EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000084623 (Gene tree)
Gene ID: 8668
Gene Symbol: EIF3I
Alias: EIF3S2|EIF3i|TRIP1
Full Name: Eukaryotic Translation Initiation Factor 3 Subunit I
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,738 bases
Position: chr1:32,221,867-32,231,604
Accession: 3272
RBP type: non-canonical RBP
Summary: EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Diseases associated with EIF3I include Stomatitis. Among its related pathways are Translation Factors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000355082	EIF3I-201	564	-	ENSP00000347194	125 (aa)	-	Q5TFK1
ENST00000489353	EIF3I-206	527	-	-	- (aa)	-	-
ENST00000373586	EIF3I-202	1458	XM_024450518	ENSP00000362688	325 (aa)	XP_024306286	Q13347
ENST00000483517	EIF3I-205	744	-	-	- (aa)	-	-
ENST00000471486	EIF3I-203	825	-	-	- (aa)	-	-
ENST00000474371	EIF3I-204	643	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000084623's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000084623's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000084623	EIF3I	99	60.736	FBgn0015834	eIF3i	100	60.736	Drosophila_melanogaster
ENSG00000084623	EIF3I	100	100.000	ENSMUSG00000028798	Eif3i	100	99.385	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001732	formation of cytoplasmic translation initiation complex	-	IEA	Process
GO:0003743	translation initiation factor activity	17322308.18599441.	IC	Function
GO:0003743	translation initiation factor activity	17581632.	IDA	Function
GO:0003743	translation initiation factor activity	25849773.	IDA	Function
GO:0005515	protein binding	14688252.17094969.18599441.18624398.18628297.24965446.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	17322308.17581632.18599441.25849773.	IDA	Component
GO:0006413	translational initiation	17322308.18599441.	IC	Process
GO:0006413	translational initiation	17581632.	IDA	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0016282	eukaryotic 43S preinitiation complex	-	IEA	Component
GO:0033290	eukaryotic 48S preinitiation complex	-	IEA	Component
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16929481	Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation.	Mol Carcinog	2006 Dec	Ahlemann M	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	32222579	Missense_Mutation	NA	Q15H	0.23
BLCA	chr1	32224455	Missense_Mutation	NA	R77P	0.08
BLCA	chr1	32222453	Intron	novel		0.18
BLCA	chr1	32224455	Missense_Mutation	NA	R77P	0.09
BLCA	chr1	32226316	Missense_Mutation	NA	Q132H	0.53
BLCA	chr1	32226316	Missense_Mutation	NA	Q132H	0.24
BLCA	chr1	32231161	Missense_Mutation	novel	D315N	0.23
BLCA	chr1	32226474	Missense_Mutation	novel	G158R	0.12
BRCA	chr1	32234453	3'Flank	rs536610076		0.3
BRCA	chr1	32228775	Missense_Mutation	NA	R230C	0.32
BRCA	chr1	32226498	Missense_Mutation	NA	E166K	0.2
BRCA	chr1	32222455	Intron	novel		0.2
