EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000086102 (Gene tree)
Gene ID: 4799
Gene Symbol: NFX1
Alias: NFX2|MGC20369|Tex42|TEG-42
Full Name: nuclear transcription factor, X-box binding 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 80,738 bases
Position: chr9:33,290,420-33,371,157
Accession: 7803
RBP type: canonical RBP
Summary: MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000368856	R3H	PF01424.22	6.8e-20	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17333237	XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1.	Chromosoma	2007 Aug	Cohen HR	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000379521	NFX1-202	3609	-	-	- (aa)	-	-
ENST00000318524	NFX1-201	3513	-	ENSP00000317695	833 (aa)	-	Q12986
ENST00000463421	NFX1-204	987	-	-	- (aa)	-	-
ENST00000466971	NFX1-206	566	-	-	- (aa)	-	-
ENST00000379540	NFX1-203	4604	-	ENSP00000368856	1120 (aa)	-	Q12986
ENST00000466359	NFX1-205	391	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000086102's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05165	Human papillomavirus infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000086102	rs199840084	9	33302080	C	Interleukin-12p70 levels	27989323	[0.16-0.39] SD units increase	0.2732	EFO_0004753

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000086102's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000086102	NFX1	73	65.526	ENSAPOG00000016671	si:dkey-10f23.2	76	65.526	Acanthochromis_polyacanthus
ENSG00000086102	NFX1	100	92.239	ENSAMEG00000007472	NFX1	100	92.239	Ailuropoda_melanoleuca
ENSG00000086102	NFX1	72	65.136	ENSACIG00000021055	si:dkey-10f23.2	75	65.385	Amphilophus_citrinellus
ENSG00000086102	NFX1	73	65.648	ENSAOCG00000017316	si:dkey-10f23.2	81	65.648	Amphiprion_ocellaris
ENSG00000086102	NFX1	73	65.526	ENSAPEG00000012401	si:dkey-10f23.2	79	65.526	Amphiprion_percula
ENSG00000086102	NFX1	89	54.960	ENSATEG00000002080	si:dkey-10f23.2	89	54.985	Anabas_testudineus
ENSG00000086102	NFX1	99	59.755	ENSAPLG00000005524	NFX1	99	59.965	Anas_platyrhynchos
ENSG00000086102	NFX1	100	58.995	ENSACAG00000002412	NFX1	100	58.466	Anolis_carolinensis
ENSG00000086102	NFX1	100	96.699	ENSANAG00000001809	NFX1	100	96.699	Aotus_nancymaae
ENSG00000086102	NFX1	72	66.749	ENSACLG00000003795	si:dkey-10f23.2	75	66.749	Astatotilapia_calliptera
ENSG00000086102	NFX1	70	62.832	ENSAMXG00000006963	si:dkey-10f23.2	85	54.490	Astyanax_mexicanus
ENSG00000086102	NFX1	100	90.625	ENSBTAG00000012385	NFX1	100	90.179	Bos_taurus
ENSG00000086102	NFX1	72	38.773	WBGene00007048	nfx-1	71	39.206	Caenorhabditis_elegans
ENSG00000086102	NFX1	100	96.518	ENSCJAG00000008142	NFX1	100	96.518	Callithrix_jacchus
ENSG00000086102	NFX1	100	92.349	ENSCAFG00000001848	NFX1	100	92.349	Canis_familiaris
