EuRBPDB

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000082516 (Gene tree)
Gene ID: 25929
Gene Symbol: GEMIN5
Alias: N
Full Name: gem nuclear organelle associated protein 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 50,801 bases
Position: chr5:154,887,416-154,938,216
Accession: 20043
RBP type: non-canonical RBP
Summary: This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19377484	Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains.	Nat Struct Mol Biol	2009 May	Lau CK	doi: 10.1038/nsmb.1584
17381311	The SMN complex: an assembly machine for RNPs.	Cold Spring Harb Symp Quant Biol	2006	Battle DJ	-
23221641	Gemin5 promotes IRES interaction and translation control through its C-terminal region.	Nucleic Acids Res	2013 Jan	Pineiro D	doi: 10.1093/nar/gks1212
24598255	Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation.	Nucleic Acids Res	2014 May	Fernandez-Chamorro J	doi: 10.1093/nar/gku177
27507887	The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation.	Nucleic Acids Res	2016 Sep 30	Francisco-Velilla R	doi: 10.1093/nar/gkw702
26828962	A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.	Nat Struct Mol Biol	2016 Mar	So BR	doi: 10.1038/nsmb.3167
25898402	Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control.	Biomolecules	2015 Apr 17	Pineiro D	doi: 10.3390/biom5020528.
29771365	The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation.	Nucleic Acids Res	2018 Aug 21	Francisco-Velilla R	doi: 10.1093/nar/gky361.
29537490	Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.	FEBS Lett	2018 Apr	Jiang D	doi: 10.1002/1873-3468.13031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000285873	GEMIN5-201	5397	-	ENSP00000285873	1508 (aa)	-	Q8TEQ6
ENST00000522075	GEMIN5-202	573	-	-	- (aa)	-	-
ENST00000523355	GEMIN5-203	557	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000082516's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000082516	Respiratory Function Tests	5.60146183386526E-5	17903307
ENSG00000082516	Respiratory Function Tests	6.66326637042001E-5	17903307
ENSG00000082516	Cholesterol, HDL	3.15472351082073E-5	17903299
ENSG00000082516	Cholesterol, HDL	8.5299839548396E-5	17903299
ENSG00000082516	Sodium	8.0050000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000082516	rs188533234	5	154908369	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000082516's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000082516	GEMIN5	99	82.185	ENSMUSG00000037275	Gemin5	99	92.045	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000340	RNA 7-methylguanosine cap binding	19750007.27881600.27881601.	IDA	Function
GO:0000387	spliceosomal snRNP assembly	18984161.	IDA	Process
GO:0000387	spliceosomal snRNP assembly	11714716.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	11714716.	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	25911097.	IDA	Function
GO:0005515	protein binding	11714716.16739988.19750007.	IPI	Function
GO:0005654	nucleoplasm	11714716.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	11714716.	IDA	Component
GO:0005829	cytosol	18984161.19750007.20513430.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	-	IEA	Process
GO:0006417	regulation of translation	25911097.27507887.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016604	nuclear body	11714716.	IDA	Component
GO:0017069	snRNA binding	16857593.	IDA	Function
GO:0022625	cytosolic large ribosomal subunit	27507887.	IDA	Component
GO:0030619	U1 snRNA binding	19377484.19750007.27881600.	IDA	Function
GO:0030621	U4 snRNA binding	19377484.27881601.	IDA	Function
GO:0030622	U4atac snRNA binding	20513430.	IDA	Function
GO:0032797	SMN complex	18984161.20513430.	IDA	Component
GO:0034718	SMN-Gemin2 complex	19377484.	IDA	Component
GO:0034719	SMN-Sm protein complex	18984161.	IDA	Component
GO:0043022	ribosome binding	27507887.	IDA	Function
GO:0051170	import into nucleus	-	TAS	Process
GO:0065003	protein-containing complex assembly	11714716.	TAS	Process
GO:0097504	Gemini of coiled bodies	-	IEA	Component