EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000084072 (Gene tree)
Gene ID: 10450
Gene Symbol: PPIE
Alias: CyP-33|MGC3736|MGC111222
Full Name: peptidylprolyl isomerase E
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 71,733 bases
Position: chr1:39,692,182-39,763,914
Accession: 9258
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000431714	RRM_1	PF00076.22	1.1e-20	1	1
ENSP00000348904	RRM_1	PF00076.22	1.8e-20	1	1
ENSP00000312769	RRM_1	PF00076.22	1.9e-20	1	1
ENSP00000361918	RRM_1	PF00076.22	1.9e-20	1	1
ENSP00000361925	RRM_1	PF00076.22	8.2e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20460131	Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.	J Mol Biol	2010 Jul 9	Hom RA	doi: 10.1016/j.jmb.2010.04.067
8977107	A nuclear RNA-binding cyclophilin in human T cells.	FEBS Lett	1996 Dec 2	Mi H	-
15963461	1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase.	Biochem Biophys Res Commun	2005 Aug 5	Wang T	-
18258190	Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33.	FEBS Lett	2008 Mar 5	Wang Y	doi: 10.1016/j.febslet.2008.01.055

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000456578	PPIE-205	615	-	-	- (aa)	-	-
ENST00000480169	PPIE-211	891	-	-	- (aa)	-	-
ENST00000356511	PPIE-202	1079	-	ENSP00000348904	296 (aa)	-	Q9UNP9
ENST00000470018	PPIE-207	947	-	ENSP00000436689	71 (aa)	-	E9PIB0
ENST00000495526	PPIE-214	4651	-	ENSP00000434989	38 (aa)	-	E9PMH0
ENST00000372835	PPIE-204	842	-	ENSP00000361925	250 (aa)	-	E9PEQ6
ENST00000474804	PPIE-209	793	-	ENSP00000432396	37 (aa)	-	H0YCV4
ENST00000475350	PPIE-210	1213	-	ENSP00000434888	36 (aa)	-	H0YE31
ENST00000372830	PPIE-203	1198	XM_006710289	ENSP00000361918	314 (aa)	XP_006710352	Q9UNP9
ENST00000324379	PPIE-201	1277	XM_006710290	ENSP00000312769	301 (aa)	XP_006710353	Q9UNP9
ENST00000497370	PPIE-215	913	XM_011540501	ENSP00000433475	213 (aa)	XP_011538803	E9PKY5
ENST00000482751	PPIE-212	2564	-	-	- (aa)	-	-
ENST00000485507	PPIE-213	783	-	-	- (aa)	-	-
ENST00000467741	PPIE-206	626	-	-	- (aa)	-	-
ENST00000470213	PPIE-208	927	-	ENSP00000431714	208 (aa)	-	E9PK21

Gene Model

Click here to download ENSG00000084072's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000084072	rs12086750	1	39744796	C	Blood protein levels	29875488	[0.32-0.44] unit decrease	0.38	EFO_0007937
ENSG00000084072	rs11577371	1	39694913	G	Bone mineral density (Ward's triangle area)	27397699	[NR] unit decrease	0.15	EFO_0007785
ENSG00000084072	rs9787249	1	39747206	A	Blood protein levels	28240269	[0.37-0.55] unit decrease	0.4596	EFO_0008257
ENSG00000084072	rs506424	1	39719316	?	Cold sores	28928442	[0.041-0.107] unit decrease	0.074	EFO_0008402
ENSG00000084072	rs1046988	1	39753393	C	Blood protein levels	30072576	[0.21-0.31] unit increase	0.26	EFO_0007937
ENSG00000084072	rs76571594	1	39739351	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000084072's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000084072	PPIE	51	39.474	ENSG00000070756	PABPC1	81	39.344

