EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000083290 (Gene tree)
Gene ID: 9706
Gene Symbol: ULK2
Alias: KIAA0623|Unc51.2|ATG1B
Full Name: unc-51 like autophagy activating kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 97,109 bases
Position: chr17:19,770,828-19,867,936
Accession: 13480
RBP type: canonical RBP
Summary: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000354877	RIO1	PF01163.22	0.00011	1	1
ENSP00000378914	RIO1	PF01163.22	0.00011	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30917721	Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.	Autophagy	2019 Sep	Fernandez-Mosquera L	doi: 10.1080/15548627.2019.1586256

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000574732	ULK2-207	564	-	ENSP00000465666	21 (aa)	-	K7EKK9
ENST00000574854	ULK2-208	493	-	-	- (aa)	-	-
ENST00000575432	ULK2-209	594	-	ENSP00000464892	198 (aa)	-	K7EIU2
ENST00000395544	ULK2-202	6010	XM_011524087	ENSP00000378914	1036 (aa)	XP_011522389	Q8IYT8
ENST00000571137	ULK2-204	615	-	-	- (aa)	-	-
ENST00000580118	ULK2-210	577	-	ENSP00000467277	49 (aa)	-	K7EP89
ENST00000571177	ULK2-205	492	-	-	- (aa)	-	-
ENST00000580130	ULK2-211	627	-	-	- (aa)	-	-
ENST00000570983	ULK2-203	3096	-	-	- (aa)	-	-
ENST00000361658	ULK2-201	3908	XM_017025425	ENSP00000354877	1036 (aa)	XP_016880914	Q8IYT8
ENST00000571454	ULK2-206	562	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000083290's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04136	Autophagy - other	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04150	mTOR signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000083290	Parkinson Disease	2.505542E-5	17052657

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000083290's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000083290	ULK2	100	72.993	ENSAPOG00000004920	ulk2	99	73.491	Acanthochromis_polyacanthus
ENSG00000083290	ULK2	97	93.545	ENSAMEG00000004430	ULK2	100	93.545	Ailuropoda_melanoleuca
ENSG00000083290	ULK2	100	73.088	ENSAOCG00000006514	ulk2	99	73.585	Amphiprion_ocellaris
ENSG00000083290	ULK2	97	86.871	ENSAPLG00000003309	ULK2	99	86.871	Anas_platyrhynchos
ENSG00000083290	ULK2	100	62.946	ENSACAG00000000631	ULK2	87	93.609	Anolis_carolinensis
ENSG00000083290	ULK2	100	72.590	ENSACLG00000020477	ulk2	99	72.805	Astatotilapia_calliptera
ENSG00000083290	ULK2	100	74.525	ENSAMXG00000009215	ulk2	99	74.905	Astyanax_mexicanus
ENSG00000083290	ULK2	100	96.622	ENSCJAG00000011832	ULK2	100	96.622	Callithrix_jacchus
ENSG00000083290	ULK2	100	94.793	ENSCAFG00000018126	ULK2	100	94.793	Canis_familiaris
ENSG00000083290	ULK2	100	89.479	ENSCHIG00000011283	ULK2	100	89.479	Capra_hircus
ENSG00000083290	ULK2	99	95.141	ENSTSYG00000003217	ULK2	99	95.044	Carlito_syrichta
ENSG00000083290	ULK2	100	93.147	ENSCPOG00000010048	ULK2	100	93.147	Cavia_porcellus
ENSG00000083290	ULK2	97	96.875	ENSCATG00000032753	ULK2	100	96.875	Cercocebus_atys
ENSG00000083290	ULK2	97	93.539	ENSCLAG00000008483	ULK2	100	93.539	Chinchilla_lanigera
ENSG00000083290	ULK2	100	97.973	ENSCSAG00000007819	ULK2	100	97.973	Chlorocebus_sabaeus
ENSG00000083290	ULK2	83	90.647	ENSCHOG00000012625	ULK2	85	87.050	Choloepus_hoffmanni
ENSG00000083290	ULK2	100	84.716	ENSCPBG00000015808	ULK2	99	84.716	Chrysemys_picta_bellii
ENSG00000083290	ULK2	100	94.208	ENSCGRG00001011469	Ulk2	100	94.208	Cricetulus_griseus_chok1gshd
ENSG00000083290	ULK2	97	94.036	ENSCGRG00000009104	Ulk2	100	94.036	Cricetulus_griseus_crigri
ENSG00000083290	ULK2	100	73.926	ENSDARG00000097205	ulk2	99	74.141	Danio_rerio
ENSG00000083290	ULK2	97	91.576	ENSDNOG00000048497	ULK2	61	91.576	Dasypus_novemcinctus
