EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000084092 (Gene tree)
Gene ID: 84273
Gene Symbol: NOA1
Alias: MGC3232|hAtNOS1|hNOA1|MTG3|C4orf14
Full Name: nitric oxide associated 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 15,474 bases
Position: chr4:56,963,350-56,978,823
Accession: 28473
RBP type: canonical RBP
Summary: The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000264230	MMR_HSR1	PF01926.23	4.8e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25072814	NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import.	PLoS One	2014 Jul 29	Al-Furoukh N	doi: 10.1371/journal.pone.0103141
23933583	Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1.	Biochim Biophys Acta	2013 Dec	Al-Furoukh N	doi: 10.1016/j.bbamcr.2013.07.022

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000264230	NOA1-201	3415	-	ENSP00000264230	698 (aa)	-	Q8NC60

Gene Model

Click here to download ENSG00000084092's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000084092	Coronary Artery Disease	5E-8	26343387

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000084092	rs17087335	4	56972417	T	Coronary artery disease	26343387	[1.04-1.09]	1.06	EFO_0000378
ENSG00000084092	rs57265257	4	56973114	A	Coronary artery disease	29212778	[0.032-0.062] unit decrease	0.0468	EFO_0000378
ENSG00000084092	rs35514852	4	56969803	T	Automobile speeding propensity	30643258	[0.011-0.02] unit decrease	0.015113897	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000084092's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000084092	NOA1	81	54.497	ENSAPOG00000004267	noa1	75	54.497	Acanthochromis_polyacanthus
ENSG00000084092	NOA1	99	80.432	ENSAMEG00000008549	NOA1	100	80.432	Ailuropoda_melanoleuca
ENSG00000084092	NOA1	81	51.327	ENSACIG00000022566	noa1	76	51.590	Amphilophus_citrinellus
ENSG00000084092	NOA1	86	52.902	ENSAOCG00000021120	noa1	70	54.417	Amphiprion_ocellaris
ENSG00000084092	NOA1	81	54.513	ENSAPEG00000018447	noa1	71	54.594	Amphiprion_percula
ENSG00000084092	NOA1	86	53.167	ENSATEG00000018828	noa1	82	53.004	Anabas_testudineus
ENSG00000084092	NOA1	90	55.102	ENSACAG00000002327	NOA1	85	58.304	Anolis_carolinensis
ENSG00000084092	NOA1	99	86.944	ENSANAG00000026721	NOA1	100	86.714	Aotus_nancymaae
ENSG00000084092	NOA1	81	54.306	ENSACLG00000015378	noa1	71	54.306	Astatotilapia_calliptera
ENSG00000084092	NOA1	81	55.088	ENSAMXG00000004024	noa1	72	54.895	Astyanax_mexicanus
ENSG00000084092	NOA1	99	76.801	ENSBTAG00000019362	NOA1A	95	76.801	Bos_taurus
ENSG00000084092	NOA1	99	85.877	ENSCJAG00000004102	NOA1	100	85.653	Callithrix_jacchus
ENSG00000084092	NOA1	99	77.698	ENSCAFG00000002256	NOA1	99	78.993	Canis_familiaris
ENSG00000084092	NOA1	99	77.554	ENSCAFG00020027319	NOA1	99	78.849	Canis_lupus_dingo
ENSG00000084092	NOA1	99	76.369	ENSCHIG00000017563	NOA1	100	76.369	Capra_hircus
ENSG00000084092	NOA1	71	81.100	ENSTSYG00000036252	NOA1	99	81.100	Carlito_syrichta
ENSG00000084092	NOA1	99	77.201	ENSCPOG00000031454	NOA1	98	77.023	Cavia_porcellus
ENSG00000084092	NOA1	99	87.338	ENSCCAG00000032900	NOA1	100	87.106	Cebus_capucinus
ENSG00000084092	NOA1	100	93.983	ENSCATG00000008000	NOA1	100	93.983	Cercocebus_atys
ENSG00000084092	NOA1	87	81.559	ENSCLAG00000008077	NOA1	99	77.778	Chinchilla_lanigera
