EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000085760 (Gene tree)
Gene ID: 4528
Gene Symbol: MTIF2
Alias: IF-2mt
Full Name: mitochondrial translational initiation factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 32,753 bases
Position: chr2:55,236,595-55,269,347
Accession: 7441
RBP type: canonical RBP
Summary: During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000403492	IF-2	PF11987.8	2e-29	1	1
ENSP00000263629	IF-2	PF11987.8	4.9e-29	1	1
ENSP00000378099	IF-2	PF11987.8	4.9e-29	1	1
ENSP00000384481	IF-2	PF11987.8	4.9e-29	1	1
ENSP00000263629	GTP_EFTU	PF00009.27	8.6e-32	1	1
ENSP00000378099	GTP_EFTU	PF00009.27	8.6e-32	1	1
ENSP00000384481	GTP_EFTU	PF00009.27	8.6e-32	1	1
ENSP00000263629	MMR_HSR1	PF01926.23	1.4e-08	1	1
ENSP00000378099	MMR_HSR1	PF01926.23	1.4e-08	1	1
ENSP00000384481	MMR_HSR1	PF01926.23	1.4e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000420637	MTIF2-210	517	-	ENSP00000416057	26 (aa)	-	C9JIY5
ENST00000403721	MTIF2-204	2386	XM_011532871	ENSP00000384481	727 (aa)	XP_011531173	P46199
ENST00000404297	MTIF2-205	437	-	ENSP00000383880	70 (aa)	-	B5MCU1
ENST00000412530	MTIF2-206	580	-	ENSP00000393025	7 (aa)	-	A0A1Y8EJN7
ENST00000263629	MTIF2-201	2528	XM_017004162	ENSP00000263629	727 (aa)	XP_016859651	P46199
ENST00000417363	MTIF2-207	566	-	ENSP00000399531	10 (aa)	-	A0A1D5RMP2
ENST00000417741	MTIF2-208	658	-	-	- (aa)	-	-
ENST00000446660	MTIF2-212	865	-	-	- (aa)	-	-
ENST00000418823	MTIF2-209	903	-	ENSP00000403492	301 (aa)	-	H7C213
ENST00000394600	MTIF2-203	2221	XM_005264335	ENSP00000378099	727 (aa)	XP_005264392	P46199
ENST00000441307	MTIF2-211	583	-	ENSP00000388640	70 (aa)	-	B5MCU1
ENST00000366137	MTIF2-202	955	-	ENSP00000393337	72 (aa)	-	E7EW07

Gene Model

Click here to download ENSG00000085760's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000085760	rs74910171	2	55248851	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085760's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000085760	MTIF2	99	54.094	ENSAPOG00000007546	mtif2	98	60.632	Acanthochromis_polyacanthus
ENSG00000085760	MTIF2	100	85.970	ENSAMEG00000003983	MTIF2	100	85.970	Ailuropoda_melanoleuca
ENSG00000085760	MTIF2	88	56.454	ENSACIG00000007794	mtif2	93	56.454	Amphilophus_citrinellus
ENSG00000085760	MTIF2	94	60.294	ENSAOCG00000011132	mtif2	97	60.294	Amphiprion_ocellaris
ENSG00000085760	MTIF2	94	61.111	ENSAPEG00000015985	mtif2	95	63.893	Amphiprion_percula
ENSG00000085760	MTIF2	91	61.027	ENSATEG00000015320	mtif2	95	60.296	Anabas_testudineus
ENSG00000085760	MTIF2	99	66.025	ENSACAG00000003328	MTIF2	99	66.025	Anolis_carolinensis
ENSG00000085760	MTIF2	100	100.000	ENSANAG00000036247	MTIF2	100	91.197	Aotus_nancymaae
ENSG00000085760	MTIF2	99	53.529	ENSACLG00000003856	mtif2	90	63.125	Astatotilapia_calliptera
ENSG00000085760	MTIF2	99	54.412	ENSAMXG00000013112	mtif2	91	61.276	Astyanax_mexicanus
ENSG00000085760	MTIF2	100	88.462	ENSBTAG00000015481	MTIF2	100	85.007	Bos_taurus
