EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000086758 (Gene tree)
Gene ID: 10075
Gene Symbol: HUWE1
Alias: Ib772|KIAA0312|UREB1
Full Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 154,634 bases
Position: chrX:53,532,096-53,686,729
Accession: 30892
RBP type: non-canonical RBP
Summary: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23241214	Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones.	Clin Epigenetics	2012 Dec 17	Gill-Sharma MK	doi: 10.1186/1868-7083-4-23.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000463852	HUWE1-206	586	-	-	- (aa)	-	-
ENST00000262854	HUWE1-202	14739	XM_011530747	ENSP00000262854	4374 (aa)	XP_011529049	Q7Z6Z7
ENST00000474971	HUWE1-210	598	-	-	- (aa)	-	-
ENST00000474288	HUWE1-209	1254	-	-	- (aa)	-	-
ENST00000218328	HUWE1-201	5488	-	-	- (aa)	-	-
ENST00000426907	HUWE1-204	4805	-	ENSP00000403236	1197 (aa)	-	H0Y659
ENST00000480438	HUWE1-211	564	-	-	- (aa)	-	-
ENST00000342160	HUWE1-203	14796	XM_005261965	ENSP00000340648	4374 (aa)	XP_005262022	Q7Z6Z7
ENST00000468322	HUWE1-207	729	-	ENSP00000483891	191 (aa)	-	A0A087X146
ENST00000446750	HUWE1-205	872	-	ENSP00000413651	92 (aa)	-	A0A1B0GXC7
ENST00000471676	HUWE1-208	501	-	-	- (aa)	-	-
ENST00000612484	HUWE1-214	14311	-	ENSP00000479451	4365 (aa)	-	Q7Z6Z7
ENST00000489876	HUWE1-213	754	-	-	- (aa)	-	-
ENST00000622887	HUWE1-215	688	-	ENSP00000484417	230 (aa)	-	A0A087X1S3
ENST00000488459	HUWE1-212	800	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000086758's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000086758's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000086758	HUWE1	100	98.913	ENSMUSG00000025261	Huwe1	100	98.667	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	21873635.	IBA	Process
GO:0000209	protein polyubiquitination	15989957.	IDA	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0003677	DNA binding	-	ISS	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004842	ubiquitin-protein transferase activity	15989957.19713937.	IDA	Function
GO:0005515	protein binding	15989956.19713937.20023629.20534529.21507240.21522127.25277244.26496610.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	19713937.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006284	base-excision repair	19713937.	IMP	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006513	protein monoubiquitination	19713937.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	21873635.	IBA	Process
GO:0016574	histone ubiquitination	15767685.	IDA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0031398	positive regulation of protein ubiquitination	20534529.	IDA	Process
GO:0032922	circadian regulation of gene expression	20534529.	IMP	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0061630	ubiquitin protein ligase activity	21873635.	IBA	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:1903955	positive regulation of protein targeting to mitochondrion	24270810.	HMP	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15989956	ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.	Cell	2005 Jul 1	Chen D	-