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000084072	PPIE	100	85.762	ENSAPOG00000001160	ppie	100	86.093	Acanthochromis_polyacanthus
ENSG00000084072	PPIE	100	82.800	ENSACIG00000022599	ppie	100	82.800	Amphilophus_citrinellus
ENSG00000084072	PPIE	100	85.762	ENSAOCG00000021474	ppie	100	86.093	Amphiprion_ocellaris
ENSG00000084072	PPIE	100	85.762	ENSAPEG00000019253	ppie	100	86.093	Amphiprion_percula
ENSG00000084072	PPIE	100	85.714	ENSATEG00000007395	ppie	100	85.714	Anabas_testudineus
ENSG00000084072	PPIE	100	90.610	ENSACAG00000002688	PPIE	100	90.365	Anolis_carolinensis
ENSG00000084072	PPIE	100	98.671	ENSANAG00000033595	PPIE	100	98.671	Aotus_nancymaae
ENSG00000084072	PPIE	100	85.762	ENSACLG00000019518	ppie	100	86.093	Astatotilapia_calliptera
ENSG00000084072	PPIE	100	86.379	ENSAMXG00000018767	ppie	100	86.379	Astyanax_mexicanus
ENSG00000084072	PPIE	100	98.007	ENSBTAG00000047314	PPIE	100	98.007	Bos_taurus
ENSG00000084072	PPIE	100	98.800	ENSCJAG00000002589	PPIE	100	98.800	Callithrix_jacchus
ENSG00000084072	PPIE	100	99.336	ENSCAFG00000003031	PPIE	100	99.336	Canis_familiaris
ENSG00000084072	PPIE	100	99.336	ENSCAFG00020004132	PPIE	100	99.336	Canis_lupus_dingo
ENSG00000084072	PPIE	99	97.642	ENSCHIG00000012509	-	100	95.017	Capra_hircus
ENSG00000084072	PPIE	98	56.766	ENSCHIG00000023905	-	100	56.766	Capra_hircus
ENSG00000084072	PPIE	100	99.003	ENSTSYG00000000401	PPIE	100	99.003	Carlito_syrichta
ENSG00000084072	PPIE	100	98.339	ENSCPOG00000007365	PPIE	100	98.339	Cavia_porcellus
ENSG00000084072	PPIE	100	99.336	ENSCCAG00000024434	PPIE	100	99.336	Cebus_capucinus
ENSG00000084072	PPIE	100	99.668	ENSCATG00000034495	PPIE	100	99.668	Cercocebus_atys
ENSG00000084072	PPIE	100	97.183	ENSCLAG00000010288	PPIE	100	92.359	Chinchilla_lanigera
ENSG00000084072	PPIE	100	99.531	ENSCSAG00000001131	PPIE	100	98.684	Chlorocebus_sabaeus
ENSG00000084072	PPIE	77	76.970	ENSCHOG00000009018	-	100	68.831	Choloepus_hoffmanni
ENSG00000084072	PPIE	100	91.200	ENSCPBG00000001090	PPIE	100	91.200	Chrysemys_picta_bellii
ENSG00000084072	PPIE	100	99.336	ENSCANG00000029996	PPIE	100	99.336	Colobus_angolensis_palliatus
ENSG00000084072	PPIE	100	98.339	ENSCGRG00001018491	Ppie	100	98.339	Cricetulus_griseus_chok1gshd
ENSG00000084072	PPIE	100	98.339	ENSCGRG00000005685	Ppie	100	98.339	Cricetulus_griseus_crigri
ENSG00000084072	PPIE	100	84.314	ENSCSEG00000000047	ppie	100	83.882	Cynoglossus_semilaevis
ENSG00000084072	PPIE	100	86.047	ENSCVAG00000019238	ppie	100	86.047	Cyprinodon_variegatus
ENSG00000084072	PPIE	100	86.093	ENSDARG00000103234	ppie	91	86.424	Danio_rerio
ENSG00000084072	PPIE	97	91.304	ENSDNOG00000002404	-	99	87.055	Dasypus_novemcinctus
ENSG00000084072	PPIE	100	97.653	ENSDNOG00000034942	-	99	98.000	Dasypus_novemcinctus
ENSG00000084072	PPIE	100	99.531	ENSDORG00000005175	Ppie	100	99.336	Dipodomys_ordii
ENSG00000084072	PPIE	100	98.400	ENSEASG00005014118	-	100	98.400	Equus_asinus_asinus
ENSG00000084072	PPIE	100	98.671	ENSECAG00000031692	-	100	98.671	Equus_caballus
ENSG00000084072	PPIE	100	98.400	ENSECAG00000038706	-	100	98.400	Equus_caballus