ENSG00000085760	MTIF2	100	96.154	ENSCJAG00000010030	MTIF2	100	90.922	Callithrix_jacchus
ENSG00000085760	MTIF2	100	85.144	ENSCAFG00000002829	MTIF2	100	85.144	Canis_familiaris
ENSG00000085760	MTIF2	100	85.420	ENSCAFG00020026538	MTIF2	100	85.420	Canis_lupus_dingo
ENSG00000085760	MTIF2	100	88.462	ENSCHIG00000010297	MTIF2	100	84.594	Capra_hircus
ENSG00000085760	MTIF2	100	87.637	ENSTSYG00000000850	MTIF2	100	87.637	Carlito_syrichta
ENSG00000085760	MTIF2	78	80.357	ENSCAPG00000014189	MTIF2	98	80.357	Cavia_aperea
ENSG00000085760	MTIF2	100	88.462	ENSCPOG00000005823	MTIF2	100	84.457	Cavia_porcellus
ENSG00000085760	MTIF2	100	100.000	ENSCCAG00000022488	MTIF2	100	89.684	Cebus_capucinus
ENSG00000085760	MTIF2	100	100.000	ENSCATG00000038926	MTIF2	100	91.884	Cercocebus_atys
ENSG00000085760	MTIF2	100	84.615	ENSCLAG00000007900	MTIF2	100	84.319	Chinchilla_lanigera
ENSG00000085760	MTIF2	100	100.000	ENSCSAG00000014153	MTIF2	100	91.884	Chlorocebus_sabaeus
ENSG00000085760	MTIF2	78	85.854	ENSCHOG00000012644	MTIF2	86	85.854	Choloepus_hoffmanni
ENSG00000085760	MTIF2	99	62.603	ENSCPBG00000020894	MTIF2	99	62.603	Chrysemys_picta_bellii
ENSG00000085760	MTIF2	97	33.038	ENSCING00000000152	-	99	44.902	Ciona_intestinalis
ENSG00000085760	MTIF2	97	32.448	ENSCSAVG00000004697	-	98	52.542	Ciona_savignyi
ENSG00000085760	MTIF2	100	100.000	ENSCANG00000030529	MTIF2	100	93.122	Colobus_angolensis_palliatus
ENSG00000085760	MTIF2	100	92.308	ENSCGRG00001019217	Mtif2	100	83.081	Cricetulus_griseus_chok1gshd
ENSG00000085760	MTIF2	100	92.308	ENSCGRG00000016517	Mtif2	100	83.081	Cricetulus_griseus_crigri
ENSG00000085760	MTIF2	82	48.966	ENSCSEG00000001309	mtif2	92	59.295	Cynoglossus_semilaevis
ENSG00000085760	MTIF2	99	54.094	ENSCVAG00000007185	mtif2	95	61.677	Cyprinodon_variegatus
ENSG00000085760	MTIF2	98	59.078	ENSDARG00000063213	mtif2	99	59.078	Danio_rerio
ENSG00000085760	MTIF2	100	84.732	ENSDNOG00000004817	MTIF2	100	84.732	Dasypus_novemcinctus
ENSG00000085760	MTIF2	100	84.319	ENSDORG00000006292	Mtif2	100	84.319	Dipodomys_ordii
ENSG00000085760	MTIF2	99	46.473	FBgn0039588	mIF2	100	46.473	Drosophila_melanogaster
ENSG00000085760	MTIF2	100	84.615	ENSETEG00000001075	MTIF2	100	73.177	Echinops_telfairi
ENSG00000085760	MTIF2	99	48.495	ENSEBUG00000011845	mtif2	88	65.934	Eptatretus_burgeri
ENSG00000085760	MTIF2	100	87.895	ENSEASG00005000740	MTIF2	100	87.895	Equus_asinus_asinus
ENSG00000085760	MTIF2	100	87.895	ENSECAG00000009169	MTIF2	100	87.895	Equus_caballus
ENSG00000085760	MTIF2	92	75.000	ENSEEUG00000002375	MTIF2	82	81.013	Erinaceus_europaeus
ENSG00000085760	MTIF2	91	63.746	ENSELUG00000003685	mtif2	94	63.746	Esox_lucius
ENSG00000085760	MTIF2	100	86.382	ENSFCAG00000013626	MTIF2	100	86.382	Felis_catus
ENSG00000085760	MTIF2	99	63.398	ENSFALG00000011256	MTIF2	90	63.398	Ficedula_albicollis
ENSG00000085760	MTIF2	100	84.869	ENSFDAG00000007307	MTIF2	100	84.869	Fukomys_damarensis