27581931	Tumour suppressive function of HUWE1 in thyroid cancer.	J Biosci	2016 Sep	Ma W	-
25543140	HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.	Cell Rep	2015 Jan 6	Vaughan L	doi: 10.1016/j.celrep.2014.12.012
21730980	Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells.	Br J Cancer	2011 Jul 26	Pervin S	doi: 10.1038/bjc.2011.242
24342616	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.	Biochem Biophys Res Commun	2014 Feb 14	Wang X	doi: 10.1016/j.bbrc.2013.12.053
28687618	Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.	Cancer Res	2017 Sep 15	Yang D	doi: 10.1158/0008-5472.CAN-16-2597

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	53589651	Missense_Mutation	novel	E1453K	0.24
ACC	chrX	53549413	Missense_Mutation	novel	F3194S	0.53
ACC	chrX	53581026	Missense_Mutation	novel	V1841F	0.16
ACC	chrX	53534172	Missense_Mutation	rs782290958	R4286H	0.23
ACC	chrX	53575777	Missense_Mutation	novel	D1966Y	0.18
BLCA	chrX	53594557	Missense_Mutation	novel	P1149S	0.27
BLCA	chrX	53595385	Missense_Mutation	novel	R1061L	0.73
BLCA	chrX	53548173	Missense_Mutation	NA	S3379F	0.56
BLCA	chrX	53534651	Silent	novel	E4232E	0.2
BLCA	chrX	53584303	Missense_Mutation	novel	L1682V	0.11
BLCA	chrX	53576919	Silent	NA	A1955A	0.42
BLCA	chrX	53548177	Nonsense_Mutation	novel	Q3378*	0.48
BLCA	chrX	53625889	Intron	novel		0.89
BLCA	chrX	53647406	Missense_Mutation	novel	E105K	0.09
BLCA	chrX	53593555	Missense_Mutation	novel	E1184Q	0.25
BLCA	chrX	53593539	Nonsense_Mutation	NA	S1189*	0.38
BLCA	chrX	53595280	In_Frame_Del	novel	T1095_P1096del	0.1
BLCA	chrX	53603492	Missense_Mutation	novel	R918C	0.94
BLCA	chrX	53560265	Silent	NA	L2553L	0.29
BLCA	chrX	53551311	Silent	NA	V3017V	0.29
BLCA	chrX	53628589	Frame_Shift_Del	novel	*F382Lfs27**	0.43
BLCA	chrX	53604622	Missense_Mutation	NA	I903M	1
BLCA	chrX	53575669	Missense_Mutation	novel	D2002N	0.26
BLCA	chrX	53575763	Silent	novel	G1970G	0.27
BLCA	chrX	53580908	Missense_Mutation	novel	R1880P	0.33
BLCA	chrX	53537688	Missense_Mutation	novel	R4002L	0.19
BLCA	chrX	53645413	Silent	NA	V134V	0.67
BLCA	chrX	53538943	Frame_Shift_Ins	novel	*T3924Qfs16**	0.12
BLCA	chrX	53588448	Silent	novel	Q1516Q	0.2
BLCA	chrX	53565121	Missense_Mutation	novel	E2276K	0.57
BLCA	chrX	53607579	Missense_Mutation	novel	D814H	0.89
BLCA	chrX	53549119	Missense_Mutation	novel	A3292V	0.08
BLCA	chrX	53547981	Missense_Mutation	novel	I3443T	0.14
BLCA	chrX	53538422	Missense_Mutation	novel	R3971W	0.42
BLCA	chrX	53627840	Missense_Mutation	novel	F428V	0.84
BLCA	chrX	53568758	Missense_Mutation	NA	R2214Q	1
BLCA	chrX	53537630	Silent	novel	V4021V	0.73
BLCA	chrX	53592430	Missense_Mutation	novel	E1314K	0.44
BLCA	chrX	53590465	Missense_Mutation	NA	R1377T	0.91
BLCA	chrX	53604633	Missense_Mutation	novel	H900Y	0.54
BLCA	chrX	53575750	Missense_Mutation	novel	E1975Q	0.35
BLCA	chrX	53550965	Silent	novel	L3107L	0.59