ENSG00000084092	NOA1	72	93.478	ENSCSAG00000018378	NOA1	100	93.478	Chlorocebus_sabaeus
ENSG00000084092	NOA1	99	72.662	ENSCHOG00000005248	NOA1	100	72.662	Choloepus_hoffmanni
ENSG00000084092	NOA1	76	61.070	ENSCPBG00000015009	NOA1	87	58.703	Chrysemys_picta_bellii
ENSG00000084092	NOA1	100	93.840	ENSCANG00000005800	NOA1	100	93.840	Colobus_angolensis_palliatus
ENSG00000084092	NOA1	99	74.348	ENSCGRG00001019606	Noa1	99	75.652	Cricetulus_griseus_chok1gshd
ENSG00000084092	NOA1	99	71.470	ENSCGRG00000007031	Noa1	100	72.767	Cricetulus_griseus_crigri
ENSG00000084092	NOA1	82	53.206	ENSCSEG00000005517	noa1	76	53.206	Cynoglossus_semilaevis
ENSG00000084092	NOA1	81	53.792	ENSCVAG00000005104	noa1	76	53.792	Cyprinodon_variegatus
ENSG00000084092	NOA1	89	48.291	ENSDARG00000102934	noa1	75	53.403	Danio_rerio
ENSG00000084092	NOA1	99	77.188	ENSDNOG00000031811	NOA1	100	77.188	Dasypus_novemcinctus
ENSG00000084092	NOA1	87	43.671	ENSEBUG00000006034	noa1	76	44.228	Eptatretus_burgeri
ENSG00000084092	NOA1	100	82.571	ENSEASG00005017733	NOA1	100	82.571	Equus_asinus_asinus
ENSG00000084092	NOA1	100	82.286	ENSECAG00000020627	NOA1	100	82.286	Equus_caballus
ENSG00000084092	NOA1	90	59.936	ENSEEUG00000009773	NOA1	100	59.936	Erinaceus_europaeus
ENSG00000084092	NOA1	84	53.220	ENSELUG00000023295	noa1	72	53.899	Esox_lucius
ENSG00000084092	NOA1	99	80.488	ENSFCAG00000024100	NOA1	94	80.488	Felis_catus
ENSG00000084092	NOA1	54	61.842	ENSFALG00000005875	NOA1	99	55.955	Ficedula_albicollis
ENSG00000084092	NOA1	89	84.416	ENSFDAG00000012726	NOA1	100	84.314	Fukomys_damarensis
ENSG00000084092	NOA1	87	50.897	ENSFHEG00000006213	noa1	88	54.301	Fundulus_heteroclitus
ENSG00000084092	NOA1	85	52.685	ENSGMOG00000004944	noa1	89	54.724	Gadus_morhua
ENSG00000084092	NOA1	85	52.980	ENSGALG00000038585	NOA1	95	52.031	Gallus_gallus
ENSG00000084092	NOA1	57	47.183	ENSGAFG00000013373	noa1	69	53.936	Gambusia_affinis
ENSG00000084092	NOA1	78	59.392	ENSGAGG00000013927	NOA1	82	60.821	Gopherus_agassizii
ENSG00000084092	NOA1	100	99.284	ENSGGOG00000040999	NOA1	100	99.284	Gorilla_gorilla
ENSG00000084092	NOA1	81	54.306	ENSHBUG00000021318	noa1	82	53.311	Haplochromis_burtoni
ENSG00000084092	NOA1	97	77.566	ENSHGLG00000006204	NOA1	98	77.155	Heterocephalus_glaber_female
ENSG00000084092	NOA1	97	75.953	ENSHGLG00100013673	NOA1	99	75.575	Heterocephalus_glaber_male
ENSG00000084092	NOA1	59	49.639	ENSHCOG00000017459	noa1	72	49.639	Hippocampus_comes
ENSG00000084092	NOA1	80	54.965	ENSIPUG00000015583	noa1	73	54.561	Ictalurus_punctatus
ENSG00000084092	NOA1	100	78.827	ENSSTOG00000003793	NOA1	100	78.827	Ictidomys_tridecemlineatus
ENSG00000084092	NOA1	97	72.141	ENSJJAG00000014213	Noa1	100	72.515	Jaculus_jaculus
ENSG00000084092	NOA1	79	52.252	ENSKMAG00000018991	noa1	81	52.330	Kryptolebias_marmoratus
ENSG00000084092	NOA1	80	45.196	ENSLBEG00000023897	noa1	73	49.160	Labrus_bergylta
ENSG00000084092	NOA1	89	48.657	ENSLACG00000001755	NOA1	89	52.007	Latimeria_chalumnae
ENSG00000084092	NOA1	81	53.765	ENSLOCG00000011439	noa1	88	53.765	Lepisosteus_oculatus
ENSG00000084092	NOA1	99	78.736	ENSLAFG00000003197	NOA1	100	78.736	Loxodonta_africana
ENSG00000084092	NOA1	100	93.840	ENSMFAG00000035534	NOA1	100	93.840	Macaca_fascicularis
ENSG00000084092	NOA1	100	93.983	ENSMMUG00000022530	NOA1	100	93.983	Macaca_mulatta
