EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000082898 (Gene tree)
Gene ID: 7514
Gene Symbol: XPO1
Alias: CRM1|CRM-1|emb
Full Name: exportin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 60,778 bases
Position: chr2:61,477,849-61,538,626
Accession: 12825
RBP type: canonical RBP
Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000384863	CRM1_C	PF08767.11	3.6e-133	1	1
ENSP00000385559	CRM1_C	PF08767.11	3.6e-133	1	1
ENSP00000385942	CRM1_C	PF08767.11	3.6e-133	1	1
ENSP00000384863	Xpo1	PF08389.12	2.5e-41	1	1
ENSP00000385559	Xpo1	PF08389.12	2.5e-41	1	1
ENSP00000385942	Xpo1	PF08389.12	2.5e-41	1	1
ENSP00000413853	Xpo1	PF08389.12	2.8e-14	1	1
ENSP00000406428	IBN_N	PF03810.19	1e-12	1	1
ENSP00000413853	IBN_N	PF03810.19	1.1e-12	1	1
ENSP00000384863	IBN_N	PF03810.19	1e-11	1	1
ENSP00000385559	IBN_N	PF03810.19	1e-11	1	1
ENSP00000385942	IBN_N	PF03810.19	1e-11	1	1
ENSP00000393484	IBN_N	PF03810.19	3.1e-09	1	1
ENSP00000408190	IBN_N	PF03810.19	1.2e-08	1	1
ENSP00000394951	IBN_N	PF03810.19	1.7e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18559344	Characterization of the molecular basis of group II intron RNA recognition by CRS1-CRM domains.	J Biol Chem	2008 Aug 22	Keren I	doi: 10.1074/jbc.M710488200
10400785	Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.	J Virol	1999 Aug	Boyle SM	-
19299463	The nuclear pore component Nup358 promotes transportin-dependent nuclear import.	J Cell Sci	2009 Apr 15	Hutten S	doi: 10.1242/jcs.040154
11911364	Both ran and importins have the ability to function as nuclear mRNA export factors.	RNA	2002 Feb	Yi R	-
11836381	Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.	J Virol	2002 Mar	Yi R	-
10766770	Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity.	J Biol Chem	2000 Apr 21	Askjaer P	-
14968132	Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.	EMBO Rep	2004 Mar	Bono F	-
19130553	Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression.	Eur J Immunol	2009 Jan	Chemnitz J	doi: 10.1002/eji.200838619.
18715912	Characterization of a CRM1-dependent nuclear export signal in the C terminus of herpes simplex virus type 1 tegument protein UL47.	J Virol	2008 Nov	Williams P	doi: 10.1128/JVI.01403-08
17921352	Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway.	Eukaryot Cell	2007 Dec	Hellman K	-
20237019	Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains.	Plant Physiol	2010 May	Rausin G	doi: 10.1104/pp.110.154740
28142187	Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe.	Mol Microbiol	2017 May	Satoh R	doi: 10.1111/mmi.13636
23471078	Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.	Nitric Oxide	2013 Apr 1	Bollmann F	doi: 10.1016/j.niox.2013.02.083
11333016	The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export.	RNA	2001 Mar	Segref A	-
11312326	Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.	J Virol	2001 May	Nappi F	-
10786834	PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation.	Cell	2000 Apr 14	Ohno M	-
14612415	A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.	Mol Cell Biol	2003 Dec	Hakata Y	-
22933280	Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.	J Virol	2012 Nov	Elinav H	doi: 10.1128/JVI.01970-12
20953181	Structural basis for cooperative RNA binding and export complex assembly by HIV Rev.	Nat Struct Mol Biol	2010 Nov	Daugherty MD	doi: 10.1038/nsmb.1902
24413662	p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.	Nucleic Acids Res	2014 Apr	Izumi H	doi: 10.1093/nar/gkt1365

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000443240	XPO1-209	565	-	ENSP00000406428	132 (aa)	-	C9J673
ENST00000436018	XPO1-207	318	-	ENSP00000390843	59 (aa)	-	C9JF49
ENST00000457483	XPO1-212	488	-	ENSP00000394951	94 (aa)	-	C9IZS4
ENST00000481073	XPO1-219	3706	-	-	- (aa)	-	-
ENST00000451765	XPO1-211	643	-	ENSP00000413853	179 (aa)	-	C9JKM9
ENST00000437159	XPO1-208	537	-	ENSP00000388927	72 (aa)	-	H7BZC5
ENST00000406957	XPO1-203	3479	-	ENSP00000385559	1071 (aa)	-	O14980
ENST00000469337	XPO1-216	568	-	-	- (aa)	-	-
ENST00000420673	XPO1-204	682	-	ENSP00000393484	100 (aa)	-	C9JV99
ENST00000494468	XPO1-223	562	-	-	- (aa)	-	-
ENST00000401558	XPO1-201	4915	XM_005264544	ENSP00000384863	1071 (aa)	XP_005264601	O14980
ENST00000449444	XPO1-210	579	-	ENSP00000406819	62 (aa)	-	C9IYM2
ENST00000475744	XPO1-217	249	-	-	- (aa)	-	-
ENST00000460037	XPO1-213	573	-	-	- (aa)	-	-
ENST00000404992	XPO1-202	4105	XM_024453125	ENSP00000385942	1071 (aa)	XP_024308893	O14980
ENST00000428210	XPO1-206	6776	-	ENSP00000407170	82 (aa)	-	F8WF71
ENST00000468259	XPO1-215	600	-	-	- (aa)	-	-
ENST00000489954	XPO1-221	583	-	-	- (aa)	-	-
ENST00000461407	XPO1-214	2676	-	-	- (aa)	-	-
ENST00000476585	XPO1-218	342	-	-	- (aa)	-	-
ENST00000492182	XPO1-222	827	-	-	- (aa)	-	-
ENST00000422552	XPO1-205	382	-	ENSP00000408190	95 (aa)	-	C9JQ02
ENST00000495003	XPO1-224	568	-	-	- (aa)	-	-
ENST00000481214	XPO1-220	720	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000082898's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03013	RNA transport	KEGG
hsa05164	Influenza A	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000082898	Cholesterol, HDL	6.46942529538563E-5	17903299
ENSG00000082898	Tuberculosis	5E-6	20694014