BLCA	chrX	53584185	Splice_Site	novel	X1721_splice	0.44
BRCA	chrX	53543842	Missense_Mutation	NA	T3793M	0.13
BRCA	chrX	53628619	Splice_Region	NA	D372D	0.18
BRCA	chrX	53548031	Silent	rs146554767	L3426L	0.12
BRCA	chrX	53538393	Silent	NA	G3980G	0.15
BRCA	chrX	53546500	Silent	NA	D3617D	0.43
BRCA	chrX	53604783	Missense_Mutation	NA	S850A	0.3
BRCA	chrX	53538922	Frame_Shift_Del	novel	*D3932Tfs35**	0.1
BRCA	chrX	53614552	Frame_Shift_Ins	novel	*E748Gfs33**	0.04
BRCA	chrX	53589723	Missense_Mutation	NA	D1429N	0.38
BRCA	chrX	53617080	Missense_Mutation	NA	R616L	0.19
BRCA	chrX	53561873	Missense_Mutation	NA	E2464K	0.08
BRCA	chrX	53634274	Missense_Mutation	NA	F177I	0.31
BRCA	chrX	53550921	Missense_Mutation	novel	S3122F	0.38
BRCA	chrX	53604591	Missense_Mutation	NA	Q914E	0.15
BRCA	chrX	53549473	Missense_Mutation	NA	R3174H	0.31
BRCA	chrX	53625165	Missense_Mutation	NA	I528T	0.17
BRCA	chrX	53562836	Missense_Mutation	NA	R2400Q	0.24
BRCA	chrX	53533374	Missense_Mutation	NA	E4354Q	0.17
BRCA	chrX	53604687	Missense_Mutation	novel	D882N	0.09
BRCA	chrX	53561813	Missense_Mutation	NA	R2484C	0.33
BRCA	chrX	53543863	Missense_Mutation	NA	R3786Q	0.39
BRCA	chrX	53545072	Missense_Mutation	novel	E3669K	0.08
BRCA	chrX	53534049	Missense_Mutation	NA	R4327Q	0.29
BRCA	chrX	53590437	Missense_Mutation	NA	D1386E	0.18
BRCA	chrX	53549172	Silent	novel	K3274K	0.04
BRCA	chrX	53548179	Nonsense_Mutation	NA	S3377*	0.36
BRCA	chrX	53573891	Silent	novel	Q2057Q	0.04
BRCA	chrX	53534637	Missense_Mutation	NA	R4237H	0.2
BRCA	chrX	53562863	Missense_Mutation	NA	S2391T	0.17
BRCA	chrX	53617122	Missense_Mutation	NA	G602A	0.12
BRCA	chrX	53554714	Missense_Mutation	novel	E2805Q	0.05
BRCA	chrX	53562132	Silent	NA	E2439E	0.17
BRCA	chrX	53554785	Missense_Mutation	NA	G2781E	0.33
BRCA	chrX	53600185	Silent	novel	S1032S	0.06
BRCA	chrX	53604666	Missense_Mutation	novel	A889T	0.3
BRCA	chrX	53551175	Missense_Mutation	NA	Q3037H	0.22
BRCA	chrX	53580839	Nonsense_Mutation	NA	S1903*	0.08
BRCA	chrX	53583681	Missense_Mutation	NA	K1799N	0.26
BRCA	chrX	53615780	Silent	NA	P671P	0.17
BRCA	chrX	53583783	Missense_Mutation	NA	M1765I	0.25
BRCA	chrX	53546706	Missense_Mutation	NA	E3586Q	0.15
BRCA	chrX	53549030	Missense_Mutation	rs782714213	V3322I	0.2
BRCA	chrX	53533333	Silent	NA	C4367C	0.23
BRCA	chrX	53539063	Missense_Mutation	NA	E3884K	0.13
BRCA	chrX	53547727	Missense_Mutation	rs781782992	V3528I	0.12
BRCA	chrX	53550928	Missense_Mutation	NA	A3120T	0.16
BRCA	chrX	53561766	Missense_Mutation	novel	F2499L	0.04
BRCA	chrX	53536565	Missense_Mutation	NA	L4080F	0.29
BRCA	chrX	53589672	Missense_Mutation	novel	G1446R	0.09
BRCA	chrX	53556319	Intron	novel		0.23
BRCA	chrX	53548045	Missense_Mutation	novel	S3422T	0.1
BRCA	chrX	53535491	Missense_Mutation	NA	F4181C	0.23
BRCA	chrX	53549172	Missense_Mutation	novel	K3274N	0.19
BRCA	chrX	53549365	Missense_Mutation	novel	R3210T	0.44
BRCA	chrX	53592490	Missense_Mutation	novel	E1294K	0.08
BRCA	chrX	53562200	Missense_Mutation	NA	Q2417E	0.25
BRCA	chrX	53648268	Missense_Mutation	NA	N30D	0.22
