ENSPCOG00000028185	DDX1	99	96.185	Propithecus_coquereli
ENSG00000079785	DDX1	100	97.162	ENSPVAG00000013618	DDX1	100	97.162	Pteropus_vampyrus
ENSG00000079785	DDX1	100	84.459	ENSPNYG00000013839	ddx1	100	84.459	Pundamilia_nyererei
ENSG00000079785	DDX1	99	83.384	ENSPNAG00000017033	ddx1	97	83.511	Pygocentrus_nattereri
ENSG00000079785	DDX1	100	97.703	ENSRNOG00000006652	Ddx1	100	97.703	Rattus_norvegicus
ENSG00000079785	DDX1	100	98.243	ENSRBIG00000041664	DDX1	100	98.560	Rhinopithecus_bieti
ENSG00000079785	DDX1	100	99.054	ENSRROG00000031167	DDX1	100	99.054	Rhinopithecus_roxellana
ENSG00000079785	DDX1	100	99.324	ENSSBOG00000027577	DDX1	100	99.324	Saimiri_boliviensis_boliviensis
ENSG00000079785	DDX1	99	89.755	ENSSHAG00000009363	DDX1	99	86.703	Sarcophilus_harrisii
ENSG00000079785	DDX1	100	83.243	ENSSFOG00015014476	ddx1	100	83.243	Scleropages_formosus
ENSG00000079785	DDX1	100	82.973	ENSSMAG00000010094	ddx1	100	82.973	Scophthalmus_maximus
ENSG00000079785	DDX1	100	84.459	ENSSDUG00000012334	ddx1	100	84.459	Seriola_dumerili
ENSG00000079785	DDX1	100	84.054	ENSSLDG00000025345	ddx1	100	84.054	Seriola_lalandi_dorsalis
ENSG00000079785	DDX1	99	85.831	ENSSARG00000004536	DDX1	92	96.535	Sorex_araneus
ENSG00000079785	DDX1	100	91.081	ENSSPUG00000018835	DDX1	100	91.081	Sphenodon_punctatus
ENSG00000079785	DDX1	100	79.459	ENSSPAG00000023554	ddx1	100	79.459	Stegastes_partitus
ENSG00000079785	DDX1	100	97.568	ENSSSCG00000008619	DDX1	100	97.568	Sus_scrofa
ENSG00000079785	DDX1	100	92.297	ENSTGUG00000013096	DDX1	100	92.297	Taeniopygia_guttata
ENSG00000079785	DDX1	99	83.740	ENSTRUG00000015765	ddx1	99	83.740	Takifugu_rubripes
ENSG00000079785	DDX1	100	84.189	ENSTNIG00000016309	ddx1	100	84.189	Tetraodon_nigroviridis
ENSG00000079785	DDX1	99	93.324	ENSTBEG00000008454	DDX1	100	93.324	Tupaia_belangeri
ENSG00000079785	DDX1	100	96.351	ENSTTRG00000005081	DDX1	100	96.351	Tursiops_truncatus
ENSG00000079785	DDX1	69	87.033	ENSUAMG00000017375	DDX1	92	87.033	Ursus_americanus
ENSG00000079785	DDX1	99	97.956	ENSUMAG00000023450	DDX1	100	97.956	Ursus_maritimus
ENSG00000079785	DDX1	85	98.077	ENSVPAG00000007764	DDX1	85	98.077	Vicugna_pacos
ENSG00000079785	DDX1	99	97.687	ENSVVUG00000013085	DDX1	96	97.687	Vulpes_vulpes
ENSG00000079785	DDX1	100	90.270	ENSXETG00000017825	ddx1	100	90.270	Xenopus_tropicalis
ENSG00000079785	DDX1	100	80.991	ENSXCOG00000007082	ddx1	100	80.991	Xiphophorus_couchianus
ENSG00000079785	DDX1	100	83.514	ENSXMAG00000004555	ddx1	100	83.514	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	7689221.	NAS	Process
GO:0002735	positive regulation of myeloid dendritic cell cytokine production	-	IEA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	19058135.	IDA	Function
GO:0003712	transcription coregulator activity	19058135.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003724	RNA helicase activity	7689221.	TAS	Function
GO:0003725	double-stranded RNA binding	-	IEA	Function
GO:0004518	nuclease activity	18710941.	IDA	Function
GO:0004527	exonuclease activity	-	IEA	Function
GO:0005515	protein binding	11598190.12183465.18335541.18710941.19058135.28040436.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	19058135.24608264.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	24608264.24965446.	IDA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006302	double-strand break repair	18710941.	IDA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	24870230.	IMP	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006446	regulation of translational initiation	7689221.	NAS	Process
