EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000085872 (Gene tree)
Gene ID: 10523
Gene Symbol: CHERP
Alias: ERPROT213-21|DAN16
Full Name: calcium homeostasis endoplasmic reticulum protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,642 bases
Position: chr19:16,517,889-16,542,530
Accession: 16930
RBP type: canonical RBP
Summary: (Calcium Homeostasis Endoplasmic Reticulum Protein) is a Protein Coding gene. Diseases associated with CHERP include Primary Cerebellar Degeneration and Spinocerebellar Ataxia 1. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000439856	Surp	PF01805.20	1.9e-15	1	1
ENSP00000198939	Surp	PF01805.20	2e-15	1	1
ENSP00000439856	G-patch	PF01585.23	1.5e-11	1	1
ENSP00000198939	G-patch	PF01585.23	1.6e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30332651	RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins.	Cell Rep	2018 Oct 16	De Maio A	doi: 10.1016/j.celrep.2018.09.041.
24078636	Nuclear ALG-2 protein interacts with Ca2+ homeostasis endoplasmic reticulum protein (CHERP) Ca2+-dependently and participates in regulation of alternative splicing of inositol trisphosphate receptor type 1 (IP3R1) pre-mRNA.	J Biol Chem	2013 Nov 15	Sasaki-Osugi K	doi: 10.1074/jbc.M113.497479

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000600432	CHERP-207	554	-	-	- (aa)	-	-
ENST00000546361	CHERP-203	4173	-	ENSP00000439856	916 (aa)	-	Q8IWX8
ENST00000597261	CHERP-206	674	-	-	- (aa)	-	-
ENST00000551747	CHERP-205	886	-	-	- (aa)	-	-
ENST00000546538	CHERP-204	1429	-	-	- (aa)	-	-
ENST00000198939	CHERP-201	4084	-	ENSP00000198939	927 (aa)	-	J3QK89
ENST00000544299	CHERP-202	1755	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000085872's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000085872	Platelet Function Tests	2.7200000E-006	-
ENSG00000085872	Lymphocytes	4.1500000E-006	21738480
ENSG00000085872	Lymphocytes	3.9200000E-006	21738480
ENSG00000085872	Lymphocytes	4.2680000E-006	21738480

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000085872's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000085872	CHERP	60	60.954	ENSAPOG00000009646	cherp	96	62.366	Acanthochromis_polyacanthus
ENSG00000085872	CHERP	99	88.719	ENSAMEG00000010048	CHERP	80	93.964	Ailuropoda_melanoleuca
ENSG00000085872	CHERP	80	66.579	ENSACIG00000019242	cherp	80	66.623	Amphilophus_citrinellus
ENSG00000085872	CHERP	99	66.169	ENSAOCG00000017846	cherp	79	66.932	Amphiprion_ocellaris
ENSG00000085872	CHERP	99	65.278	ENSAPEG00000021128	cherp	78	67.021	Amphiprion_percula
ENSG00000085872	CHERP	99	65.096	ENSATEG00000006341	cherp	98	66.273	Anabas_testudineus
ENSG00000085872	CHERP	77	84.344	ENSAPLG00000010773	CHERP	99	84.452	Anas_platyrhynchos
ENSG00000085872	CHERP	50	81.971	ENSACAG00000011583	CHERP	61	85.034	Anolis_carolinensis