CESC	chrX	53558772	Silent	novel	L2681L	0.22
CESC	chrX	53562882	Missense_Mutation	NA	E2385K	0.13
CESC	chrX	53616996	Missense_Mutation	NA	R644Q	0.31
CESC	chrX	53600184	Frame_Shift_Ins	novel	K1033*	0.44
CESC	chrX	53588519	Missense_Mutation	novel	D1493N	0.34
CESC	chrX	53532915	3'UTR	novel		0.22
CESC	chrX	53549251	Missense_Mutation	novel	S3248N	0.41
CESC	chrX	53648282	Missense_Mutation	NA	K25T	0.48
CESC	chrX	53645407	Missense_Mutation	novel	N136K	0.15
CESC	chrX	53616993	Missense_Mutation	novel	R645M	0.15
CESC	chrX	53533365	Missense_Mutation	NA	R4357C	0.46
CESC	chrX	53561766	Missense_Mutation	NA	F2499L	0.36
CESC	chrX	53562143	Missense_Mutation	NA	E2436K	0.43
CESC	chrX	53628871	Missense_Mutation	NA	T332R	0.52
CESC	chrX	53547757	Frame_Shift_Del	novel	*V3518Lfs11**	0.18
CESC	chrX	53627491	Missense_Mutation	novel	E470Q	0.19
CESC	chrX	53550706	Missense_Mutation	NA	G3150R	0.38
CESC	chrX	53564663	Missense_Mutation	novel	A2314P	0.08
CESC	chrX	53534087	Silent	rs782813587	L4314L	0.26
CESC	chrX	53551304	Missense_Mutation	novel	E3020K	0.33
CESC	chrX	53552370	Missense_Mutation	NA	R2941Q	0.23
CESC	chrX	53617433	Silent	NA	V562V	0.14
CESC	chrX	53631455	Missense_Mutation	novel	E241K	0.4
CESC	chrX	53549164	Missense_Mutation	novel	S3277L	0.11
CESC	chrX	53560344	Missense_Mutation	novel	S2527Y	0.12
CESC	chrX	53568851	Missense_Mutation	novel	I2183S	0.1
CESC	chrX	53603381	Missense_Mutation	novel	C955R	0.4
CESC	chrX	53626023	Intron	novel		0.36
CESC	chrX	53537656	Missense_Mutation	rs121918525	R4013W	0.44
CESC	chrX	53686303	5'UTR	novel		0.23
CESC	chrX	53588456	Missense_Mutation	NA	I1514V	0.27
CESC	chrX	53575686	Missense_Mutation	rs200650762	R1996H	0.1
CESC	chrX	53600310	Splice_Site	novel	X991_splice	0.2
CESC	chrX	53575154	Splice_Site	novel	X2033_splice	0.25
CESC	chrX	53537559	Missense_Mutation	NA	R4045Q	0.38
CESC	chrX	53538446	Missense_Mutation	novel	R3963C	0.05
CESC	chrX	53559405	Missense_Mutation	novel	E2622K	0.18
CESC	chrX	53532850	3'UTR	novel		0.49
CESC	chrX	53562197	Nonsense_Mutation	NA	E2418*	0.49
CESC	chrX	53552844	Silent	novel	V2848V	0.27
CESC	chrX	53533141	3'UTR	novel		0.15
CESC	chrX	53558995	Missense_Mutation	novel	E2661K	0.12
CESC	chrX	53631615	Splice_Site	novel	X216_splice	0.09
CESC	chrX	53552771	Missense_Mutation	NA	D2873N	0.5
CESC	chrX	53580980	Missense_Mutation	novel	G1856A	0.5
CESC	chrX	53552747	Missense_Mutation	novel	E2881K	0.49
CESC	chrX	53564600	Missense_Mutation	NA	E2335Q	0.42
CESC	chrX	53593481	Missense_Mutation	novel	K1208N	0.23
CHOL	chrX	53557261	Intron	novel		0.15
COAD	chrX	53589785	Missense_Mutation	NA	R1408L	0.34
COAD	chrX	53544560	Missense_Mutation	NA	G3751C	0.57
COAD	chrX	53580960	Missense_Mutation	novel	G1863C	0.16
COAD	chrX	53631005	Silent	NA	A264A	0.18
COAD	chrX	53569646	Missense_Mutation	novel	A2165G	0.21
COAD	chrX	53568759	Missense_Mutation	NA	R2214W	0.72
COAD	chrX	53557261	Intron	novel		0.37
COAD	chrX	53576919	Silent	NA	A1955A	0.48
COAD	chrX	53586524	Missense_Mutation	NA	A1597V	0.31