GO:0007275	multicellular organism development	7689221.	IEP	Process
GO:0008026	ATP-dependent helicase activity	12183465.	IDA	Function
GO:0008143	poly(A) binding	12183465.	IDA	Function
GO:0010494	cytoplasmic stress granule	18335541.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0032508	DNA duplex unwinding	18710941.	IDA	Process
GO:0033677	DNA/RNA helicase activity	18710941.	IDA	Function
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	ISS	Process
GO:0043330	response to exogenous dsRNA	-	IEA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:0071920	cleavage body	11598190.	IDA	Component
GO:0072669	tRNA-splicing ligase complex	21311021.24870230.	IDA	Component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	18710941.	IDA	Process
GO:1903506	regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1903608	protein localization to cytoplasmic stress granule	24965446.	IMP	Process
GO:1990904	ribonucleoprotein complex	18809582.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19398953	DDX1 is required for testicular tumorigenesis, partially through the transcriptional activation of 12p stem cell genes.	Oncogene	2009 May 28	Tanaka K	doi: 10.1038/onc.2009.89
20499159	DEAD box 1: a novel and independent prognostic marker for early recurrence in breast cancer.	Breast Cancer Res Treat	2011 May	Germain DR	doi: 10.1007/s10549-010-0943-7
28040436	FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.	Int J Biochem Cell Biol	2017 Mar	Akter KA	doi: 10.1016/j.biocel.2016.12.013
29869821	DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.	Cancer Sci	2018 Aug	Tanaka K	doi: 10.1111/cas.13661

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	15618263	Missense_Mutation	rs146515867	R400T	0.42
BLCA	chr2	15605975	Missense_Mutation	novel	E217D	0.46	DEAD
BLCA	chr2	15606173	Silent	rs201850199	F242F	0.41
BLCA	chr2	15602601	Missense_Mutation	novel	G121W	0.25
BLCA	chr2	15621107	Missense_Mutation	novel	N480D	0.27
BLCA	chr2	15628840	Splice_Site	novel	X625_splice	0.43
BLCA	chr2	15613283	Missense_Mutation	NA	G339A	0.22
BLCA	chr2	15603876	Missense_Mutation	novel	D180H	0.09
BLCA	chr2	15623580	Missense_Mutation	novel	G531V	0.26
BRCA	chr2	15618232	Nonsense_Mutation	NA	Q390*	0.17
BRCA	chr2	15630778	Missense_Mutation	novel	G699R	0.11
BRCA	chr2	15603249	Missense_Mutation	NA	S150F	0.34
BRCA	chr2	15621102	Missense_Mutation	NA	G478A	0.2
CESC	chr2	15603836	Silent	novel	G166G	0.13
CESC	chr2	15629651	Missense_Mutation	NA	R642K	0.36
CESC	chr2	15602591	Missense_Mutation	novel	K117N	0.45
CESC	chr2	15606233	Silent	novel	P262P	0.18
CESC	chr2	15630985	3'UTR	novel		0.33
COAD	chr2	15629688	Silent	rs371305987	N654N	0.41
COAD	chr2	15631075	3'UTR	novel		0.48
COAD	chr2	15618258	Frame_Shift_Del	novel	*R400Dfs4**	0.32
COAD	chr2	15628515	Missense_Mutation	NA	Y586C	0.1
COAD	chr2	15597450	Missense_Mutation	novel	T80A	0.09
COAD	chr2	15631020	3'UTR	novel		0.35
COAD	chr2	15620275	Missense_Mutation	NA	F425S	0.34
COAD	chr2	15628823	Missense_Mutation	NA	A620V	0.37
COAD	chr2	15630916	3'UTR	novel		0.39
COAD	chr2	15602627	Missense_Mutation	NA	M129I	0.2
COAD	chr2	15613228	Missense_Mutation	NA	L321I	0.13	DEAD
ESCA	chr2	15595158	Missense_Mutation	novel	M10I	0.14
GBM	chr2	15602568	Missense_Mutation	novel	C110S	0.08
