EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000083520 (Gene tree)
Gene ID: 22894
Gene Symbol: DIS3
Alias: dis3p|RRP44|EXOSC11|KIAA1008
Full Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,985 bases
Position: chr13:72,752,169-72,782,153
Accession: 20604
RBP type: canonical RBP
Summary: (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3 include Combat Disorder and Acute Stress Disorder. Among its related pathways are PERK regulates gene expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000440058	RNB	PF00773.19	3.8e-103	1	1
ENSP00000366997	RNB	PF00773.19	5e-103	1	1
ENSP00000367011	RNB	PF00773.19	5.1e-103	1	1
ENSP00000366997	PIN_4	PF13638.6	3.9e-14	1	1
ENSP00000367011	PIN_4	PF13638.6	1.3e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23417976	Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity.	Wiley Interdiscip Rev RNA	2013 Mar-Apr	Schmidt K	doi: 10.1002/wrna.1155
28355211	Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.	PLoS Genet	2017 Mar 29	Delan-Forino C	doi: 10.1371/journal.pgen.1006699
24146636	The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay.	PLoS Genet	2013	Bresson SM	doi: 10.1371/journal.pgen.1003893
30990031	Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA.	Anal Chem	2019 May 7	Zeng W	doi: 10.1021/acs.analchem.9b00554

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490646	DIS3-204	2934	-	ENSP00000436350	559 (aa)	-	F2Z2C0
ENST00000377780	DIS3-202	5232	-	ENSP00000367011	928 (aa)	-	Q9Y2L1
ENST00000475871	DIS3-203	716	-	-	- (aa)	-	-
ENST00000377767	DIS3-201	10604	-	ENSP00000366997	958 (aa)	-	Q9Y2L1
ENST00000545453	DIS3-205	3651	-	ENSP00000440058	796 (aa)	-	G3V1J5

Gene Model

Click here to download ENSG00000083520's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000083520	Blood Pressure	2.2591816E-006	-
ENSG00000083520	Emotions	5E-6	27089181

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000083520	rs6562728	13	72756804	A	Subjective well-being	27089181	[0.13-0.31] unit decrease	0.21967527	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000083520's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000083520	DIS3	99	37.585	ENSG00000166938	DIS3L	92	36.175
ENSG00000083520	DIS3	88	35.460	ENSG00000144535	DIS3L2	93	41.690

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000083520	DIS3	99	36.364	ENSAPOG00000002380	dis3l	90	35.010	Acanthochromis_polyacanthus
ENSG00000083520	DIS3	82	33.653	ENSAPOG00000020342	dis3l2	74	36.961	Acanthochromis_polyacanthus
ENSG00000083520	DIS3	100	73.514	ENSAPOG00000002890	dis3	98	74.805	Acanthochromis_polyacanthus
ENSG00000083520	DIS3	91	35.093	ENSAMEG00000016594	DIS3L2	88	34.571	Ailuropoda_melanoleuca
ENSG00000083520	DIS3	99	94.794	ENSAMEG00000012436	DIS3	99	94.626	Ailuropoda_melanoleuca
ENSG00000083520	DIS3	96	37.187	ENSAMEG00000003166	DIS3L	90	36.055	Ailuropoda_melanoleuca
ENSG00000083520	DIS3	84	33.617	ENSACIG00000008363	dis3l2	92	33.617	Amphilophus_citrinellus
ENSG00000083520	DIS3	99	69.773	ENSACIG00000006056	dis3	98	70.308	Amphilophus_citrinellus
ENSG00000083520	DIS3	95	34.698	ENSACIG00000003161	dis3l	89	33.811	Amphilophus_citrinellus
ENSG00000083520	DIS3	53	38.785	ENSAOCG00000023503	dis3l	92	38.785	Amphiprion_ocellaris
ENSG00000083520	DIS3	100	73.827	ENSAOCG00000014376	dis3	98	75.361	Amphiprion_ocellaris
ENSG00000083520	DIS3	82	32.642	ENSAOCG00000013852	dis3l2	67	32.780	Amphiprion_ocellaris
ENSG00000083520	DIS3	99	36.833	ENSAPEG00000000072	dis3l	88	36.452	Amphiprion_percula
ENSG00000083520	DIS3	99	74.653	ENSAPEG00000006585	dis3	99	74.681	Amphiprion_percula
ENSG00000083520	DIS3	82	32.780	ENSAPEG00000022654	dis3l2	67	32.918	Amphiprion_percula
ENSG00000083520	DIS3	100	73.465	ENSATEG00000008235	dis3	98	74.654	Anabas_testudineus
ENSG00000083520	DIS3	99	36.535	ENSATEG00000022464	dis3l	91	34.248	Anabas_testudineus
ENSG00000083520	DIS3	88	31.969	ENSATEG00000003336	dis3l2	73	31.748	Anabas_testudineus
ENSG00000083520	DIS3	82	34.896	ENSAPLG00000012888	DIS3L2	74	34.896	Anas_platyrhynchos
ENSG00000083520	DIS3	99	36.185	ENSAPLG00000015294	DIS3L	92	35.380	Anas_platyrhynchos
ENSG00000083520	DIS3	59	87.234	ENSAPLG00000012686	-	100	87.234	Anas_platyrhynchos
ENSG00000083520	DIS3	69	34.783	ENSACAG00000011987	DIS3L2	99	34.783	Anolis_carolinensis
ENSG00000083520	DIS3	86	35.541	ENSACAG00000004194	-	91	33.567	Anolis_carolinensis
ENSG00000083520	DIS3	100	82.581	ENSACAG00000000649	DIS3	91	81.990	Anolis_carolinensis
ENSG00000083520	DIS3	99	36.905	ENSANAG00000024523	DIS3L	92	35.785	Aotus_nancymaae
ENSG00000083520	DIS3	100	97.114	ENSANAG00000025580	DIS3	100	97.080	Aotus_nancymaae
ENSG00000083520	DIS3	88	35.015	ENSANAG00000020336	DIS3L2	81	36.923	Aotus_nancymaae
ENSG00000083520	DIS3	99	74.937	ENSACLG00000017915	dis3	98	74.582	Astatotilapia_calliptera
ENSG00000083520	DIS3	88	32.097	ENSACLG00000015831	dis3l2	74	32.353	Astatotilapia_calliptera
ENSG00000083520	DIS3	99	35.506	ENSAMXG00000006220	dis3l	91	34.369	Astyanax_mexicanus
ENSG00000083520	DIS3	99	71.634	ENSAMXG00000000563	dis3	99	74.889	Astyanax_mexicanus
ENSG00000083520	DIS3	81	31.392	ENSAMXG00000019663	dis3l2	58	34.015	Astyanax_mexicanus
ENSG00000083520	DIS3	50	62.624	ENSAMXG00000042551	-	90	64.829	Astyanax_mexicanus
ENSG00000083520	DIS3	99	36.581	ENSBTAG00000000371	DIS3L	92	35.558	Bos_taurus
ENSG00000083520	DIS3	100	93.342	ENSBTAG00000019889	DIS3	99	93.572	Bos_taurus
ENSG00000083520	DIS3	90	34.877	ENSBTAG00000011964	DIS3L2	83	35.508	Bos_taurus
ENSG00000083520	DIS3	94	50.130	WBGene00001001	dis-3	97	45.037	Caenorhabditis_elegans
ENSG00000083520	DIS3	82	31.171	WBGene00018612	disl-2	83	31.030	Caenorhabditis_elegans
ENSG00000083520	DIS3	100	97.240	ENSCJAG00000021117	DIS3	100	97.201	Callithrix_jacchus
ENSG00000083520	DIS3	99	37.245	ENSCJAG00000007411	DIS3L	83	35.785	Callithrix_jacchus
ENSG00000083520	DIS3	63	36.543	ENSCJAG00000013674	DIS3L2	56	36.916	Callithrix_jacchus
ENSG00000083520	DIS3	97	31.642	ENSCAFG00000017271	DIS3L	78	37.571	Canis_familiaris
ENSG00000083520	DIS3	88	35.905	ENSCAFG00000011170	DIS3L2	86	35.015	Canis_familiaris
ENSG00000083520	DIS3	99	95.691	ENSCAFG00000005016	DIS3	99	95.153	Canis_familiaris