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000082898	rs11125883	2	61483438	?	Systolic blood pressure	30595370			EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000082898's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000082898	XPO1	100	95.612	ENSAPOG00000004984	-	100	95.612	Acanthochromis_polyacanthus
ENSG00000082898	XPO1	88	89.681	ENSAPOG00000002354	xpo1a	100	89.681	Acanthochromis_polyacanthus
ENSG00000082898	XPO1	100	100.000	ENSAMEG00000003460	XPO1	100	98.787	Ailuropoda_melanoleuca
ENSG00000082898	XPO1	88	92.128	ENSACIG00000010259	xpo1a	100	92.128	Amphilophus_citrinellus
ENSG00000082898	XPO1	88	95.851	ENSACIG00000010818	-	100	95.851	Amphilophus_citrinellus
ENSG00000082898	XPO1	100	95.612	ENSAOCG00000010121	-	100	95.612	Amphiprion_ocellaris
ENSG00000082898	XPO1	100	91.410	ENSAOCG00000018914	xpo1a	100	91.410	Amphiprion_ocellaris
ENSG00000082898	XPO1	100	95.612	ENSAPEG00000007038	-	100	95.612	Amphiprion_percula
ENSG00000082898	XPO1	91	91.864	ENSAPEG00000006583	xpo1a	99	91.864	Amphiprion_percula
ENSG00000082898	XPO1	100	91.036	ENSATEG00000020750	xpo1a	100	91.036	Anabas_testudineus
ENSG00000082898	XPO1	100	95.612	ENSATEG00000008816	-	100	95.612	Anabas_testudineus
ENSG00000082898	XPO1	100	99.441	ENSAPLG00000004008	XPO1	100	98.599	Anas_platyrhynchos
ENSG00000082898	XPO1	100	99.441	ENSACAG00000002501	XPO1	100	98.413	Anolis_carolinensis
ENSG00000082898	XPO1	100	100.000	ENSANAG00000020802	XPO1	100	100.000	Aotus_nancymaae
ENSG00000082898	XPO1	88	92.234	ENSACLG00000015669	xpo1a	100	92.234	Astatotilapia_calliptera
ENSG00000082898	XPO1	100	95.425	ENSACLG00000015192	-	100	95.425	Astatotilapia_calliptera
ENSG00000082898	XPO1	88	93.326	ENSAMXG00000003069	xpo1a	100	93.326	Astyanax_mexicanus
ENSG00000082898	XPO1	100	95.892	ENSAMXG00000012704	xpo1b	100	95.892	Astyanax_mexicanus
ENSG00000082898	XPO1	100	100.000	ENSBTAG00000013254	XPO1	100	98.880	Bos_taurus
ENSG00000082898	XPO1	99	51.479	WBGene00002078	xpo-1	99	51.479	Caenorhabditis_elegans
ENSG00000082898	XPO1	100	100.000	ENSCJAG00000008877	XPO1	100	100.000	Callithrix_jacchus
ENSG00000082898	XPO1	100	100.000	ENSCAFG00000003050	XPO1	100	98.880	Canis_familiaris
ENSG00000082898	XPO1	93	98.695	ENSCAFG00020026910	XPO1	99	98.695	Canis_lupus_dingo
ENSG00000082898	XPO1	100	100.000	ENSCHIG00000018132	XPO1	100	98.880	Capra_hircus
ENSG00000082898	XPO1	100	100.000	ENSTSYG00000004330	XPO1	100	98.880	Carlito_syrichta
ENSG00000082898	XPO1	53	93.972	ENSCAPG00000006454	-	100	93.972	Cavia_aperea
ENSG00000082898	XPO1	100	99.441	ENSCPOG00000034053	XPO1	100	97.386	Cavia_porcellus
ENSG00000082898	XPO1	100	100.000	ENSCCAG00000037445	XPO1	100	80.705	Cebus_capucinus
ENSG00000082898	XPO1	100	100.000	ENSCATG00000032674	XPO1	100	100.000	Cercocebus_atys
ENSG00000082898	XPO1	100	100.000	ENSCLAG00000012953	XPO1	100	98.599	Chinchilla_lanigera
ENSG00000082898	XPO1	100	100.000	ENSCSAG00000014606	XPO1	100	100.000	Chlorocebus_sabaeus
ENSG00000082898	XPO1	100	100.000	ENSCHOG00000012088	XPO1	83	99.481	Choloepus_hoffmanni
ENSG00000082898	XPO1	100	99.441	ENSCPBG00000026239	XPO1	100	98.506	Chrysemys_picta_bellii
ENSG00000082898	XPO1	100	80.819	ENSCING00000024562	-	100	80.819	Ciona_intestinalis
ENSG00000082898	XPO1	99	79.832	ENSCSAVG00000005965	-	99	79.832	Ciona_savignyi
ENSG00000082898	XPO1	100	100.000	ENSCANG00000028883	XPO1	100	100.000	Colobus_angolensis_palliatus
ENSG00000082898	XPO1	100	100.000	ENSCGRG00001000263	Xpo1	100	97.666	Cricetulus_griseus_chok1gshd
ENSG00000082898	XPO1	100	100.000	ENSCGRG00000001520	Xpo1	100	97.666	Cricetulus_griseus_crigri
ENSG00000082898	XPO1	88	94.681	ENSCSEG00000001693	XPO1	100	94.681	Cynoglossus_semilaevis
ENSG00000082898	XPO1	100	95.518	ENSCVAG00000016788	-	100	95.518	Cyprinodon_variegatus
ENSG00000082898	XPO1	100	90.663	ENSCVAG00000016558	xpo1a	100	90.663	Cyprinodon_variegatus
ENSG00000082898	XPO1	100	92.717	ENSDARG00000078041	xpo1a	100	94.892	Danio_rerio
ENSG00000082898	XPO1	100	96.265	ENSDARG00000063229	xpo1b	100	96.265	Danio_rerio
ENSG00000082898	XPO1	100	100.000	ENSDNOG00000005805	XPO1	100	98.786	Dasypus_novemcinctus
ENSG00000082898	XPO1	100	100.000	ENSDORG00000013050	Xpo1	100	95.857	Dipodomys_ordii
ENSG00000082898	XPO1	97	73.563	FBgn0020497	emb	99	70.853	Drosophila_melanogaster
ENSG00000082898	XPO1	100	100.000	ENSETEG00000018045	XPO1	94	97.970	Echinops_telfairi
ENSG00000082898	XPO1	90	79.046	ENSEBUG00000012580	-	100	87.500	Eptatretus_burgeri
ENSG00000082898	XPO1	100	100.000	ENSEASG00005007223	XPO1	100	98.880	Equus_asinus_asinus
ENSG00000082898	XPO1	100	100.000	ENSECAG00000024920	XPO1	100	98.880	Equus_caballus
ENSG00000082898	XPO1	100	99.441	ENSEEUG00000009479	XPO1	92	91.667	Erinaceus_europaeus
ENSG00000082898	XPO1	88	94.362	ENSELUG00000012707	xpo1a	100	94.362	Esox_lucius
ENSG00000082898	XPO1	87	92.184	ENSELUG00000014306	-	99	92.184	Esox_lucius
ENSG00000082898	XPO1	100	100.000	ENSFCAG00000002702	XPO1	100	98.880	Felis_catus
ENSG00000082898	XPO1	100	99.441	ENSFALG00000010989	XPO1	100	98.319	Ficedula_albicollis
ENSG00000082898	XPO1	100	98.000	ENSFDAG00000014716	XPO1	100	97.012	Fukomys_damarensis
ENSG00000082898	XPO1	100	93.000	ENSFHEG00000018933	-	97	82.508	Fundulus_heteroclitus
ENSG00000082898	XPO1	100	90.943	ENSFHEG00000002412	xpo1a	100	90.943	Fundulus_heteroclitus
ENSG00000082898	XPO1	100	94.000	ENSGMOG00000019063	-	100	89.636	Gadus_morhua
ENSG00000082898	XPO1	100	92.157	ENSGMOG00000004441	xpo1a	100	92.157	Gadus_morhua
