EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000086200 (Gene tree)
Gene ID: 51194
Gene Symbol: IPO11
Alias: RanBP11
Full Name: importin 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 224,618 bases
Position: chr5:62,403,972-62,628,589
Accession: 20628
RBP type: canonical RBP
Summary: Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000427129	IBN_N	PF03810.19	2.1e-19	1	1
ENSP00000427274	IBN_N	PF03810.19	2.4e-19	1	1
ENSP00000316651	IBN_N	PF03810.19	9.1e-19	1	1
ENSP00000386992	IBN_N	PF03810.19	1e-18	1	1
ENSP00000425573	IBN_N	PF03810.19	3.9e-09	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000511133	IPO11-211	506	-	-	- (aa)	-	-
ENST00000424533	IPO11-205	3005	-	ENSP00000395685	863 (aa)	-	F8WDV0
ENST00000413749	IPO11-204	1368	-	ENSP00000398230	59 (aa)	-	F8WBN4
ENST00000505902	IPO11-207	530	-	ENSP00000425573	63 (aa)	-	D6RCQ2
ENST00000502862	IPO11-206	655	-	-	- (aa)	-	-
ENST00000409534	IPO11-203	1725	-	ENSP00000387039	94 (aa)	-	E7EMB7
ENST00000512177	IPO11-213	599	-	-	- (aa)	-	-
ENST00000514647	IPO11-214	584	-	ENSP00000427129	148 (aa)	-	D6RCN7
ENST00000506200	IPO11-208	554	-	ENSP00000427274	162 (aa)	-	D6RJB1
ENST00000511713	IPO11-212	1865	-	ENSP00000421517	160 (aa)	-	H0Y8M5
ENST00000325324	IPO11-201	4356	-	ENSP00000316651	975 (aa)	-	Q9UI26
ENST00000507640	IPO11-210	458	-	-	- (aa)	-	-
ENST00000506905	IPO11-209	550	-	-	- (aa)	-	-
ENST00000409296	IPO11-202	3564	-	ENSP00000386992	1015 (aa)	-	Q9UI26

Gene Model

Click here to download ENSG00000086200's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000086200	Creatinine	8.9320000E-005	-
ENSG00000086200	Creatinine	9.4940000E-005	-
ENSG00000086200	Platelet Function Tests	3.7021823E-007	-
ENSG00000086200	Platelet Function Tests	8.5947423E-007	-
ENSG00000086200	Platelet Function Tests	1.3758000E-005	-
ENSG00000086200	Platelet Function Tests	1.1233934E-006	-
ENSG00000086200	Venous Thromboembolism	5E-9	23509962
ENSG00000086200	Uric Acid	8E-6	21294900
ENSG00000086200	Venous Thromboembolism	2E-9	23509962

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000086200	rs40110	5	62468025	A	Diffusing capacity of the lung for carbon monoxide traits	30049742	[0.013-0.027] unit increase	0.02	EFO_0009369
ENSG00000086200	rs6897129	5	62604283	A	Adventurousness	30643258	[0.0093-0.0173] unit increase	0.013310496	EFO_0008579
ENSG00000086200	rs6897129	5	62604283	A	General risk tolerance (MTAG)	30643258	[0.0045-0.0095] unit increase	0.007	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000086200's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000086200	IPO11	100	90.123	ENSAPOG00000009256	ipo11	100	84.615	Acanthochromis_polyacanthus
ENSG00000086200	IPO11	100	100.000	ENSAMEG00000004080	IPO11	99	98.059	Ailuropoda_melanoleuca
ENSG00000086200	IPO11	100	90.123	ENSACIG00000003345	ipo11	98	86.104	Amphilophus_citrinellus
ENSG00000086200	IPO11	100	90.123	ENSAOCG00000000164	ipo11	100	81.084	Amphiprion_ocellaris