COAD	chrX	53544639	Missense_Mutation	NA	L3724F	0.17
COAD	chrX	53538929	Silent	novel	P3928P	0.11
COAD	chrX	53536152	In_Frame_Del	novel	S4175del	0.04
COAD	chrX	53538365	Missense_Mutation	NA	R3990C	0.07
COAD	chrX	53558747	Nonsense_Mutation	novel	R2690*	0.06
COAD	chrX	53536241	Missense_Mutation	novel	M4146T	0.26
COAD	chrX	53627449	Missense_Mutation	novel	T484A	0.06
COAD	chrX	53585043	Frame_Shift_Ins	novel	*R1657Mfs13**	0.21
COAD	chrX	53560213	Missense_Mutation	NA	P2571S	0.51
COAD	chrX	53538346	Missense_Mutation	NA	V3996A	0.32
COAD	chrX	53546536	Silent	NA	L3605L	0.3
COAD	chrX	53589718	Silent	rs373465190	P1430P	0.37
COAD	chrX	53564654	Missense_Mutation	novel	D2317N	0.72
COAD	chrX	53533250	3'UTR	novel		0.68
COAD	chrX	53536665	Frame_Shift_Ins	novel	*Y4047Ffs3**	0.09
COAD	chrX	53549473	Missense_Mutation	NA	R3174H	0.15
COAD	chrX	53583877	Missense_Mutation	NA	E1734G	0.16
COAD	chrX	53588486	Missense_Mutation	novel	T1504P	0.35
COAD	chrX	53645422	Silent	NA	V131V	0.33
COAD	chrX	53589594	Missense_Mutation	NA	N1472D	0.19
COAD	chrX	53547982	Missense_Mutation	NA	I3443V	0.46
COAD	chrX	53577018	Silent	novel	V1922V	0.06
COAD	chrX	53575172	Missense_Mutation	novel	G2027V	0.37
COAD	chrX	53547979	Missense_Mutation	novel	R3444C	0.42
COAD	chrX	53537629	Missense_Mutation	NA	R4022C	0.75
COAD	chrX	53544606	Silent	NA	D3735D	0.39
COAD	chrX	53559433	Silent	rs782495073	D2612D	0.12
COAD	chrX	53535414	Missense_Mutation	NA	V4207I	0.08
COAD	chrX	53564656	Missense_Mutation	novel	G2316V	0.12
COAD	chrX	53551011	Missense_Mutation	NA	E3092G	0.64
COAD	chrX	53593459	Missense_Mutation	NA	L1216I	0.54
COAD	chrX	53575704	Missense_Mutation	novel	Q1990L	0.04
COAD	chrX	53548209	Missense_Mutation	NA	R3367M	0.13
COAD	chrX	53562129	Silent	NA	E2440E	0.18
COAD	chrX	53584210	Missense_Mutation	NA	K1713E	0.09
COAD	chrX	53543961	Silent	novel	S3753S	0.67
COAD	chrX	53535394	Missense_Mutation	NA	M4213I	0.19
COAD	chrX	53551421	Missense_Mutation	novel	R2981C	0.13
COAD	chrX	53595274	Missense_Mutation	NA	A1098V	0.2
COAD	chrX	53562895	Silent	NA	D2380D	0.32
COAD	chrX	53631451	Missense_Mutation	NA	S242F	0.2
COAD	chrX	53546463	Silent	novel	L3630L	0.41
COAD	chrX	53554712	Silent	novel	E2805E	0.08
COAD	chrX	53617356	Missense_Mutation	novel	A588V	0.19
COAD	chrX	53588475	Silent	novel	T1507T	0.21
COAD	chrX	53583852	Silent	rs185657233	I1742I	0.36
COAD	chrX	53548246	Missense_Mutation	rs782740424	R3355W	0.29
COAD	chrX	53589667	Silent	novel	C1447C	0.06
COAD	chrX	53538987	Missense_Mutation	NA	A3909V	0.58
COAD	chrX	53537629	Missense_Mutation	NA	R4022C	0.39
ESCA	chrX	53549444	Missense_Mutation	NA	E3184K	0.57
ESCA	chrX	53538374	Missense_Mutation	novel	D3987N	0.13
ESCA	chrX	53532750	3'UTR	novel		0.92
ESCA	chrX	53543899	Missense_Mutation	novel	A3774V	0.22
ESCA	chrX	53534064	Missense_Mutation	novel	K4322R	0.08
ESCA	chrX	53608867	Missense_Mutation	novel	D768E	0.37
ESCA	chrX	53625873	Intron	novel		0.77
ESCA	chrX	53548168	Missense_Mutation	novel	S3381G	0.21
ESCA	chrX	53594597	Silent	novel	V1135V	0.59