ENSG00000084072	PPIE	100	82.781	ENSELUG00000003162	ppie	100	82.781	Esox_lucius
ENSG00000084072	PPIE	100	99.336	ENSFCAG00000006027	-	100	99.336	Felis_catus
ENSG00000084072	PPIE	99	89.632	ENSFALG00000000545	PPIE	93	89.632	Ficedula_albicollis
ENSG00000084072	PPIE	100	97.653	ENSFDAG00000017337	PPIE	97	96.918	Fukomys_damarensis
ENSG00000084072	PPIE	100	86.711	ENSFHEG00000007560	ppie	100	86.711	Fundulus_heteroclitus
ENSG00000084072	PPIE	100	82.450	ENSGMOG00000019015	ppie	100	82.450	Gadus_morhua
ENSG00000084072	PPIE	100	91.080	ENSGALG00000013383	PPIE	91	91.781	Gallus_gallus
ENSG00000084072	PPIE	100	86.047	ENSGAFG00000018146	ppie	100	86.047	Gambusia_affinis
ENSG00000084072	PPIE	100	83.444	ENSGACG00000007165	ppie	100	83.775	Gasterosteus_aculeatus
ENSG00000084072	PPIE	100	91.549	ENSGAGG00000001882	PPIE	95	93.966	Gopherus_agassizii
ENSG00000084072	PPIE	100	100.000	ENSGGOG00000015783	PPIE	100	100.000	Gorilla_gorilla
ENSG00000084072	PPIE	100	85.430	ENSHBUG00000020159	ppie	100	85.762	Haplochromis_burtoni
ENSG00000084072	PPIE	100	97.674	ENSHGLG00000012598	PPIE	100	97.674	Heterocephalus_glaber_female
ENSG00000084072	PPIE	100	97.183	ENSHGLG00100001779	PPIE	98	97.251	Heterocephalus_glaber_male
ENSG00000084072	PPIE	100	85.050	ENSHCOG00000012644	ppie	100	85.050	Hippocampus_comes
ENSG00000084072	PPIE	99	88.704	ENSIPUG00000016601	ppie	99	89.037	Ictalurus_punctatus
ENSG00000084072	PPIE	100	98.671	ENSSTOG00000010445	PPIE	100	98.671	Ictidomys_tridecemlineatus
ENSG00000084072	PPIE	100	98.592	ENSJJAG00000022703	Ppie	100	98.007	Jaculus_jaculus
ENSG00000084072	PPIE	100	85.382	ENSKMAG00000013555	ppie	100	85.382	Kryptolebias_marmoratus
ENSG00000084072	PPIE	100	88.742	ENSLACG00000011207	PPIE	100	88.742	Latimeria_chalumnae
ENSG00000084072	PPIE	100	98.007	ENSLAFG00000028312	-	100	98.007	Loxodonta_africana
ENSG00000084072	PPIE	100	99.668	ENSMFAG00000002082	PPIE	100	99.668	Macaca_fascicularis
ENSG00000084072	PPIE	100	99.668	ENSMMUG00000018869	PPIE	100	99.668	Macaca_mulatta
ENSG00000084072	PPIE	100	99.668	ENSMNEG00000031362	PPIE	100	99.668	Macaca_nemestrina
ENSG00000084072	PPIE	100	99.668	ENSMLEG00000040735	PPIE	100	99.668	Mandrillus_leucophaeus
ENSG00000084072	PPIE	100	83.444	ENSMAMG00000010005	ppie	100	83.775	Mastacembelus_armatus
ENSG00000084072	PPIE	100	85.762	ENSMZEG00005006117	ppie	100	86.093	Maylandia_zebra
ENSG00000084072	PPIE	100	95.775	ENSMAUG00000020323	Ppie	100	98.225	Mesocricetus_auratus
ENSG00000084072	PPIE	100	98.339	ENSMOCG00000018443	-	100	98.339	Microtus_ochrogaster
ENSG00000084072	PPIE	100	95.775	ENSMOCG00000020138	-	82	95.238	Microtus_ochrogaster
ENSG00000084072	PPIE	100	84.385	ENSMMOG00000002329	ppie	100	84.385	Mola_mola
ENSG00000084072	PPIE	100	93.688	ENSMODG00000017659	PPIE	100	93.688	Monodelphis_domestica
ENSG00000084072	PPIE	100	84.437	ENSMALG00000011041	ppie	100	84.106	Monopterus_albus
ENSG00000084072	PPIE	100	98.122	MGP_CAROLIEiJ_G0026431	Ppie	100	98.007	Mus_caroli
ENSG00000084072	PPIE	100	98.592	ENSMUSG00000028651	Ppie	100	98.339	Mus_musculus