ENSG00000086200	IPO11	100	90.123	ENSAPEG00000005496	ipo11	100	80.982	Amphiprion_percula
ENSG00000086200	IPO11	100	90.123	ENSATEG00000016853	ipo11	99	84.707	Anabas_testudineus
ENSG00000086200	IPO11	100	96.825	ENSAPLG00000009338	IPO11	100	85.584	Anas_platyrhynchos
ENSG00000086200	IPO11	100	93.651	ENSACAG00000008472	IPO11	99	89.026	Anolis_carolinensis
ENSG00000086200	IPO11	100	100.000	ENSANAG00000027877	IPO11	100	99.181	Aotus_nancymaae
ENSG00000086200	IPO11	100	90.123	ENSACLG00000014997	ipo11	100	79.346	Astatotilapia_calliptera
ENSG00000086200	IPO11	100	87.037	ENSAMXG00000005993	ipo11	100	76.742	Astyanax_mexicanus
ENSG00000086200	IPO11	100	100.000	ENSBTAG00000018616	IPO11	100	97.567	Bos_taurus
ENSG00000086200	IPO11	100	100.000	ENSCJAG00000015559	IPO11	100	99.284	Callithrix_jacchus
ENSG00000086200	IPO11	100	100.000	ENSCAFG00000007240	IPO11	100	98.667	Canis_familiaris
ENSG00000086200	IPO11	100	100.000	ENSCAFG00020022776	-	99	96.302	Canis_lupus_dingo
ENSG00000086200	IPO11	100	100.000	ENSCHIG00000013218	IPO11	100	97.914	Capra_hircus
ENSG00000086200	IPO11	100	98.936	ENSCPOG00000009412	IPO11	100	96.410	Cavia_porcellus
ENSG00000086200	IPO11	100	100.000	ENSCCAG00000024860	IPO11	100	99.284	Cebus_capucinus
ENSG00000086200	IPO11	100	100.000	ENSCATG00000040159	IPO11	100	99.692	Cercocebus_atys
ENSG00000086200	IPO11	100	98.765	ENSCLAG00000003889	IPO11	100	98.359	Chinchilla_lanigera
ENSG00000086200	IPO11	100	100.000	ENSCSAG00000016001	IPO11	97	99.083	Chlorocebus_sabaeus
ENSG00000086200	IPO11	100	98.413	ENSCHOG00000002780	IPO11	77	96.689	Choloepus_hoffmanni
ENSG00000086200	IPO11	100	96.825	ENSCPBG00000026824	IPO11	100	92.000	Chrysemys_picta_bellii
ENSG00000086200	IPO11	94	45.570	ENSCING00000006626	-	99	35.377	Ciona_intestinalis
ENSG00000086200	IPO11	99	34.943	ENSCSAVG00000003664	-	99	34.483	Ciona_savignyi
ENSG00000086200	IPO11	100	100.000	ENSCANG00000042405	IPO11	99	98.372	Colobus_angolensis_palliatus
ENSG00000086200	IPO11	100	97.872	ENSCGRG00001012206	Ipo11	100	97.026	Cricetulus_griseus_chok1gshd
ENSG00000086200	IPO11	100	97.872	ENSCGRG00000003026	-	100	97.026	Cricetulus_griseus_crigri
ENSG00000086200	IPO11	100	89.506	ENSCSEG00000017257	ipo11	100	82.974	Cynoglossus_semilaevis
ENSG00000086200	IPO11	100	90.741	ENSCVAG00000011995	ipo11	100	83.795	Cyprinodon_variegatus
ENSG00000086200	IPO11	100	89.506	ENSDARG00000054224	ipo11	99	83.881	Danio_rerio
ENSG00000086200	IPO11	100	98.936	ENSDORG00000002721	Ipo11	100	93.846	Dipodomys_ordii
ENSG00000086200	IPO11	99	36.860	FBgn0284254	Impbeta11	95	34.808	Drosophila_melanogaster
ENSG00000086200	IPO11	100	72.840	ENSEBUG00000003347	ipo11	99	60.391	Eptatretus_burgeri
ENSG00000086200	IPO11	100	100.000	ENSEASG00005006951	-	98	92.264	Equus_asinus_asinus
ENSG00000086200	IPO11	100	100.000	ENSECAG00000014185	IPO11	99	97.862	Equus_caballus
ENSG00000086200	IPO11	100	100.000	ENSEEUG00000000271	IPO11	92	95.955	Erinaceus_europaeus