ESCA	chrX	53551401	Silent	novel	N2987N	0.28
ESCA	chrX	53575162	Missense_Mutation	novel	Q2030H	0.45
ESCA	chrX	53532922	3'UTR	novel		0.55
ESCA	chrX	53546528	Missense_Mutation	novel	L3608R	0.26
ESCA	chrX	53573797	Missense_Mutation	novel	I2089F	0.38
ESCA	chrX	53551010	Missense_Mutation	novel	E3092D	0.68
ESCA	chrX	53560290	Missense_Mutation	rs782597093	R2545H	0.86
ESCA	chrX	53535394	Missense_Mutation	NA	M4213I	0.82
ESCA	chrX	53548206	Missense_Mutation	novel	G3368D	0.53
ESCA	chrX	53631599	Missense_Mutation	novel	L221I	0.33
ESCA	chrX	53626017	Intron	novel		0.85
GBM	chrX	53546470	Silent	NA	A3627A	0.21
GBM	chrX	53565129	Frame_Shift_Del	novel	*N2273Tfs57**	0.12
GBM	chrX	53564607	Frame_Shift_Del	novel	*Q2333Sfs19**	0.42
GBM	chrX	53647479	Silent	novel	V80V	0.13
GBM	chrX	53544730	Missense_Mutation	novel	A3694V	0.17
GBM	chrX	53627787	Silent	novel	A445A	0.12
GBM	chrX	53549383	Missense_Mutation	NA	R3204H	0.35
GBM	chrX	53563770	Missense_Mutation	NA	G2361R	0.15
GBM	chrX	53557422	Frame_Shift_Del	novel	*A2723Hfs79**	0.07
GBM	chrX	53604822	Nonsense_Mutation	novel	E837*	0.13
GBM	chrX	53536202	Missense_Mutation	novel	Y4159F	0.2
GBM	chrX	53534087	Silent	rs782813587	L4314L	0.65
GBM	chrX	53536660	Missense_Mutation	novel	V4049L	0.2
GBM	chrX	53546542	Silent	rs201891783	N3603N	0.26
GBM	chrX	53548213	Nonsense_Mutation	novel	E3366*	0.17
GBM	chrX	53549042	Missense_Mutation	rs144721096	G3318S	0.37
GBM	chrX	53558993	Missense_Mutation	novel	E2661D	0.32
GBM	chrX	53575698	Missense_Mutation	rs199846544	R1992Q	0.29
GBM	chrX	53580933	Missense_Mutation	novel	R1872C	0.3
GBM	chrX	53607690	Missense_Mutation	novel	V777M	0.15
GBM	chrX	53627446	Missense_Mutation	novel	T485A	0.28
GBM	chrX	53630998	Missense_Mutation	novel	F267V	0.57
GBM	chrX	53645364	Missense_Mutation	novel	L151M	0.29
GBM	chrX	53647520	Missense_Mutation	novel	D67Y	0.23
GBM	chrX	53654129	Splice_Region	rs782018361		0.15
GBM	chrX	53535437	Missense_Mutation	novel	T4199I	0.21
GBM	chrX	53617446	Missense_Mutation	novel	A558G	0.22
GBM	chrX	53557421	Missense_Mutation	novel	A2723S	0.15
GBM	chrX	53589752	Missense_Mutation	novel	A1419V	0.24
GBM	chrX	53549205	Missense_Mutation	novel	S3263R	0.13
GBM	chrX	53585050	Nonsense_Mutation	NA	R1655*	0.29
GBM	chrX	53562177	Silent	novel	S2424S	0.33
GBM	chrX	53647548	Silent	novel	L57L	0.19
GBM	chrX	53544606	Silent	NA	D3735D	0.56
HNSC	chrX	53592437	Silent	novel	S1311S	0.25
HNSC	chrX	53533404	Missense_Mutation	novel	Q4344E	0.16
HNSC	chrX	53573755	Nonsense_Mutation	novel	K2103*	0.35
HNSC	chrX	53645366	Missense_Mutation	novel	R150P	0.55
HNSC	chrX	53595388	Missense_Mutation	novel	G1060D	0.67
HNSC	chrX	53575682	Missense_Mutation	novel	Q1997H	0.47
HNSC	chrX	53614689	Silent	novel	P702P	0.61
HNSC	chrX	53551012	Missense_Mutation	novel	E3092K	0.46
HNSC	chrX	53533325	Missense_Mutation	novel	G4370D	0.33
HNSC	chrX	53534029	Missense_Mutation	novel	R4334C	0.57
HNSC	chrX	53591047	Missense_Mutation	novel	E1350K	0.58
HNSC	chrX	53535390	Missense_Mutation	novel	M4215V	0.15