ENSG00000083520	DIS3	99	36.735	ENSCAFG00020008413	DIS3L	92	35.785	Canis_lupus_dingo
ENSG00000083520	DIS3	99	95.691	ENSCAFG00020025806	DIS3	99	95.691	Canis_lupus_dingo
ENSG00000083520	DIS3	88	35.905	ENSCAFG00020023170	DIS3L2	86	35.015	Canis_lupus_dingo
ENSG00000083520	DIS3	99	36.163	ENSCHIG00000009744	DIS3L	92	35.516	Capra_hircus
ENSG00000083520	DIS3	100	93.528	ENSCHIG00000015396	DIS3	92	93.888	Capra_hircus
ENSG00000083520	DIS3	90	34.732	ENSCHIG00000022192	DIS3L2	83	35.250	Capra_hircus
ENSG00000083520	DIS3	99	35.788	ENSTSYG00000001936	DIS3L	93	34.684	Carlito_syrichta
ENSG00000083520	DIS3	57	35.802	ENSTSYG00000011825	DIS3L2	88	35.802	Carlito_syrichta
ENSG00000083520	DIS3	99	96.050	ENSTSYG00000007441	DIS3	99	95.153	Carlito_syrichta
ENSG00000083520	DIS3	99	36.469	ENSCAPG00000016431	DIS3L	89	36.034	Cavia_aperea
ENSG00000083520	DIS3	88	32.695	ENSCAPG00000000495	DIS3L2	82	32.923	Cavia_aperea
ENSG00000083520	DIS3	100	86.591	ENSCAPG00000005630	DIS3	99	84.615	Cavia_aperea
ENSG00000083520	DIS3	99	36.644	ENSCPOG00000000250	DIS3L	92	36.128	Cavia_porcellus
ENSG00000083520	DIS3	87	34.880	ENSCPOG00000005205	DIS3L2	81	35.211	Cavia_porcellus
ENSG00000083520	DIS3	100	93.023	ENSCPOG00000007178	DIS3	99	93.467	Cavia_porcellus
ENSG00000083520	DIS3	100	97.393	ENSCCAG00000029240	DIS3	100	97.464	Cebus_capucinus
ENSG00000083520	DIS3	72	38.015	ENSCCAG00000036091	DIS3L2	80	38.614	Cebus_capucinus
ENSG00000083520	DIS3	96	32.773	ENSCCAG00000037964	DIS3L	89	32.124	Cebus_capucinus
ENSG00000083520	DIS3	88	34.673	ENSCATG00000044446	DIS3L2	71	34.837	Cercocebus_atys
ENSG00000083520	DIS3	100	98.643	ENSCATG00000037705	DIS3	100	98.643	Cercocebus_atys
ENSG00000083520	DIS3	99	36.797	ENSCATG00000044661	DIS3L	92	35.721	Cercocebus_atys
ENSG00000083520	DIS3	90	34.111	ENSCLAG00000010200	DIS3L2	84	33.382	Chinchilla_lanigera
ENSG00000083520	DIS3	100	93.528	ENSCLAG00000003424	DIS3	99	93.994	Chinchilla_lanigera
ENSG00000083520	DIS3	90	38.303	ENSCLAG00000005741	DIS3L	91	35.821	Chinchilla_lanigera
ENSG00000083520	DIS3	88	35.312	ENSCSAG00000006618	DIS3L2	69	35.504	Chlorocebus_sabaeus
ENSG00000083520	DIS3	100	98.330	ENSCSAG00000017617	DIS3	100	98.330	Chlorocebus_sabaeus
ENSG00000083520	DIS3	96	36.874	ENSCSAG00000013140	DIS3L	92	35.956	Chlorocebus_sabaeus
ENSG00000083520	DIS3	83	37.321	ENSCHOG00000004843	DIS3L	80	35.556	Choloepus_hoffmanni
ENSG00000083520	DIS3	85	100.000	ENSCHOG00000008758	DIS3	91	100.000	Choloepus_hoffmanni
ENSG00000083520	DIS3	88	34.796	ENSCPBG00000016428	DIS3L2	82	34.844	Chrysemys_picta_bellii
ENSG00000083520	DIS3	97	37.414	ENSCPBG00000014111	DIS3L	91	35.536	Chrysemys_picta_bellii
ENSG00000083520	DIS3	98	85.000	ENSCPBG00000010365	DIS3	92	84.120	Chrysemys_picta_bellii
ENSG00000083520	DIS3	82	33.287	ENSCING00000003927	-	95	33.287	Ciona_intestinalis
ENSG00000083520	DIS3	97	60.641	ENSCING00000024053	-	100	59.048	Ciona_intestinalis
ENSG00000083520	DIS3	99	53.763	ENSCSAVG00000000496	-	100	58.817	Ciona_savignyi
ENSG00000083520	DIS3	96	37.470	ENSCANG00000041576	DIS3L	88	36.306	Colobus_angolensis_palliatus
ENSG00000083520	DIS3	100	98.367	ENSCANG00000010365	DIS3	100	98.017	Colobus_angolensis_palliatus
ENSG00000083520	DIS3	88	31.619	ENSCANG00000036420	DIS3L2	70	31.962	Colobus_angolensis_palliatus
ENSG00000083520	DIS3	99	36.395	ENSCGRG00001017825	Dis3l	92	35.189	Cricetulus_griseus_chok1gshd
ENSG00000083520	DIS3	100	92.588	ENSCGRG00001022496	Dis3	99	92.932	Cricetulus_griseus_chok1gshd
ENSG00000083520	DIS3	88	34.737	ENSCGRG00001005191	DIS3L2	81	34.633	Cricetulus_griseus_chok1gshd
ENSG00000083520	DIS3	100	92.588	ENSCGRG00000012184	Dis3	99	93.463	Cricetulus_griseus_crigri
ENSG00000083520	DIS3	88	34.737	ENSCGRG00000012668	DIS3L2	81	34.633	Cricetulus_griseus_crigri
ENSG00000083520	DIS3	99	36.395	ENSCGRG00000017247	Dis3l	92	35.189	Cricetulus_griseus_crigri
ENSG00000083520	DIS3	99	36.021	ENSCSEG00000008022	dis3l	92	33.736	Cynoglossus_semilaevis
ENSG00000083520	DIS3	100	73.125	ENSCSEG00000003028	dis3	98	74.149	Cynoglossus_semilaevis
ENSG00000083520	DIS3	82	33.702	ENSCSEG00000018729	dis3l2	76	33.564	Cynoglossus_semilaevis
ENSG00000083520	DIS3	90	34.979	ENSCVAG00000013781	dis3l	91	34.979	Cyprinodon_variegatus
ENSG00000083520	DIS3	99	73.459	ENSCVAG00000019095	dis3	98	74.566	Cyprinodon_variegatus
ENSG00000083520	DIS3	88	33.205	ENSCVAG00000020679	dis3l2	76	32.861	Cyprinodon_variegatus
ENSG00000083520	DIS3	100	73.904	ENSDARG00000060559	dis3	99	74.183	Danio_rerio
ENSG00000083520	DIS3	88	32.723	ENSDARG00000033259	dis3l2	76	32.592	Danio_rerio
ENSG00000083520	DIS3	99	36.301	ENSDARG00000053200	dis3l	91	33.936	Danio_rerio
ENSG00000083520	DIS3	99	92.280	ENSDNOG00000003369	DIS3	99	92.105	Dasypus_novemcinctus
ENSG00000083520	DIS3	71	35.679	ENSDNOG00000018938	DIS3L2	76	36.021	Dasypus_novemcinctus
ENSG00000083520	DIS3	99	36.054	ENSDNOG00000016967	DIS3L	92	35.323	Dasypus_novemcinctus
ENSG00000083520	DIS3	76	47.826	ENSDORG00000014909	Dis3l	90	38.829	Dipodomys_ordii
ENSG00000083520	DIS3	82	34.370	ENSDORG00000013139	Dis3l2	65	34.708	Dipodomys_ordii
ENSG00000083520	DIS3	99	94.973	ENSDORG00000007295	Dis3	99	90.072	Dipodomys_ordii
ENSG00000083520	DIS3	99	54.991	FBgn0039183	Dis3	98	54.948	Drosophila_melanogaster
ENSG00000083520	DIS3	73	31.230	FBgn0035111	Dis3l2	50	33.716	Drosophila_melanogaster
ENSG00000083520	DIS3	69	35.613	ENSETEG00000013215	DIS3L	61	35.613	Echinops_telfairi
ENSG00000083520	DIS3	100	90.363	ENSETEG00000016363	DIS3	99	90.887	Echinops_telfairi
ENSG00000083520	DIS3	75	67.337	ENSEBUG00000010372	dis3	97	68.158	Eptatretus_burgeri
ENSG00000083520	DIS3	81	33.098	ENSEBUG00000008467	-	79	33.098	Eptatretus_burgeri
ENSG00000083520	DIS3	56	59.425	ENSEBUG00000001974	-	93	59.425	Eptatretus_burgeri
ENSG00000083520	DIS3	93	35.976	ENSEBUG00000016190	dis3l	90	35.243	Eptatretus_burgeri
ENSG00000083520	DIS3	99	35.605	ENSEASG00005006407	DIS3L	92	35.095	Equus_asinus_asinus
ENSG00000083520	DIS3	88	35.127	ENSEASG00005008747	DIS3L2	72	35.469	Equus_asinus_asinus
ENSG00000083520	DIS3	100	94.885	ENSEASG00005015539	DIS3	99	95.258	Equus_asinus_asinus
ENSG00000083520	DIS3	88	35.672	ENSECAG00000023375	DIS3L2	80	34.078	Equus_caballus
ENSG00000083520	DIS3	100	94.990	ENSECAG00000023994	DIS3	99	95.364	Equus_caballus