ENSG00000086200	IPO11	100	90.123	ENSELUG00000002842	ipo11	98	86.857	Esox_lucius
ENSG00000086200	IPO11	100	100.000	ENSFCAG00000003236	IPO11	100	98.667	Felis_catus
ENSG00000086200	IPO11	100	96.825	ENSFALG00000011086	IPO11	100	90.051	Ficedula_albicollis
ENSG00000086200	IPO11	100	98.765	ENSFDAG00000016117	IPO11	100	97.949	Fukomys_damarensis
ENSG00000086200	IPO11	100	89.506	ENSFHEG00000017985	ipo11	100	88.372	Fundulus_heteroclitus
ENSG00000086200	IPO11	100	88.889	ENSGMOG00000007727	ipo11	100	81.949	Gadus_morhua
ENSG00000086200	IPO11	100	93.827	ENSGALG00000014740	IPO11	100	90.154	Gallus_gallus
ENSG00000086200	IPO11	100	90.741	ENSGAFG00000012342	ipo11	100	83.822	Gambusia_affinis
ENSG00000086200	IPO11	100	90.123	ENSGACG00000006939	ipo11	100	82.667	Gasterosteus_aculeatus
ENSG00000086200	IPO11	100	96.825	ENSGAGG00000008880	IPO11	100	86.458	Gopherus_agassizii
ENSG00000086200	IPO11	100	100.000	ENSGGOG00000003240	IPO11	100	99.897	Gorilla_gorilla
ENSG00000086200	IPO11	100	90.123	ENSHBUG00000004364	ipo11	100	84.410	Haplochromis_burtoni
ENSG00000086200	IPO11	100	98.765	ENSHGLG00000002375	IPO11	100	98.051	Heterocephalus_glaber_female
ENSG00000086200	IPO11	100	98.765	ENSHGLG00100011662	IPO11	100	98.154	Heterocephalus_glaber_male
ENSG00000086200	IPO11	100	88.889	ENSHCOG00000013529	ipo11	100	80.244	Hippocampus_comes
ENSG00000086200	IPO11	100	76.543	ENSIPUG00000019077	clc4f	99	70.154	Ictalurus_punctatus
ENSG00000086200	IPO11	100	98.765	ENSSTOG00000006070	IPO11	100	98.667	Ictidomys_tridecemlineatus
ENSG00000086200	IPO11	100	100.000	ENSJJAG00000007223	Ipo11	100	97.128	Jaculus_jaculus
ENSG00000086200	IPO11	100	90.741	ENSKMAG00000013674	ipo11	100	83.128	Kryptolebias_marmoratus
ENSG00000086200	IPO11	100	88.889	ENSLBEG00000003126	ipo11	100	84.000	Labrus_bergylta
ENSG00000086200	IPO11	100	90.123	ENSLOCG00000007848	ipo11	100	86.102	Lepisosteus_oculatus
ENSG00000086200	IPO11	100	97.436	ENSLAFG00000003115	IPO11	100	97.245	Loxodonta_africana
ENSG00000086200	IPO11	100	100.000	ENSMFAG00000035631	IPO11	100	99.310	Macaca_fascicularis
ENSG00000086200	IPO11	100	100.000	ENSMMUG00000001233	IPO11	100	100.000	Macaca_mulatta
ENSG00000086200	IPO11	100	100.000	ENSMNEG00000032061	IPO11	100	99.113	Macaca_nemestrina
ENSG00000086200	IPO11	100	100.000	ENSMLEG00000014468	IPO11	100	99.590	Mandrillus_leucophaeus
ENSG00000086200	IPO11	100	89.506	ENSMAMG00000020889	ipo11	100	87.791	Mastacembelus_armatus
ENSG00000086200	IPO11	100	90.123	ENSMZEG00005006586	ipo11	100	84.410	Maylandia_zebra
ENSG00000086200	IPO11	100	93.827	ENSMGAG00000004204	IPO11	100	79.162	Meleagris_gallopavo
ENSG00000086200	IPO11	100	98.413	ENSMAUG00000020293	Ipo11	100	84.678	Mesocricetus_auratus
ENSG00000086200	IPO11	100	97.531	ENSMICG00000036842	-	100	96.103	Microcebus_murinus
ENSG00000086200	IPO11	100	98.765	ENSMICG00000016463	-	100	98.154	Microcebus_murinus
ENSG00000086200	IPO11	100	97.531	ENSMOCG00000000236	Ipo11	100	95.692	Microtus_ochrogaster
