EuRBPDB

Description

Ensembl ID: ENSG00000080603 (Gene tree)
Gene ID: 10847
Gene Symbol: SRCAP
Alias: KIAA0309|EAF1|SWR1|DOMO1
Full Name: Snf2 related CREBBP activator protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 43,201 bases
Position: chr16:30,698,209-30,741,409
Accession: 16974
RBP type: canonical RBP
Summary: This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000483329	ResIII	PF04851.15	0.00022	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21673954	Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.	PLoS One	2011	Iwai A	doi: 10.1371/journal.pone.0020718

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000411466	SRCAP-203	836	-	ENSP00000405186	100 (aa)	-	C9J4U4
ENST00000395059	SRCAP-202	9126	-	ENSP00000378499	2971 (aa)	-	A0A0A0MS59
ENST00000262518	SRCAP-201	11754	-	ENSP00000262518	3230 (aa)	-	Q6ZRS2
ENST00000474008	SRCAP-204	730	-	-	- (aa)	-	-
ENST00000483083	SRCAP-205	5937	-	ENSP00000483329	1610 (aa)	-	A0A087X0E3

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000080603	rs8058578	16	30714927	A	Systemic lupus erythematosus	28714469	[1.06-1.16]	1.11	EFO_0002690
ENSG00000080603	rs8058578	16	30714927	T	Multiple myeloma	27363682	[NR]	1.1	EFO_0001378
ENSG00000080603	rs113715277	16	30701667	T	Pulse pressure	30578418	[0.14-0.26] mmHg increase	0.2026	EFO_0005763

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000080603	SRCAP	59	93.220	ENSSTOG00000020765	-	99	90.074	Ictidomys_tridecemlineatus
ENSG00000080603	SRCAP	100	90.000	MGP_CAROLIEiJ_G0030507	-	100	88.712	Mus_caroli
ENSG00000080603	SRCAP	100	71.000	ENSNGAG00000022162	-	99	85.177	Nannospalax_galili

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000812	Swr1 complex	21873635.	IBA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003713	transcription coactivator activity	10347196.	TAS	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0004402	histone acetyltransferase activity	10347196.	TAS	Function
GO:0005515	protein binding	10702287.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	10702287.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006357	regulation of transcription by RNA polymerase II	10347196.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016458	gene silencing	21873635.	IBA	Process
GO:0016573	histone acetylation	-	IEA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0032991	protein-containing complex	14966270.	IDA	Component
GO:0042393	histone binding	21873635.	IBA	Function
GO:0043044	ATP-dependent chromatin remodeling	21873635.	IBA	Process
GO:0043486	histone exchange	21873635.	IBA	Process
GO:0048471	perinuclear region of cytoplasm	10702287.	IDA	Component
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process