ENSG00000086102	NFX1	100	92.679	ENSCAFG00020015630	NFX1	100	92.679	Canis_lupus_dingo
ENSG00000086102	NFX1	100	90.625	ENSCHIG00000020037	NFX1	100	90.179	Capra_hircus
ENSG00000086102	NFX1	100	93.304	ENSTSYG00000004125	NFX1	100	93.304	Carlito_syrichta
ENSG00000086102	NFX1	87	83.282	ENSCAPG00000005611	NFX1	100	83.282	Cavia_aperea
ENSG00000086102	NFX1	100	90.982	ENSCPOG00000003470	NFX1	100	90.982	Cavia_porcellus
ENSG00000086102	NFX1	100	96.696	ENSCCAG00000025001	NFX1	100	96.696	Cebus_capucinus
ENSG00000086102	NFX1	100	86.161	ENSCLAG00000002893	NFX1	100	87.143	Chinchilla_lanigera
ENSG00000086102	NFX1	100	98.214	ENSCSAG00000009971	NFX1	100	98.214	Chlorocebus_sabaeus
ENSG00000086102	NFX1	88	88.073	ENSCHOG00000009225	NFX1	91	86.291	Choloepus_hoffmanni
ENSG00000086102	NFX1	99	64.462	ENSCPBG00000017928	NFX1	98	64.021	Chrysemys_picta_bellii
ENSG00000086102	NFX1	71	47.323	ENSCING00000004746	nf-x-like	70	47.453	Ciona_intestinalis
ENSG00000086102	NFX1	67	48.635	ENSCSAVG00000005762	-	68	48.635	Ciona_savignyi
ENSG00000086102	NFX1	100	95.285	ENSCANG00000028364	NFX1	100	95.285	Colobus_angolensis_palliatus
ENSG00000086102	NFX1	99	84.712	ENSCGRG00001002869	Nfx1	100	84.712	Cricetulus_griseus_chok1gshd
ENSG00000086102	NFX1	99	88.659	ENSCGRG00000016032	Nfx1	100	88.659	Cricetulus_griseus_crigri
ENSG00000086102	NFX1	68	66.104	ENSCSEG00000019832	si:dkey-10f23.2	74	66.711	Cynoglossus_semilaevis
ENSG00000086102	NFX1	72	66.625	ENSCVAG00000010039	si:dkey-10f23.2	75	66.625	Cyprinodon_variegatus
ENSG00000086102	NFX1	100	51.086	ENSDARG00000105669	NFX1	100	51.311	Danio_rerio
ENSG00000086102	NFX1	100	86.922	ENSDNOG00000002079	NFX1	100	86.922	Dasypus_novemcinctus
ENSG00000086102	NFX1	99	84.843	ENSDORG00000001989	Nfx1	99	84.843	Dipodomys_ordii
ENSG00000086102	NFX1	74	41.396	FBgn0001978	stc	72	41.363	Drosophila_melanogaster
ENSG00000086102	NFX1	97	85.846	ENSETEG00000001427	NFX1	95	83.830	Echinops_telfairi
ENSG00000086102	NFX1	80	51.819	ENSEBUG00000006923	si:dkey-10f23.2	62	55.890	Eptatretus_burgeri
ENSG00000086102	NFX1	100	91.607	ENSEASG00005004230	NFX1	93	91.607	Equus_asinus_asinus
ENSG00000086102	NFX1	100	91.429	ENSECAG00000021305	NFX1	93	91.429	Equus_caballus
ENSG00000086102	NFX1	96	89.153	ENSEEUG00000001694	NFX1	88	89.153	Erinaceus_europaeus
ENSG00000086102	NFX1	70	62.690	ENSELUG00000007422	si:dkey-10f23.2	70	62.310	Esox_lucius
ENSG00000086102	NFX1	100	91.786	ENSFCAG00000007905	NFX1	100	91.786	Felis_catus
ENSG00000086102	NFX1	99	60.702	ENSFALG00000013143	NFX1	99	60.439	Ficedula_albicollis
ENSG00000086102	NFX1	100	91.875	ENSFDAG00000012320	NFX1	100	91.875	Fukomys_damarensis
ENSG00000086102	NFX1	70	67.430	ENSFHEG00000017330	si:dkey-10f23.2	73	67.430	Fundulus_heteroclitus
ENSG00000086102	NFX1	66	65.041	ENSGMOG00000006198	si:dkey-10f23.2	99	65.041	Gadus_morhua