ENSG00000085760	MTIF2	97	51.940	ENSGMOG00000000221	mtif2	98	59.938	Gadus_morhua
ENSG00000085760	MTIF2	100	65.569	ENSGALG00000031265	MTIF2	100	65.569	Gallus_gallus
ENSG00000085760	MTIF2	94	59.736	ENSGAFG00000014766	mtif2	98	59.736	Gambusia_affinis
ENSG00000085760	MTIF2	91	61.596	ENSGACG00000019926	mtif2	100	61.596	Gasterosteus_aculeatus
ENSG00000085760	MTIF2	99	69.326	ENSGAGG00000014724	MTIF2	99	69.326	Gopherus_agassizii
ENSG00000085760	MTIF2	100	100.000	ENSGGOG00000007681	MTIF2	100	98.900	Gorilla_gorilla
ENSG00000085760	MTIF2	99	53.846	ENSHBUG00000014269	mtif2	97	72.393	Haplochromis_burtoni
ENSG00000085760	MTIF2	100	88.462	ENSHGLG00000009152	-	100	86.657	Heterocephalus_glaber_female
ENSG00000085760	MTIF2	100	72.627	ENSHGLG00000013021	-	100	72.627	Heterocephalus_glaber_female
ENSG00000085760	MTIF2	100	88.462	ENSHGLG00100012609	MTIF2	100	86.657	Heterocephalus_glaber_male
ENSG00000085760	MTIF2	94	54.124	ENSHCOG00000011607	mtif2	97	54.113	Hippocampus_comes
ENSG00000085760	MTIF2	99	55.556	ENSIPUG00000013801	mtif2	92	65.312	Ictalurus_punctatus
ENSG00000085760	MTIF2	100	86.085	ENSSTOG00000028059	MTIF2	100	86.085	Ictidomys_tridecemlineatus
ENSG00000085760	MTIF2	100	78.159	ENSJJAG00000017300	Mtif2	100	78.159	Jaculus_jaculus
ENSG00000085760	MTIF2	83	54.795	ENSKMAG00000014876	mtif2	88	62.193	Kryptolebias_marmoratus
ENSG00000085760	MTIF2	89	62.888	ENSLBEG00000013573	mtif2	96	60.673	Labrus_bergylta
ENSG00000085760	MTIF2	99	63.374	ENSLACG00000007159	MTIF2	99	63.374	Latimeria_chalumnae
ENSG00000085760	MTIF2	99	61.202	ENSLOCG00000015555	mtif2	99	61.644	Lepisosteus_oculatus
ENSG00000085760	MTIF2	100	76.923	ENSLAFG00000007341	MTIF2	100	80.061	Loxodonta_africana
ENSG00000085760	MTIF2	100	100.000	ENSMFAG00000044949	MTIF2	100	92.022	Macaca_fascicularis
ENSG00000085760	MTIF2	100	100.000	ENSMMUG00000030833	MTIF2	100	90.797	Macaca_mulatta
ENSG00000085760	MTIF2	100	100.000	ENSMNEG00000034768	MTIF2	100	92.022	Macaca_nemestrina
ENSG00000085760	MTIF2	100	96.154	ENSMLEG00000031165	MTIF2	100	90.851	Mandrillus_leucophaeus
ENSG00000085760	MTIF2	94	61.111	ENSMAMG00000017811	mtif2	96	61.111	Mastacembelus_armatus
ENSG00000085760	MTIF2	99	53.235	ENSMZEG00005010545	mtif2	99	62.969	Maylandia_zebra
ENSG00000085760	MTIF2	100	65.158	ENSMGAG00000002262	MTIF2	100	65.158	Meleagris_gallopavo
ENSG00000085760	MTIF2	100	92.308	ENSMAUG00000014969	Mtif2	100	77.854	Mesocricetus_auratus
ENSG00000085760	MTIF2	100	88.462	ENSMICG00000017441	MTIF2	100	88.033	Microcebus_murinus
ENSG00000085760	MTIF2	98	82.725	ENSMOCG00000012426	Mtif2	100	82.669	Microtus_ochrogaster
ENSG00000085760	MTIF2	99	51.613	ENSMMOG00000018443	mtif2	98	61.466	Mola_mola
ENSG00000085760	MTIF2	99	71.252	ENSMODG00000001833	MTIF2	99	71.252	Monodelphis_domestica
ENSG00000085760	MTIF2	94	60.965	ENSMALG00000006521	mtif2	93	60.965	Monopterus_albus
ENSG00000085760	MTIF2	100	81.568	MGP_CAROLIEiJ_G0016158	Mtif2	100	82.793	Mus_caroli
