EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000081177 (Gene tree)
Gene ID: 55218
Gene Symbol: EXD2
Alias: FLJ10738|C14orf114|EXDL2
Full Name: exonuclease 3'-5' domain containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 52,544 bases
Position: chr14:69,191,477-69,244,020
Accession: 20217
RBP type: canonical RBP
Summary: EXD2 (Exonuclease 3'-5' Domain Containing 2) is a Protein Coding gene. Diseases associated with EXD2 include Atrial Heart Septal Defect. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5' exonuclease activity. An important paralog of this gene is EXD3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000313140	DNA_pol_A_exo1	PF01612.20	1.1e-16	1	1
ENSP00000387331	DNA_pol_A_exo1	PF01612.20	1.1e-16	1	1
ENSP00000386632	DNA_pol_A_exo1	PF01612.20	2e-13	1	1
ENSP00000386762	DNA_pol_A_exo1	PF01612.20	2e-13	1	1
ENSP00000386839	DNA_pol_A_exo1	PF01612.20	2e-13	1	1
ENSP00000386915	DNA_pol_A_exo1	PF01612.20	2e-13	1	1
ENSP00000409089	DNA_pol_A_exo1	PF01612.20	4.7e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409949	EXD2-206	2688	-	ENSP00000386632	496 (aa)	-	Q9NVH0
ENST00000413191	EXD2-207	1143	-	ENSP00000409089	114 (aa)	-	C9JLF4
ENST00000492815	EXD2-212	3243	-	-	- (aa)	-	-
ENST00000312994	EXD2-201	5107	-	ENSP00000313140	621 (aa)	-	Q9NVH0
ENST00000409018	EXD2-203	3252	-	ENSP00000387331	621 (aa)	-	Q9NVH0
ENST00000409675	EXD2-205	2828	XM_005267817	ENSP00000386762	496 (aa)	XP_005267874	Q9NVH0
ENST00000409014	EXD2-202	3404	-	ENSP00000386915	496 (aa)	-	Q9NVH0
ENST00000465286	EXD2-209	678	-	-	- (aa)	-	-
ENST00000494629	EXD2-213	493	-	-	- (aa)	-	-
ENST00000409242	EXD2-204	2496	XM_011536908	ENSP00000386839	496 (aa)	XP_011535210	Q9NVH0
ENST00000489133	EXD2-211	521	-	-	- (aa)	-	-
ENST00000461908	EXD2-208	579	-	-	- (aa)	-	-
ENST00000487724	EXD2-210	544	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000081177's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000081177	Parkinson Disease	5.752E-5	17052657
ENSG00000081177	Parkinson Disease	2.750898E-5	17052657

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000081177	rs4899292	14	69237335	A	Neuroticism	29255261	z score decrease	5.41	EFO_0007660
ENSG00000081177	rs6573878	14	69235611	T	Intelligence (MTAG)	29326435	[0.014-0.028] unit increase	0.021243362	EFO_0004337
ENSG00000081177	rs1043254	14	69241524	A	Cognitive performance	30038396	[0.013-0.026] unit decrease	0.0197	EFO_0008354
ENSG00000081177	rs4899292	14	69237335	A	Feeling fed-up	29500382	z score decrease	5.61	EFO_0009588
ENSG00000081177	rs2102923	14	69195388	A	Feeling hurt	29500382	z score decrease	5.77	EFO_0009599
ENSG00000081177	rs4902704	14	69236871	G	Depressed affect	29942085	[0.0089-0.0182] unit decrease	0.01353	EFO_0003761\|EFO_0004247
ENSG00000081177	rs4902704	14	69236871	C	Neurociticism	29500382	z score increase	5.97	EFO_0007660
ENSG00000081177	rs4899292	14	69237335	?	Neuroticism	30595370			EFO_0007660

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000081177's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000081177	EXD2	100	61.554	ENSAPOG00000004053	exd2	100	54.755	Acanthochromis_polyacanthus