ENSG00000085872	CHERP	100	99.784	ENSANAG00000024284	CHERP	100	99.784	Aotus_nancymaae
ENSG00000085872	CHERP	99	65.916	ENSACLG00000020053	cherp	79	67.557	Astatotilapia_calliptera
ENSG00000085872	CHERP	99	67.759	ENSAMXG00000021637	cherp	93	67.508	Astyanax_mexicanus
ENSG00000085872	CHERP	100	97.162	ENSBTAG00000005289	CHERP	100	97.162	Bos_taurus
ENSG00000085872	CHERP	100	99.676	ENSCJAG00000040462	CHERP	100	99.676	Callithrix_jacchus
ENSG00000085872	CHERP	100	98.253	ENSCAFG00000015671	CHERP	100	98.253	Canis_familiaris
ENSG00000085872	CHERP	100	98.274	ENSCAFG00020009941	CHERP	100	98.274	Canis_lupus_dingo
ENSG00000085872	CHERP	95	97.895	ENSCHIG00000013765	CHERP	100	97.895	Capra_hircus
ENSG00000085872	CHERP	93	91.715	ENSCAPG00000000910	CHERP	72	94.659	Cavia_aperea
ENSG00000085872	CHERP	99	95.874	ENSCPOG00000019949	CHERP	99	95.874	Cavia_porcellus
ENSG00000085872	CHERP	100	99.784	ENSCCAG00000031534	CHERP	100	99.784	Cebus_capucinus
ENSG00000085872	CHERP	100	99.677	ENSCATG00000031409	CHERP	100	99.677	Cercocebus_atys
ENSG00000085872	CHERP	93	95.460	ENSCLAG00000005484	CHERP	98	95.460	Chinchilla_lanigera
ENSG00000085872	CHERP	100	99.782	ENSCSAG00000005740	CHERP	100	99.782	Chlorocebus_sabaeus
ENSG00000085872	CHERP	100	85.854	ENSCPBG00000014970	CHERP	100	85.948	Chrysemys_picta_bellii
ENSG00000085872	CHERP	70	56.655	ENSCING00000004814	-	54	71.277	Ciona_intestinalis
ENSG00000085872	CHERP	51	76.667	ENSCSAVG00000002455	-	51	66.346	Ciona_savignyi
ENSG00000085872	CHERP	100	99.672	ENSCANG00000032053	CHERP	100	99.672	Colobus_angolensis_palliatus
ENSG00000085872	CHERP	99	96.017	ENSCGRG00001023316	Cherp	99	96.017	Cricetulus_griseus_chok1gshd
ENSG00000085872	CHERP	99	95.514	ENSCGRG00000015901	Cherp	99	95.733	Cricetulus_griseus_crigri
ENSG00000085872	CHERP	80	67.368	ENSCSEG00000019700	cherp	79	66.667	Cynoglossus_semilaevis
ENSG00000085872	CHERP	77	66.806	ENSCVAG00000003622	cherp	97	64.314	Cyprinodon_variegatus
ENSG00000085872	CHERP	99	67.965	ENSDARG00000021812	cherp	100	78.113	Danio_rerio
ENSG00000085872	CHERP	99	93.122	ENSDORG00000027623	Cherp	100	93.013	Dipodomys_ordii
ENSG00000085872	CHERP	65	57.333	FBgn0261872	scaf6	59	57.333	Drosophila_melanogaster
ENSG00000085872	CHERP	83	95.536	ENSETEG00000019543	CHERP	83	95.536	Echinops_telfairi
ENSG00000085872	CHERP	50	76.471	ENSEBUG00000009109	cherp	55	70.833	Eptatretus_burgeri
ENSG00000085872	CHERP	100	97.817	ENSEASG00005000428	CHERP	92	97.817	Equus_asinus_asinus
ENSG00000085872	CHERP	100	97.707	ENSECAG00000012713	CHERP	100	97.707	Equus_caballus
ENSG00000085872	CHERP	80	68.316	ENSELUG00000023026	cherp	80	68.309	Esox_lucius
ENSG00000085872	CHERP	100	98.062	ENSFCAG00000013172	CHERP	100	98.062	Felis_catus
ENSG00000085872	CHERP	80	85.889	ENSFALG00000013410	CHERP	86	85.169	Ficedula_albicollis
ENSG00000085872	CHERP	79	85.230	ENSFDAG00000015981	CHERP	81	83.112	Fukomys_damarensis