ENSG00000083520	DIS3	99	36.735	ENSECAG00000007302	DIS3L	92	35.885	Equus_caballus
ENSG00000083520	DIS3	99	93.381	ENSEEUG00000000249	DIS3	100	88.565	Erinaceus_europaeus
ENSG00000083520	DIS3	99	37.245	ENSELUG00000019420	dis3l	90	35.035	Esox_lucius
ENSG00000083520	DIS3	82	33.661	ENSELUG00000022719	dis3l2	68	32.542	Esox_lucius
ENSG00000083520	DIS3	99	74.937	ENSELUG00000002309	dis3	99	73.517	Esox_lucius
ENSG00000083520	DIS3	99	35.849	ENSFCAG00000029869	DIS3L	92	35.529	Felis_catus
ENSG00000083520	DIS3	91	35.345	ENSFCAG00000012529	DIS3L2	88	34.626	Felis_catus
ENSG00000083520	DIS3	99	95.871	ENSFCAG00000028493	DIS3	99	95.469	Felis_catus
ENSG00000083520	DIS3	82	33.492	ENSFALG00000007642	DIS3L2	82	33.491	Ficedula_albicollis
ENSG00000083520	DIS3	99	36.700	ENSFALG00000010033	DIS3L	92	35.079	Ficedula_albicollis
ENSG00000083520	DIS3	98	84.487	ENSFALG00000001001	DIS3	99	83.893	Ficedula_albicollis
ENSG00000083520	DIS3	96	37.410	ENSFDAG00000008259	DIS3L	91	35.928	Fukomys_damarensis
ENSG00000083520	DIS3	100	93.342	ENSFDAG00000016444	DIS3	99	94.476	Fukomys_damarensis
ENSG00000083520	DIS3	64	30.109	ENSFDAG00000020276	DIS3L2	71	30.109	Fukomys_damarensis
ENSG00000083520	DIS3	99	68.873	ENSFHEG00000021783	dis3	100	68.873	Fundulus_heteroclitus
ENSG00000083520	DIS3	99	37.629	ENSFHEG00000002133	dis3l	92	36.080	Fundulus_heteroclitus
ENSG00000083520	DIS3	88	32.143	ENSFHEG00000019523	dis3l2	72	32.015	Fundulus_heteroclitus
ENSG00000083520	DIS3	73	49.102	ENSGMOG00000003012	dis3l	90	35.813	Gadus_morhua
ENSG00000083520	DIS3	63	34.586	ENSGMOG00000006607	dis3l2	72	34.586	Gadus_morhua
ENSG00000083520	DIS3	98	72.211	ENSGMOG00000018499	dis3	98	72.211	Gadus_morhua
ENSG00000083520	DIS3	88	32.899	ENSGALG00000007767	DIS3L2	73	33.807	Gallus_gallus
ENSG00000083520	DIS3	99	35.932	ENSGALG00000007643	DIS3L	92	35.545	Gallus_gallus
ENSG00000083520	DIS3	97	84.109	ENSGALG00000016930	DIS3	98	83.429	Gallus_gallus
ENSG00000083520	DIS3	90	30.826	ENSGAFG00000011865	dis3l2	85	33.893	Gambusia_affinis
ENSG00000083520	DIS3	99	36.021	ENSGAFG00000016532	dis3l	93	34.517	Gambusia_affinis
ENSG00000083520	DIS3	100	72.680	ENSGAFG00000012015	dis3	98	73.695	Gambusia_affinis
ENSG00000083520	DIS3	82	32.794	ENSGACG00000016435	dis3l2	78	36.204	Gasterosteus_aculeatus
ENSG00000083520	DIS3	99	72.566	ENSGACG00000009812	dis3	97	73.800	Gasterosteus_aculeatus
ENSG00000083520	DIS3	72	49.112	ENSGACG00000017315	dis3l	77	40.119	Gasterosteus_aculeatus
ENSG00000083520	DIS3	99	82.711	ENSGAGG00000000602	DIS3	99	81.781	Gopherus_agassizii
ENSG00000083520	DIS3	88	34.796	ENSGAGG00000009026	DIS3L2	74	34.945	Gopherus_agassizii
ENSG00000083520	DIS3	97	37.414	ENSGAGG00000004493	DIS3L	91	36.009	Gopherus_agassizii
ENSG00000083520	DIS3	80	36.379	ENSGGOG00000027129	DIS3L2	66	36.649	Gorilla_gorilla
ENSG00000083520	DIS3	100	99.497	ENSGGOG00000006630	DIS3	100	99.461	Gorilla_gorilla
ENSG00000083520	DIS3	96	37.112	ENSGGOG00000001549	DIS3L	91	35.692	Gorilla_gorilla
ENSG00000083520	DIS3	99	35.223	ENSHBUG00000021157	dis3l	92	33.735	Haplochromis_burtoni
ENSG00000083520	DIS3	88	32.097	ENSHBUG00000001086	dis3l2	74	32.353	Haplochromis_burtoni
ENSG00000083520	DIS3	99	74.937	ENSHBUG00000000479	dis3	98	74.582	Haplochromis_burtoni
ENSG00000083520	DIS3	88	34.421	ENSHGLG00000002429	DIS3L2	82	34.615	Heterocephalus_glaber_female
ENSG00000083520	DIS3	99	36.986	ENSHGLG00000007770	DIS3L	92	35.828	Heterocephalus_glaber_female
ENSG00000083520	DIS3	100	91.858	ENSHGLG00000013785	DIS3	99	92.202	Heterocephalus_glaber_female
ENSG00000083520	DIS3	96	37.170	ENSHGLG00100011280	DIS3L	91	36.034	Heterocephalus_glaber_male
ENSG00000083520	DIS3	88	34.421	ENSHGLG00100010938	DIS3L2	82	34.615	Heterocephalus_glaber_male
ENSG00000083520	DIS3	99	92.844	ENSHGLG00100005780	DIS3	99	90.852	Heterocephalus_glaber_male
ENSG00000083520	DIS3	99	68.402	ENSHCOG00000017710	dis3	99	72.414	Hippocampus_comes
ENSG00000083520	DIS3	80	35.380	ENSHCOG00000002371	dis3l2	92	34.949	Hippocampus_comes
ENSG00000083520	DIS3	99	36.878	ENSHCOG00000000183	dis3l	91	35.276	Hippocampus_comes
ENSG00000083520	DIS3	99	68.402	ENSHCOG00000017752	dis3	95	67.864	Hippocampus_comes
ENSG00000083520	DIS3	81	32.633	ENSIPUG00000005868	dis3l2	75	32.863	Ictalurus_punctatus
ENSG00000083520	DIS3	99	75.379	ENSIPUG00000022296	dis3	98	75.586	Ictalurus_punctatus
ENSG00000083520	DIS3	99	37.075	ENSIPUG00000019669	dis3l	91	35.494	Ictalurus_punctatus
ENSG00000083520	DIS3	96	36.993	ENSSTOG00000009158	DIS3L	91	35.881	Ictidomys_tridecemlineatus
ENSG00000083520	DIS3	88	35.127	ENSSTOG00000005668	DIS3L2	73	35.312	Ictidomys_tridecemlineatus
ENSG00000083520	DIS3	99	96.050	ENSSTOG00000000311	DIS3	99	95.574	Ictidomys_tridecemlineatus
ENSG00000083520	DIS3	99	36.752	ENSJJAG00000016147	Dis3l	75	35.714	Jaculus_jaculus
ENSG00000083520	DIS3	100	93.737	ENSJJAG00000011607	Dis3	99	94.099	Jaculus_jaculus
ENSG00000083520	DIS3	85	35.812	ENSJJAG00000002276	Dis3l2	79	36.133	Jaculus_jaculus
ENSG00000083520	DIS3	99	36.269	ENSKMAG00000014185	dis3l	92	35.081	Kryptolebias_marmoratus
ENSG00000083520	DIS3	88	32.576	ENSKMAG00000007743	dis3l2	80	31.985	Kryptolebias_marmoratus
ENSG00000083520	DIS3	100	72.216	ENSKMAG00000000313	dis3	98	73.220	Kryptolebias_marmoratus
ENSG00000083520	DIS3	100	72.604	ENSLBEG00000021617	dis3	99	73.539	Labrus_bergylta
ENSG00000083520	DIS3	99	36.473	ENSLBEG00000019430	dis3l	93	34.787	Labrus_bergylta
ENSG00000083520	DIS3	88	32.648	ENSLBEG00000005475	dis3l2	73	32.391	Labrus_bergylta
ENSG00000083520	DIS3	72	35.930	ENSLACG00000012787	DIS3L2	89	35.930	Latimeria_chalumnae
ENSG00000083520	DIS3	100	77.570	ENSLACG00000010807	DIS3	98	78.307	Latimeria_chalumnae
ENSG00000083520	DIS3	99	37.288	ENSLACG00000007995	DIS3L	92	35.020	Latimeria_chalumnae
ENSG00000083520	DIS3	82	34.229	ENSLOCG00000004804	dis3l2	69	33.566	Lepisosteus_oculatus
ENSG00000083520	DIS3	99	36.082	ENSLOCG00000013846	dis3l	100	35.959	Lepisosteus_oculatus
ENSG00000083520	DIS3	99	77.820	ENSLOCG00000011319	dis3	98	76.533	Lepisosteus_oculatus
ENSG00000083520	DIS3	99	37.925	ENSLAFG00000006866	DIS3L	92	35.522	Loxodonta_africana
ENSG00000083520	DIS3	100	93.424	ENSLAFG00000009120	DIS3	99	93.783	Loxodonta_africana