ENSG00000082898	XPO1	100	99.441	ENSGALG00000029476	XPO1	100	98.599	Gallus_gallus
ENSG00000082898	XPO1	91	95.572	ENSGAFG00000003355	-	98	95.572	Gambusia_affinis
ENSG00000082898	XPO1	88	91.915	ENSGAFG00000004408	xpo1a	100	91.915	Gambusia_affinis
ENSG00000082898	XPO1	100	90.850	ENSGACG00000019736	xpo1a	100	90.850	Gasterosteus_aculeatus
ENSG00000082898	XPO1	100	95.331	ENSGACG00000002743	-	100	95.331	Gasterosteus_aculeatus
ENSG00000082898	XPO1	100	99.441	ENSGAGG00000017558	XPO1	100	98.413	Gopherus_agassizii
ENSG00000082898	XPO1	100	100.000	ENSGGOG00000034878	XPO1	100	100.000	Gorilla_gorilla
ENSG00000082898	XPO1	100	95.518	ENSHBUG00000020037	-	100	95.518	Haplochromis_burtoni
ENSG00000082898	XPO1	100	91.503	ENSHBUG00000007128	xpo1a	100	91.503	Haplochromis_burtoni
ENSG00000082898	XPO1	100	100.000	ENSHGLG00000003115	XPO1	100	98.506	Heterocephalus_glaber_female
ENSG00000082898	XPO1	100	100.000	ENSHGLG00100012227	XPO1	100	98.506	Heterocephalus_glaber_male
ENSG00000082898	XPO1	88	94.681	ENSHCOG00000006949	XPO1	100	94.681	Hippocampus_comes
ENSG00000082898	XPO1	100	95.892	ENSIPUG00000012891	Xpo1	100	95.892	Ictalurus_punctatus
ENSG00000082898	XPO1	100	93.371	ENSIPUG00000024394	XPO1	100	93.371	Ictalurus_punctatus
ENSG00000082898	XPO1	100	100.000	ENSSTOG00000016122	XPO1	100	98.880	Ictidomys_tridecemlineatus
ENSG00000082898	XPO1	100	100.000	ENSJJAG00000020468	Xpo1	100	98.599	Jaculus_jaculus
ENSG00000082898	XPO1	100	90.850	ENSKMAG00000004830	xpo1a	100	90.850	Kryptolebias_marmoratus
ENSG00000082898	XPO1	100	95.145	ENSKMAG00000016218	-	100	95.145	Kryptolebias_marmoratus
ENSG00000082898	XPO1	88	89.301	ENSLBEG00000002104	xpo1a	100	89.301	Labrus_bergylta
ENSG00000082898	XPO1	100	95.612	ENSLBEG00000005740	-	100	95.612	Labrus_bergylta
ENSG00000082898	XPO1	100	100.000	ENSLACG00000018213	XPO1	100	76.916	Latimeria_chalumnae
ENSG00000082898	XPO1	100	96.774	ENSLOCG00000016095	xpo1b	99	96.359	Lepisosteus_oculatus
ENSG00000082898	XPO1	100	100.000	ENSLAFG00000014553	XPO1	100	98.506	Loxodonta_africana
ENSG00000082898	XPO1	100	100.000	ENSMFAG00000038679	XPO1	100	100.000	Macaca_fascicularis
ENSG00000082898	XPO1	100	100.000	ENSMMUG00000006941	XPO1	100	100.000	Macaca_mulatta
ENSG00000082898	XPO1	100	100.000	ENSMNEG00000030909	XPO1	100	100.000	Macaca_nemestrina
ENSG00000082898	XPO1	100	100.000	ENSMLEG00000032004	XPO1	100	98.140	Mandrillus_leucophaeus
ENSG00000082898	XPO1	100	95.425	ENSMAMG00000010568	-	100	95.425	Mastacembelus_armatus
ENSG00000082898	XPO1	100	91.317	ENSMAMG00000023037	xpo1a	100	91.317	Mastacembelus_armatus
ENSG00000082898	XPO1	100	91.503	ENSMZEG00005005105	xpo1a	100	91.503	Maylandia_zebra
ENSG00000082898	XPO1	100	95.425	ENSMZEG00005018158	-	98	95.572	Maylandia_zebra
ENSG00000082898	XPO1	68	98.072	ENSMGAG00000001496	-	100	98.072	Meleagris_gallopavo
ENSG00000082898	XPO1	100	98.387	ENSMGAG00000001494	-	100	88.265	Meleagris_gallopavo
ENSG00000082898	XPO1	100	100.000	ENSMAUG00000006769	Xpo1	100	97.666	Mesocricetus_auratus
ENSG00000082898	XPO1	100	100.000	ENSMICG00000027770	XPO1	100	98.880	Microcebus_murinus
ENSG00000082898	XPO1	100	100.000	ENSMOCG00000012169	Xpo1	100	97.946	Microtus_ochrogaster
ENSG00000082898	XPO1	87	95.518	ENSMMOG00000008001	-	99	95.518	Mola_mola
ENSG00000082898	XPO1	88	92.021	ENSMMOG00000018767	xpo1a	100	92.021	Mola_mola
ENSG00000082898	XPO1	100	99.441	ENSMODG00000002831	XPO1	100	97.572	Monodelphis_domestica
ENSG00000082898	XPO1	100	95.145	ENSMALG00000007085	-	100	95.145	Monopterus_albus
ENSG00000082898	XPO1	88	90.967	ENSMALG00000008617	xpo1a	100	90.967	Monopterus_albus
ENSG00000082898	XPO1	100	100.000	MGP_CAROLIEiJ_G0016136	Xpo1	100	98.039	Mus_caroli
ENSG00000082898	XPO1	100	100.000	ENSMUSG00000020290	Xpo1	100	98.039	Mus_musculus
ENSG00000082898	XPO1	100	100.000	MGP_PahariEiJ_G0016754	Xpo1	100	97.946	Mus_pahari
ENSG00000082898	XPO1	100	100.000	MGP_SPRETEiJ_G0016979	Xpo1	100	98.039	Mus_spretus
ENSG00000082898	XPO1	100	100.000	ENSMPUG00000005560	XPO1	100	98.880	Mustela_putorius_furo
ENSG00000082898	XPO1	100	100.000	ENSMLUG00000010670	XPO1	100	98.786	Myotis_lucifugus
ENSG00000082898	XPO1	100	100.000	ENSNGAG00000022158	Xpo1	100	98.786	Nannospalax_galili
ENSG00000082898	XPO1	100	94.413	ENSNBRG00000012229	-	100	95.957	Neolamprologus_brichardi
ENSG00000082898	XPO1	100	91.503	ENSNBRG00000003776	xpo1a	100	91.503	Neolamprologus_brichardi
ENSG00000082898	XPO1	100	100.000	ENSNLEG00000009680	XPO1	100	96.087	Nomascus_leucogenys
ENSG00000082898	XPO1	97	91.954	ENSMEUG00000013277	-	63	100.000	Notamacropus_eugenii
ENSG00000082898	XPO1	100	93.184	ENSOPRG00000012615	XPO1	100	93.184	Ochotona_princeps
ENSG00000082898	XPO1	100	100.000	ENSODEG00000012632	XPO1	100	97.292	Octodon_degus
ENSG00000082898	XPO1	93	95.582	ENSONIG00000002969	-	99	95.582	Oreochromis_niloticus
ENSG00000082898	XPO1	100	89.385	ENSONIG00000000019	xpo1a	100	88.246	Oreochromis_niloticus
ENSG00000082898	XPO1	96	98.643	ENSOANG00000012417	XPO1	100	98.643	Ornithorhynchus_anatinus
ENSG00000082898	XPO1	100	100.000	ENSOCUG00000004986	XPO1	100	98.786	Oryctolagus_cuniculus
ENSG00000082898	XPO1	100	95.051	ENSORLG00000001642	-	99	95.051	Oryzias_latipes
ENSG00000082898	XPO1	100	90.289	ENSORLG00000001559	xpo1a	100	90.289	Oryzias_latipes
ENSG00000082898	XPO1	100	90.383	ENSORLG00020015852	xpo1a	100	90.383	Oryzias_latipes_hni