HNSC	chrX	53534023	Missense_Mutation	novel	P4336S	0.37
HNSC	chrX	53561801	Missense_Mutation	novel	E2488Q	0.06
HNSC	chrX	53543909	Missense_Mutation	NA	E3771K	0.39
HNSC	chrX	53565123	Frame_Shift_Del	novel	*K2274Mfs55**	0.54
HNSC	chrX	53536229	Missense_Mutation	novel	D4150V	0.31
HNSC	chrX	53607597	Missense_Mutation	novel	L808F	0.09
HNSC	chrX	53549030	Missense_Mutation	rs782714213	V3322I	0.18
HNSC	chrX	53647553	Missense_Mutation	novel	D56N	0.07
HNSC	chrX	53560403	Frame_Shift_Ins	novel	*S2508Ifs81**	0.64
HNSC	chrX	53544737	Missense_Mutation	novel	I3692L	0.08
HNSC	chrX	53534561	Silent	novel	L4262L	0.29
HNSC	chrX	53554636	Missense_Mutation	novel	I2831V	0.5
HNSC	chrX	53627802	Silent	novel	T440T	0.1
HNSC	chrX	53627436	Missense_Mutation	novel	G488E	0.7
HNSC	chrX	53536233	Missense_Mutation	NA	E4149K	0.32
HNSC	chrX	53534106	Missense_Mutation	novel	L4308R	0.12
HNSC	chrX	53534014	Missense_Mutation	novel	H4339Y	0.39
HNSC	chrX	53544595	Missense_Mutation	rs782183494	R3739Q	0.75
HNSC	chrX	53533347	Missense_Mutation	novel	A4363S	0.57
HNSC	chrX	53562194	Missense_Mutation	novel	E2419K	0.56
HNSC	chrX	53536149	Missense_Mutation	NA	E4177K	0.17
HNSC	chrX	53545075	Missense_Mutation	novel	E3668K	0.42
HNSC	chrX	53550977	Silent	novel	R3103R	0.21
HNSC	chrX	53604697	Silent	novel	G878G	0.35
HNSC	chrX	53586515	Nonsense_Mutation	novel	S1600*	0.15
HNSC	chrX	53631601	Missense_Mutation	novel	T220R	0.22
HNSC	chrX	53543909	Missense_Mutation	NA	E3771K	0.17
HNSC	chrX	53562836	Missense_Mutation	NA	R2400Q	0.17
HNSC	chrX	53591026	Missense_Mutation	NA	P1357S	0.14
HNSC	chrX	53592424	Missense_Mutation	novel	Q1316E	0.25
HNSC	chrX	53536593	Missense_Mutation	novel	R4071Q	0.1
HNSC	chrX	53592451	Missense_Mutation	novel	E1307Q	0.19
HNSC	chrX	53562197	Nonsense_Mutation	NA	E2418*	0.16
HNSC	chrX	53546594	Splice_Site	novel	X3587_splice	0.5
HNSC	chrX	53628819	Frame_Shift_Del	novel	*C349Yfs23**	0.16
HNSC	chrX	53585124	Missense_Mutation	novel	Y1630C	0.64
HNSC	chrX	53561801	Missense_Mutation	novel	E2488K	0.73
HNSC	chrX	53536149	Missense_Mutation	NA	E4177K	0.71
KICH	chrX	53588395	Missense_Mutation	novel	T1534M	0.09
KIRC	chrX	53551375	Missense_Mutation	novel	R2996L	0.07
KIRC	chrX	53600137	Missense_Mutation	novel	Q1048H	0.27
KIRC	chrX	53585145	Missense_Mutation	NA	R1623L	0.47
KIRC	chrX	53647460	Missense_Mutation	NA	E87Q	0.17
KIRC	chrX	53588396	Missense_Mutation	NA	T1534S	0.7
KIRC	chrX	53568774	Missense_Mutation	NA	M2209V	0.28
KIRC	chrX	53559424	Silent	NA	I2615I	0.2
KIRC	chrX	53552687	Missense_Mutation	NA	Q2901K	0.44
KIRP	chrX	53539706	Silent	novel	G3861G	0.49
KIRP	chrX	53562213	Silent	NA	E2412E	0.3
KIRP	chrX	53538844	Missense_Mutation	novel	R3957S	0.57
KIRP	chrX	53557422	Silent	NA	T2722T	0.75
KIRP	chrX	53614645	Missense_Mutation	novel	R717T	0.22
KIRP	chrX	53533110	3'UTR	novel		0.25
KIRP	chrX	53592480	Missense_Mutation	novel	G1297E	0.93
KIRP	chrX	53614598	Missense_Mutation	NA	E733K	0.36
KIRP	chrX	53538924	Missense_Mutation	novel	S3930F	0.87