ENSG00000083520	DIS3	100	98.539	ENSMFAG00000027055	DIS3	100	98.539	Macaca_fascicularis
ENSG00000083520	DIS3	99	36.905	ENSMFAG00000035628	DIS3L	92	35.686	Macaca_fascicularis
ENSG00000083520	DIS3	58	38.722	ENSMFAG00000030972	DIS3L2	68	38.947	Macaca_fascicularis
ENSG00000083520	DIS3	100	98.330	ENSMMUG00000000787	DIS3	100	98.330	Macaca_mulatta
ENSG00000083520	DIS3	99	36.905	ENSMMUG00000003693	DIS3L	92	35.956	Macaca_mulatta
ENSG00000083520	DIS3	88	34.911	ENSMMUG00000015167	DIS3L2	88	41.261	Macaca_mulatta
ENSG00000083520	DIS3	99	36.905	ENSMNEG00000035066	DIS3L	92	35.729	Macaca_nemestrina
ENSG00000083520	DIS3	100	98.434	ENSMNEG00000030275	DIS3	100	98.434	Macaca_nemestrina
ENSG00000083520	DIS3	88	34.873	ENSMNEG00000037549	DIS3L2	71	35.047	Macaca_nemestrina
ENSG00000083520	DIS3	96	36.874	ENSMLEG00000034558	DIS3L	91	35.881	Mandrillus_leucophaeus
ENSG00000083520	DIS3	88	35.312	ENSMLEG00000042840	DIS3L2	71	35.504	Mandrillus_leucophaeus
ENSG00000083520	DIS3	100	98.330	ENSMLEG00000030670	DIS3	100	98.330	Mandrillus_leucophaeus
ENSG00000083520	DIS3	99	73.770	ENSMAMG00000016693	dis3	99	74.015	Mastacembelus_armatus
ENSG00000083520	DIS3	99	36.174	ENSMAMG00000017229	dis3l	93	34.255	Mastacembelus_armatus
ENSG00000083520	DIS3	82	33.241	ENSMAMG00000018174	dis3l2	68	32.732	Mastacembelus_armatus
ENSG00000083520	DIS3	59	34.236	ENSMZEG00005011908	DIS3L	87	33.512	Maylandia_zebra
ENSG00000083520	DIS3	88	32.097	ENSMZEG00005010059	dis3l2	74	32.353	Maylandia_zebra
ENSG00000083520	DIS3	99	74.937	ENSMZEG00005027441	dis3	98	74.582	Maylandia_zebra
ENSG00000083520	DIS3	99	31.469	ENSMZEG00005017095	dis3l	52	31.469	Maylandia_zebra
ENSG00000083520	DIS3	59	34.236	ENSMZEG00005025145	-	81	34.429	Maylandia_zebra
ENSG00000083520	DIS3	87	33.701	ENSMGAG00000008209	DIS3L2	73	33.807	Meleagris_gallopavo
ENSG00000083520	DIS3	99	36.041	ENSMGAG00000009805	DIS3L	92	35.382	Meleagris_gallopavo
ENSG00000083520	DIS3	84	44.842	ENSMGAG00000017114	-	100	41.475	Meleagris_gallopavo
ENSG00000083520	DIS3	88	35.135	ENSMAUG00000011690	Dis3l2	82	35.101	Mesocricetus_auratus
ENSG00000083520	DIS3	100	92.589	ENSMAUG00000014832	Dis3	99	92.940	Mesocricetus_auratus
ENSG00000083520	DIS3	99	36.735	ENSMAUG00000008265	Dis3l	92	35.487	Mesocricetus_auratus
ENSG00000083520	DIS3	99	36.054	ENSMICG00000004374	DIS3L	92	35.288	Microcebus_murinus
ENSG00000083520	DIS3	88	34.718	ENSMICG00000012086	DIS3L2	80	35.194	Microcebus_murinus
ENSG00000083520	DIS3	100	94.990	ENSMICG00000004703	DIS3	99	95.258	Microcebus_murinus
ENSG00000083520	DIS3	99	36.395	ENSMOCG00000005278	Dis3l	92	35.388	Microtus_ochrogaster
ENSG00000083520	DIS3	84	35.814	ENSMOCG00000017509	Dis3l2	81	35.814	Microtus_ochrogaster
ENSG00000083520	DIS3	99	35.529	ENSMMOG00000008377	dis3l	93	33.234	Mola_mola
ENSG00000083520	DIS3	82	30.802	ENSMMOG00000017651	dis3l2	74	30.802	Mola_mola
ENSG00000083520	DIS3	99	70.916	ENSMMOG00000008128	dis3	99	70.370	Mola_mola
ENSG00000083520	DIS3	99	87.737	ENSMODG00000000208	DIS3	99	87.368	Monodelphis_domestica
ENSG00000083520	DIS3	99	36.627	ENSMODG00000009760	DIS3L	92	35.622	Monodelphis_domestica
ENSG00000083520	DIS3	99	74.275	ENSMALG00000018789	dis3	99	74.121	Monopterus_albus
ENSG00000083520	DIS3	88	32.429	ENSMALG00000004604	dis3l2	98	31.500	Monopterus_albus
ENSG00000083520	DIS3	99	35.911	ENSMALG00000003209	dis3l	92	33.936	Monopterus_albus
ENSG00000083520	DIS3	99	37.182	MGP_CAROLIEiJ_G0032344	Dis3l	92	36.166	Mus_caroli
ENSG00000083520	DIS3	88	35.407	MGP_CAROLIEiJ_G0014369	Dis3l2	82	35.759	Mus_caroli
ENSG00000083520	DIS3	100	91.457	MGP_CAROLIEiJ_G0019560	Dis3	99	91.570	Mus_caroli
ENSG00000083520	DIS3	100	91.332	ENSMUSG00000033166	Dis3	99	91.465	Mus_musculus
ENSG00000083520	DIS3	99	37.543	ENSMUSG00000032396	Dis3l	92	35.793	Mus_musculus
ENSG00000083520	DIS3	88	35.259	ENSMUSG00000053333	Dis3l2	82	35.604	Mus_musculus
ENSG00000083520	DIS3	99	36.672	MGP_PahariEiJ_G0015209	Dis3l	92	36.166	Mus_pahari
ENSG00000083520	DIS3	100	91.709	MGP_PahariEiJ_G0030577	Dis3	99	91.878	Mus_pahari
ENSG00000083520	DIS3	88	31.592	MGP_PahariEiJ_G0027606	Dis3l2	82	35.294	Mus_pahari
ENSG00000083520	DIS3	100	91.080	MGP_SPRETEiJ_G0020456	Dis3	99	91.254	Mus_spretus
ENSG00000083520	DIS3	88	35.259	MGP_SPRETEiJ_G0015171	Dis3l2	94	34.304	Mus_spretus
ENSG00000083520	DIS3	99	37.094	MGP_SPRETEiJ_G0033483	Dis3l	92	35.996	Mus_spretus
ENSG00000083520	DIS3	88	35.852	ENSMPUG00000004893	DIS3L2	86	35.259	Mustela_putorius_furo
ENSG00000083520	DIS3	99	36.239	ENSMPUG00000000378	DIS3L	92	35.194	Mustela_putorius_furo
ENSG00000083520	DIS3	99	94.614	ENSMPUG00000010253	DIS3	99	94.521	Mustela_putorius_furo
ENSG00000083520	DIS3	99	94.255	ENSMLUG00000000553	DIS3	99	94.006	Myotis_lucifugus
ENSG00000083520	DIS3	96	37.515	ENSMLUG00000008589	-	91	36.637	Myotis_lucifugus
ENSG00000083520	DIS3	88	33.778	ENSMLUG00000016921	DIS3L2	85	33.185	Myotis_lucifugus
ENSG00000083520	DIS3	99	35.445	ENSNGAG00000017008	Dis3l	93	34.476	Nannospalax_galili
ENSG00000083520	DIS3	100	93.528	ENSNGAG00000018581	Dis3	99	93.888	Nannospalax_galili
ENSG00000083520	DIS3	88	35.769	ENSNGAG00000024235	Dis3l2	72	35.814	Nannospalax_galili
ENSG00000083520	DIS3	88	34.987	ENSNBRG00000012970	dis3l	87	34.487	Neolamprologus_brichardi
ENSG00000083520	DIS3	88	32.061	ENSNBRG00000008893	dis3l2	74	32.353	Neolamprologus_brichardi
ENSG00000083520	DIS3	99	73.485	ENSNBRG00000015801	dis3	98	73.220	Neolamprologus_brichardi
ENSG00000083520	DIS3	100	98.747	ENSNLEG00000016050	DIS3	100	98.747	Nomascus_leucogenys
ENSG00000083520	DIS3	88	33.888	ENSNLEG00000014226	DIS3L2	80	34.019	Nomascus_leucogenys
ENSG00000083520	DIS3	99	37.415	ENSNLEG00000012891	DIS3L	92	36.083	Nomascus_leucogenys
ENSG00000083520	DIS3	74	32.177	ENSMEUG00000014085	DIS3L2	73	32.334	Notamacropus_eugenii
ENSG00000083520	DIS3	76	85.156	ENSMEUG00000003644	DIS3	75	85.156	Notamacropus_eugenii
ENSG00000083520	DIS3	62	46.429	ENSMEUG00000015895	DIS3L	65	43.810	Notamacropus_eugenii
ENSG00000083520	DIS3	88	33.333	ENSOPRG00000015911	DIS3L2	82	34.043	Ochotona_princeps
ENSG00000083520	DIS3	100	90.188	ENSOPRG00000015854	DIS3	99	90.794	Ochotona_princeps
ENSG00000083520	DIS3	85	32.782	ENSOPRG00000004753	-	98	31.281	Ochotona_princeps
ENSG00000083520	DIS3	100	93.216	ENSODEG00000006366	DIS3	99	93.678	Octodon_degus