ENSG00000082898	XPO1	100	95.051	ENSORLG00020020577	-	99	95.051	Oryzias_latipes_hni
ENSG00000082898	XPO1	91	95.263	ENSORLG00015008640	-	98	95.263	Oryzias_latipes_hsok
ENSG00000082898	XPO1	100	90.383	ENSORLG00015015414	xpo1a	100	90.383	Oryzias_latipes_hsok
ENSG00000082898	XPO1	88	91.170	ENSOMEG00000007343	xpo1a	100	91.170	Oryzias_melastigma
ENSG00000082898	XPO1	100	95.145	ENSOMEG00000001384	-	100	95.426	Oryzias_melastigma
ENSG00000082898	XPO1	100	100.000	ENSOGAG00000000143	XPO1	100	95.251	Otolemur_garnettii
ENSG00000082898	XPO1	100	100.000	ENSOARG00000020174	XPO1	100	98.787	Ovis_aries
ENSG00000082898	XPO1	100	100.000	ENSPPAG00000029699	XPO1	100	99.907	Pan_paniscus
ENSG00000082898	XPO1	100	100.000	ENSPPRG00000024625	XPO1	100	98.880	Panthera_pardus
ENSG00000082898	XPO1	100	100.000	ENSPTIG00000012259	XPO1	100	98.880	Panthera_tigris_altaica
ENSG00000082898	XPO1	100	100.000	ENSPTRG00000011962	XPO1	100	99.907	Pan_troglodytes
ENSG00000082898	XPO1	100	100.000	ENSPANG00000006892	XPO1	100	100.000	Papio_anubis
ENSG00000082898	XPO1	100	93.931	ENSPKIG00000005688	XPO1	100	93.931	Paramormyrops_kingsleyae
ENSG00000082898	XPO1	100	98.387	ENSPKIG00000003545	xpo1b	100	96.495	Paramormyrops_kingsleyae
ENSG00000082898	XPO1	100	99.242	ENSPSIG00000014457	XPO1	100	98.451	Pelodiscus_sinensis
ENSG00000082898	XPO1	100	93.657	ENSPMGG00000010632	XPO1	100	93.657	Periophthalmus_magnuspinnatus
ENSG00000082898	XPO1	86	90.781	ENSPMGG00000019000	XPO1	100	90.781	Periophthalmus_magnuspinnatus
ENSG00000082898	XPO1	100	100.000	ENSPEMG00000010103	Xpo1	100	98.133	Peromyscus_maniculatus_bairdii
ENSG00000082898	XPO1	100	90.000	ENSPMAG00000001270	-	100	87.220	Petromyzon_marinus
ENSG00000082898	XPO1	100	90.526	ENSPMAG00000008887	-	100	90.119	Petromyzon_marinus
ENSG00000082898	XPO1	100	99.242	ENSPCIG00000027737	XPO1	100	98.226	Phascolarctos_cinereus
ENSG00000082898	XPO1	100	95.425	ENSPFOG00000013233	-	100	95.425	Poecilia_formosa
ENSG00000082898	XPO1	100	90.943	ENSPFOG00000001349	xpo1a	100	90.943	Poecilia_formosa
ENSG00000082898	XPO1	100	90.943	ENSPLAG00000000356	xpo1a	100	90.943	Poecilia_latipinna
ENSG00000082898	XPO1	100	95.425	ENSPLAG00000018279	-	100	95.425	Poecilia_latipinna
ENSG00000082898	XPO1	100	90.943	ENSPMEG00000003659	xpo1a	100	90.943	Poecilia_mexicana
ENSG00000082898	XPO1	100	95.154	ENSPMEG00000003904	-	100	95.154	Poecilia_mexicana
ENSG00000082898	XPO1	100	91.036	ENSPREG00000020796	xpo1a	100	91.036	Poecilia_reticulata
ENSG00000082898	XPO1	100	95.425	ENSPREG00000010135	-	100	95.425	Poecilia_reticulata
ENSG00000082898	XPO1	100	100.000	ENSPPYG00000012383	XPO1	100	96.545	Pongo_abelii
ENSG00000082898	XPO1	96	95.335	ENSPCAG00000006798	XPO1	100	95.335	Procavia_capensis
ENSG00000082898	XPO1	100	100.000	ENSPCOG00000023123	XPO1	100	98.880	Propithecus_coquereli
ENSG00000082898	XPO1	100	87.582	ENSPVAG00000002535	XPO1	100	87.582	Pteropus_vampyrus
ENSG00000082898	XPO1	53	88.298	ENSPNYG00000006874	-	100	88.298	Pundamilia_nyererei
ENSG00000082898	XPO1	100	91.503	ENSPNYG00000023463	xpo1a	100	91.503	Pundamilia_nyererei
ENSG00000082898	XPO1	100	95.892	ENSPNAG00000008916	xpo1b	100	95.892	Pygocentrus_nattereri
ENSG00000082898	XPO1	100	93.651	ENSPNAG00000014209	xpo1a	100	93.651	Pygocentrus_nattereri
ENSG00000082898	XPO1	100	100.000	ENSRNOG00000009935	Xpo1	100	97.852	Rattus_norvegicus
ENSG00000082898	XPO1	100	100.000	ENSRBIG00000029189	XPO1	100	91.620	Rhinopithecus_bieti
ENSG00000082898	XPO1	100	100.000	ENSRROG00000038442	XPO1	100	100.000	Rhinopithecus_roxellana
ENSG00000082898	XPO1	98	46.994	YGR218W	CRM1	99	46.994	Saccharomyces_cerevisiae
ENSG00000082898	XPO1	100	100.000	ENSSBOG00000034467	XPO1	100	96.545	Saimiri_boliviensis_boliviensis
ENSG00000082898	XPO1	100	99.441	ENSSHAG00000011230	XPO1	100	98.599	Sarcophilus_harrisii
ENSG00000082898	XPO1	100	98.387	ENSSFOG00015011598	xpo1b	100	96.359	Scleropages_formosus
ENSG00000082898	XPO1	100	95.705	ENSSFOG00015001881	XPO1	100	95.705	Scleropages_formosus
ENSG00000082898	XPO1	100	95.518	ENSSMAG00000015718	-	100	95.518	Scophthalmus_maximus
ENSG00000082898	XPO1	100	90.850	ENSSMAG00000021007	xpo1a	100	90.850	Scophthalmus_maximus
ENSG00000082898	XPO1	100	95.518	ENSSDUG00000017709	-	100	95.518	Seriola_dumerili
ENSG00000082898	XPO1	86	91.196	ENSSDUG00000000812	xpo1a	99	91.196	Seriola_dumerili
ENSG00000082898	XPO1	100	95.518	ENSSLDG00000019530	-	100	95.518	Seriola_lalandi_dorsalis
ENSG00000082898	XPO1	100	89.944	ENSSLDG00000017381	xpo1a	98	90.099	Seriola_lalandi_dorsalis
ENSG00000082898	XPO1	51	90.909	ENSSLDG00000017407	xpo1a	95	90.909	Seriola_lalandi_dorsalis
ENSG00000082898	XPO1	91	97.935	ENSSARG00000014000	-	91	97.935	Sorex_araneus
ENSG00000082898	XPO1	100	99.441	ENSSPUG00000009057	XPO1	100	98.150	Sphenodon_punctatus
ENSG00000082898	XPO1	100	91.223	ENSSPAG00000010307	xpo1a	100	91.223	Stegastes_partitus
ENSG00000082898	XPO1	100	95.425	ENSSPAG00000008738	-	100	95.425	Stegastes_partitus
ENSG00000082898	XPO1	100	100.000	ENSSSCG00000028228	XPO1	100	98.804	Sus_scrofa
ENSG00000082898	XPO1	100	98.387	ENSTGUG00000006512	XPO1	100	97.312	Taeniopygia_guttata
ENSG00000082898	XPO1	100	95.518	ENSTRUG00000005571	-	100	95.518	Takifugu_rubripes
ENSG00000082898	XPO1	99	91.284	ENSTRUG00000001415	xpo1a	100	91.284	Takifugu_rubripes
ENSG00000082898	XPO1	100	89.729	ENSTNIG00000003360	xpo1a	100	89.729	Tetraodon_nigroviridis