ENSG00000086102	NFX1	100	60.156	ENSGALG00000043724	NFX1	100	59.809	Gallus_gallus
ENSG00000086102	NFX1	72	64.969	ENSGAFG00000000226	si:dkey-10f23.2	76	64.969	Gambusia_affinis
ENSG00000086102	NFX1	66	64.382	ENSGACG00000004560	si:dkey-10f23.2	98	64.382	Gasterosteus_aculeatus
ENSG00000086102	NFX1	100	99.732	ENSGGOG00000006751	NFX1	100	99.732	Gorilla_gorilla
ENSG00000086102	NFX1	72	66.501	ENSHBUG00000015403	si:dkey-10f23.2	75	66.501	Haplochromis_burtoni
ENSG00000086102	NFX1	100	92.589	ENSHGLG00000008375	NFX1	100	92.589	Heterocephalus_glaber_female
ENSG00000086102	NFX1	100	92.589	ENSHGLG00100016433	NFX1	100	92.589	Heterocephalus_glaber_male
ENSG00000086102	NFX1	83	56.944	ENSHCOG00000001235	si:dkey-10f23.2	90	56.944	Hippocampus_comes
ENSG00000086102	NFX1	70	65.605	ENSIPUG00000005961	si:dkey-10f23.2	72	65.605	Ictalurus_punctatus
ENSG00000086102	NFX1	100	91.518	ENSSTOG00000006984	NFX1	100	91.518	Ictidomys_tridecemlineatus
ENSG00000086102	NFX1	100	88.750	ENSJJAG00000023303	Nfx1	100	88.750	Jaculus_jaculus
ENSG00000086102	NFX1	70	65.903	ENSKMAG00000016306	si:dkey-10f23.2	73	65.903	Kryptolebias_marmoratus
ENSG00000086102	NFX1	80	56.393	ENSLBEG00000013253	si:dkey-10f23.2	88	54.395	Labrus_bergylta
ENSG00000086102	NFX1	99	59.008	ENSLACG00000000769	NFX1	100	62.331	Latimeria_chalumnae
ENSG00000086102	NFX1	98	55.685	ENSLOCG00000011211	si:dkey-10f23.2	91	69.823	Lepisosteus_oculatus
ENSG00000086102	NFX1	100	98.125	ENSMFAG00000038715	NFX1	100	98.125	Macaca_fascicularis
ENSG00000086102	NFX1	100	98.125	ENSMMUG00000043096	NFX1	100	98.125	Macaca_mulatta
ENSG00000086102	NFX1	100	98.214	ENSMNEG00000036057	NFX1	100	98.214	Macaca_nemestrina
ENSG00000086102	NFX1	100	98.214	ENSMLEG00000040882	NFX1	100	98.214	Mandrillus_leucophaeus
ENSG00000086102	NFX1	71	66.164	ENSMAMG00000010139	si:dkey-10f23.2	73	66.164	Mastacembelus_armatus
ENSG00000086102	NFX1	72	66.749	ENSMZEG00005018390	si:dkey-10f23.2	75	66.749	Maylandia_zebra
ENSG00000086102	NFX1	100	90.455	ENSMICG00000012124	NFX1	100	90.455	Microcebus_murinus
ENSG00000086102	NFX1	100	87.500	ENSMOCG00000007616	Nfx1	100	87.500	Microtus_ochrogaster
ENSG00000086102	NFX1	80	57.393	ENSMMOG00000004171	si:dkey-10f23.2	99	57.393	Mola_mola
ENSG00000086102	NFX1	100	70.833	ENSMODG00000003990	NFX1	100	70.833	Monodelphis_domestica
ENSG00000086102	NFX1	72	64.516	ENSMALG00000017326	si:dkey-10f23.2	86	64.516	Monopterus_albus
ENSG00000086102	NFX1	100	88.482	MGP_CAROLIEiJ_G0025904	Nfx1	100	88.482	Mus_caroli
ENSG00000086102	NFX1	100	88.214	ENSMUSG00000028423	Nfx1	100	88.214	Mus_musculus
ENSG00000086102	NFX1	100	88.214	MGP_PahariEiJ_G0024027	Nfx1	100	88.214	Mus_pahari
ENSG00000086102	NFX1	100	88.214	MGP_SPRETEiJ_G0026852	Nfx1	100	88.214	Mus_spretus
ENSG00000086102	NFX1	100	92.321	ENSMPUG00000004111	NFX1	100	92.321	Mustela_putorius_furo