ENSG00000085872	CHERP	99	60.843	ENSFHEG00000009720	cherp	90	85.556	Fundulus_heteroclitus
ENSG00000085872	CHERP	80	65.918	ENSGMOG00000008654	cherp	99	65.558	Gadus_morhua
ENSG00000085872	CHERP	80	85.559	ENSGALG00000003824	CHERP	88	85.185	Gallus_gallus
ENSG00000085872	CHERP	99	62.593	ENSGACG00000002053	cherp	98	62.128	Gasterosteus_aculeatus
ENSG00000085872	CHERP	100	85.419	ENSGAGG00000014208	CHERP	100	85.730	Gopherus_agassizii
ENSG00000085872	CHERP	90	99.809	ENSGGOG00000016348	CHERP	100	89.082	Gorilla_gorilla
ENSG00000085872	CHERP	99	65.632	ENSHBUG00000007405	cherp	79	67.156	Haplochromis_burtoni
ENSG00000085872	CHERP	99	95.405	ENSHGLG00000002993	CHERP	99	95.415	Heterocephalus_glaber_female
ENSG00000085872	CHERP	60	85.615	ENSHGLG00100010390	CHERP	68	85.383	Heterocephalus_glaber_male
ENSG00000085872	CHERP	80	66.223	ENSHCOG00000007691	cherp	79	64.453	Hippocampus_comes
ENSG00000085872	CHERP	99	68.319	ENSIPUG00000025008	cherp	99	68.099	Ictalurus_punctatus
ENSG00000085872	CHERP	99	97.901	ENSSTOG00000012089	CHERP	99	97.901	Ictidomys_tridecemlineatus
ENSG00000085872	CHERP	99	89.387	ENSJJAG00000017982	Cherp	81	96.180	Jaculus_jaculus
ENSG00000085872	CHERP	80	65.918	ENSKMAG00000009101	cherp	79	65.786	Kryptolebias_marmoratus
ENSG00000085872	CHERP	79	65.775	ENSLBEG00000007586	cherp	91	66.846	Labrus_bergylta
ENSG00000085872	CHERP	99	79.979	ENSLACG00000018221	CHERP	80	78.864	Latimeria_chalumnae
ENSG00000085872	CHERP	99	75.777	ENSLOCG00000003654	cherp	79	74.373	Lepisosteus_oculatus
ENSG00000085872	CHERP	99	94.317	ENSLAFG00000009096	CHERP	100	94.317	Loxodonta_africana
ENSG00000085872	CHERP	100	99.784	ENSMFAG00000033267	CHERP	100	99.784	Macaca_fascicularis
ENSG00000085872	CHERP	100	96.009	ENSMMUG00000012958	CHERP	100	96.009	Macaca_mulatta
ENSG00000085872	CHERP	100	99.784	ENSMNEG00000004125	CHERP	100	99.784	Macaca_nemestrina
ENSG00000085872	CHERP	95	99.702	ENSMLEG00000044337	CHERP	100	99.773	Mandrillus_leucophaeus
ENSG00000085872	CHERP	80	66.756	ENSMAMG00000022269	cherp	79	66.755	Mastacembelus_armatus
ENSG00000085872	CHERP	99	65.916	ENSMZEG00005018014	cherp	79	67.557	Maylandia_zebra
ENSG00000085872	CHERP	69	85.512	ENSMGAG00000005571	CHERP	93	85.381	Meleagris_gallopavo
ENSG00000085872	CHERP	99	95.901	ENSMAUG00000015856	Cherp	99	96.117	Mesocricetus_auratus
ENSG00000085872	CHERP	100	96.078	ENSMICG00000004577	CHERP	100	96.078	Microcebus_murinus
ENSG00000085872	CHERP	99	95.738	ENSMOCG00000014697	Cherp	99	96.175	Microtus_ochrogaster
ENSG00000085872	CHERP	99	66.917	ENSMMOG00000008525	cherp	77	66.934	Mola_mola
ENSG00000085872	CHERP	99	91.132	ENSMODG00000014938	CHERP	100	91.239	Monodelphis_domestica
ENSG00000085872	CHERP	99	65.217	ENSMALG00000020688	cherp	79	66.102	Monopterus_albus
ENSG00000085872	CHERP	99	94.469	MGP_CAROLIEiJ_G0031220	Cherp	99	94.685	Mus_caroli