ENSG00000083290	ULK2	100	93.919	ENSDORG00000012863	Ulk2	100	93.919	Dipodomys_ordii
ENSG00000083290	ULK2	84	89.103	ENSETEG00000002660	ULK2	86	95.440	Echinops_telfairi
ENSG00000083290	ULK2	100	94.788	ENSEASG00005017583	ULK2	100	94.788	Equus_asinus_asinus
ENSG00000083290	ULK2	100	94.691	ENSECAG00000008882	ULK2	100	92.687	Equus_caballus
ENSG00000083290	ULK2	100	73.764	ENSELUG00000017192	ulk2	99	73.979	Esox_lucius
ENSG00000083290	ULK2	100	93.173	ENSFCAG00000005190	ULK2	100	93.173	Felis_catus
ENSG00000083290	ULK2	100	83.784	ENSFALG00000005884	ULK2	99	83.784	Ficedula_albicollis
ENSG00000083290	ULK2	100	93.822	ENSFDAG00000004531	ULK2	98	93.822	Fukomys_damarensis
ENSG00000083290	ULK2	100	71.321	ENSFHEG00000001152	ulk2	99	71.631	Fundulus_heteroclitus
ENSG00000083290	ULK2	100	72.060	ENSGMOG00000002637	ulk2	100	72.274	Gadus_morhua
ENSG00000083290	ULK2	99	71.851	ENSGAFG00000019721	ulk2	98	72.069	Gambusia_affinis
ENSG00000083290	ULK2	100	72.049	ENSGACG00000013524	ulk2	100	72.170	Gasterosteus_aculeatus
ENSG00000083290	ULK2	100	84.623	ENSGAGG00000011573	ULK2	99	84.623	Gopherus_agassizii
ENSG00000083290	ULK2	100	99.614	ENSGGOG00000007689	ULK2	100	99.614	Gorilla_gorilla
ENSG00000083290	ULK2	100	72.495	ENSHBUG00000006775	ulk2	99	72.710	Haplochromis_burtoni
ENSG00000083290	ULK2	100	73.594	ENSIPUG00000007930	ulk2	99	74.000	Ictalurus_punctatus
ENSG00000083290	ULK2	100	94.981	ENSSTOG00000007174	ULK2	100	94.981	Ictidomys_tridecemlineatus
ENSG00000083290	ULK2	100	72.212	ENSKMAG00000002479	ulk2	99	72.427	Kryptolebias_marmoratus
ENSG00000083290	ULK2	100	79.048	ENSLACG00000001863	ULK2	99	79.143	Latimeria_chalumnae
ENSG00000083290	ULK2	100	74.597	ENSLOCG00000005372	ulk2	99	75.000	Lepisosteus_oculatus
ENSG00000083290	ULK2	100	98.069	ENSMFAG00000037593	ULK2	100	98.069	Macaca_fascicularis
ENSG00000083290	ULK2	100	98.069	ENSMMUG00000021156	ULK2	100	98.069	Macaca_mulatta
ENSG00000083290	ULK2	100	97.394	ENSMNEG00000030857	ULK2	100	97.394	Macaca_nemestrina
ENSG00000083290	ULK2	97	98.012	ENSMLEG00000041408	ULK2	100	98.012	Mandrillus_leucophaeus
ENSG00000083290	ULK2	100	72.091	ENSMAMG00000002940	ulk2	99	72.753	Mastacembelus_armatus
ENSG00000083290	ULK2	100	72.590	ENSMZEG00005001956	ulk2	99	72.805	Maylandia_zebra
ENSG00000083290	ULK2	100	86.481	ENSMGAG00000006805	ULK2	100	86.481	Meleagris_gallopavo
ENSG00000083290	ULK2	94	94.964	ENSMICG00000031631	ULK2	99	94.964	Microcebus_murinus
ENSG00000083290	ULK2	100	93.726	ENSMOCG00000012863	Ulk2	100	93.726	Microtus_ochrogaster
ENSG00000083290	ULK2	100	89.317	ENSMODG00000010934	ULK2	99	89.317	Monodelphis_domestica
ENSG00000083290	ULK2	100	72.375	ENSMALG00000019136	ulk2	99	72.968	Monopterus_albus
ENSG00000083290	ULK2	100	93.443	MGP_CAROLIEiJ_G0016485	Ulk2	100	93.443	Mus_caroli
ENSG00000083290	ULK2	100	93.635	ENSMUSG00000004798	Ulk2	100	93.635	Mus_musculus
ENSG00000083290	ULK2	100	93.539	MGP_SPRETEiJ_G0017320	Ulk2	100	93.539	Mus_spretus
ENSG00000083290	ULK2	94	83.750	ENSMLUG00000007422	-	100	83.750	Myotis_lucifugus
ENSG00000083290	ULK2	97	89.812	ENSMLUG00000017762	-	99	89.812	Myotis_lucifugus
ENSG00000083290	ULK2	100	94.305	ENSNGAG00000009072	Ulk2	100	94.305	Nannospalax_galili
ENSG00000083290	ULK2	100	93.629	ENSODEG00000000757	ULK2	100	93.629	Octodon_degus
ENSG00000083290	ULK2	100	72.495	ENSONIG00000010482	ulk2	99	72.710	Oreochromis_niloticus
ENSG00000083290	ULK2	100	94.884	ENSOCUG00000013388	ULK2	100	95.174	Oryctolagus_cuniculus
ENSG00000083290	ULK2	100	70.833	ENSORLG00000014987	ulk2	99	71.117	Oryzias_latipes