ENSG00000085760	MTIF2	100	84.615	ENSMUSG00000020459	Mtif2	100	82.793	Mus_musculus
ENSG00000085760	MTIF2	100	84.615	MGP_PahariEiJ_G0016732	Mtif2	100	83.791	Mus_pahari
ENSG00000085760	MTIF2	100	88.462	MGP_SPRETEiJ_G0017001	Mtif2	100	82.793	Mus_spretus
ENSG00000085760	MTIF2	100	86.933	ENSMPUG00000010461	MTIF2	100	86.933	Mustela_putorius_furo
ENSG00000085760	MTIF2	100	88.462	ENSMLUG00000017067	-	100	86.107	Myotis_lucifugus
ENSG00000085760	MTIF2	100	82.830	ENSNGAG00000023658	Mtif2	100	82.830	Nannospalax_galili
ENSG00000085760	MTIF2	100	100.000	ENSNLEG00000009228	MTIF2	100	96.424	Nomascus_leucogenys
ENSG00000085760	MTIF2	90	68.445	ENSMEUG00000008935	MTIF2	99	68.445	Notamacropus_eugenii
ENSG00000085760	MTIF2	100	75.791	ENSOPRG00000010479	MTIF2	100	75.791	Ochotona_princeps
ENSG00000085760	MTIF2	100	92.308	ENSODEG00000013203	MTIF2	100	84.044	Octodon_degus
ENSG00000085760	MTIF2	96	59.886	ENSONIG00000007239	mtif2	99	59.886	Oreochromis_niloticus
ENSG00000085760	MTIF2	99	70.839	ENSOANG00000011187	MTIF2	99	70.839	Ornithorhynchus_anatinus
ENSG00000085760	MTIF2	99	76.023	ENSOCUG00000003617	MTIF2	96	86.080	Oryctolagus_cuniculus
ENSG00000085760	MTIF2	99	53.982	ENSORLG00000026006	mtif2	85	63.636	Oryzias_latipes
ENSG00000085760	MTIF2	99	53.982	ENSORLG00020022048	mtif2	92	63.636	Oryzias_latipes_hni
ENSG00000085760	MTIF2	100	86.795	ENSOGAG00000004306	MTIF2	100	86.795	Otolemur_garnettii
ENSG00000085760	MTIF2	100	88.462	ENSOARG00000002596	MTIF2	100	84.457	Ovis_aries
ENSG00000085760	MTIF2	100	100.000	ENSPPAG00000039404	-	96	98.630	Pan_paniscus
ENSG00000085760	MTIF2	100	86.245	ENSPPRG00000004891	MTIF2	100	86.245	Panthera_pardus
ENSG00000085760	MTIF2	100	86.245	ENSPTIG00000020552	MTIF2	100	86.245	Panthera_tigris_altaica
ENSG00000085760	MTIF2	100	100.000	ENSPTRG00000011929	MTIF2	100	99.175	Pan_troglodytes
ENSG00000085760	MTIF2	100	100.000	ENSPANG00000014549	MTIF2	100	92.160	Papio_anubis
ENSG00000085760	MTIF2	97	60.280	ENSPKIG00000021512	mtif2	100	59.209	Paramormyrops_kingsleyae
ENSG00000085760	MTIF2	100	68.673	ENSPSIG00000012738	MTIF2	99	68.673	Pelodiscus_sinensis
ENSG00000085760	MTIF2	88	58.915	ENSPMGG00000008013	mtif2	97	58.915	Periophthalmus_magnuspinnatus
ENSG00000085760	MTIF2	100	92.308	ENSPEMG00000022952	Mtif2	100	83.631	Peromyscus_maniculatus_bairdii
ENSG00000085760	MTIF2	99	44.798	ENSPMAG00000005400	mtif2	99	55.624	Petromyzon_marinus
ENSG00000085760	MTIF2	99	71.527	ENSPCIG00000010405	MTIF2	98	71.527	Phascolarctos_cinereus
ENSG00000085760	MTIF2	94	58.515	ENSPFOG00000018485	mtif2	99	58.515	Poecilia_formosa
ENSG00000085760	MTIF2	94	58.712	ENSPLAG00000005403	mtif2	98	58.712	Poecilia_latipinna
ENSG00000085760	MTIF2	94	58.806	ENSPMEG00000022347	mtif2	98	58.806	Poecilia_mexicana
ENSG00000085760	MTIF2	94	58.515	ENSPREG00000005632	mtif2	98	58.515	Poecilia_reticulata
ENSG00000085760	MTIF2	100	97.249	ENSPPYG00000012403	MTIF2	100	97.249	Pongo_abelii
ENSG00000085760	MTIF2	100	70.977	ENSPCAG00000007183	MTIF2	100	70.977	Procavia_capensis