ENSG00000085872	CHERP	99	92.757	ENSMUSG00000052488	Cherp	99	92.865	Mus_musculus
ENSG00000085872	CHERP	99	94.426	MGP_PahariEiJ_G0021685	Cherp	99	94.863	Mus_pahari
ENSG00000085872	CHERP	99	94.457	MGP_SPRETEiJ_G0032341	Cherp	99	94.674	Mus_spretus
ENSG00000085872	CHERP	100	96.980	ENSMPUG00000016023	CHERP	98	96.980	Mustela_putorius_furo
ENSG00000085872	CHERP	80	91.440	ENSMLUG00000013881	CHERP	80	91.440	Myotis_lucifugus
ENSG00000085872	CHERP	100	92.597	ENSNGAG00000023323	Cherp	100	92.811	Nannospalax_galili
ENSG00000085872	CHERP	80	65.430	ENSNBRG00000001914	cherp	81	66.490	Neolamprologus_brichardi
ENSG00000085872	CHERP	100	99.563	ENSNLEG00000005536	CHERP	100	99.563	Nomascus_leucogenys
ENSG00000085872	CHERP	91	93.346	ENSMEUG00000010840	CHERP	91	94.640	Notamacropus_eugenii
ENSG00000085872	CHERP	79	95.592	ENSODEG00000001528	CHERP	81	95.436	Octodon_degus
ENSG00000085872	CHERP	99	64.968	ENSONIG00000007686	cherp	79	66.579	Oreochromis_niloticus
ENSG00000085872	CHERP	80	66.360	ENSORLG00000000138	cherp	79	67.154	Oryzias_latipes
ENSG00000085872	CHERP	80	66.229	ENSORLG00020013142	cherp	86	69.697	Oryzias_latipes_hni
ENSG00000085872	CHERP	80	66.097	ENSORLG00015008911	cherp	79	67.021	Oryzias_latipes_hsok
ENSG00000085872	CHERP	80	65.703	ENSOMEG00000016947	cherp	99	64.094	Oryzias_melastigma
ENSG00000085872	CHERP	99	96.401	ENSOGAG00000005834	CHERP	99	96.401	Otolemur_garnettii
ENSG00000085872	CHERP	100	85.233	ENSOARG00000018876	CHERP	78	85.753	Ovis_aries
ENSG00000085872	CHERP	100	99.892	ENSPPAG00000029195	CHERP	100	99.892	Pan_paniscus
ENSG00000085872	CHERP	100	98.062	ENSPPRG00000003275	CHERP	100	98.062	Panthera_pardus
ENSG00000085872	CHERP	99	70.362	ENSPTIG00000019778	CHERP	84	74.419	Panthera_tigris_altaica
ENSG00000085872	CHERP	100	99.891	ENSPTRG00000010647	CHERP	100	99.891	Pan_troglodytes
ENSG00000085872	CHERP	100	99.784	ENSPANG00000011698	CHERP	100	99.784	Papio_anubis
ENSG00000085872	CHERP	78	66.713	ENSPKIG00000000423	cherp	80	65.059	Paramormyrops_kingsleyae
ENSG00000085872	CHERP	99	85.294	ENSPSIG00000011974	CHERP	100	86.319	Pelodiscus_sinensis
ENSG00000085872	CHERP	99	62.032	ENSPMGG00000023606	cherp	88	92.405	Periophthalmus_magnuspinnatus
ENSG00000085872	CHERP	99	94.855	ENSPEMG00000011238	Cherp	99	95.070	Peromyscus_maniculatus_bairdii
ENSG00000085872	CHERP	100	91.738	ENSPCIG00000019615	CHERP	95	91.738	Phascolarctos_cinereus
ENSG00000085872	CHERP	99	65.645	ENSPFOG00000016899	cherp	99	64.807	Poecilia_formosa
ENSG00000085872	CHERP	85	64.484	ENSPMEG00000002214	cherp	76	66.667	Poecilia_mexicana
ENSG00000085872	CHERP	99	64.957	ENSPREG00000020774	cherp	99	64.225	Poecilia_reticulata
ENSG00000085872	CHERP	100	94.105	ENSPPYG00000009691	CHERP	100	94.323	Pongo_abelii
ENSG00000085872	CHERP	100	85.590	ENSPCAG00000001337	CHERP	90	96.774	Procavia_capensis