ENSG00000081177	EXD2	100	91.935	ENSAMEG00000014467	EXD2	100	89.263	Ailuropoda_melanoleuca
ENSG00000081177	EXD2	100	60.479	ENSACIG00000012036	exd2	100	54.446	Amphilophus_citrinellus
ENSG00000081177	EXD2	100	61.355	ENSAOCG00000008005	exd2	100	54.281	Amphiprion_ocellaris
ENSG00000081177	EXD2	100	61.600	ENSAPEG00000006784	exd2	100	54.869	Amphiprion_percula
ENSG00000081177	EXD2	100	61.155	ENSATEG00000019834	exd2	100	55.470	Anabas_testudineus
ENSG00000081177	EXD2	100	74.044	ENSAPLG00000003322	EXD2	99	73.783	Anas_platyrhynchos
ENSG00000081177	EXD2	99	68.410	ENSACAG00000005306	EXD2	99	64.640	Anolis_carolinensis
ENSG00000081177	EXD2	100	96.976	ENSANAG00000024026	EXD2	100	96.618	Aotus_nancymaae
ENSG00000081177	EXD2	100	59.681	ENSACLG00000000445	exd2	100	54.025	Astatotilapia_calliptera
ENSG00000081177	EXD2	100	60.355	ENSAMXG00000043700	exd2	100	54.255	Astyanax_mexicanus
ENSG00000081177	EXD2	100	94.737	ENSBTAG00000010052	EXD2	99	89.793	Bos_taurus
ENSG00000081177	EXD2	100	97.581	ENSCJAG00000014987	EXD2	100	97.424	Callithrix_jacchus
ENSG00000081177	EXD2	100	95.614	ENSCAFG00000016557	EXD2	100	89.904	Canis_familiaris
ENSG00000081177	EXD2	100	95.614	ENSCAFG00020005886	EXD2	100	89.904	Canis_lupus_dingo
ENSG00000081177	EXD2	100	93.145	ENSCHIG00000021919	EXD2	99	90.177	Capra_hircus
ENSG00000081177	EXD2	100	92.105	ENSTSYG00000002206	EXD2	100	87.440	Carlito_syrichta
ENSG00000081177	EXD2	100	89.474	ENSCAPG00000011298	EXD2	100	86.196	Cavia_aperea
ENSG00000081177	EXD2	100	89.474	ENSCPOG00000010018	EXD2	100	86.196	Cavia_porcellus
ENSG00000081177	EXD2	100	97.782	ENSCCAG00000032107	EXD2	100	96.779	Cebus_capucinus
ENSG00000081177	EXD2	100	97.984	ENSCATG00000030404	EXD2	100	97.585	Cercocebus_atys
ENSG00000081177	EXD2	100	92.982	ENSCLAG00000005648	EXD2	99	87.948	Chinchilla_lanigera
ENSG00000081177	EXD2	100	98.246	ENSCSAG00000013084	EXD2	100	95.133	Chlorocebus_sabaeus
ENSG00000081177	EXD2	100	76.316	ENSCPBG00000021585	EXD2	100	71.268	Chrysemys_picta_bellii
ENSG00000081177	EXD2	100	45.614	ENSCING00000016481	-	87	44.717	Ciona_intestinalis
ENSG00000081177	EXD2	100	98.589	ENSCANG00000036359	EXD2	100	98.229	Colobus_angolensis_palliatus
ENSG00000081177	EXD2	100	88.596	ENSCGRG00001022081	Exd2	100	82.569	Cricetulus_griseus_chok1gshd
ENSG00000081177	EXD2	100	88.596	ENSCGRG00000010700	Exd2	100	81.903	Cricetulus_griseus_crigri
ENSG00000081177	EXD2	100	59.363	ENSCSEG00000009761	exd2	74	58.453	Cynoglossus_semilaevis
ENSG00000081177	EXD2	100	60.878	ENSCVAG00000016150	exd2	94	55.070	Cyprinodon_variegatus
ENSG00000081177	EXD2	100	61.323	ENSDARG00000016117	exd2	100	55.276	Danio_rerio
ENSG00000081177	EXD2	99	89.718	ENSDNOG00000046970	EXD2	99	88.245	Dasypus_novemcinctus
ENSG00000081177	EXD2	100	90.927	ENSDORG00000015087	Exd2	100	86.551	Dipodomys_ordii
ENSG00000081177	EXD2	100	42.105	FBgn0037901	CG6744	84	40.734	Drosophila_melanogaster
ENSG00000081177	EXD2	100	89.474	ENSETEG00000013803	EXD2	100	87.298	Echinops_telfairi
ENSG00000081177	EXD2	100	41.007	ENSEBUG00000013264	exd2	98	43.686	Eptatretus_burgeri