ENSG00000084072	PPIE	100	98.122	MGP_PahariEiJ_G0028761	Ppie	100	98.007	Mus_pahari
ENSG00000084072	PPIE	100	98.592	MGP_SPRETEiJ_G0027411	Ppie	100	98.339	Mus_spretus
ENSG00000084072	PPIE	100	98.675	ENSMPUG00000014345	PPIE	100	98.675	Mustela_putorius_furo
ENSG00000084072	PPIE	100	98.122	ENSMLUG00000006201	-	100	97.342	Myotis_lucifugus
ENSG00000084072	PPIE	100	97.183	ENSMLUG00000016233	-	100	98.276	Myotis_lucifugus
ENSG00000084072	PPIE	99	50.704	ENSMLUG00000027940	-	97	54.000	Myotis_lucifugus
ENSG00000084072	PPIE	100	99.668	ENSNLEG00000011979	PPIE	100	99.668	Nomascus_leucogenys
ENSG00000084072	PPIE	99	88.571	ENSMEUG00000005090	PPIE	100	89.177	Notamacropus_eugenii
ENSG00000084072	PPIE	100	95.775	ENSOPRG00000015178	-	99	85.556	Ochotona_princeps
ENSG00000084072	PPIE	100	97.342	ENSODEG00000007670	-	100	97.342	Octodon_degus
ENSG00000084072	PPIE	100	75.415	ENSODEG00000013727	-	74	75.415	Octodon_degus
ENSG00000084072	PPIE	100	85.430	ENSONIG00000008165	ppie	100	85.762	Oreochromis_niloticus
ENSG00000084072	PPIE	100	94.684	ENSOANG00000010003	PPIE	100	93.023	Ornithorhynchus_anatinus
ENSG00000084072	PPIE	100	98.122	ENSOCUG00000007665	PPIE	100	98.007	Oryctolagus_cuniculus
ENSG00000084072	PPIE	100	85.762	ENSORLG00015015095	ppie	100	85.762	Oryzias_latipes_hsok
ENSG00000084072	PPIE	100	85.762	ENSOMEG00000014458	ppie	100	85.762	Oryzias_melastigma
ENSG00000084072	PPIE	100	98.122	ENSOGAG00000003620	PPIE	100	97.697	Otolemur_garnettii
ENSG00000084072	PPIE	100	97.653	ENSOARG00000020124	PPIE	100	97.039	Ovis_aries
ENSG00000084072	PPIE	100	100.000	ENSPPAG00000042403	PPIE	100	100.000	Pan_paniscus
ENSG00000084072	PPIE	100	99.336	ENSPPRG00000014232	PPIE	100	99.336	Panthera_pardus
ENSG00000084072	PPIE	100	99.336	ENSPTIG00000003196	PPIE	100	99.336	Panthera_tigris_altaica
ENSG00000084072	PPIE	100	100.000	ENSPTRG00000000577	PPIE	100	100.000	Pan_troglodytes
ENSG00000084072	PPIE	100	99.668	ENSPANG00000000575	PPIE	100	99.668	Papio_anubis
ENSG00000084072	PPIE	100	90.610	ENSPSIG00000016383	PPIE	88	90.847	Pelodiscus_sinensis
ENSG00000084072	PPIE	100	85.149	ENSPMGG00000009082	ppie	100	85.149	Periophthalmus_magnuspinnatus
ENSG00000084072	PPIE	100	95.775	ENSPEMG00000013681	Ppie	100	98.225	Peromyscus_maniculatus_bairdii
ENSG00000084072	PPIE	100	93.023	ENSPCIG00000021413	PPIE	100	93.023	Phascolarctos_cinereus
ENSG00000084072	PPIE	100	85.099	ENSPFOG00000002535	ppie	100	85.099	Poecilia_formosa
ENSG00000084072	PPIE	100	85.382	ENSPLAG00000010126	ppie	100	85.382	Poecilia_latipinna
ENSG00000084072	PPIE	100	85.382	ENSPMEG00000019748	ppie	100	85.382	Poecilia_mexicana
ENSG00000084072	PPIE	99	85.000	ENSPREG00000001551	ppie	99	85.000	Poecilia_reticulata
ENSG00000084072	PPIE	100	99.531	ENSPPYG00000001501	PPIE	98	98.980	Pongo_abelii
ENSG00000084072	PPIE	100	99.061	ENSPVAG00000002120	PPIE	100	99.283	Pteropus_vampyrus
ENSG00000084072	PPIE	100	83.113	ENSPNYG00000006336	ppie	100	83.444	Pundamilia_nyererei
ENSG00000084072	PPIE	100	87.417	ENSPNAG00000007122	ppie	100	87.417	Pygocentrus_nattereri
