EuRBPDB

Description

Ensembl ID: ENSG00000084463 (Gene tree)
Gene ID: 51729
Gene Symbol: WBP11
Alias: NPWBP|SIPP1|PPP1R165
Full Name: WW domain binding protein 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 18,962 bases
Position: chr12:14,784,579-14,803,540
Accession: 16461
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000535328	WBP11-202	494	-	ENSP00000440988	53 (aa)	-	F5GXS9
ENST00000261167	WBP11-201	4646	-	ENSP00000261167	641 (aa)	-	Q9Y2W2
ENST00000544764	WBP11-205	564	-	-	- (aa)	-	-
ENST00000543316	WBP11-204	554	-	-	- (aa)	-	-
ENST00000535638	WBP11-203	787	-	ENSP00000443420	194 (aa)	-	F5H5G4

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003697	single-stranded DNA binding	10593949.	TAS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	16189514.16713569.21988832.22321011.22365833.24136289.25416956.27173435.27314904.	IPI	Function
GO:0005634	nucleus	10593949.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:0050699	WW domain binding	19592703.	IPI	Function