ENSG00000081177	EXD2	100	94.737	ENSEASG00005016586	EXD2	100	90.545	Equus_asinus_asinus
ENSG00000081177	EXD2	100	94.737	ENSECAG00000019103	EXD2	85	90.600	Equus_caballus
ENSG00000081177	EXD2	100	94.737	ENSEEUG00000007011	EXD2	100	90.927	Erinaceus_europaeus
ENSG00000081177	EXD2	100	60.558	ENSELUG00000022318	exd2	99	55.924	Esox_lucius
ENSG00000081177	EXD2	100	92.982	ENSFCAG00000014350	EXD2	99	89.482	Felis_catus
ENSG00000081177	EXD2	100	74.798	ENSFALG00000005050	EXD2	100	69.342	Ficedula_albicollis
ENSG00000081177	EXD2	100	92.982	ENSFDAG00000009719	EXD2	100	87.118	Fukomys_damarensis
ENSG00000081177	EXD2	100	61.078	ENSFHEG00000010499	exd2	100	54.405	Fundulus_heteroclitus
ENSG00000081177	EXD2	100	55.652	ENSGMOG00000005937	exd2	83	56.331	Gadus_morhua
ENSG00000081177	EXD2	100	75.050	ENSGALG00000009456	EXD2	100	69.048	Gallus_gallus
ENSG00000081177	EXD2	100	60.878	ENSGAFG00000017943	exd2	100	55.046	Gambusia_affinis
ENSG00000081177	EXD2	100	61.200	ENSGACG00000005358	exd2	99	61.284	Gasterosteus_aculeatus
ENSG00000081177	EXD2	100	75.439	ENSGAGG00000023895	EXD2	100	70.144	Gopherus_agassizii
ENSG00000081177	EXD2	100	100.000	ENSGGOG00000001258	EXD2	100	99.195	Gorilla_gorilla
ENSG00000081177	EXD2	100	60.479	ENSHBUG00000019366	exd2	100	54.644	Haplochromis_burtoni
ENSG00000081177	EXD2	100	93.860	ENSHGLG00000008157	EXD2	100	85.238	Heterocephalus_glaber_female
ENSG00000081177	EXD2	100	93.860	ENSHGLG00100003936	EXD2	100	85.510	Heterocephalus_glaber_male
ENSG00000081177	EXD2	100	57.905	ENSHCOG00000018905	exd2	100	52.978	Hippocampus_comes
ENSG00000081177	EXD2	100	61.477	ENSIPUG00000000560	exd2	100	55.760	Ictalurus_punctatus
ENSG00000081177	EXD2	100	94.737	ENSSTOG00000000175	EXD2	100	89.873	Ictidomys_tridecemlineatus
ENSG00000081177	EXD2	100	90.351	ENSJJAG00000021417	-	100	83.945	Jaculus_jaculus
ENSG00000081177	EXD2	100	61.952	ENSKMAG00000016785	exd2	100	55.810	Kryptolebias_marmoratus
ENSG00000081177	EXD2	100	60.636	ENSLBEG00000028400	exd2	100	54.448	Labrus_bergylta
ENSG00000081177	EXD2	99	64.431	ENSLACG00000018609	EXD2	100	59.840	Latimeria_chalumnae
ENSG00000081177	EXD2	100	65.531	ENSLOCG00000013376	exd2	100	59.776	Lepisosteus_oculatus
ENSG00000081177	EXD2	100	92.982	ENSLAFG00000018508	EXD2	100	92.157	Loxodonta_africana
ENSG00000081177	EXD2	100	98.246	ENSMFAG00000041413	EXD2	100	97.424	Macaca_fascicularis
ENSG00000081177	EXD2	100	98.246	ENSMMUG00000020514	EXD2	100	97.262	Macaca_mulatta
ENSG00000081177	EXD2	100	98.246	ENSMNEG00000038561	EXD2	100	97.585	Macaca_nemestrina
ENSG00000081177	EXD2	100	98.246	ENSMLEG00000044130	EXD2	100	97.746	Mandrillus_leucophaeus
ENSG00000081177	EXD2	100	61.477	ENSMAMG00000000136	exd2	100	54.407	Mastacembelus_armatus
ENSG00000081177	EXD2	100	60.080	ENSMZEG00005011274	exd2	100	53.917	Maylandia_zebra
ENSG00000081177	EXD2	100	74.849	ENSMGAG00000011874	EXD2	100	69.021	Meleagris_gallopavo
ENSG00000081177	EXD2	100	82.540	ENSMICG00000009606	EXD2	100	82.540	Microcebus_murinus
ENSG00000081177	EXD2	100	87.719	ENSMOCG00000019497	Exd2	100	82.575	Microtus_ochrogaster