GBM	chr2	15607185	Missense_Mutation	novel	Q276H	0.09	DEAD
GBM	chr2	15630030	Missense_Mutation	novel	S671F	0.61
HNSC	chr2	15618263	Missense_Mutation	rs146515867	R400T	0.14
HNSC	chr2	15597414	Silent	novel	L68L	0.45
HNSC	chr2	15620291	Frame_Shift_Ins	novel	*L431Ffs23**	0.26
HNSC	chr2	15628496	Missense_Mutation	novel	D580Y	0.23
HNSC	chr2	15618221	Missense_Mutation	novel	R386K	0.24
KIRC	chr2	15618234	Missense_Mutation	NA	Q390H	0.22
KIRP	chr2	15595493	Silent	NA	L24L	0.06
LAML	chr2	15631004	3'UTR	novel		0.25
LIHC	chr2	15628683	Missense_Mutation	NA	R602Q	0.41
LIHC	chr2	15596745	Silent	rs766867235	T48T	0.45
LIHC	chr2	15618186	Silent	novel	G374G	0.4
LIHC	chr2	15597459	Missense_Mutation	novel	T83P	0.38
LUAD	chr2	15595156	Missense_Mutation	novel	M10L	0.05
LUAD	chr2	15607185	Missense_Mutation	novel	Q276H	0.34	DEAD
LUAD	chr2	15620362	Missense_Mutation	NA	R454I	0.23
LUAD	chr2	15613257	Silent	novel	R330R	0.29
LUAD	chr2	15613258	Missense_Mutation	novel	D331Y	0.29	DEAD
LUAD	chr2	15620241	Missense_Mutation	NA	D414Y	0.2
LUAD	chr2	15628656	Missense_Mutation	rs774565569	P593H	0.43
LUAD	chr2	15628676	Missense_Mutation	rs753361392	V600I	0.25
LUAD	chr2	15627095	Missense_Mutation	novel	H546D	0.13
LUAD	chr2	15618263	Missense_Mutation	rs146515867	R400T	0.08
LUAD	chr2	15602592	Nonsense_Mutation	NA	E118*	0.35
LUSC	chr2	15630084	Missense_Mutation	novel	T689I	0.3
LUSC	chr2	15617311	Missense_Mutation	NA	S362C	0.42
LUSC	chr2	15597435	Frame_Shift_Del	novel	*G77Efs12**	0.25
LUSC	chr2	15620299	Missense_Mutation	NA	G433V	0.2
LUSC	chr2	15630043	Silent	NA	P675P	0.28
LUSC	chr2	15627082	Silent	NA	S541S	0.46
LUSC	chr2	15623521	Missense_Mutation	novel	I511M	0.09
LUSC	chr2	15606253	Missense_Mutation	NA	S269L	0.17	DEAD
LUSC	chr2	15630774	Splice_Site	NA	X698_splice	0.49
LUSC	chr2	15620326	Missense_Mutation	NA	H442L	0.17
LUSC	chr2	15630062	Missense_Mutation	novel	D682Y	0.14
LUSC	chr2	15606216	Missense_Mutation	rs753510952	A257S	0.23	DEAD
MESO	chr2	15630802	Missense_Mutation	novel	I707V	0.29
MESO	chr2	15595142	Splice_Region	novel		0.2
OV	chr2	15618186	Silent	novel	G374G	0.09
OV	chr2	15630979	3'UTR	novel		0.47
OV	chr2	15630981	3'UTR	novel		0.16
OV	chr2	15620259	Missense_Mutation	NA	E420K	0.18
OV	chr2	15613256	Missense_Mutation	NA	R330Q	0.24	DEAD
PRAD	chr2	15630063	Missense_Mutation	novel	D682G	0.24
PRAD	chr2	15607281	Silent	novel	Q308Q	0.45
PRAD	chr2	15630043	Silent	rs762937956	P675P	0.14
READ	chr2	15631070	3'UTR	novel		0.33
READ	chr2	15602619	Nonsense_Mutation	NA	G127*	0.22
SARC	chr2	15629609	Missense_Mutation	novel	Y628S	0.28
SKCM	chr2	15630861	Silent	NA	F726F	0.63
SKCM	chr2	15595164	Silent	NA	E12E	0.4
SKCM	chr2	15618228	Frame_Shift_Del	novel	*N389Rfs14**	0.04
SKCM	chr2	15629611	Missense_Mutation	NA	H629D	0.3
SKCM	chr2	15621101	Missense_Mutation	NA	G478S	0.1
SKCM	chr2	15623462	Silent	NA	L492L	0.33
SKCM	chr2	15628814	Missense_Mutation	NA	S617F	0.21
SKCM	chr2	15628814	Missense_Mutation	NA	S617F	0.55
SKCM	chr2	15623503	Silent	NA	K505K	0.49
SKCM	chr2	15599693	Missense_Mutation	rs11550370	P95L	0.34
STAD	chr2	15620258	Silent	rs541970738	S419S	0.28
STAD	chr2	15628683	Missense_Mutation	NA	R602Q	0.37
STAD	chr2	15607217	Missense_Mutation	rs746176610	P287L	0.3	DEAD
STAD	chr2	15623440	Missense_Mutation	novel	M484I	0.12
STAD	chr2	15630089	Missense_Mutation	novel	G691S	0.4
STAD	chr2	15629650	Missense_Mutation	NA	R642G	0.05
STAD	chr2	15627062	Frame_Shift_Del	novel	*G537Dfs30**	0.22