ENSG00000086102	NFX1	100	89.432	ENSMLUG00000011069	NFX1	100	88.899	Myotis_lucifugus
ENSG00000086102	NFX1	100	89.821	ENSNGAG00000005385	Nfx1	100	89.821	Nannospalax_galili
ENSG00000086102	NFX1	72	66.791	ENSNBRG00000013449	si:dkey-10f23.2	75	66.791	Neolamprologus_brichardi
ENSG00000086102	NFX1	100	98.482	ENSNLEG00000005096	NFX1	100	98.482	Nomascus_leucogenys
ENSG00000086102	NFX1	99	73.253	ENSMEUG00000012002	NFX1	94	73.253	Notamacropus_eugenii
ENSG00000086102	NFX1	93	86.452	ENSOPRG00000009816	NFX1	100	86.452	Ochotona_princeps
ENSG00000086102	NFX1	100	91.339	ENSODEG00000015229	NFX1	100	91.339	Octodon_degus
ENSG00000086102	NFX1	69	66.923	ENSONIG00000006192	si:dkey-10f23.2	71	67.145	Oreochromis_niloticus
ENSG00000086102	NFX1	100	57.899	ENSOANG00000002524	NFX1	100	57.899	Ornithorhynchus_anatinus
ENSG00000086102	NFX1	100	87.411	ENSOCUG00000008957	NFX1	100	87.411	Oryctolagus_cuniculus
ENSG00000086102	NFX1	80	59.243	ENSORLG00000026662	si:dkey-10f23.2	92	59.716	Oryzias_latipes
ENSG00000086102	NFX1	81	58.552	ENSORLG00020000170	si:dkey-10f23.2	92	59.459	Oryzias_latipes_hni
ENSG00000086102	NFX1	75	63.020	ENSORLG00015008191	si:dkey-10f23.2	77	63.020	Oryzias_latipes_hsok
ENSG00000086102	NFX1	77	62.616	ENSOMEG00000001814	si:dkey-10f23.2	82	62.616	Oryzias_melastigma
ENSG00000086102	NFX1	100	90.089	ENSOGAG00000000775	NFX1	100	90.089	Otolemur_garnettii
ENSG00000086102	NFX1	100	90.366	ENSOARG00000009478	NFX1	100	89.920	Ovis_aries
ENSG00000086102	NFX1	100	100.000	ENSPPAG00000027871	NFX1	100	100.000	Pan_paniscus
ENSG00000086102	NFX1	100	92.143	ENSPPRG00000000665	NFX1	100	92.143	Panthera_pardus
ENSG00000086102	NFX1	100	92.054	ENSPTIG00000012443	NFX1	100	92.054	Panthera_tigris_altaica
ENSG00000086102	NFX1	100	100.000	ENSPTRG00000020858	NFX1	100	100.000	Pan_troglodytes
ENSG00000086102	NFX1	100	98.125	ENSPANG00000025304	NFX1	100	98.125	Papio_anubis
ENSG00000086102	NFX1	71	69.357	ENSPKIG00000016899	si:dkey-10f23.2	85	62.635	Paramormyrops_kingsleyae
ENSG00000086102	NFX1	99	62.982	ENSPSIG00000008420	NFX1	99	62.632	Pelodiscus_sinensis
ENSG00000086102	NFX1	100	88.482	ENSPEMG00000007625	Nfx1	100	88.482	Peromyscus_maniculatus_bairdii
ENSG00000086102	NFX1	70	56.946	ENSPMAG00000003556	si:dkey-10f23.2	100	56.946	Petromyzon_marinus
ENSG00000086102	NFX1	72	65.466	ENSPFOG00000012547	si:dkey-10f23.2	76	65.466	Poecilia_formosa
ENSG00000086102	NFX1	72	65.093	ENSPLAG00000010574	si:dkey-10f23.2	76	65.093	Poecilia_latipinna
ENSG00000086102	NFX1	72	65.466	ENSPMEG00000015322	si:dkey-10f23.2	76	65.466	Poecilia_mexicana
ENSG00000086102	NFX1	72	65.714	ENSPREG00000006186	si:dkey-10f23.2	75	65.714	Poecilia_reticulata
ENSG00000086102	NFX1	62	99.713	ENSPPYG00000019136	-	100	99.713	Pongo_abelii
