EuRBPDB

Description

Ensembl ID: ENSG00000084754 (Gene tree)
Gene ID: 3030
Gene Symbol: HADHA
Alias: GBP|LCEH|LCHAD|MTPA
Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 54,092 bases
Position: chr2:26,190,635-26,244,726
Accession: 4801
RBP type: non-canonical RBP
Summary: This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000643057	HADHA-205	2977	-	ENSP00000493761	37 (aa)	-	A0A2R8YDM1
ENST00000646483	HADHA-211	2158	-	ENSP00000496185	82 (aa)	-	P40939
ENST00000471743	HADHA-203	1485	-	-	- (aa)	-	-
ENST00000461025	HADHA-202	431	-	-	- (aa)	-	-
ENST00000645274	HADHA-209	2576	-	ENSP00000493996	728 (aa)	-	A0A2R8Y4F5
ENST00000643233	HADHA-207	2688	-	ENSP00000493880	37 (aa)	-	A0A2R8YDM1
ENST00000380649	HADHA-201	3037	-	ENSP00000370023	763 (aa)	-	P40939
ENST00000492433	HADHA-204	2982	-	ENSP00000438039	792 (aa)	-	H0YFD6
ENST00000646031	HADHA-210	1842	-	ENSP00000493956	54 (aa)	-	A0A2R8Y4E0
ENST00000644428	HADHA-208	3087	-	ENSP00000495560	499 (aa)	-	A0A2R8YG21
ENST00000643063	HADHA-206	2748	-	ENSP00000495353	357 (aa)	-	A0A2R8Y688

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00062	Fatty acid elongation	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00410	beta-Alanine metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa00650	Butanoate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01212	Fatty acid metabolism	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000084754	HADHA	96	57.221	FBgn0028479	Mtpalpha	99	57.221	Drosophila_melanogaster
ENSG00000084754	HADHA	100	86.501	ENSMUSG00000025745	Hadha	100	86.501	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000062	fatty-acyl-CoA binding	-	IEA	Function
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	8135828.	TAS	Function
GO:0003985	acetyl-CoA C-acetyltransferase activity	8135828.	TAS	Function
GO:0004300	enoyl-CoA hydratase activity	21873635.	IBA	Function
GO:0005515	protein binding	20562859.	IPI	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0006635	fatty acid beta-oxidation	21873635.	IBA	Process
GO:0006635	fatty acid beta-oxidation	-	IEA	Process
GO:0006635	fatty acid beta-oxidation	-	TAS	Process
GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	21873635.	IBA	Component
GO:0016508	long-chain-enoyl-CoA hydratase activity	-	IEA	Function
GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity	21873635.	IBA	Function
GO:0032868	response to insulin	-	IEA	Process
GO:0035965	cardiolipin acyl-chain remodeling	-	TAS	Process
GO:0042493	response to drug	-	IEA	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0051287	NAD binding	-	IEA	Function