STAD	chr2	15629669	Missense_Mutation	NA	G648V	0.09
STAD	chr2	15630882	Silent	NA	P733P	0.3
STAD	chr2	15602550	Missense_Mutation	NA	I104V	0.45
STAD	chr2	15602623	Missense_Mutation	NA	L128S	0.24
STAD	chr2	15603227	Missense_Mutation	NA	G143R	0.09
STAD	chr2	15605972	Silent	NA	F216F	0.17
TGCT	chr2	15591747	5'UTR	novel		0.54
THCA	chr2	15620354	Nonsense_Mutation	novel	*T452Lfs3**	0.1
UCEC	chr2	15607287	Missense_Mutation	novel	K310N	0.06	DEAD
UCEC	chr2	15620241	Missense_Mutation	NA	D414N	0.29
UCEC	chr2	15596747	Missense_Mutation	NA	G49E	0.22
UCEC	chr2	15607198	Missense_Mutation	novel	K281E	0.26	DEAD
UCEC	chr2	15630852	Missense_Mutation	novel	Q723H	0.11
UCEC	chr2	15606173	Silent	rs201850199	F242F	0.31
UCEC	chr2	15620258	Silent	rs541970738	S419S	0.47
UCEC	chr2	15631025	3'UTR	novel		0.41
UCEC	chr2	15605961	Missense_Mutation	novel	G213S	0.57	DEAD
UCEC	chr2	15620332	Missense_Mutation	novel	V444A	0.1
UCEC	chr2	15617313	Nonsense_Mutation	novel	Q363*	0.39
UCEC	chr2	15591729	5'UTR	novel		0.43
UCEC	chr2	15629605	Missense_Mutation	NA	W627R	0.44
UCEC	chr2	15620241	Missense_Mutation	NA	D414N	0.21
UCEC	chr2	15591901	5'UTR	novel		0.31
UCEC	chr2	15603252	Missense_Mutation	NA	T151I	0.45
UCEC	chr2	15605955	Missense_Mutation	novel	D211Y	0.43	DEAD
UCEC	chr2	15627095	Missense_Mutation	novel	H546N	0.38
UCEC	chr2	15597434	Frame_Shift_Ins	novel	*G77Rfs6**	0.27
UCEC	chr2	15623542	Missense_Mutation	novel	D518E	0.4
UCEC	chr2	15620358	Missense_Mutation	rs763944785	D453N	0.44
UCEC	chr2	15591939	Silent	novel	A2A	0.39
UCEC	chr2	15630988	3'UTR	novel		0.29
UCEC	chr2	15631058	3'UTR	novel		0.5
UCEC	chr2	15603854	Missense_Mutation	novel	K172N	0.3
UCEC	chr2	15607291	Missense_Mutation	novel	Y312N	0.31	DEAD
UCEC	chr2	15607292	Missense_Mutation	novel	Y312C	0.35	DEAD
UCEC	chr2	15630822	Silent	novel	Q713Q	0.32
UCEC	chr2	15623428	Splice_Site	novel	X483_splice	0.38
UCEC	chr2	15597434	Silent	novel	G74G	0.37
UCEC	chr2	15617282	Silent	rs767850626	D352D	0.21
UCEC	chr2	15595526	Missense_Mutation	novel	L35F	0.12
UCEC	chr2	15620264	Missense_Mutation	novel	K421N	0.22
UCEC	chr2	15627095	Missense_Mutation	novel	H546N	0.13
UCEC	chr2	15595505	Silent	novel	I28I	0.33
UCEC	chr2	15603241	Silent	rs745537483	V147V	0.35
UCEC	chr2	15631007	3'UTR	novel		0.33
UCEC	chr2	15604470	Silent	NA	L196L	0.3
UCEC	chr2	15631097	3'UTR	novel		0.67
UCEC	chr2	15597434	Frame_Shift_Ins	novel	*G77Rfs6**	0.51
UCEC	chr2	15591901	5'UTR	novel		0.36
UCEC	chr2	15607311	Splice_Region	novel	L318L	0.5
UCEC	chr2	15597376	Missense_Mutation	novel	A55V	0.36
UCEC	chr2	15630029	Missense_Mutation	novel	S671A	0.45
UCEC	chr2	15620231	Silent	novel	L410L	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2305	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0539	0.20634
OV	DEL	0.1434	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0297	0.18809

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0012	Kaplan-Meier Survival Analysis
HNSC	0.006	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
LUSC	0.0045	Kaplan-Meier Survival Analysis
PAAD	0.016	Kaplan-Meier Survival Analysis
BLCA	0.0011	Kaplan-Meier Survival Analysis
CESC	0.0093	Kaplan-Meier Survival Analysis
READ	0.038	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.0099	Kaplan-Meier Survival Analysis
GBM	0.0091	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.003	Kaplan-Meier Survival Analysis
OV	0.017	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742