ENSG00000083520	DIS3	96	35.817	ENSODEG00000015811	DIS3L	93	34.769	Octodon_degus
ENSG00000083520	DIS3	78	34.478	ENSODEG00000007857	DIS3L2	76	33.881	Octodon_degus
ENSG00000083520	DIS3	99	74.716	ENSONIG00000000555	dis3	98	74.255	Oreochromis_niloticus
ENSG00000083520	DIS3	88	34.444	ENSONIG00000018681	dis3l2	83	34.603	Oreochromis_niloticus
ENSG00000083520	DIS3	99	35.506	ENSONIG00000015695	dis3l	92	33.869	Oreochromis_niloticus
ENSG00000083520	DIS3	99	87.799	ENSOANG00000010027	DIS3	95	86.625	Ornithorhynchus_anatinus
ENSG00000083520	DIS3	96	34.017	ENSOANG00000009753	DIS3L	91	33.584	Ornithorhynchus_anatinus
ENSG00000083520	DIS3	100	94.572	ENSOCUG00000006663	DIS3	99	95.132	Oryctolagus_cuniculus
ENSG00000083520	DIS3	97	33.919	ENSOCUG00000002206	DIS3L	92	33.706	Oryctolagus_cuniculus
ENSG00000083520	DIS3	60	38.235	ENSOCUG00000029165	DIS3L2	72	35.866	Oryctolagus_cuniculus
ENSG00000083520	DIS3	98	74.386	ENSORLG00000005460	dis3	98	74.386	Oryzias_latipes
ENSG00000083520	DIS3	99	35.000	ENSORLG00000018364	dis3l	89	34.545	Oryzias_latipes
ENSG00000083520	DIS3	83	33.924	ENSORLG00000009374	dis3l2	88	33.473	Oryzias_latipes
ENSG00000083520	DIS3	97	75.423	ENSORLG00020010040	dis3	98	74.665	Oryzias_latipes_hni
ENSG00000083520	DIS3	99	34.471	ENSORLG00020008000	dis3l	85	34.225	Oryzias_latipes_hni
ENSG00000083520	DIS3	83	33.425	ENSORLG00020011932	dis3l2	69	32.834	Oryzias_latipes_hni
ENSG00000083520	DIS3	99	35.154	ENSORLG00015009985	dis3l	85	34.759	Oryzias_latipes_hsok
ENSG00000083520	DIS3	83	33.875	ENSORLG00015007464	dis3l2	69	33.333	Oryzias_latipes_hsok
ENSG00000083520	DIS3	98	74.066	ENSORLG00015014931	dis3	98	74.330	Oryzias_latipes_hsok
ENSG00000083520	DIS3	99	35.678	ENSOMEG00000016984	dis3l	93	33.761	Oryzias_melastigma
ENSG00000083520	DIS3	99	73.140	ENSOMEG00000009265	dis3	98	73.996	Oryzias_melastigma
ENSG00000083520	DIS3	87	32.776	ENSOMEG00000007257	dis3l2	74	32.776	Oryzias_melastigma
ENSG00000083520	DIS3	100	94.259	ENSOGAG00000009859	DIS3	99	94.521	Otolemur_garnettii
ENSG00000083520	DIS3	87	34.866	ENSOGAG00000009137	DIS3L2	84	34.273	Otolemur_garnettii
ENSG00000083520	DIS3	99	36.968	ENSOGAG00000024086	DIS3L	93	35.484	Otolemur_garnettii
ENSG00000083520	DIS3	100	93.633	ENSOARG00000015309	DIS3	99	93.994	Ovis_aries
ENSG00000083520	DIS3	90	34.877	ENSOARG00000020740	DIS3L2	83	35.401	Ovis_aries
ENSG00000083520	DIS3	96	36.949	ENSOARG00000018151	DIS3L	91	35.737	Ovis_aries
ENSG00000083520	DIS3	96	37.232	ENSPPAG00000019888	DIS3L	91	36.200	Pan_paniscus
ENSG00000083520	DIS3	88	35.460	ENSPPAG00000032052	DIS3L2	71	35.659	Pan_paniscus
ENSG00000083520	DIS3	100	99.623	ENSPPAG00000041783	DIS3	100	99.478	Pan_paniscus
ENSG00000083520	DIS3	100	94.781	ENSPPRG00000008400	DIS3	99	95.364	Panthera_pardus
ENSG00000083520	DIS3	90	35.745	ENSPPRG00000024826	DIS3L2	88	34.877	Panthera_pardus
ENSG00000083520	DIS3	99	37.075	ENSPPRG00000019912	DIS3L	92	36.183	Panthera_pardus
ENSG00000083520	DIS3	96	37.112	ENSPTIG00000009042	DIS3L	92	36.284	Panthera_tigris_altaica
ENSG00000083520	DIS3	90	35.601	ENSPTIG00000017541	DIS3L2	88	34.732	Panthera_tigris_altaica
ENSG00000083520	DIS3	100	94.221	ENSPTIG00000017886	DIS3	99	94.917	Panthera_tigris_altaica
ENSG00000083520	DIS3	100	99.623	ENSPTRG00000005926	DIS3	100	99.623	Pan_troglodytes
ENSG00000083520	DIS3	88	35.460	ENSPTRG00000013033	DIS3L2	71	35.659	Pan_troglodytes
ENSG00000083520	DIS3	99	37.585	ENSPTRG00000007191	DIS3L	92	36.284	Pan_troglodytes
ENSG00000083520	DIS3	99	37.201	ENSPANG00000016671	DIS3L	92	35.956	Papio_anubis
ENSG00000083520	DIS3	88	35.312	ENSPANG00000019815	DIS3L2	70	35.504	Papio_anubis
ENSG00000083520	DIS3	100	97.292	ENSPANG00000010053	DIS3	100	97.292	Papio_anubis
ENSG00000083520	DIS3	99	36.770	ENSPKIG00000015490	dis3l	92	34.271	Paramormyrops_kingsleyae
ENSG00000083520	DIS3	91	75.000	ENSPKIG00000013775	dis3	97	77.320	Paramormyrops_kingsleyae
ENSG00000083520	DIS3	87	32.850	ENSPKIG00000006103	dis3l2	73	32.181	Paramormyrops_kingsleyae
ENSG00000083520	DIS3	87	34.548	ENSPSIG00000007443	DIS3L2	73	34.548	Pelodiscus_sinensis
ENSG00000083520	DIS3	99	83.439	ENSPSIG00000003998	DIS3	85	82.260	Pelodiscus_sinensis
ENSG00000083520	DIS3	96	37.410	ENSPSIG00000011629	DIS3L	90	36.034	Pelodiscus_sinensis
ENSG00000083520	DIS3	100	72.633	ENSPMGG00000023439	dis3	99	73.595	Periophthalmus_magnuspinnatus
ENSG00000083520	DIS3	99	35.891	ENSPMGG00000013765	dis3l	93	34.455	Periophthalmus_magnuspinnatus
ENSG00000083520	DIS3	88	32.705	ENSPMGG00000020250	dis3l2	94	32.705	Periophthalmus_magnuspinnatus
ENSG00000083520	DIS3	88	34.763	ENSPEMG00000011060	Dis3l2	81	35.139	Peromyscus_maniculatus_bairdii
ENSG00000083520	DIS3	99	36.224	ENSPEMG00000001213	Dis3l	92	35.253	Peromyscus_maniculatus_bairdii
ENSG00000083520	DIS3	100	92.589	ENSPEMG00000019729	Dis3	99	92.940	Peromyscus_maniculatus_bairdii
ENSG00000083520	DIS3	57	44.954	ENSPMAG00000007278	-	99	44.954	Petromyzon_marinus
ENSG00000083520	DIS3	83	45.299	ENSPMAG00000009854	-	89	73.016	Petromyzon_marinus
ENSG00000083520	DIS3	99	36.159	ENSPMAG00000007299	dis3l	92	35.075	Petromyzon_marinus
ENSG00000083520	DIS3	99	36.379	ENSPCIG00000006827	DIS3L	92	35.382	Phascolarctos_cinereus
ENSG00000083520	DIS3	100	88.393	ENSPCIG00000018448	DIS3	92	87.684	Phascolarctos_cinereus
ENSG00000083520	DIS3	99	73.711	ENSPFOG00000018054	dis3	98	73.589	Poecilia_formosa
ENSG00000083520	DIS3	88	31.904	ENSPFOG00000007818	dis3l2	80	30.524	Poecilia_formosa
ENSG00000083520	DIS3	99	35.544	ENSPFOG00000017504	dis3l	93	34.449	Poecilia_formosa
ENSG00000083520	DIS3	88	32.680	ENSPLAG00000021123	dis3l2	95	32.592	Poecilia_latipinna
ENSG00000083520	DIS3	99	35.972	ENSPLAG00000017167	dis3l	93	34.886	Poecilia_latipinna
ENSG00000083520	DIS3	99	73.711	ENSPLAG00000007305	dis3	99	73.526	Poecilia_latipinna
ENSG00000083520	DIS3	88	31.692	ENSPMEG00000001083	dis3l2	79	34.732	Poecilia_mexicana
ENSG00000083520	DIS3	99	36.426	ENSPMEG00000008867	dis3l	93	34.886	Poecilia_mexicana
ENSG00000083520	DIS3	99	73.459	ENSPMEG00000010800	dis3	98	73.376	Poecilia_mexicana
ENSG00000083520	DIS3	91	30.685	ENSPREG00000002432	dis3l2	93	30.759	Poecilia_reticulata
ENSG00000083520	DIS3	89	37.384	ENSPREG00000008170	dis3l	85	36.616	Poecilia_reticulata
