EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000085832 (Gene tree)
Gene ID: 2060
Gene Symbol: EPS15
Alias: AF-1P|MLLT5
Full Name: epidermal growth factor receptor pathway substrate 15
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 165,092 bases
Position: chr1:51,354,263-51,519,354
Accession: 3419
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493793	EPS15-209	987	-	-	- (aa)	-	-
ENST00000471391	EPS15-206	731	-	-	- (aa)	-	-
ENST00000464478	EPS15-204	698	-	-	- (aa)	-	-
ENST00000486505	EPS15-208	631	-	-	- (aa)	-	-
ENST00000371730	EPS15-202	4736	-	ENSP00000360795	762 (aa)	-	B1AUU8
ENST00000371733	EPS15-203	5225	XM_005270618	ENSP00000360798	896 (aa)	XP_005270675	P42566
ENST00000371727	EPS15-201	1773	-	-	- (aa)	-	-
ENST00000465467	EPS15-205	374	-	ENSP00000474739	90 (aa)	-	S4R3U1
ENST00000478657	EPS15-207	445	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000085832's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000085832	Platelet Function Tests	6.0007755E-006	-
ENSG00000085832	Rhinitis, Allergic, Seasonal	2E-6	22036096

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000085832	rs6673480	1	51393570	T	IgE grass sensitization	22036096	[1.19-1.52]	1.35	EFO_0003956

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085832's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001921	positive regulation of receptor recycling	-	IEA	Process
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	10064583.10383425.16159959.17082820.17474147.18199683.18200045.19380743.20448150.21762413.23211419.24768539.26822536.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	15465819.	IDA	Component
GO:0005905	clathrin-coated pit	9762922.	TAS	Component
GO:0006895	Golgi to endosome transport	24768539.	IMP	Process
GO:0007173	epidermal growth factor receptor signaling pathway	8183552.	TAS	Process
GO:0008283	cell proliferation	8183552.	TAS	Process
GO:0009925	basal plasma membrane	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016050	vesicle organization	9762922.	TAS	Process
GO:0016235	aggresome	16159959.	IDA	Component
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0017124	SH3 domain binding	-	IEA	Function
GO:0019065	receptor-mediated endocytosis of virus by host cell	21047970.	IMP	Process
GO:0030122	AP-2 adaptor complex	-	IEA	Component
GO:0031593	polyubiquitin modification-dependent protein binding	24768539.	IDA	Function
GO:0031901	early endosome membrane	-	IEA	Component
GO:0032456	endocytic recycling	12807910.	IC	Process
GO:0038024	cargo receptor activity	-	IEA	Function
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	-	TAS	Process
GO:0042127	regulation of cell proliferation	-	IEA	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046718	viral entry into host cell	20202662.	IMP	Process
GO:0048268	clathrin coat assembly	12807910.	IDA	Process
GO:0060170	ciliary membrane	-	IEA	Component
GO:0061024	membrane organization	-	TAS	Process
GO:0098794	postsynapse	-	IEA	Component
GO:0098884	postsynaptic neurotransmitter receptor internalization	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component