ENSG00000084092	NOA1	100	94.269	ENSMNEG00000033975	NOA1	100	94.269	Macaca_nemestrina
ENSG00000084092	NOA1	99	93.094	ENSMLEG00000025732	NOA1	100	93.094	Mandrillus_leucophaeus
ENSG00000084092	NOA1	81	54.321	ENSMAMG00000014148	noa1	78	53.322	Mastacembelus_armatus
ENSG00000084092	NOA1	81	54.306	ENSMZEG00005006968	noa1	78	53.311	Maylandia_zebra
ENSG00000084092	NOA1	55	58.442	ENSMGAG00000008531	NOA1	99	58.442	Meleagris_gallopavo
ENSG00000084092	NOA1	99	75.469	ENSMAUG00000014203	Noa1	99	75.469	Mesocricetus_auratus
ENSG00000084092	NOA1	74	85.328	ENSMICG00000015150	NOA1	100	85.328	Microcebus_murinus
ENSG00000084092	NOA1	99	76.901	ENSMOCG00000005010	Noa1	100	76.901	Microtus_ochrogaster
ENSG00000084092	NOA1	90	66.563	ENSMODG00000020703	NOA1	91	66.303	Monodelphis_domestica
ENSG00000084092	NOA1	99	75.287	MGP_CAROLIEiJ_G0027328	Noa1	100	75.287	Mus_caroli
ENSG00000084092	NOA1	99	75.431	ENSMUSG00000036285	Noa1	100	75.431	Mus_musculus
ENSG00000084092	NOA1	90	75.949	MGP_PahariEiJ_G0017109	Noa1	98	75.949	Mus_pahari
ENSG00000084092	NOA1	99	75.718	MGP_SPRETEiJ_G0028323	Noa1	100	75.718	Mus_spretus
ENSG00000084092	NOA1	90	78.922	ENSMPUG00000004722	NOA1	99	78.922	Mustela_putorius_furo
ENSG00000084092	NOA1	66	75.431	ENSMLUG00000029379	NOA1	97	75.431	Myotis_lucifugus
ENSG00000084092	NOA1	80	83.692	ENSNGAG00000017239	Noa1	89	83.692	Nannospalax_galili
ENSG00000084092	NOA1	100	96.991	ENSNLEG00000008853	NOA1	100	96.991	Nomascus_leucogenys
ENSG00000084092	NOA1	84	62.938	ENSMEUG00000006758	NOA1	100	62.542	Notamacropus_eugenii
ENSG00000084092	NOA1	84	72.109	ENSOPRG00000008107	NOA1	100	72.109	Ochotona_princeps
ENSG00000084092	NOA1	98	75.073	ENSODEG00000010143	NOA1	99	73.004	Octodon_degus
ENSG00000084092	NOA1	81	55.009	ENSONIG00000001590	noa1	75	55.009	Oreochromis_niloticus
ENSG00000084092	NOA1	79	64.286	ENSOANG00000000235	NOA1	99	57.618	Ornithorhynchus_anatinus
ENSG00000084092	NOA1	99	72.701	ENSOCUG00000016330	NOA1	100	72.806	Oryctolagus_cuniculus
ENSG00000084092	NOA1	80	55.851	ENSORLG00000020494	noa1	76	55.830	Oryzias_latipes
ENSG00000084092	NOA1	80	56.028	ENSORLG00020009623	noa1	76	56.007	Oryzias_latipes_hni
ENSG00000084092	NOA1	81	55.654	ENSORLG00015018923	noa1	76	55.654	Oryzias_latipes_hsok
ENSG00000084092	NOA1	81	55.221	ENSOMEG00000010287	noa1	75	55.735	Oryzias_melastigma
ENSG00000084092	NOA1	100	79.399	ENSOGAG00000015994	NOA1	100	79.113	Otolemur_garnettii
ENSG00000084092	NOA1	100	73.247	ENSOARG00000005082	NOA1	100	73.534	Ovis_aries
ENSG00000084092	NOA1	100	99.284	ENSPPAG00000033775	NOA1	100	99.284	Pan_paniscus
ENSG00000084092	NOA1	99	80.836	ENSPPRG00000023695	NOA1	99	80.836	Panthera_pardus
ENSG00000084092	NOA1	81	83.333	ENSPTIG00000012020	NOA1	100	83.333	Panthera_tigris_altaica
ENSG00000084092	NOA1	100	99.427	ENSPTRG00000016088	NOA1	100	99.427	Pan_troglodytes
ENSG00000084092	NOA1	100	93.840	ENSPANG00000017817	NOA1	100	93.840	Papio_anubis
ENSG00000084092	NOA1	86	51.236	ENSPKIG00000025654	noa1	74	53.033	Paramormyrops_kingsleyae
ENSG00000084092	NOA1	72	62.055	ENSPSIG00000002984	NOA1	98	62.055	Pelodiscus_sinensis
ENSG00000084092	NOA1	87	43.719	ENSPMGG00000023269	NOA1	85	45.961	Periophthalmus_magnuspinnatus
ENSG00000084092	NOA1	99	75.793	ENSPEMG00000020457	Noa1	99	75.793	Peromyscus_maniculatus_bairdii