ENSG00000081177	EXD2	100	60.878	ENSMMOG00000000384	exd2	100	54.992	Mola_mola
ENSG00000081177	EXD2	100	71.930	ENSMODG00000010228	EXD2	99	68.647	Monodelphis_domestica
ENSG00000081177	EXD2	100	60.878	ENSMALG00000022371	exd2	100	54.405	Monopterus_albus
ENSG00000081177	EXD2	100	88.596	ENSMUSG00000032705	Exd2	100	88.393	Mus_musculus
ENSG00000081177	EXD2	100	86.842	MGP_PahariEiJ_G0029652	Exd2	100	82.759	Mus_pahari
ENSG00000081177	EXD2	100	89.474	MGP_SPRETEiJ_G0018741	Exd2	100	83.282	Mus_spretus
ENSG00000081177	EXD2	100	93.860	ENSMPUG00000007368	EXD2	100	89.600	Mustela_putorius_furo
ENSG00000081177	EXD2	100	92.540	ENSMLUG00000011848	EXD2	100	92.549	Myotis_lucifugus
ENSG00000081177	EXD2	100	60.479	ENSNBRG00000004615	exd2	100	55.608	Neolamprologus_brichardi
ENSG00000081177	EXD2	100	99.123	ENSNLEG00000001275	EXD2	100	99.034	Nomascus_leucogenys
ENSG00000081177	EXD2	100	92.105	ENSOPRG00000000078	EXD2	100	90.927	Ochotona_princeps
ENSG00000081177	EXD2	100	88.596	ENSODEG00000014245	EXD2	100	85.852	Octodon_degus
ENSG00000081177	EXD2	100	60.080	ENSONIG00000000385	exd2	100	54.083	Oreochromis_niloticus
ENSG00000081177	EXD2	100	78.070	ENSOANG00000012621	EXD2	100	64.591	Ornithorhynchus_anatinus
ENSG00000081177	EXD2	100	89.516	ENSOCUG00000006626	EXD2	100	85.093	Oryctolagus_cuniculus
ENSG00000081177	EXD2	100	59.281	ENSORLG00000019790	exd2	100	54.193	Oryzias_latipes
ENSG00000081177	EXD2	100	59.281	ENSORLG00020004434	exd2	100	54.348	Oryzias_latipes_hni
ENSG00000081177	EXD2	100	59.082	ENSORLG00015001003	exd2	100	53.882	Oryzias_latipes_hsok
ENSG00000081177	EXD2	100	59.400	ENSOMEG00000023552	exd2	100	55.226	Oryzias_melastigma
ENSG00000081177	EXD2	100	97.368	ENSOGAG00000012059	EXD2	99	90.545	Otolemur_garnettii
ENSG00000081177	EXD2	100	93.347	ENSOARG00000021181	EXD2	99	90.177	Ovis_aries
ENSG00000081177	EXD2	100	99.395	ENSPPAG00000042293	EXD2	100	99.356	Pan_paniscus
ENSG00000081177	EXD2	100	92.339	ENSPPRG00000002946	EXD2	99	89.320	Panthera_pardus
ENSG00000081177	EXD2	100	92.339	ENSPTIG00000018876	EXD2	99	89.320	Panthera_tigris_altaica
ENSG00000081177	EXD2	100	100.000	ENSPTRG00000006480	EXD2	100	99.597	Pan_troglodytes
ENSG00000081177	EXD2	100	98.246	ENSPANG00000025013	EXD2	100	97.746	Papio_anubis
ENSG00000081177	EXD2	98	59.796	ENSPKIG00000007907	exd2	99	53.492	Paramormyrops_kingsleyae
ENSG00000081177	EXD2	100	74.561	ENSPSIG00000010111	EXD2	100	67.737	Pelodiscus_sinensis
ENSG00000081177	EXD2	100	59.082	ENSPMGG00000021023	exd2	100	54.673	Periophthalmus_magnuspinnatus
ENSG00000081177	EXD2	100	77.193	ENSPCIG00000012390	-	100	76.948	Phascolarctos_cinereus
ENSG00000081177	EXD2	100	60.558	ENSPFOG00000004789	exd2	100	54.702	Poecilia_formosa
ENSG00000081177	EXD2	100	60.757	ENSPLAG00000020798	exd2	100	54.167	Poecilia_latipinna
ENSG00000081177	EXD2	100	60.558	ENSPMEG00000006063	exd2	100	54.116	Poecilia_mexicana
ENSG00000081177	EXD2	100	61.155	ENSPREG00000008479	exd2	100	55.854	Poecilia_reticulata
ENSG00000081177	EXD2	100	100.000	ENSPPYG00000005937	EXD2	100	98.712	Pongo_abelii