ENSG00000086102	NFX1	99	74.347	ENSPCAG00000006913	NFX1	100	74.347	Procavia_capensis
ENSG00000086102	NFX1	100	93.304	ENSPCOG00000015789	NFX1	100	93.304	Propithecus_coquereli
ENSG00000086102	NFX1	100	83.571	ENSPVAG00000011479	NFX1	100	83.571	Pteropus_vampyrus
ENSG00000086102	NFX1	72	66.501	ENSPNYG00000002175	si:dkey-10f23.2	75	66.501	Pundamilia_nyererei
ENSG00000086102	NFX1	70	64.475	ENSPNAG00000016667	si:dkey-10f23.2	94	52.451	Pygocentrus_nattereri
ENSG00000086102	NFX1	100	88.304	ENSRNOG00000009015	Nfx1	100	88.304	Rattus_norvegicus
ENSG00000086102	NFX1	88	91.287	ENSRBIG00000036482	NFX1	100	90.357	Rhinopithecus_bieti
ENSG00000086102	NFX1	100	98.036	ENSRROG00000026461	NFX1	100	98.036	Rhinopithecus_roxellana
ENSG00000086102	NFX1	70	30.607	YNL023C	-	77	31.274	Saccharomyces_cerevisiae
ENSG00000086102	NFX1	97	91.708	ENSSBOG00000035261	NFX1	100	87.679	Saimiri_boliviensis_boliviensis
ENSG00000086102	NFX1	100	70.406	ENSSHAG00000010272	NFX1	100	70.406	Sarcophilus_harrisii
ENSG00000086102	NFX1	71	69.105	ENSSFOG00015019271	si:dkey-10f23.2	72	69.105	Scleropages_formosus
ENSG00000086102	NFX1	72	64.764	ENSSMAG00000015963	si:dkey-10f23.2	76	64.764	Scophthalmus_maximus
ENSG00000086102	NFX1	70	66.922	ENSSDUG00000009395	si:dkey-10f23.2	71	66.922	Seriola_dumerili
ENSG00000086102	NFX1	70	67.050	ENSSLDG00000023817	si:dkey-10f23.2	71	67.050	Seriola_lalandi_dorsalis
ENSG00000086102	NFX1	72	96.875	ENSSARG00000014320	NFX1	82	96.875	Sorex_araneus
ENSG00000086102	NFX1	72	66.005	ENSSPAG00000012861	si:dkey-10f23.2	74	66.005	Stegastes_partitus
ENSG00000086102	NFX1	100	89.750	ENSSSCG00000010994	NFX1	100	89.750	Sus_scrofa
ENSG00000086102	NFX1	70	67.383	ENSTGUG00000007055	NFX1	100	67.130	Taeniopygia_guttata
ENSG00000086102	NFX1	61	91.398	ENSTBEG00000004560	NFX1	59	91.398	Tupaia_belangeri
ENSG00000086102	NFX1	97	97.093	ENSTTRG00000010576	NFX1	93	93.388	Tursiops_truncatus
ENSG00000086102	NFX1	100	92.321	ENSUMAG00000006016	NFX1	100	92.321	Ursus_maritimus
ENSG00000086102	NFX1	100	92.417	ENSVVUG00000021100	NFX1	100	92.417	Vulpes_vulpes
ENSG00000086102	NFX1	99	59.422	ENSXETG00000014997	nfx1	100	59.422	Xenopus_tropicalis
ENSG00000086102	NFX1	83	59.052	ENSXMAG00000001963	si:dkey-10f23.2	76	64.969	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	7964459.	IDA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	7964459.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7964459.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	7964459.	TAS	Process
GO:0006954	inflammatory response	7964459.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016032	viral process	-	IEA	Process
GO:0016567	protein ubiquitination	15371341.	TAS	Process
GO:0045347	negative regulation of MHC class II biosynthetic process	-	IEA	Process
GO:0061630	ubiquitin protein ligase activity	15371341.	TAS	Function