ENSG00000083520	DIS3	100	71.950	ENSPREG00000011150	dis3	98	73.133	Poecilia_reticulata
ENSG00000083520	DIS3	99	37.075	ENSPPYG00000006575	DIS3L	92	35.189	Pongo_abelii
ENSG00000083520	DIS3	77	34.872	ENSPPYG00000013274	DIS3L2	78	35.180	Pongo_abelii
ENSG00000083520	DIS3	100	98.643	ENSPPYG00000005413	DIS3	100	98.643	Pongo_abelii
ENSG00000083520	DIS3	80	37.947	ENSPCAG00000003114	DIS3L	85	37.947	Procavia_capensis
ENSG00000083520	DIS3	99	93.537	ENSPCAG00000011101	DIS3	99	89.463	Procavia_capensis
ENSG00000083520	DIS3	99	95.512	ENSPCOG00000026058	DIS3	100	91.085	Propithecus_coquereli
ENSG00000083520	DIS3	88	34.421	ENSPCOG00000026117	DIS3L2	80	34.884	Propithecus_coquereli
ENSG00000083520	DIS3	99	35.764	ENSPCOG00000015776	DIS3L	92	35.312	Propithecus_coquereli
ENSG00000083520	DIS3	84	37.022	ENSPVAG00000004927	DIS3L	76	37.885	Pteropus_vampyrus
ENSG00000083520	DIS3	91	94.431	ENSPVAG00000012649	DIS3	90	94.866	Pteropus_vampyrus
ENSG00000083520	DIS3	99	72.638	ENSPNYG00000003418	dis3	98	74.582	Pundamilia_nyererei
ENSG00000083520	DIS3	88	32.097	ENSPNYG00000002208	dis3l2	74	32.353	Pundamilia_nyererei
ENSG00000083520	DIS3	99	35.223	ENSPNYG00000002066	dis3l	92	33.735	Pundamilia_nyererei
ENSG00000083520	DIS3	99	37.138	ENSPNAG00000014400	dis3l	91	35.030	Pygocentrus_nattereri
ENSG00000083520	DIS3	100	74.244	ENSPNAG00000011385	dis3	98	75.373	Pygocentrus_nattereri
ENSG00000083520	DIS3	81	33.104	ENSPNAG00000029602	dis3l2	69	32.418	Pygocentrus_nattereri
ENSG00000083520	DIS3	88	35.259	ENSRNOG00000018931	Dis3l2	82	35.449	Rattus_norvegicus
ENSG00000083520	DIS3	99	36.333	ENSRNOG00000010537	Dis3l	92	35.353	Rattus_norvegicus
ENSG00000083520	DIS3	100	92.337	ENSRNOG00000009125	Dis3	92	92.413	Rattus_norvegicus
ENSG00000083520	DIS3	96	36.993	ENSRBIG00000029360	DIS3L	91	36.151	Rhinopithecus_bieti
ENSG00000083520	DIS3	100	98.017	ENSRBIG00000034236	DIS3	100	98.017	Rhinopithecus_bieti
ENSG00000083520	DIS3	88	32.460	ENSRBIG00000033993	DIS3L2	71	32.675	Rhinopithecus_bieti
ENSG00000083520	DIS3	88	35.163	ENSRROG00000038106	DIS3L2	71	35.504	Rhinopithecus_roxellana
ENSG00000083520	DIS3	100	98.017	ENSRROG00000012179	DIS3	100	98.017	Rhinopithecus_roxellana
ENSG00000083520	DIS3	99	37.075	ENSRROG00000038323	DIS3L	92	35.885	Rhinopithecus_roxellana
ENSG00000083520	DIS3	99	41.475	YOL021C	DIS3	96	43.165	Saccharomyces_cerevisiae
ENSG00000083520	DIS3	88	34.421	ENSSBOG00000025395	DIS3L2	71	35.194	Saimiri_boliviensis_boliviensis
ENSG00000083520	DIS3	100	97.185	ENSSBOG00000028346	DIS3	100	97.464	Saimiri_boliviensis_boliviensis
ENSG00000083520	DIS3	99	88.243	ENSSHAG00000015153	DIS3	99	87.895	Sarcophilus_harrisii
ENSG00000083520	DIS3	99	36.210	ENSSHAG00000010970	DIS3L	92	34.985	Sarcophilus_harrisii
ENSG00000083520	DIS3	99	75.348	ENSSFOG00015006865	dis3	98	74.947	Scleropages_formosus
ENSG00000083520	DIS3	81	33.566	ENSSFOG00015013209	dis3l2	82	33.333	Scleropages_formosus
ENSG00000083520	DIS3	99	36.410	ENSSFOG00015024038	dis3l	90	35.366	Scleropages_formosus
ENSG00000083520	DIS3	99	35.678	ENSSMAG00000004147	dis3l	92	34.070	Scophthalmus_maximus
ENSG00000083520	DIS3	99	74.492	ENSSMAG00000017337	dis3	99	74.362	Scophthalmus_maximus
ENSG00000083520	DIS3	81	34.094	ENSSMAG00000012119	dis3l2	86	34.184	Scophthalmus_maximus
ENSG00000083520	DIS3	88	31.599	ENSSDUG00000005457	dis3l2	74	31.122	Seriola_dumerili
ENSG00000083520	DIS3	99	36.707	ENSSDUG00000002630	dis3l	92	34.315	Seriola_dumerili
ENSG00000083520	DIS3	99	74.340	ENSSDUG00000017652	dis3	98	74.527	Seriola_dumerili
ENSG00000083520	DIS3	88	31.472	ENSSLDG00000005136	dis3l2	74	30.995	Seriola_lalandi_dorsalis
ENSG00000083520	DIS3	99	74.465	ENSSLDG00000015135	dis3	98	74.389	Seriola_lalandi_dorsalis
ENSG00000083520	DIS3	99	37.050	ENSSLDG00000009525	dis3l	92	34.036	Seriola_lalandi_dorsalis
ENSG00000083520	DIS3	61	88.991	ENSSARG00000008629	-	61	88.991	Sorex_araneus
ENSG00000083520	DIS3	86	35.495	ENSSARG00000001350	DIS3L	84	35.495	Sorex_araneus
ENSG00000083520	DIS3	77	91.841	ENSSARG00000011803	-	100	92.614	Sorex_araneus
ENSG00000083520	DIS3	78	33.835	ENSSPUG00000011982	DIS3L2	57	34.165	Sphenodon_punctatus
ENSG00000083520	DIS3	98	36.780	ENSSPUG00000013652	DIS3L	93	35.491	Sphenodon_punctatus
ENSG00000083520	DIS3	100	80.927	ENSSPUG00000011738	DIS3	99	79.424	Sphenodon_punctatus
ENSG00000083520	DIS3	99	36.239	ENSSPAG00000019455	dis3l	92	35.035	Stegastes_partitus
ENSG00000083520	DIS3	82	33.102	ENSSPAG00000021224	dis3l2	87	32.361	Stegastes_partitus
ENSG00000083520	DIS3	99	73.797	ENSSPAG00000019530	dis3	99	73.673	Stegastes_partitus
ENSG00000083520	DIS3	100	94.363	ENSSSCG00000009460	DIS3	99	94.731	Sus_scrofa
ENSG00000083520	DIS3	99	36.581	ENSSSCG00000004941	DIS3L	92	35.593	Sus_scrofa
ENSG00000083520	DIS3	91	34.339	ENSSSCG00000022177	DIS3L2	87	33.764	Sus_scrofa
ENSG00000083520	DIS3	99	82.872	ENSTGUG00000012500	DIS3	98	81.896	Taeniopygia_guttata
ENSG00000083520	DIS3	96	37.500	ENSTGUG00000009315	DIS3L	93	34.990	Taeniopygia_guttata
ENSG00000083520	DIS3	99	35.445	ENSTRUG00000009567	dis3l	92	33.766	Takifugu_rubripes
ENSG00000083520	DIS3	81	33.010	ENSTRUG00000006319	dis3l2	62	35.889	Takifugu_rubripes
ENSG00000083520	DIS3	99	72.658	ENSTRUG00000010021	dis3	99	72.611	Takifugu_rubripes
ENSG00000083520	DIS3	97	73.677	ENSTNIG00000017037	dis3	98	72.311	Tetraodon_nigroviridis
ENSG00000083520	DIS3	96	35.024	ENSTNIG00000004764	dis3l	91	34.335	Tetraodon_nigroviridis
ENSG00000083520	DIS3	88	31.846	ENSTNIG00000007891	dis3l2	97	31.891	Tetraodon_nigroviridis
ENSG00000083520	DIS3	100	86.216	ENSTBEG00000006813	DIS3	99	86.983	Tupaia_belangeri
ENSG00000083520	DIS3	82	34.150	ENSTTRG00000009186	DIS3L2	84	33.478	Tursiops_truncatus
ENSG00000083520	DIS3	100	92.589	ENSTTRG00000004248	DIS3	99	92.940	Tursiops_truncatus
ENSG00000083520	DIS3	84	35.334	ENSTTRG00000010174	DIS3L	74	35.334	Tursiops_truncatus
ENSG00000083520	DIS3	100	94.097	ENSUAMG00000027931	DIS3	100	93.617	Ursus_americanus
ENSG00000083520	DIS3	91	32.810	ENSUAMG00000020532	DIS3L2	88	32.286	Ursus_americanus
ENSG00000083520	DIS3	74	38.949	ENSUAMG00000004022	-	88	38.725	Ursus_americanus
ENSG00000083520	DIS3	82	37.459	ENSUMAG00000015745	DIS3L2	75	37.134	Ursus_maritimus