ENSG00000083290	ULK2	100	70.644	ENSORLG00020008437	ulk2	99	70.928	Oryzias_latipes_hni
ENSG00000083290	ULK2	100	70.739	ENSORLG00015014264	ulk2	99	71.023	Oryzias_latipes_hsok
ENSG00000083290	ULK2	100	71.429	ENSOMEG00000008411	ulk2	99	71.429	Oryzias_melastigma
ENSG00000083290	ULK2	99	92.967	ENSOGAG00000017081	ULK2	99	92.967	Otolemur_garnettii
ENSG00000083290	ULK2	97	88.340	ENSOARG00000017770	ULK2	100	88.340	Ovis_aries
ENSG00000083290	ULK2	97	99.503	ENSPPAG00000037047	ULK2	100	99.503	Pan_paniscus
ENSG00000083290	ULK2	97	93.168	ENSPTIG00000012203	ULK2	97	93.168	Panthera_tigris_altaica
ENSG00000083290	ULK2	100	99.517	ENSPTRG00000008875	ULK2	100	99.517	Pan_troglodytes
ENSG00000083290	ULK2	100	98.166	ENSPANG00000023620	ULK2	100	98.166	Papio_anubis
ENSG00000083290	ULK2	92	65.106	ENSPKIG00000018902	-	56	65.106	Paramormyrops_kingsleyae
ENSG00000083290	ULK2	97	86.673	ENSPSIG00000015566	ULK2	99	86.772	Pelodiscus_sinensis
ENSG00000083290	ULK2	100	93.070	ENSPEMG00000016139	Ulk2	100	93.070	Peromyscus_maniculatus_bairdii
ENSG00000083290	ULK2	100	89.028	ENSPCIG00000014203	ULK2	99	89.028	Phascolarctos_cinereus
ENSG00000083290	ULK2	100	71.226	ENSPFOG00000016656	ulk2	99	71.536	Poecilia_formosa
ENSG00000083290	ULK2	100	71.604	ENSPREG00000015581	ulk2	99	71.913	Poecilia_reticulata
ENSG00000083290	ULK2	100	94.691	ENSPCOG00000014882	ULK2	100	94.691	Propithecus_coquereli
ENSG00000083290	ULK2	100	72.495	ENSPNYG00000023925	ulk2	99	72.710	Pundamilia_nyererei
ENSG00000083290	ULK2	100	75.143	ENSPNAG00000007165	ulk2	99	75.357	Pygocentrus_nattereri
ENSG00000083290	ULK2	100	93.828	ENSRNOG00000002763	Ulk2	100	93.828	Rattus_norvegicus
ENSG00000083290	ULK2	97	89.219	ENSSHAG00000003186	ULK2	100	89.219	Sarcophilus_harrisii
ENSG00000083290	ULK2	100	72.144	ENSSMAG00000013811	ulk2	100	73.007	Scophthalmus_maximus
ENSG00000083290	ULK2	100	72.710	ENSSLDG00000011160	ulk2	99	72.925	Seriola_lalandi_dorsalis
ENSG00000083290	ULK2	100	72.049	ENSSPAG00000010229	ulk2	99	72.427	Stegastes_partitus
ENSG00000083290	ULK2	100	84.119	ENSSSCG00000018045	ULK2	100	83.542	Sus_scrofa
ENSG00000083290	ULK2	99	86.403	ENSTGUG00000007111	-	99	86.403	Taeniopygia_guttata
ENSG00000083290	ULK2	99	68.994	ENSTNIG00000014387	ulk2	99	69.367	Tetraodon_nigroviridis
ENSG00000083290	ULK2	78	82.759	ENSVPAG00000007776	-	84	73.699	Vicugna_pacos
ENSG00000083290	ULK2	97	94.362	ENSVVUG00000030016	ULK2	93	94.362	Vulpes_vulpes
ENSG00000083290	ULK2	100	78.011	ENSXETG00000032595	ULK2	100	78.298	Xenopus_tropicalis
ENSG00000083290	ULK2	100	72.196	ENSXMAG00000005775	ulk2	99	72.411	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000045	autophagosome assembly	21873635.	IBA	Process
GO:0000407	phagophore assembly site	21873635.	IBA	Component
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	18936157.	IDA	Function
GO:0005515	protein binding	18936157.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006914	autophagy	18936157.	IDA	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0010506	regulation of autophagy	21873635.	IBA	Process
GO:0016020	membrane	21873635.	IBA	Component
GO:0030659	cytoplasmic vesicle membrane	-	IEA	Component
GO:0034045	phagophore assembly site membrane	18936157.	IDA	Component
GO:0042594	response to starvation	-	ISS	Process
GO:0046777	protein autophosphorylation	21873635.	IBA	Process
GO:0046777	protein autophosphorylation	18936157.	IDA	Process
GO:0048671	negative regulation of collateral sprouting	-	IEA	Process
GO:0048675	axon extension	21873635.	IBA	Process
GO:0075044	autophagy of host cells involved in interaction with symbiont	28389568.	IGI	Process