ENSG00000084092	NOA1	90	66.509	ENSPCIG00000000886	NOA1	99	63.047	Phascolarctos_cinereus
ENSG00000084092	NOA1	81	51.742	ENSPFOG00000001578	noa1	78	51.742	Poecilia_formosa
ENSG00000084092	NOA1	81	51.568	ENSPLAG00000020687	noa1	78	51.568	Poecilia_latipinna
ENSG00000084092	NOA1	81	51.916	ENSPMEG00000015333	noa1	78	51.916	Poecilia_mexicana
ENSG00000084092	NOA1	82	52.182	ENSPREG00000011564	noa1	78	52.456	Poecilia_reticulata
ENSG00000084092	NOA1	100	96.705	ENSPPYG00000014744	NOA1	100	96.705	Pongo_abelii
ENSG00000084092	NOA1	100	77.000	ENSPCAG00000001494	NOA1	100	77.000	Procavia_capensis
ENSG00000084092	NOA1	99	84.317	ENSPCOG00000017583	NOA1	100	84.317	Propithecus_coquereli
ENSG00000084092	NOA1	100	81.429	ENSPVAG00000010949	NOA1	100	81.429	Pteropus_vampyrus
ENSG00000084092	NOA1	81	54.306	ENSPNYG00000002554	noa1	75	54.306	Pundamilia_nyererei
ENSG00000084092	NOA1	80	53.996	ENSPNAG00000012000	noa1	73	53.954	Pygocentrus_nattereri
ENSG00000084092	NOA1	99	73.352	ENSRNOG00000002055	Noa1	100	75.862	Rattus_norvegicus
ENSG00000084092	NOA1	100	93.266	ENSRBIG00000014858	NOA1	100	93.266	Rhinopithecus_bieti
ENSG00000084092	NOA1	100	93.266	ENSRROG00000035032	NOA1	100	93.266	Rhinopithecus_roxellana
ENSG00000084092	NOA1	99	88.302	ENSSBOG00000022956	NOA1	100	88.068	Saimiri_boliviensis_boliviensis
ENSG00000084092	NOA1	82	52.595	ENSSFOG00015000914	noa1	74	52.768	Scleropages_formosus
ENSG00000084092	NOA1	80	54.352	ENSSDUG00000015865	noa1	72	53.072	Seriola_dumerili
ENSG00000084092	NOA1	80	54.707	ENSSLDG00000017344	noa1	75	54.707	Seriola_lalandi_dorsalis
ENSG00000084092	NOA1	90	62.594	ENSSPUG00000018285	NOA1	79	62.594	Sphenodon_punctatus
ENSG00000084092	NOA1	80	55.240	ENSSPAG00000012235	noa1	72	55.221	Stegastes_partitus
ENSG00000084092	NOA1	100	77.240	ENSSSCG00000025792	NOA1	100	77.571	Sus_scrofa
ENSG00000084092	NOA1	54	61.155	ENSTGUG00000002923	NOA1	99	61.155	Taeniopygia_guttata
ENSG00000084092	NOA1	89	47.819	ENSTRUG00000017686	noa1	79	51.241	Takifugu_rubripes
ENSG00000084092	NOA1	80	54.122	ENSTNIG00000006356	noa1	98	54.122	Tetraodon_nigroviridis
ENSG00000084092	NOA1	56	54.453	ENSTNIG00000002042	-	99	54.453	Tetraodon_nigroviridis
ENSG00000084092	NOA1	74	86.590	ENSTBEG00000014550	NOA1	99	86.590	Tupaia_belangeri
ENSG00000084092	NOA1	99	80.576	ENSUAMG00000002692	NOA1	99	80.576	Ursus_americanus
ENSG00000084092	NOA1	99	80.576	ENSUMAG00000008221	NOA1	99	80.576	Ursus_maritimus
ENSG00000084092	NOA1	80	73.393	ENSVPAG00000000467	NOA1	78	73.393	Vicugna_pacos
ENSG00000084092	NOA1	99	77.842	ENSVVUG00000005990	NOA1	99	79.137	Vulpes_vulpes
ENSG00000084092	NOA1	82	55.786	ENSXETG00000005348	noa1	99	55.786	Xenopus_tropicalis
ENSG00000084092	NOA1	79	49.192	ENSXCOG00000014613	noa1	90	49.192	Xiphophorus_couchianus
ENSG00000084092	NOA1	82	52.870	ENSXMAG00000014913	noa1	94	52.870	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	19103604.	IPI	Function
GO:0005525	GTP binding	19103604.	IDA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0010941	regulation of cell death	19103604.	IMP	Process
GO:0031314	extrinsic component of mitochondrial inner membrane	19103604.	IDA	Component
GO:0032543	mitochondrial translation	-	ISS	Process
GO:0043457	regulation of cellular respiration	19103604.	IMP	Process