ENSG00000082898	XPO1	64	100.000	ENSTBEG00000014485	-	70	100.000	Tupaia_belangeri
ENSG00000082898	XPO1	100	100.000	ENSTTRG00000013369	XPO1	100	88.661	Tursiops_truncatus
ENSG00000082898	XPO1	100	100.000	ENSUAMG00000026512	XPO1	100	98.880	Ursus_americanus
ENSG00000082898	XPO1	100	100.000	ENSUMAG00000019859	XPO1	100	98.786	Ursus_maritimus
ENSG00000082898	XPO1	100	100.000	ENSVPAG00000011446	XPO1	100	94.917	Vicugna_pacos
ENSG00000082898	XPO1	100	100.000	ENSVVUG00000012009	XPO1	100	98.880	Vulpes_vulpes
ENSG00000082898	XPO1	100	100.000	ENSXETG00000002224	xpo1	100	97.106	Xenopus_tropicalis
ENSG00000082898	XPO1	78	96.164	ENSXCOG00000006625	-	97	96.164	Xiphophorus_couchianus
ENSG00000082898	XPO1	88	91.915	ENSXCOG00000011889	XPO1	100	91.915	Xiphophorus_couchianus
ENSG00000082898	XPO1	100	95.331	ENSXMAG00000007353	-	100	95.331	Xiphophorus_maculatus
ENSG00000082898	XPO1	100	91.130	ENSXMAG00000005790	xpo1a	100	91.130	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000054	ribosomal subunit export from nucleus	12724356.	IMP	Process
GO:0000055	ribosomal large subunit export from nucleus	21873635.	IBA	Process
GO:0000055	ribosomal large subunit export from nucleus	12773398.	IMP	Process
GO:0000056	ribosomal small subunit export from nucleus	21873635.	IBA	Process
GO:0000056	ribosomal small subunit export from nucleus	12773398.	IMP	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000776	kinetochore	17363900.	IDA	Component
GO:0003723	RNA binding	-	IEA	Function
GO:0005049	nuclear export signal receptor activity	21873635.	IBA	Function
GO:0005049	nuclear export signal receptor activity	12724356.12773398.	IMP	Function
GO:0005215	transporter activity	-	TAS	Function
GO:0005515	protein binding	10358091.10557333.11000203.11545741.12724356.15161933.16302269.16314522.16319068.17099693.17268548.18952844.19339969.19339972.19955415.20485264.20826784.20921223.21378169.22022502.22084111.22250199.22500989.22730302.23850451.24169621.25893289.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005635	nuclear envelope	9368044.	TAS	Component
GO:0005642	annulate lamellae	12210765.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	23782956.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23782956.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006611	protein export from nucleus	21378169.	IC	Process
GO:0006611	protein export from nucleus	22250199.	IDA	Process
GO:0006611	protein export from nucleus	12773398.22427340.	IMP	Process
GO:0006913	nucleocytoplasmic transport	11000203.	IMP	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	-	IEA	Function
GO:0010824	regulation of centrosome duplication	-	IEA	Process
GO:0015030	Cajal body	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0032991	protein-containing complex	10557333.	IDA	Component
GO:0034504	protein localization to nucleus	-	IEA	Process
GO:0042176	regulation of protein catabolic process	-	IEA	Process
GO:0042254	ribosome biogenesis	12724356.	IMP	Process
GO:0042493	response to drug	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043657	host cell	-	IEA	Component
GO:0046825	regulation of protein export from nucleus	21873635.	IBA	Process
GO:0051028	mRNA transport	-	IEA	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1990904	ribonucleoprotein complex	18809582.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26340096	Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.	PLoS One	2015 Sep 4	Tabe Y	doi: 10.1371/journal.pone.0137210
23950892	TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6.	PLoS One	2013 Aug 7	Ouyang S	doi: 10.1371/journal.pone.0069356
27693556	Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.	Cancer Lett	2016 Dec 28	Muqbil I	doi: 10.1016/j.canlet.2016.09.016
27533791	ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization.	Mol Endocrinol	2016 Oct	Wrobel K	-
20003838	Prognostic value of CRM1 in pancreas cancer.	Clin Invest Med	2009 Dec 1	Huang WY	-
24898882	Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma.	Oncol Rep	2014 Aug	van der Watt PJ	doi: 10.3892/or.2014.3231
26055813	Novel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancer.	J Ovarian Res	2015 Jun 10	Liu X	doi: 10.1186/s13048-015-0166-y.
19117056	The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.	Int J Cancer	2009 Apr 15	van der Watt PJ	doi: 10.1002/ijc.24146.
25996664	Novel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells.	Cancer Biol Ther	2015	Niu M	doi: 10.1080/15384047.2015.1047569
24018641	Knockdown of CRM1 inhibits the nuclear export of p27(Kip1) phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer.	Cancer Lett	2014 Feb 1	Wang Y	doi: 10.1016/j.canlet.2013.09.002
17616652	Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential.	Cancer Res	2007 Jul 1	Stauber RH	-
21683812	The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage.	Biochim Biophys Acta	2011 Jul	van der Watt PJ	doi: 10.1016/j.bbagrm.2011.05.017
24431073	XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer.	Mol Cancer Ther	2014 Mar	Cheng Y	doi: 10.1158/1535-7163.MCT-13-0416
27312238	A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.	Cell Mol Life Sci	2016 Dec	Garc??a-Santisteban I	-
28373767	Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer.	World J Gastroenterol	2017 Mar 21	Sun YQ	doi: 10.3748/wjg.v23.i11.2012.