ENSG00000083520	DIS3	96	37.232	ENSUMAG00000012227	DIS3L	90	35.775	Ursus_maritimus
ENSG00000083520	DIS3	99	93.774	ENSUMAG00000009496	DIS3	99	94.196	Ursus_maritimus
ENSG00000083520	DIS3	63	37.952	ENSVPAG00000004273	DIS3L2	72	37.952	Vicugna_pacos
ENSG00000083520	DIS3	88	37.255	ENSVPAG00000006742	DIS3L	91	34.860	Vicugna_pacos
ENSG00000083520	DIS3	99	93.896	ENSVPAG00000003584	DIS3	99	92.940	Vicugna_pacos
ENSG00000083520	DIS3	99	95.691	ENSVVUG00000018095	DIS3	99	95.153	Vulpes_vulpes
ENSG00000083520	DIS3	88	35.905	ENSVVUG00000025543	DIS3L2	85	35.163	Vulpes_vulpes
ENSG00000083520	DIS3	96	36.754	ENSVVUG00000014492	DIS3L	92	35.745	Vulpes_vulpes
ENSG00000083520	DIS3	99	37.075	ENSXETG00000015865	dis3l	92	35.435	Xenopus_tropicalis
ENSG00000083520	DIS3	74	34.585	ENSXETG00000033647	DIS3L2	82	34.585	Xenopus_tropicalis
ENSG00000083520	DIS3	99	81.472	ENSXETG00000012344	dis3	99	79.641	Xenopus_tropicalis
ENSG00000083520	DIS3	99	68.817	ENSXCOG00000009941	dis3	98	73.021	Xiphophorus_couchianus
ENSG00000083520	DIS3	76	34.865	ENSXCOG00000001383	dis3l	83	34.755	Xiphophorus_couchianus
ENSG00000083520	DIS3	88	32.232	ENSXMAG00000011688	dis3l2	78	35.460	Xiphophorus_maculatus
ENSG00000083520	DIS3	99	34.321	ENSXMAG00000013661	dis3l	92	35.419	Xiphophorus_maculatus
ENSG00000083520	DIS3	100	72.054	ENSXMAG00000018215	dis3	99	72.979	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000175	3'-5'-exoribonuclease activity	20531386.	IMP	Function
GO:0000175	3'-5'-exoribonuclease activity	-	TAS	Function
GO:0000176	nuclear exosome (RNase complex)	21873635.	IBA	Component
GO:0000176	nuclear exosome (RNase complex)	20531386.	IDA	Component
GO:0000177	cytoplasmic exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	9562621.	TAS	Component
GO:0003723	RNA binding	-	IEA	Function
GO:0004519	endonuclease activity	21873635.	IBA	Function
GO:0004519	endonuclease activity	20531386.	IMP	Function
GO:0005085	guanyl-nucleotide exchange factor activity	9562621.	IDA	Function
GO:0005515	protein binding	15231747.20531386.20531389.21255825.23756462.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	20531389.	IDA	Component
GO:0005730	nucleolus	20531386.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	9562621.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016075	rRNA catabolic process	21873635.	IBA	Process
GO:0016075	rRNA catabolic process	20368444.	IMP	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0071034	CUT catabolic process	19056938.	IMP	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26305418	A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.	Oncotarget	2015 Sep 22	Lionetti M	doi: 10.18632/oncotarget.4674.
24478024	Gene-dosage dependent overexpression at the 13q amplicon identifies DIS3 as candidate oncogene in colorectal cancer progression.	Genes Chromosomes Cancer	2014 Apr	de Groen FL	doi: 10.1002/gcc.22144
28172817	Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.	Hum Mol Genet	2016 Nov 1	Hoskins JW	doi: 10.1093/hmg/ddw300.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr13	72773807	Silent	novel	L372L	0.46
BLCA	chr13	72760607	Silent	rs779087641	D905D	0.17
BLCA	chr13	72772737	Missense_Mutation	novel	V448L	0.55
BLCA	chr13	72760619	Missense_Mutation	novel	F901L	0.67
BLCA	chr13	72777458	Missense_Mutation	rs760670933	E206K	0.4
BLCA	chr13	72760578	Missense_Mutation	rs754234020	S915L	0.59
BLCA	chr13	72761964	Missense_Mutation	NA	L767F	0.22
BLCA	chr13	72761990	Missense_Mutation	novel	D759N	0.66
BLCA	chr13	72768883	Silent	novel	L595L	0.23
BRCA	chr13	72775364	Silent	NA	Q278Q	0.45
BRCA	chr13	72777458	Missense_Mutation	rs760670933	E206K	0.15
BRCA	chr13	72774046	Missense_Mutation	NA	V334A	0.22
BRCA	chr13	72763512	Missense_Mutation	NA	R689Q	0.15
BRCA	chr13	72771089	Missense_Mutation	NA	D554E	0.29
BRCA	chr13	72763545	Frame_Shift_Ins	NA	*I678Nfs3**	0.25
BRCA	chr13	72773750	Silent	novel	S391S	0.05
CESC	chr13	72775293	Nonsense_Mutation	novel	W302*	0.09
CESC	chr13	72762008	Missense_Mutation	novel	Y753H	0.42
CESC	chr13	72770904	Splice_Region	NA	K585K	0.22
CESC	chr13	72762101	Missense_Mutation	novel	A722T	0.31
COAD	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.07
COAD	chr13	72775945	Missense_Mutation	rs373230191	D268N	0.3
COAD	chr13	72771860	Missense_Mutation	novel	R514W	0.25
COAD	chr13	72763512	Missense_Mutation	NA	R689Q	0.3
COAD	chr13	72771882	Silent	NA	I506I	0.08
COAD	chr13	72761809	Missense_Mutation	NA	A783V	0.35
COAD	chr13	72773736	Missense_Mutation	rs369590515	R396Q	0.37
COAD	chr13	72761940	Frame_Shift_Del	novel	*F775Lfs30**	0.43
COAD	chr13	72772750	Silent	NA	P443P	0.24
COAD	chr13	72761713	Missense_Mutation	NA	K815T	0.1
COAD	chr13	72768860	Missense_Mutation	novel	N603T	0.11
COAD	chr13	72761488	Missense_Mutation	NA	E849K	0.3
COAD	chr13	72766003	Missense_Mutation	NA	D647N	0.48
ESCA	chr13	72755395	3'UTR	rs765266815		0.25
ESCA	chr13	72771806	Missense_Mutation	novel	L532F	0.24
ESCA	chr13	72759795	Nonstop_Mutation	novel	959Yext14	0.48
GBM	chr13	72780867	Missense_Mutation	NA	T122I	0.54	RNB
GBM	chr13	72772262	Missense_Mutation	rs201674523	R467Q	0.6
GBM	chr13	72763578	Frame_Shift_Del	novel	*M667Vfs13**	0.44
GBM	chr13	72761964	Missense_Mutation	NA	L767F	0.42
HNSC	chr13	72763542	Missense_Mutation	novel	H679P	0.18
HNSC	chr13	72772765	Silent	novel	D438D	0.27
HNSC	chr13	72771114	Missense_Mutation	rs779209129	S546F	0.29
HNSC	chr13	72776025	Missense_Mutation	novel	I241R	0.26
HNSC	chr13	72775330	Missense_Mutation	novel	D290H	0.24
HNSC	chr13	72760589	Silent	novel	I911I	0.16
KICH	chr13	72774041	Missense_Mutation	rs757537527	E336K	0.49
KIRC	chr13	72766021	Missense_Mutation	NA	M641V	0.22
KIRC	chr13	72773797	Missense_Mutation	NA	A376P	0.2
KIRC	chr13	72761433	Missense_Mutation	NA	Y867C	0.24
KIRC	chr13	72761925	Missense_Mutation	NA	R780S	0.27
KIRC	chr13	72759754	3'UTR	novel		0.34
LAML	chr13	72763579	Missense_Mutation	novel	M667V	0.35
LGG	chr13	72771102	Missense_Mutation	NA	S550F	0.18
LGG	chr13	72772199	Missense_Mutation	NA	D488G	0.38
LIHC	chr13	72772254	Missense_Mutation	novel	L470M	0.07
LIHC	chr13	72772723	Silent	novel	L452L	0.35
LIHC	chr13	72761964	Missense_Mutation	NA	L767F	0.3
LUAD	chr13	72772277	Splice_Site	novel	X463_splice	0.92