BRCA	chr1	32224036	Splice_Region	NA	I33I	0.19
BRCA	chr1	32228767	Frame_Shift_Del	NA	*R227Hfs15**	0.3
BRCA	chr1	32222528	Intron	novel		0.5
BRCA	chr1	32224454	Missense_Mutation	novel	R77S	0.37
BRCA	chr1	32226305	Missense_Mutation	NA	D129N	0.54
BRCA	chr1	32228739	Missense_Mutation	NA	T218A	0.18
BRCA	chr1	32234492	3'Flank	novel		0.29
BRCA	chr1	32226210	Missense_Mutation	NA	R97Q	0.2
CESC	chr1	32222562	Missense_Mutation	novel	E10K	0.18
CESC	chr1	32226505	Missense_Mutation	NA	G168E	0.62
CESC	chr1	32222480	Intron	novel		0.36
CESC	chr1	32229188	Missense_Mutation	novel	R261S	0.21
CHOL	chr1	32222405	5'UTR	novel		0.19
COAD	chr1	32228766	Missense_Mutation	rs759750490	R227W	0.27
COAD	chr1	32226178	Silent	novel	Q86Q	0.07
COAD	chr1	32224467	Missense_Mutation	novel	C81Y	0.19
COAD	chr1	32226223	Silent	novel	F101F	0.06
COAD	chr1	32222615	Silent	novel	T27T	0.35
COAD	chr1	32230967	Frame_Shift_Del	novel	*K282Rfs76**	0.04
COAD	chr1	32224085	Missense_Mutation	novel	G50C	0.49
COAD	chr1	32228587	Missense_Mutation	rs762483424	A206V	0.06
COAD	chr1	32231122	Missense_Mutation	NA	S302G	0.44
COAD	chr1	32231248	3'UTR	rs770941829		0.63
COAD	chr1	32222466	Intron	rs778498204		0.21
GBM	chr1	32224074	Missense_Mutation	novel	G46D	0.17
GBM	chr1	32222594	Silent	rs769837607	R20R	0.05
HNSC	chr1	32231182	Missense_Mutation	novel	E322K	0.17
HNSC	chr1	32228812	Missense_Mutation	novel	D242G	0.24
HNSC	chr1	32222396	5'UTR	novel		0.2
KIRC	chr1	32231253	3'UTR	novel		0.36
KIRC	chr1	32229208	Frame_Shift_Del	novel		0.08
KIRP	chr1	32222388	5'UTR	novel		0.05
LGG	chr1	32222624	Silent	NA	K30K	0.36
LGG	chr1	32222614	Missense_Mutation	novel	T27I	0.39
LIHC	chr1	32222476	Intron	novel		0.43
LIHC	chr1	32231348	3'UTR	novel		0.14
LUAD	chr1	32226288	Missense_Mutation	novel	S123N	0.1
LUAD	chr1	32230969	Missense_Mutation	NA	K282N	0.28
LUAD	chr1	32228735	Silent	NA	D216D	0.05
LUAD	chr1	32222409	5'UTR	rs369217492		0.42
LUSC	chr1	32222436	5'UTR	novel		0.1
LUSC	chr1	32222378	5'UTR	rs376701041		0.33
OV	chr1	32222377	5'UTR	novel		0.09
OV	chr1	32222547	Missense_Mutation	NA	L5V	0.33
PRAD	chr1	32222389	5'UTR	NA		0.1
PRAD	chr1	32224426	Silent	NA	V67V	0.1
READ	chr1	32226259	Silent	NA	D113D	0.31
READ	chr1	32226476	Silent	novel	G158G	0.06
SKCM	chr1	32222377	5'UTR	rs530943189		0.22
SKCM	chr1	32222396	5'UTR	novel		0.11
SKCM	chr1	32222378	5'UTR	rs376701041		0.29
SKCM	chr1	32222399	5'UTR	novel		0.36
SKCM	chr1	32222396	5'UTR	novel		0.48
SKCM	chr1	32222396	5'UTR	novel		0.22
SKCM	chr1	32222388	5'UTR	novel		0.69
SKCM	chr1	32222378	5'UTR	rs376701041		0.32
SKCM	chr1	32222546	Silent	novel	I4I	0.1
SKCM	chr1	32228745	Missense_Mutation	NA	L220F	0.44
SKCM	chr1	32222389	5'UTR	novel		0.23
SKCM	chr1	32222378	5'UTR	rs376701041		0.73
SKCM	chr1	32222399	5'UTR	novel		0.4
SKCM	chr1	32226185	Missense_Mutation	NA	L89F	0.21
SKCM	chr1	32222399	5'UTR	novel		0.26
SKCM	chr1	32222399	5'UTR	novel		0.41