ENSG00000086200	IPO11	100	89.506	ENSMMOG00000001391	ipo11	100	81.365	Mola_mola
ENSG00000086200	IPO11	100	96.914	ENSMODG00000019612	IPO11	100	95.179	Monodelphis_domestica
ENSG00000086200	IPO11	100	89.506	ENSMALG00000017198	ipo11	100	83.487	Monopterus_albus
ENSG00000086200	IPO11	100	98.413	MGP_CAROLIEiJ_G0018871	Ipo11	100	96.615	Mus_caroli
ENSG00000086200	IPO11	100	98.413	ENSMUSG00000042590	Ipo11	100	96.821	Mus_musculus
ENSG00000086200	IPO11	100	98.413	MGP_PahariEiJ_G0015943	Ipo11	100	95.282	Mus_pahari
ENSG00000086200	IPO11	100	98.413	MGP_SPRETEiJ_G0019750	Ipo11	100	96.821	Mus_spretus
ENSG00000086200	IPO11	100	100.000	ENSMPUG00000007026	IPO11	100	95.385	Mustela_putorius_furo
ENSG00000086200	IPO11	100	96.296	ENSMLUG00000011760	IPO11	100	95.612	Myotis_lucifugus
ENSG00000086200	IPO11	100	100.000	ENSNGAG00000007024	Ipo11	100	97.128	Nannospalax_galili
ENSG00000086200	IPO11	100	79.787	ENSNBRG00000013831	ipo11	99	78.788	Neolamprologus_brichardi
ENSG00000086200	IPO11	100	100.000	ENSNLEG00000003072	IPO11	100	99.692	Nomascus_leucogenys
ENSG00000086200	IPO11	100	95.062	ENSMEUG00000003783	-	74	94.203	Notamacropus_eugenii
ENSG00000086200	IPO11	100	98.154	ENSODEG00000017269	IPO11	100	98.154	Octodon_degus
ENSG00000086200	IPO11	100	90.123	ENSONIG00000015147	ipo11	100	84.513	Oreochromis_niloticus
ENSG00000086200	IPO11	95	93.023	ENSOANG00000012524	IPO11	91	93.023	Ornithorhynchus_anatinus
ENSG00000086200	IPO11	100	88.889	ENSORLG00000004267	ipo11	100	87.209	Oryzias_latipes
ENSG00000086200	IPO11	100	90.123	ENSORLG00020002280	ipo11	100	83.077	Oryzias_latipes_hni
ENSG00000086200	IPO11	100	90.123	ENSORLG00015010565	ipo11	100	88.372	Oryzias_latipes_hsok
ENSG00000086200	IPO11	100	89.506	ENSOMEG00000021765	ipo11	100	83.385	Oryzias_melastigma
ENSG00000086200	IPO11	100	100.000	ENSOGAG00000000533	IPO11	99	98.567	Otolemur_garnettii
ENSG00000086200	IPO11	100	100.000	ENSOARG00000006763	IPO11	99	97.851	Ovis_aries
ENSG00000086200	IPO11	100	100.000	ENSPPAG00000042249	IPO11	100	99.803	Pan_paniscus
ENSG00000086200	IPO11	100	100.000	ENSPPRG00000000856	IPO11	100	98.772	Panthera_pardus
ENSG00000086200	IPO11	100	100.000	ENSPTIG00000015280	IPO11	100	98.769	Panthera_tigris_altaica
ENSG00000086200	IPO11	100	100.000	ENSPTRG00000016915	IPO11	100	99.803	Pan_troglodytes
ENSG00000086200	IPO11	100	100.000	ENSPANG00000013348	IPO11	100	99.692	Papio_anubis
ENSG00000086200	IPO11	100	91.975	ENSPKIG00000016964	ipo11	100	84.513	Paramormyrops_kingsleyae
ENSG00000086200	IPO11	100	93.827	ENSPSIG00000002959	IPO11	100	91.291	Pelodiscus_sinensis
ENSG00000086200	IPO11	93	77.182	ENSPMGG00000013232	ipo11	96	77.314	Periophthalmus_magnuspinnatus
ENSG00000086200	IPO11	100	98.413	ENSPEMG00000018393	Ipo11	100	96.513	Peromyscus_maniculatus_bairdii
ENSG00000086200	IPO11	100	78.395	ENSPMAG00000003334	ipo11	100	62.916	Petromyzon_marinus
ENSG00000086200	IPO11	100	95.062	ENSPCIG00000023292	IPO11	100	94.481	Phascolarctos_cinereus
ENSG00000086200	IPO11	100	90.123	ENSPFOG00000019348	ipo11	98	82.671	Poecilia_formosa