ENSG00000084072	PPIE	100	97.674	ENSRNOG00000014762	Ppie	100	97.674	Rattus_norvegicus
ENSG00000084072	PPIE	100	99.668	ENSRBIG00000041625	PPIE	100	99.668	Rhinopithecus_bieti
ENSG00000084072	PPIE	100	99.600	ENSRROG00000044935	PPIE	100	99.600	Rhinopithecus_roxellana
ENSG00000084072	PPIE	100	99.336	ENSSBOG00000035061	PPIE	100	99.336	Saimiri_boliviensis_boliviensis
ENSG00000084072	PPIE	100	92.691	ENSSHAG00000018113	PPIE	100	92.691	Sarcophilus_harrisii
ENSG00000084072	PPIE	100	88.040	ENSSFOG00015007542	ppie	100	88.040	Scleropages_formosus
ENSG00000084072	PPIE	100	85.099	ENSSMAG00000008993	ppie	100	84.768	Scophthalmus_maximus
ENSG00000084072	PPIE	100	85.430	ENSSDUG00000012593	ppie	100	85.430	Seriola_dumerili
ENSG00000084072	PPIE	100	85.430	ENSSLDG00000013079	ppie	100	85.430	Seriola_lalandi_dorsalis
ENSG00000084072	PPIE	100	95.775	ENSSARG00000005703	PPIE	100	93.907	Sorex_araneus
ENSG00000084072	PPIE	100	91.549	ENSSPUG00000003147	PPIE	100	89.547	Sphenodon_punctatus
ENSG00000084072	PPIE	100	86.424	ENSSPAG00000009232	ppie	100	86.755	Stegastes_partitus
ENSG00000084072	PPIE	100	98.592	ENSSSCG00000003664	-	96	98.276	Sus_scrofa
ENSG00000084072	PPIE	100	88.732	ENSTGUG00000001276	PPIE	100	84.549	Taeniopygia_guttata
ENSG00000084072	PPIE	100	85.714	ENSTRUG00000006308	ppie	100	85.714	Takifugu_rubripes
ENSG00000084072	PPIE	100	85.430	ENSTNIG00000016901	ppie	100	85.762	Tetraodon_nigroviridis
ENSG00000084072	PPIE	100	96.714	ENSTTRG00000014385	PPIE	98	93.506	Tursiops_truncatus
ENSG00000084072	PPIE	100	99.336	ENSUMAG00000017319	PPIE	100	99.336	Ursus_maritimus
ENSG00000084072	PPIE	86	98.370	ENSVPAG00000010049	PPIE	100	86.809	Vicugna_pacos
ENSG00000084072	PPIE	100	99.336	ENSVVUG00000005268	-	92	99.336	Vulpes_vulpes
ENSG00000084072	PPIE	100	88.704	ENSXETG00000010944	ppie	100	88.704	Xenopus_tropicalis
ENSG00000084072	PPIE	100	86.047	ENSXMAG00000019027	ppie	100	86.047	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000413	protein peptidyl-prolyl isomerization	20676357.	IDA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003723	RNA binding	11313484.	TAS	Function
GO:0003729	mRNA binding	18258190.	IDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	21873635.	IBA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	18258190.20676357.	IDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	11313484.	TAS	Function
GO:0005515	protein binding	11313484.16189514.20541251.22365833.25416956.25599396.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	11313484.28076346.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006355	regulation of transcription, DNA-templated	11313484.	IMP	Process
GO:0008143	poly(A) binding	18258190.	IDA	Function
GO:0016018	cyclosporin A binding	21873635.	IBA	Function
GO:0016018	cyclosporin A binding	20676357.	IDA	Function
GO:0016607	nuclear speck	-	IDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045070	positive regulation of viral genome replication	19932913.	IMP	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component