ENSG00000085872	CHERP	66	100.000	ENSPCOG00000022788	CHERP	99	100.000	Propithecus_coquereli
ENSG00000085872	CHERP	100	88.004	ENSPVAG00000004320	CHERP	100	88.004	Pteropus_vampyrus
ENSG00000085872	CHERP	99	65.595	ENSPNYG00000003942	cherp	79	67.023	Pundamilia_nyererei
ENSG00000085872	CHERP	99	67.296	ENSPNAG00000017179	cherp	99	66.771	Pygocentrus_nattereri
ENSG00000085872	CHERP	99	94.469	ENSRNOG00000012323	Cherp	99	94.577	Rattus_norvegicus
ENSG00000085872	CHERP	100	99.676	ENSRBIG00000038621	CHERP	100	99.676	Rhinopithecus_bieti
ENSG00000085872	CHERP	100	99.784	ENSRROG00000040770	CHERP	100	99.784	Rhinopithecus_roxellana
ENSG00000085872	CHERP	100	99.677	ENSSBOG00000014492	CHERP	100	99.677	Saimiri_boliviensis_boliviensis
ENSG00000085872	CHERP	99	91.595	ENSSHAG00000010752	CHERP	99	91.353	Sarcophilus_harrisii
ENSG00000085872	CHERP	88	84.810	ENSSFOG00015008022	cherp	84	76.276	Scleropages_formosus
ENSG00000085872	CHERP	99	64.942	ENSSMAG00000005362	cherp	79	65.752	Scophthalmus_maximus
ENSG00000085872	CHERP	99	67.591	ENSSDUG00000019712	cherp	79	68.414	Seriola_dumerili
ENSG00000085872	CHERP	99	67.773	ENSSLDG00000012659	cherp	79	68.553	Seriola_lalandi_dorsalis
ENSG00000085872	CHERP	100	84.457	ENSSPUG00000008901	CHERP	100	84.565	Sphenodon_punctatus
ENSG00000085872	CHERP	99	66.952	ENSSPAG00000010681	cherp	79	65.526	Stegastes_partitus
ENSG00000085872	CHERP	100	97.926	ENSSSCG00000013860	CHERP	100	97.926	Sus_scrofa
ENSG00000085872	CHERP	100	87.350	ENSTGUG00000000680	CHERP	100	87.350	Taeniopygia_guttata
ENSG00000085872	CHERP	80	64.136	ENSTRUG00000007429	cherp	93	60.000	Takifugu_rubripes
ENSG00000085872	CHERP	100	63.714	ENSTNIG00000003363	cherp	80	62.891	Tetraodon_nigroviridis
ENSG00000085872	CHERP	89	96.816	ENSTTRG00000015006	CHERP	89	96.816	Tursiops_truncatus
ENSG00000085872	CHERP	100	90.119	ENSUAMG00000017295	CHERP	80	96.914	Ursus_americanus
ENSG00000085872	CHERP	68	92.739	ENSUMAG00000000965	CHERP	70	88.994	Ursus_maritimus
ENSG00000085872	CHERP	100	97.744	ENSVVUG00000016546	CHERP	100	97.744	Vulpes_vulpes
ENSG00000085872	CHERP	56	83.041	ENSXETG00000002072	cherp	97	79.543	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	22365833.26420826.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	10794731.12656674.	IDA	Component
GO:0006874	cellular calcium ion homeostasis	10794731.	IDA	Process
GO:0007399	nervous system development	8896557.	TAS	Process
GO:0008285	negative regulation of cell proliferation	10794731.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0033017	sarcoplasmic reticulum membrane	-	ISS	Component
GO:0044325	ion channel binding	21454501.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	12656674.	IDA	Component
GO:0051209	release of sequestered calcium ion into cytosol	12656674.	IMP	Process
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	12656674.	IMP	Process