ENSG00000086200	IPO11	100	90.123	ENSPLAG00000023917	ipo11	100	83.487	Poecilia_latipinna
ENSG00000086200	IPO11	100	90.123	ENSPMEG00000013269	ipo11	100	83.385	Poecilia_mexicana
ENSG00000086200	IPO11	100	90.741	ENSPREG00000016551	ipo11	98	83.179	Poecilia_reticulata
ENSG00000086200	IPO11	100	100.000	ENSPPYG00000015498	IPO11	100	97.538	Pongo_abelii
ENSG00000086200	IPO11	100	98.765	ENSPCOG00000018118	IPO11	100	83.487	Propithecus_coquereli
ENSG00000086200	IPO11	100	100.000	ENSPVAG00000005364	IPO11	88	98.551	Pteropus_vampyrus
ENSG00000086200	IPO11	100	90.123	ENSPNYG00000015409	ipo11	100	76.176	Pundamilia_nyererei
ENSG00000086200	IPO11	100	87.037	ENSPNAG00000022135	ipo11	100	74.668	Pygocentrus_nattereri
ENSG00000086200	IPO11	100	98.413	ENSRNOG00000039717	Ipo11	100	91.701	Rattus_norvegicus
ENSG00000086200	IPO11	100	100.000	ENSRBIG00000038296	IPO11	99	96.176	Rhinopithecus_bieti
ENSG00000086200	IPO11	100	100.000	ENSRROG00000040336	IPO11	100	99.692	Rhinopithecus_roxellana
ENSG00000086200	IPO11	100	100.000	ENSSBOG00000019916	IPO11	100	99.284	Saimiri_boliviensis_boliviensis
ENSG00000086200	IPO11	100	94.462	ENSSHAG00000005436	IPO11	100	94.286	Sarcophilus_harrisii
ENSG00000086200	IPO11	100	91.358	ENSSFOG00015006427	ipo11	100	90.230	Scleropages_formosus
ENSG00000086200	IPO11	100	90.741	ENSSMAG00000002409	ipo11	100	84.103	Scophthalmus_maximus
ENSG00000086200	IPO11	100	89.506	ENSSDUG00000012263	ipo11	100	84.205	Seriola_dumerili
ENSG00000086200	IPO11	100	89.506	ENSSLDG00000018490	ipo11	100	84.103	Seriola_lalandi_dorsalis
ENSG00000086200	IPO11	100	96.914	ENSSARG00000003977	IPO11	99	80.287	Sorex_araneus
ENSG00000086200	IPO11	100	95.238	ENSSPUG00000018027	IPO11	99	83.837	Sphenodon_punctatus
ENSG00000086200	IPO11	100	90.123	ENSSPAG00000004399	ipo11	100	88.953	Stegastes_partitus
ENSG00000086200	IPO11	100	98.936	ENSSSCG00000016938	IPO11	100	97.949	Sus_scrofa
ENSG00000086200	IPO11	100	95.238	ENSTGUG00000002759	IPO11	100	88.718	Taeniopygia_guttata
ENSG00000086200	IPO11	100	89.506	ENSTRUG00000014721	ipo11	100	83.795	Takifugu_rubripes
ENSG00000086200	IPO11	100	89.506	ENSTNIG00000005025	ipo11	100	70.408	Tetraodon_nigroviridis
ENSG00000086200	IPO11	100	100.000	ENSTTRG00000008770	IPO11	93	92.114	Tursiops_truncatus
ENSG00000086200	IPO11	100	100.000	ENSUMAG00000008799	IPO11	99	93.390	Ursus_maritimus
ENSG00000086200	IPO11	100	100.000	ENSVPAG00000008867	IPO11	100	96.743	Vicugna_pacos
ENSG00000086200	IPO11	100	100.000	ENSVVUG00000005421	IPO11	100	95.282	Vulpes_vulpes
ENSG00000086200	IPO11	100	92.593	ENSXETG00000014823	ipo11	100	82.172	Xenopus_tropicalis
ENSG00000086200	IPO11	100	90.741	ENSXMAG00000015801	ipo11	100	83.795	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005635	nuclear envelope	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0006610	ribosomal protein import into nucleus	-	IEA	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function