27807105	-	-	-	-	-
27013579	Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.	Oncotarget	2016 Apr 26	Ortega JF	doi: 10.18632/oncotarget.8248.
27649553	Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer.	Clin Cancer Res	2017 Mar 15	Chen Y	doi: 10.1158/1078-0432.CCR-16-1333
29729696	Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer.	Cell Mol Biol (Noisy-le-grand)	2018 Apr 30	zda S	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	61502296	Missense_Mutation	novel	V106I	0.07
BLCA	chr2	61492125	Silent	rs371003962	F599F	0.3
BLCA	chr2	61493100	Intron	novel		0.55
BLCA	chr2	61488246	Silent	novel	L744L	0.46
BLCA	chr2	61485794	Missense_Mutation	novel	E828K	0.09
BLCA	chr2	61478927	Missense_Mutation	NA	E1037Q	0.53
BLCA	chr2	61499748	Missense_Mutation	novel	Q185H	0.49
BLCA	chr2	61494058	Missense_Mutation	NA	E361K	0.1
BLCA	chr2	61494068	Silent	novel	V357V	0.12
BLCA	chr2	61483023	Missense_Mutation	NA	Q916E	0.28
BLCA	chr2	61497002	Silent	NA	L255L	0.67
BLCA	chr2	61492463	Missense_Mutation	novel	E529K	0.14
BRCA	chr2	61492337	Missense_Mutation	NA	E571K	0.21
BRCA	chr2	61482437	Missense_Mutation	NA	I972T	0.34
BRCA	chr2	61492735	Missense_Mutation	novel	H466Q	0.04
BRCA	chr2	61488659	Missense_Mutation	NA	R712K	0.23
BRCA	chr2	61492337	Missense_Mutation	NA	E571K	0.35
BRCA	chr2	61481221	Missense_Mutation	NA	F1011L	0.24
BRCA	chr2	61498892	Silent	NA	Q204Q	0.25
BRCA	chr2	61488587	Splice_Site	novel	X736_splice	0.22
BRCA	chr2	61490721	Missense_Mutation	NA	T648I	0.1
BRCA	chr2	61492423	Nonsense_Mutation	NA	S542*	0.4
BRCA	chr2	61492967	Missense_Mutation	NA	F444L	0.2
BRCA	chr2	61492625	Missense_Mutation	NA	S503C	0.25
BRCA	chr2	61493006	Missense_Mutation	NA	L431F	0.45
BRCA	chr2	61533858	Missense_Mutation	rs769916613	R14C	0.23
BRCA	chr2	61484080	Missense_Mutation	NA	R845I	0.11
BRCA	chr2	61488232	Missense_Mutation	NA	R749Q	0.27
BRCA	chr2	61492596	Missense_Mutation	NA	E513K	0.14
BRCA	chr2	61492807	Intron	novel		0.34
BRCA	chr2	61494154	Intron	novel		0.17
BRCA	chr2	61493979	Missense_Mutation	NA	S387C	0.13
BRCA	chr2	61482994	Silent	rs761859739	H925H	0.19
BRCA	chr2	61538107	5'UTR	novel		0.1
CESC	chr2	61494049	Missense_Mutation	novel	E364K	0.13
CESC	chr2	61478740	3'UTR	novel		0.33
CESC	chr2	61478840	Missense_Mutation	novel	P1066A	0.21
CESC	chr2	61482393	Missense_Mutation	NA	P987S	0.21
CESC	chr2	61538134	5'UTR	novel		0.11
CESC	chr2	61493071	Intron	novel		0.24
CESC	chr2	61493072	Intron	novel		0.42
CESC	chr2	61484082	Missense_Mutation	NA	H844Q	0.51
CESC	chr2	61484047	Missense_Mutation	rs768499033	N856S	0.31
COAD	chr2	61488232	Missense_Mutation	NA	R749Q	0.41
COAD	chr2	61482475	Silent	NA	S959S	0.11
COAD	chr2	61495558	Missense_Mutation	NA	E315G	0.2
COAD	chr2	61488232	Missense_Mutation	NA	R749Q	0.05
COAD	chr2	61478876	Missense_Mutation	novel	M1054L	0.33
COAD	chr2	61481225	Missense_Mutation	NA	A1010D	0.21
COAD	chr2	61478795	3'UTR	rs764301580		0.32
COAD	chr2	61478816	3'UTR	novel		0.35
COAD	chr2	61493030	Silent	novel	R423R	0.13
COAD	chr2	61488232	Missense_Mutation	NA	R749Q	0.29
COAD	chr2	61482421	Silent	novel	Y977Y	0.13
COAD	chr2	61485863	Missense_Mutation	novel	A805T	0.06
COAD	chr2	61499765	Missense_Mutation	NA	D180Y	0.3
COAD	chr2	61483939	Missense_Mutation	rs755621083	T892M	0.38
COAD	chr2	61478795	3'UTR	rs764301580		0.3
DLBC	chr2	61492337	Missense_Mutation	NA	E571K	0.3
ESCA	chr2	61538228	5'UTR	novel		0.15
ESCA	chr2	61492144	Missense_Mutation	novel	Q593L	0.3
ESCA	chr2	61478803	3'UTR	novel		0.28
ESCA	chr2	61498682	Missense_Mutation	novel	L250F	0.39
GBM	chr2	61483082	Missense_Mutation	novel	I896T	0.28
GBM	chr2	61493117	Intron	novel		0.08
GBM	chr2	61483991	Silent	novel	L875L	0.04
GBM	chr2	61483946	Missense_Mutation	novel	A890T	0.52
GBM	chr2	61494023	Nonsense_Mutation	novel	Y372*	0.04
GBM	chr2	61490775	Missense_Mutation	novel	V630A	0.19
GBM	chr2	61496895	Missense_Mutation	novel	M291K	0.12
HNSC	chr2	61492441	Missense_Mutation	novel	N536T	0.35
HNSC	chr2	61492088	Missense_Mutation	NA	D612N	0.14
HNSC	chr2	61498675	Missense_Mutation	novel	K253E	0.28
HNSC	chr2	61533795	Silent	novel	L35L	0.26
HNSC	chr2	61499739	Missense_Mutation	novel	Q188H	0.36
HNSC	chr2	61488243	Missense_Mutation	rs762581181	I745M	0.19
HNSC	chr2	61484015	Missense_Mutation	rs190205938	P867S	0.14
HNSC	chr2	61493823	Intron	novel		0.28
HNSC	chr2	61492976	Silent	novel	V441V	0.53
KIRC	chr2	61496906	Frame_Shift_Del	novel	*F287Lfs3**	0.34
KIRC	chr2	61478887	Missense_Mutation	rs756595032	H1050R	0.27
KIRC	chr2	61494242	Intron	novel		0.16
KIRC	chr2	61494243	Intron	novel		0.16
KIRC	chr2	61482402	Missense_Mutation	NA	S984P	0.22
KIRP	chr2	61478794	3'UTR	rs750314461		0.53
KIRP	chr2	61493134	Intron	novel		0.63