ENSG00000085760	MTIF2	100	88.446	ENSPCOG00000013936	MTIF2	100	88.446	Propithecus_coquereli
ENSG00000085760	MTIF2	98	87.413	ENSPVAG00000016474	MTIF2	100	87.413	Pteropus_vampyrus
ENSG00000085760	MTIF2	96	58.665	ENSPNYG00000016432	mtif2	99	58.665	Pundamilia_nyererei
ENSG00000085760	MTIF2	91	62.425	ENSPNAG00000006293	mtif2	94	62.425	Pygocentrus_nattereri
ENSG00000085760	MTIF2	100	80.743	ENSRNOG00000004161	Mtif2	100	80.743	Rattus_norvegicus
ENSG00000085760	MTIF2	100	96.154	ENSSBOG00000026993	MTIF2	100	90.234	Saimiri_boliviensis_boliviensis
ENSG00000085760	MTIF2	99	71.429	ENSSHAG00000004418	MTIF2	99	71.429	Sarcophilus_harrisii
ENSG00000085760	MTIF2	85	59.289	ENSSFOG00015017713	mtif2	92	59.289	Scleropages_formosus
ENSG00000085760	MTIF2	88	51.634	ENSSMAG00000021040	mtif2	97	60.870	Scophthalmus_maximus
ENSG00000085760	MTIF2	88	61.934	ENSSDUG00000021733	mtif2	91	61.934	Seriola_dumerili
ENSG00000085760	MTIF2	91	61.469	ENSSLDG00000013201	mtif2	98	59.712	Seriola_lalandi_dorsalis
ENSG00000085760	MTIF2	100	81.706	ENSSARG00000004548	MTIF2	100	81.706	Sorex_araneus
ENSG00000085760	MTIF2	100	58.117	ENSSPUG00000012071	MTIF2	99	59.200	Sphenodon_punctatus
ENSG00000085760	MTIF2	99	52.924	ENSSPAG00000003141	mtif2	91	62.813	Stegastes_partitus
ENSG00000085760	MTIF2	100	88.462	ENSSSCG00000008404	MTIF2	100	85.832	Sus_scrofa
ENSG00000085760	MTIF2	99	63.812	ENSTGUG00000007064	MTIF2	99	63.812	Taeniopygia_guttata
ENSG00000085760	MTIF2	95	58.321	ENSTRUG00000012596	mtif2	93	61.719	Takifugu_rubripes
ENSG00000085760	MTIF2	88	60.374	ENSTNIG00000006453	mtif2	100	60.374	Tetraodon_nigroviridis
ENSG00000085760	MTIF2	96	89.216	ENSTBEG00000004711	MTIF2	100	78.523	Tupaia_belangeri
ENSG00000085760	MTIF2	100	88.462	ENSTTRG00000013952	MTIF2	100	78.680	Tursiops_truncatus
ENSG00000085760	MTIF2	100	86.795	ENSUAMG00000019639	MTIF2	100	86.795	Ursus_americanus
ENSG00000085760	MTIF2	100	88.462	ENSUMAG00000016809	MTIF2	100	86.795	Ursus_maritimus
ENSG00000085760	MTIF2	100	84.732	ENSVPAG00000007092	MTIF2	100	85.557	Vicugna_pacos
ENSG00000085760	MTIF2	100	85.007	ENSVVUG00000009923	MTIF2	100	85.007	Vulpes_vulpes
ENSG00000085760	MTIF2	100	63.165	ENSXETG00000032249	MTIF2	100	63.165	Xenopus_tropicalis
ENSG00000085760	MTIF2	96	53.746	ENSXCOG00000010285	mtif2	99	59.431	Xiphophorus_couchianus
ENSG00000085760	MTIF2	94	59.297	ENSXMAG00000004447	mtif2	98	59.297	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0003924	GTPase activity	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	12095986.	TAS	Component
GO:0006446	regulation of translational initiation	7829522.	TAS	Process
GO:0008135	translation factor activity, RNA binding	-	ISS	Function
GO:0032790	ribosome disassembly	-	ISS	Process
GO:0043024	ribosomal small subunit binding	-	ISS	Function
GO:0070124	mitochondrial translational initiation	21873635.	IBA	Process
GO:0070124	mitochondrial translational initiation	-	ISS	Process