LUAD	chr13	72781770	Silent	NA	R21R	0.58
LUAD	chr13	72778287	Silent	rs778838980	L160L	0.1
LUAD	chr13	72775945	Missense_Mutation	rs373230191	D268N	0.24
LUAD	chr13	72759844	Frame_Shift_Del	novel	*N943Tfs12**	0.53
LUAD	chr13	72770982	Silent	NA	A559A	0.4
LUAD	chr13	72771101	Silent	NA	S550S	0.41
LUAD	chr13	72759856	Missense_Mutation	NA	T939S	0.28
LUAD	chr13	72772257	Missense_Mutation	novel	D469Y	0.49
LUAD	chr13	72774016	Missense_Mutation	novel	R344I	0.33
LUAD	chr13	72772199	Missense_Mutation	NA	D488A	0.18
LUAD	chr13	72772200	Missense_Mutation	NA	D488N	0.25
LUAD	chr13	72760578	Missense_Mutation	rs754234020	S915L	0.12
LUAD	chr13	72774016	Missense_Mutation	NA	R344T	0.23
LUSC	chr13	72759760	3'UTR	novel		0.81
LUSC	chr13	72776049	Missense_Mutation	NA	P233L	0.33
LUSC	chr13	72774047	Missense_Mutation	novel	V334L	0.13
LUSC	chr13	72763493	Silent	novel	P695P	0.73
LUSC	chr13	72773945	Splice_Site	rs776543561	X367_splice	0.3
OV	chr13	72755220	3'UTR	novel		0.36
PRAD	chr13	72763513	Missense_Mutation	novel	R689G	0.28
PRAD	chr13	72773694	Missense_Mutation	NA	R410K	0.17
PRAD	chr13	72771863	Missense_Mutation	novel	I513V	0.06
READ	chr13	72763512	Missense_Mutation	NA	R689Q	0.23
READ	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.26
READ	chr13	72761783	Missense_Mutation	NA	A792T	0.27
READ	chr13	72761473	Missense_Mutation	novel	F854L	0.39
READ	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.43
READ	chr13	72762012	Silent	NA	A751A	0.27
READ	chr13	72763512	Missense_Mutation	NA	R689Q	0.38
READ	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.42
READ	chr13	72777488	Nonsense_Mutation	NA	E196*	0.22
SKCM	chr13	72775311	Missense_Mutation	NA	L296P	0.24
SKCM	chr13	72771887	Missense_Mutation	NA	H505Y	0.16
SKCM	chr13	72755305	3'UTR	novel		0.2
SKCM	chr13	72766030	Nonsense_Mutation	rs770832001	R638*	0.22
SKCM	chr13	72775992	Missense_Mutation	NA	R252T	0.96
SKCM	chr13	72759840	Missense_Mutation	novel	M944I	0.25
SKCM	chr13	72760589	Silent	NA	I911I	0.22
SKCM	chr13	72761513	Silent	NA	F840F	0.21
SKCM	chr13	72762064	Missense_Mutation	NA	P734L	0.33
SKCM	chr13	72776049	Missense_Mutation	NA	P233L	0.39
SKCM	chr13	72773773	Missense_Mutation	rs146500302	R384C	0.45
STAD	chr13	72778224	Frame_Shift_Del	novel	*K181Rfs14**	0.39
STAD	chr13	72763546	Frame_Shift_Del	rs771690280	*I678Ffs59**	0.41
STAD	chr13	72761503	Missense_Mutation	NA	G844R	0.32
STAD	chr13	72762029	Missense_Mutation	rs541536936	R746C	0.22
STAD	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.3
STAD	chr13	72776015	Silent	NA	G244G	0.07
STAD	chr13	72772746	Frame_Shift_Del	NA	*S445Hfs20**	0.21
STAD	chr13	72775209	Splice_Site	NA	X329_splice	0.18
TGCT	chr13	72761432	Frame_Shift_Del	novel	*Y867Wfs9**	0.3
THCA	chr13	72771810	Silent	NA	V530V	0.1
THCA	chr13	72761468	In_Frame_Ins	novel	V855_R856insNSQ	0.07
THCA	chr13	72761470	Missense_Mutation	novel	V855I	0.05
THCA	chr13	72755305	3'UTR	novel		0.13
THCA	chr13	72755307	3'UTR	novel		0.07
UCEC	chr13	72768881	Missense_Mutation	NA	R596I	0.32
UCEC	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.37
UCEC	chr13	72778208	Nonsense_Mutation	NA	E187*	0.17
UCEC	chr13	72780933	Missense_Mutation	novel	N100T	0.13
UCEC	chr13	72776072	Missense_Mutation	NA	K225N	0.37
UCEC	chr13	72761810	Missense_Mutation	rs746546609	A783T	0.1
UCEC	chr13	72763512	Missense_Mutation	NA	R689Q	0.43
UCEC	chr13	72780878	Silent	novel	K118K	0.44
UCEC	chr13	72755514	3'UTR	novel		0.24
UCEC	chr13	72772157	Splice_Site	novel	X501_splice	0.16
UCEC	chr13	72759840	Missense_Mutation	novel	M944I	0.18
UCEC	chr13	72755238	3'UTR	novel		0.44
UCEC	chr13	72762080	Missense_Mutation	rs755761632	E729K	0.39
UCEC	chr13	72763549	Missense_Mutation	novel	K677Q	0.26
UCEC	chr13	72763512	Missense_Mutation	NA	R689Q	0.11
UCEC	chr13	72762036	Frame_Shift_Ins	novel	*A744Gfs20**	0.11
UCEC	chr13	72773736	Missense_Mutation	rs369590515	R396Q	0.39
UCEC	chr13	72776019	Missense_Mutation	NA	S243Y	0.12
UCEC	chr13	72778336	Missense_Mutation	novel	R144M	0.07	RNB
UCEC	chr13	72781863	5'UTR	novel		0.36
UCEC	chr13	72766038	Missense_Mutation	novel	P635H	0.13
UCEC	chr13	72780853	Missense_Mutation	novel	H127Y	0.17	RNB
UCEC	chr13	72755278	3'UTR	novel		0.43
UCEC	chr13	72768800	Missense_Mutation	novel	R623I	0.08
UCEC	chr13	72763490	Silent	NA	P696P	0.37
UCEC	chr13	72774049	Missense_Mutation	novel	A333V	0.21
UCEC	chr13	72760624	Missense_Mutation	novel	V900L	0.4
UCEC	chr13	72780930	Missense_Mutation	NA	R101H	0.44
UCEC	chr13	72771876	Silent	NA	D508D	0.4
UCEC	chr13	72761660	Missense_Mutation	NA	A833T	0.4
UCEC	chr13	72773778	Missense_Mutation	rs139907646	R382Q	0.29
UCEC	chr13	72772244	Missense_Mutation	novel	L473P	0.2
UCEC	chr13	72755336	3'UTR	novel		0.11
UCEC	chr13	72781815	Silent	novel	T6T	0.36
UCEC	chr13	72771809	Missense_Mutation	novel	Y531H	0.39
UCEC	chr13	72773787	Missense_Mutation	novel	R379I	0.22
UCEC	chr13	72773812	Missense_Mutation	novel	H371Y	0.21
UCEC	chr13	72766030	Nonsense_Mutation	rs770832001	R638*	0.26
UCEC	chr13	72775242	Missense_Mutation	novel	D319G	0.46
UCEC	chr13	72762064	Missense_Mutation	NA	P734L	0.4
UCEC	chr13	72770984	Missense_Mutation	novel	A559T	0.32
UCEC	chr13	72765989	Silent	NA	L651L	0.29
UCEC	chr13	72772276	Splice_Site	NA	X463_splice	0.45
UCEC	chr13	72781742	Missense_Mutation	novel	C31R	0.27
UCEC	chr13	72761932	Missense_Mutation	NA	P778H	0.25
UCEC	chr13	72773784	Missense_Mutation	NA	I380S	0.31
UCEC	chr13	72778324	Missense_Mutation	rs768054707	A148V	0.24	RNB
UCEC	chr13	72780929	Silent	NA	R101R	0.14
UCEC	chr13	72778324	Missense_Mutation	rs768054707	A148V	0.43	RNB
UCS	chr13	72772177	Silent	rs774554288	L495L	0.52

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.076931
GBM	DEL	0.3622	4.92e-12
PRAD	DEL	0.315	1.7107e-36

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00025	Kaplan-Meier Survival Analysis
SARC	0.033	Kaplan-Meier Survival Analysis
ACC	0.0043	Kaplan-Meier Survival Analysis
HNSC	0.024	Kaplan-Meier Survival Analysis
SKCM	0.048	Kaplan-Meier Survival Analysis
PRAD	0.0029	Kaplan-Meier Survival Analysis
LUSC	0.032	Kaplan-Meier Survival Analysis
PAAD	0.0019	Kaplan-Meier Survival Analysis
READ	0.045	Kaplan-Meier Survival Analysis
LGG	0.0079	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742