SKCM	chr1	32222400	5'UTR	novel		0.87
SKCM	chr1	32222395	5'UTR	novel		0.19
SKCM	chr1	32222358	5'Flank	novel		0.33
SKCM	chr1	32222359	5'Flank	novel		0.32
SKCM	chr1	32222399	5'UTR	novel		0.41
SKCM	chr1	32222396	5'UTR	novel		0.23
STAD	chr1	32224115	Missense_Mutation	NA	A60T	0.18
STAD	chr1	32222389	5'UTR	NA		0.26
STAD	chr1	32228767	Missense_Mutation	NA	R227Q	0.21
STAD	chr1	32228519	Frame_Shift_Del	novel	*N183Kfs16**	0.14
STAD	chr1	32230974	Missense_Mutation	NA	H284R	0.09
STAD	chr1	32224120	Splice_Region	rs780091515	D61D	0.33
STAD	chr1	32226230	Frame_Shift_Del	novel	*G105Afs18**	0.24
STAD	chr1	32228809	Missense_Mutation	NA	Y241C	0.04
STAD	chr1	32228766	Missense_Mutation	rs759750490	R227W	0.25
STAD	chr1	32224420	Silent	NA	K65K	0.11
UCEC	chr1	32231248	3'UTR	rs770941829		0.48
UCEC	chr1	32226424	Missense_Mutation	novel	K141R	0.05
UCEC	chr1	32226201	Missense_Mutation	novel	S94L	0.33
UCEC	chr1	32224049	Missense_Mutation	rs1149056	Y38H	0.37
UCEC	chr1	32226303	Missense_Mutation	novel	R128Q	0.49
UCEC	chr1	32229132	Splice_Region	novel		0.29
UCEC	chr1	32231958	3'Flank	novel		0.39
UCEC	chr1	32226218	Missense_Mutation	rs750288369	G100S	0.34
UCEC	chr1	32231319	3'UTR	novel		0.24
UCEC	chr1	32222389	5'UTR	novel		0.44
UCEC	chr1	32222568	Missense_Mutation	novel	S12P	0.15
UCEC	chr1	32222471	Intron	novel		0.29
UCEC	chr1	32231248	3'UTR	rs770941829		0.39
UCEC	chr1	32226218	Missense_Mutation	rs750288369	G100S	0.38
UCEC	chr1	32228728	Frame_Shift_Del	novel	*F215Lfs41**	0.08
UCEC	chr1	32231248	3'UTR	rs770941829		0.83
UCEC	chr1	32224033	Splice_Site	NA	X33_splice	0.46
UCEC	chr1	32231128	Missense_Mutation	novel	G304S	0.54
UCEC	chr1	32224415	Missense_Mutation	novel	T64A	0.39
UCEC	chr1	32222394	5'UTR	novel		0.33
UCEC	chr1	32228801	Silent	novel	S238S	0.3
UCEC	chr1	32231248	3'UTR	rs770941829		0.38
UCEC	chr1	32224455	Missense_Mutation	novel	R77H	0.09
UCEC	chr1	32222394	5'UTR	novel		0.35
UCEC	chr1	32231176	Missense_Mutation	NA	E320K	0.24
UCEC	chr1	32226201	Missense_Mutation	novel	S94L	0.42
UCEC	chr1	32231124	Silent	rs142210722	S302S	0.29
UCEC	chr1	32231875	3'Flank	novel		0.39
UCEC	chr1	32231959	3'Flank	novel		0.35
UCS	chr1	32229179	Silent	novel	T258T	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.125	0.011841
LIHC	DEL	0.3216	1.6679e-20
TGCT	DEL	0.14	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0022	Kaplan-Meier Survival Analysis
SARC	0.04	Kaplan-Meier Survival Analysis
HNSC	0.032	Kaplan-Meier Survival Analysis
SKCM	0.043	Kaplan-Meier Survival Analysis
BRCA	0.018	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
PCPG	0.05	Kaplan-Meier Survival Analysis
BLCA	0.042	Kaplan-Meier Survival Analysis
LAML	0.0038	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
GBM	0.029	Kaplan-Meier Survival Analysis
LIHC	0.0036	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0053	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742