ENSG00000081177	EXD2	100	94.737	ENSPCAG00000007242	EXD2	100	91.129	Procavia_capensis
ENSG00000081177	EXD2	100	97.368	ENSPCOG00000028702	EXD2	99	93.408	Propithecus_coquereli
ENSG00000081177	EXD2	100	92.982	ENSPVAG00000016901	EXD2	100	92.742	Pteropus_vampyrus
ENSG00000081177	EXD2	100	60.479	ENSPNYG00000010343	exd2	100	54.644	Pundamilia_nyererei
ENSG00000081177	EXD2	100	59.562	ENSPNAG00000009476	exd2	100	54.984	Pygocentrus_nattereri
ENSG00000081177	EXD2	100	89.474	ENSRNOG00000027707	Exd2	100	83.513	Rattus_norvegicus
ENSG00000081177	EXD2	100	98.387	ENSRBIG00000031108	EXD2	100	98.068	Rhinopithecus_bieti
ENSG00000081177	EXD2	100	98.387	ENSRROG00000033249	EXD2	100	98.068	Rhinopithecus_roxellana
ENSG00000081177	EXD2	100	97.581	ENSSBOG00000035171	EXD2	100	97.424	Saimiri_boliviensis_boliviensis
ENSG00000081177	EXD2	100	78.947	ENSSHAG00000005008	EXD2	100	72.960	Sarcophilus_harrisii
ENSG00000081177	EXD2	100	61.277	ENSSFOG00015006470	exd2	100	56.162	Scleropages_formosus
ENSG00000081177	EXD2	100	57.018	ENSSMAG00000009321	exd2	100	52.000	Scophthalmus_maximus
ENSG00000081177	EXD2	100	62.550	ENSSDUG00000001321	exd2	100	58.373	Seriola_dumerili
ENSG00000081177	EXD2	100	62.475	ENSSLDG00000011348	exd2	100	56.250	Seriola_lalandi_dorsalis
ENSG00000081177	EXD2	100	90.351	ENSSARG00000012747	EXD2	87	89.516	Sorex_araneus
ENSG00000081177	EXD2	100	72.379	ENSSPUG00000002120	EXD2	100	72.353	Sphenodon_punctatus
ENSG00000081177	EXD2	100	62.475	ENSSPAG00000002512	exd2	100	55.385	Stegastes_partitus
ENSG00000081177	EXD2	100	92.982	ENSSSCG00000002305	EXD2	95	91.569	Sus_scrofa
ENSG00000081177	EXD2	100	75.605	ENSTGUG00000011469	EXD2	100	70.305	Taeniopygia_guttata
ENSG00000081177	EXD2	100	60.359	ENSTRUG00000003672	exd2	100	56.329	Takifugu_rubripes
ENSG00000081177	EXD2	100	58.835	ENSTNIG00000003046	exd2	100	58.228	Tetraodon_nigroviridis
ENSG00000081177	EXD2	100	92.742	ENSTTRG00000013954	EXD2	100	92.742	Tursiops_truncatus
ENSG00000081177	EXD2	100	93.860	ENSUAMG00000010774	EXD2	100	89.936	Ursus_americanus
ENSG00000081177	EXD2	100	93.860	ENSUMAG00000010083	EXD2	99	89.920	Ursus_maritimus
ENSG00000081177	EXD2	85	92.689	ENSVPAG00000005658	EXD2	100	92.689	Vicugna_pacos
ENSG00000081177	EXD2	100	95.614	ENSVVUG00000003704	EXD2	99	90.385	Vulpes_vulpes
ENSG00000081177	EXD2	100	68.421	ENSXETG00000017930	exd2	99	61.611	Xenopus_tropicalis
ENSG00000081177	EXD2	100	52.632	ENSXCOG00000014338	exd2	67	50.790	Xiphophorus_couchianus
ENSG00000081177	EXD2	100	61.078	ENSXMAG00000003565	exd2	100	54.938	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	26807646.	IDA	Process
GO:0000729	DNA double-strand break processing	26807646.	IDA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	26807646.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006302	double-strand break repair	26807646.	IDA	Process
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	26807646.	IDA	Function
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	26807646.	IDA	Function
GO:0008852	exodeoxyribonuclease I activity	-	IEA	Function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	26807646.	IDA	Process