KIRP	chr2	61478854	Missense_Mutation	NA	N1061S	0.47
KIRP	chr2	61482401	Missense_Mutation	rs751737799	S984L	0.07
LAML	chr2	61493784	Intron	novel		0.09
LGG	chr2	61493088	Intron	novel		0.34
LGG	chr2	61492867	Intron	novel		0.24
LIHC	chr2	61499773	Missense_Mutation	novel	E177V	0.05
LIHC	chr2	61499774	Missense_Mutation	novel	E177K	0.05
LIHC	chr2	61499848	Missense_Mutation	novel	D152V	0.16
LIHC	chr2	61478955	Silent	NA	G1027G	0.32
LIHC	chr2	61484072	Missense_Mutation	novel	F848V	0.23
LIHC	chr2	61492086	Missense_Mutation	novel	D612E	0.3
LUAD	chr2	61492981	Missense_Mutation	rs759110239	V440I	0.1
LUAD	chr2	61492982	Missense_Mutation	novel	E439D	0.1
LUAD	chr2	61493131	Intron	novel		0.12
LUAD	chr2	61499823	Silent	rs772703123	S160S	0.22
LUAD	chr2	61493952	Missense_Mutation	novel	G396V	0.35
LUAD	chr2	61493953	Nonsense_Mutation	novel	G396*	0.37
LUAD	chr2	61478874	Missense_Mutation	NA	M1054I	0.21
LUAD	chr2	61501997	Missense_Mutation	NA	Q136L	0.18
LUAD	chr2	61488618	Missense_Mutation	novel	E726K	0.06
LUAD	chr2	61483023	Missense_Mutation	NA	Q916E	0.07
LUAD	chr2	61492692	Missense_Mutation	novel	H481Y	0.11
LUAD	chr2	61478685	3'UTR	novel		0.21
LUAD	chr2	61526423	Silent	novel	T75T	0.24
LUAD	chr2	61526405	Intron	novel		0.44
LUAD	chr2	61492677	Missense_Mutation	NA	G486C	0.25
LUAD	chr2	61485815	Missense_Mutation	NA	Q821E	0.09
LUAD	chr2	61494016	Missense_Mutation	NA	H375N	0.05
LUSC	chr2	61493776	Intron	novel		0.32
LUSC	chr2	61498678	Missense_Mutation	novel	Y252N	0.13
LUSC	chr2	61478868	Silent	rs556422732	V1056V	0.16
LUSC	chr2	61493839	Intron	novel		0.39
LUSC	chr2	61498688	Silent	novel	S248S	0.16
LUSC	chr2	61493051	Splice_Region	novel	V416V	0.05
LUSC	chr2	61488600	Missense_Mutation	novel	I732L	0.44
LUSC	chr2	61492756	Splice_Region	novel		0.2
LUSC	chr2	61526518	Missense_Mutation	NA	R44G	0.16
LUSC	chr2	61478879	Missense_Mutation	NA	Q1053E	0.12
OV	chr2	61497004	Silent	NA	L255L	0.12
OV	chr2	61493132	Intron	novel		0.33
OV	chr2	61488600	Nonsense_Mutation	novel	*I732Vfs6**	0.19
PAAD	chr2	61488232	Missense_Mutation	NA	R749Q	0.13
READ	chr2	61478892	Missense_Mutation	NA	E1048D	0.13
READ	chr2	61492337	Missense_Mutation	NA	E571K	0.31
READ	chr2	61485949	Missense_Mutation	NA	F776C	0.12
READ	chr2	61533772	Splice_Region	novel	Q42Q	0.32
READ	chr2	61492337	Missense_Mutation	NA	E571K	0.18
READ	chr2	61499822	Missense_Mutation	novel	E161K	0.07
READ	chr2	61494044	Silent	rs770682729	I365I	0.37
READ	chr2	61488756	Missense_Mutation	NA	K680Q	0.32
READ	chr2	61493790	Intron	novel		0.25
READ	chr2	61495544	Missense_Mutation	NA	Q320K	0.51
READ	chr2	61498790	Missense_Mutation	NA	E214D	0.11
READ	chr2	61499727	Silent	NA	K192K	0.16
SARC	chr2	61499767	Missense_Mutation	novel	F179S	0.41
SARC	chr2	61481260	Frame_Shift_Ins	novel	*T999Ffs14**	0.08
SARC	chr2	61481262	Missense_Mutation	novel	V998M	0.03
SKCM	chr2	61492870	Intron	novel		0.47
SKCM	chr2	61482475	Silent	NA	S959S	0.55
SKCM	chr2	61493773	Intron	novel		0.59
SKCM	chr2	61493774	Intron	novel		0.56
SKCM	chr2	61493076	Intron	novel		0.36
SKCM	chr2	61499758	Missense_Mutation	novel	S182F	0.44
SKCM	chr2	61492182	Silent	NA	V580V	0.38
SKCM	chr2	61496917	Missense_Mutation	NA	V284L	0.23
SKCM	chr2	61492078	Missense_Mutation	NA	L615S	0.51
STAD	chr2	61482448	Silent	NA	V968V	0.14
STAD	chr2	61483038	Missense_Mutation	NA	A911T	0.37
STAD	chr2	61495588	Missense_Mutation	NA	R305Q	0.28
STAD	chr2	61478851	Missense_Mutation	novel	P1062L	0.46
STAD	chr2	61495588	Missense_Mutation	NA	R305Q	0.3
STAD	chr2	61478901	Silent	rs749378477	A1045A	0.07
STAD	chr2	61492598	Missense_Mutation	NA	D512G	0.13
STAD	chr2	61495582	Missense_Mutation	NA	A307V	0.2
STAD	chr2	61484102	Missense_Mutation	NA	F838V	0.11
STAD	chr2	61485959	Missense_Mutation	novel	A773T	0.28
STAD	chr2	61478776	3'UTR	novel		0.11
STAD	chr2	61497004	Missense_Mutation	novel	L255M	0.18
STAD	chr2	61485863	Missense_Mutation	novel	A805T	0.67
STAD	chr2	61502286	Missense_Mutation	NA	L109H	0.13
STAD	chr2	61492338	Silent	rs150009195	F570F	0.28
STAD	chr2	61493928	Missense_Mutation	NA	P404H	0.33
STAD	chr2	61493103	Intron	novel		0.28
TGCT	chr2	61481279	Missense_Mutation	novel	A992G	0.11
THCA	chr2	61493131	Intron	novel		0.38
THYM	chr2	61478919	Silent	novel	E1039E	0.61
UCEC	chr2	61492727	Missense_Mutation	NA	Y469C	0.35
UCEC	chr2	61478649	3'UTR	novel		0.17
UCEC	chr2	61478676	3'UTR	novel		0.41
UCEC	chr2	61492480	Missense_Mutation	NA	D523A	0.35
UCEC	chr2	61498682	Missense_Mutation	NA	L250F	0.23
UCEC	chr2	61478387	3'UTR	novel		0.36
UCEC	chr2	61488232	Missense_Mutation	NA	R749Q	0.42
UCEC	chr2	61492464	Silent	novel	C528C	0.52
UCEC	chr2	61493031	Missense_Mutation	novel	R423Q	0.4
UCEC	chr2	61493991	Missense_Mutation	novel	E383G	0.35
UCEC	chr2	61496944	Missense_Mutation	novel	S275R	0.31
