EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000086061 (Gene tree)
Gene ID: 3301
Gene Symbol: DNAJA1
Alias: HSPF4|hdj-2|dj-2|NEDD7|HSJ2
Full Name: DnaJ heat shock protein family (Hsp40) member A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,697 bases
Position: chr9:33,025,211-33,039,907
Accession: 5229
RBP type: non-canonical RBP
Summary: This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11599570	Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2.	Cell Stress Chaperones	2001 Jul	Fourie AM	-
25253355	DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.	J Virol	2014 Dec	Cao M	doi: 10.1128/JVI.02475-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000465677	DNAJA1-202	505	-	-	- (aa)	-	-
ENST00000495015	DNAJA1-203	604	-	-	- (aa)	-	-
ENST00000330899	DNAJA1-201	2381	-	ENSP00000369127	397 (aa)	-	P31689

Gene Model

Click here to download ENSG00000086061's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000086061	Pancreatic Neoplasms	1.4030000E-004	19648918
ENSG00000086061	Pancreatic Neoplasms	1.6110000E-004	19648918

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000086061	rs188517977	9	33037490	G	CTACK levels	27989323	[0.38-0.91] SD units decrease	0.6448	EFO_0008082

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000086061's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000086061	DNAJA1	100	99.496	ENSMUSG00000028410	Dnaja1	100	99.496	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	12150907.	IDA	Component
GO:0001664	G protein-coupled receptor binding	12150907.	IPI	Function
GO:0001671	ATPase activator activity	24318877.	IDA	Function
GO:0005515	protein binding	22085931.23431407.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21231916.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006457	protein folding	-	IEA	Process
GO:0006986	response to unfolded protein	8334160.	TAS	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0009408	response to heat	-	IEA	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21231916.	IDA	Component
GO:0030317	flagellated sperm motility	-	IEA	Process
GO:0030521	androgen receptor signaling pathway	-	IEA	Process
GO:0030544	Hsp70 protein binding	14752510.	IDA	Function
GO:0030957	Tat protein binding	14752510.	IPI	Function
GO:0031397	negative regulation of protein ubiquitination	12150907.	IDA	Process
GO:0031625	ubiquitin protein ligase binding	12150907.	IPI	Function
GO:0032781	positive regulation of ATPase activity	-	IEA	Process
GO:0042769	DNA damage response, detection of DNA damage	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	24512202.	IMP	Process
GO:0043066	negative regulation of apoptotic process	14752510.	IMP	Process
GO:0043508	negative regulation of JUN kinase activity	24512202.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050750	low-density lipoprotein particle receptor binding	15082773.	IDA	Function
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0051087	chaperone binding	14752510.	IDA	Function
GO:0051087	chaperone binding	21231916.	IPI	Function
GO:0051223	regulation of protein transport	14752510.	IDA	Process
GO:0055131	C3HC4-type RING finger domain binding	25281747.	IPI	Function
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:0070585	protein localization to mitochondrion	14752510.	IMP	Process
GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	12150907.	TAS	Component
GO:1901998	toxin transport	-	IEA	Process
GO:1903748	negative regulation of establishment of protein localization to mitochondrion	14752510.	IDA	Process
GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	14752510.	IDA	Process