UCEC	chr2	61526354	Intron	novel		0.33
UCEC	chr2	61478676	3'UTR	novel		0.67
UCEC	chr2	61482404	Missense_Mutation	NA	K983T	0.46
UCEC	chr2	61492658	Missense_Mutation	NA	K492R	0.41
UCEC	chr2	61494124	Intron	novel		0.38
UCEC	chr2	61492596	Missense_Mutation	NA	E513K	0.24
UCEC	chr2	61492972	Nonsense_Mutation	novel	E443*	0.58
UCEC	chr2	61493031	Missense_Mutation	novel	R423Q	0.3
UCEC	chr2	61483946	Missense_Mutation	novel	A890T	0.33
UCEC	chr2	61478173	3'UTR	novel		0.22
UCEC	chr2	61488184	Missense_Mutation	novel	R765Q	0.28
UCEC	chr2	61492083	Missense_Mutation	novel	E613D	0.29
UCEC	chr2	61488232	Missense_Mutation	NA	R749Q	0.04
UCEC	chr2	61482443	Missense_Mutation	NA	N970S	0.18
UCEC	chr2	61493068	Intron	novel		0.05
UCEC	chr2	61492614	Missense_Mutation	NA	A507S	0.26
UCEC	chr2	61495588	Missense_Mutation	NA	R305Q	0.28
UCEC	chr2	61502022	Missense_Mutation	NA	G128R	0.12
UCEC	chr2	61526517	Missense_Mutation	NA	R44I	0.18
UCEC	chr2	61492875	Intron	novel		0.17
UCEC	chr2	61496985	Missense_Mutation	rs781425578	R261Q	0.35
UCEC	chr2	61478882	Missense_Mutation	novel	R1052C	0.05
UCEC	chr2	61490699	Missense_Mutation	NA	E655D	0.39
UCEC	chr2	61478784	3'UTR	rs754032791		0.48
UCEC	chr2	61490696	Silent	novel	K656K	0.46
UCEC	chr2	61492589	Missense_Mutation	novel	R515Q	0.42
UCEC	chr2	61498677	Missense_Mutation	novel	Y252C	0.39
UCEC	chr2	61522668	Missense_Mutation	novel	I82L	0.41	CRM1_C
UCEC	chr2	61478111	3'UTR	novel		0.24
UCEC	chr2	61495599	Missense_Mutation	novel	N301K	0.32
UCEC	chr2	61502289	Missense_Mutation	novel	G108D	0.35
UCEC	chr2	61526412	Splice_Region	novel		0.35
UCEC	chr2	61533899	5'UTR	novel		0.29
UCEC	chr2	61496966	Silent	novel	C267C	0.33
UCEC	chr2	61492887	Intron	novel		0.4
UCEC	chr2	61499781	Silent	NA	L174L	0.14
UCEC	chr2	61481235	Missense_Mutation	novel	D1007Y	0.46
UCEC	chr2	61482465	Missense_Mutation	novel	N963H	0.47
UCEC	chr2	61494186	Intron	novel		0.43
UCEC	chr2	61526356	Intron	novel		0.27
UCEC	chr2	61478794	3'UTR	rs750314461		0.42
UCEC	chr2	61485905	Missense_Mutation	novel	N791H	0.48
UCEC	chr2	61522609	Splice_Site	novel	X101_splice	0.2
UCEC	chr2	61538114	5'UTR	novel		0.45
UCEC	chr2	61478196	3'UTR	novel		0.53
UCEC	chr2	61482461	Missense_Mutation	NA	P964H	0.08
UCEC	chr2	61538090	5'UTR	novel		0.18
UCEC	chr2	61492337	Missense_Mutation	NA	E571K	0.18
UCEC	chr2	61493088	Intron	novel		0.27
UCEC	chr2	61526423	Silent	rs747470901	T75T	0.2
UCEC	chr2	61478253	3'UTR	novel		0.61
UCEC	chr2	61492125	Silent	rs371003962	F599F	0.31
UCEC	chr2	61492794	Intron	novel		0.34
UCEC	chr2	61493015	Missense_Mutation	novel	E428D	0.41
UCEC	chr2	61492627	Silent	rs138664468	G502G	0.57
UCEC	chr2	61488232	Missense_Mutation	NA	R749Q	0.33
UCEC	chr2	61492325	Missense_Mutation	novel	E575K	0.27
UCEC	chr2	61478235	3'UTR	novel		0.48
UCEC	chr2	61478542	3'UTR	novel		0.71
UCEC	chr2	61478795	3'UTR	rs764301580		0.38
UCEC	chr2	61494224	Intron	novel		0.2
UCEC	chr2	61478824	Missense_Mutation	novel	D1071A	0.08
UCEC	chr2	61482500	Missense_Mutation	novel	N951T	0.17
UCEC	chr2	61478333	3'UTR	novel		0.24
UCEC	chr2	61478043	3'UTR	novel		0.39
UCEC	chr2	61492124	Missense_Mutation	NA	V600I	0.41
UCEC	chr2	61492391	Missense_Mutation	NA	R553C	0.33
UCEC	chr2	61538273	5'UTR	novel		0.51
UCEC	chr2	61502004	Missense_Mutation	novel	L134F	0.47
UCEC	chr2	61533856	Silent	NA	R14R	0.24
UCEC	chr2	61499724	Silent	rs781607844	H193H	0.42
UCEC	chr2	61485815	Missense_Mutation	NA	Q821E	0.04
UCEC	chr2	61485927	Silent	NA	A783A	0.42
UCEC	chr2	61526458	Missense_Mutation	NA	D64N	0.4	CRM1_C
UCEC	chr2	61492337	Missense_Mutation	NA	E571K	0.31
UCEC	chr2	61499823	Silent	rs772703123	S160S	0.27
UCEC	chr2	61485790	Missense_Mutation	novel	C829Y	0.52
UCEC	chr2	61492172	Missense_Mutation	novel	A584T	0.24
UCEC	chr2	61494149	Intron	novel		0.52
UCEC	chr2	61495581	Silent	rs370242599	A307A	0.17
UCEC	chr2	61526312	Intron	novel		0.19
UCEC	chr2	61493851	Intron	novel		0.6
UCEC	chr2	61484053	Missense_Mutation	novel	A854V	0.32
UCEC	chr2	61488703	Silent	novel	R697R	0.56
UCS	chr2	61490694	Missense_Mutation	novel	Y657C	0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0667	0.19022

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0021	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
PRAD	0.042	Kaplan-Meier Survival Analysis
LUSC	0.046	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
PAAD	0.0035	Kaplan-Meier Survival Analysis
READ	0.035	Kaplan-Meier Survival Analysis
KICH	0.048	Kaplan-Meier Survival Analysis
UCEC	0.0085	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
LIHC	0.00016	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.01	Kaplan-Meier Survival Analysis
UVM	0.048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742