LAML	chrX	53535433	Silent	novel	E4200E	0.04
LAML	chrX	53562919	Silent	novel	S2372S	0.02
LAML	chrX	53563771	Silent	NA	G2360G	0.05
LAML	chrX	53608872	Missense_Mutation	novel	M767V	0.06
LAML	chrX	53615832	Frame_Shift_Ins	novel	*D654Gfs12**	0.4
LAML	chrX	53628593	Missense_Mutation	novel	Q381R	0.25
LAML	chrX	53547794	Frame_Shift_Ins	novel	*T3506Yfs46**	0.45
LAML	chrX	53565151	Missense_Mutation	novel	S2266G	0.13
LAML	chrX	53537660	Silent	novel	G4011G	0.05
LAML	chrX	53565228	Missense_Mutation	novel	A2240D	0.14
LGG	chrX	53591122	Missense_Mutation	NA	L1325V	0.42
LGG	chrX	53626002	Intron	novel		0.1
LGG	chrX	53552441	Missense_Mutation	novel	S2917R	0.22
LGG	chrX	53557241	Intron	novel		0.16
LGG	chrX	53534519	Missense_Mutation	novel	I4276M	0.26
LGG	chrX	53585114	Silent	novel	S1633S	0.44
LGG	chrX	53614581	Missense_Mutation	novel	M738I	0.39
LGG	chrX	53627862	Silent	rs782704612	G420G	0.46
LGG	chrX	53625901	Intron	novel		0.47
LGG	chrX	53617080	Missense_Mutation	NA	R616L	0.27
LGG	chrX	53549184	Missense_Mutation	rs782099367	D3270E	0.17
LGG	chrX	53586549	Silent	novel	L1589L	0.09
LIHC	chrX	53547748	Missense_Mutation	novel	T3521A	0.18
LIHC	chrX	53536200	Missense_Mutation	NA	L4160V	0.22
LIHC	chrX	53628761	Missense_Mutation	NA	A369T	0.32
LIHC	chrX	53551136	Silent	novel	A3050A	0.06
LIHC	chrX	53534538	Missense_Mutation	novel	K4270M	0.69
LIHC	chrX	53592483	Missense_Mutation	novel	E1296V	0.19
LIHC	chrX	53564688	Silent	novel	D2305D	0.3
LIHC	chrX	53645311	Splice_Region	novel	E168E	0.78
LIHC	chrX	53576912	Missense_Mutation	novel	A1958T	0.83
LIHC	chrX	53552441	Missense_Mutation	novel	S2917R	0.21
LIHC	chrX	53590417	Missense_Mutation	novel	A1393V	0.85
LIHC	chrX	53552766	Silent	novel	T2874T	0.05
LIHC	chrX	53556227	Intron	novel		0.07
LIHC	chrX	53645429	Missense_Mutation	NA	Q129L	0.06
LUAD	chrX	53552742	Missense_Mutation	NA	Q2882H	0.36
LUAD	chrX	53544723	Missense_Mutation	novel	Q3696H	0.64
LUAD	chrX	53544749	Nonsense_Mutation	NA	E3688*	0.29
LUAD	chrX	53552680	Missense_Mutation	novel	R2903K	0.19
LUAD	chrX	53551409	Silent	novel	L2985L	0.34
LUAD	chrX	53547763	Missense_Mutation	novel	A3516S	0.4
LUAD	chrX	53617122	Missense_Mutation	novel	G602V	0.31
LUAD	chrX	53625163	Nonsense_Mutation	novel	R529*	0.16
LUAD	chrX	53614604	Missense_Mutation	novel	E731K	0.08
LUAD	chrX	53630963	Silent	novel	Q278Q	0.15
LUAD	chrX	53539665	Missense_Mutation	NA	A3875V	0.06
LUAD	chrX	53536374	Splice_Site	novel	X4142_splice	0.2
LUAD	chrX	53648228	Missense_Mutation	NA	T43I	0.54
LUAD	chrX	53625980	Intron	novel		0.4
LUAD	chrX	53614616	Missense_Mutation	NA	S727C	0.49
LUAD	chrX	53544601	Missense_Mutation	novel	T3737K	0.14
LUAD	chrX	53615759	Silent	NA	T678T	0.7
LUAD	chrX	53616979	Missense_Mutation	NA	D650N	0.53
LUAD	chrX	53607647	Missense_Mutation	NA	Q791L	0.24
LUAD	chrX	53583564	Missense_Mutation	novel	M1838I	0.52
LUAD	chrX	53580946	Silent	novel	I1867I	0.13
LUAD	chrX	53569739	Missense_Mutation	novel	L2134Q	0.07
LUAD	chrX	53614547	Missense_Mutation	novel	E750Q	0.21
LUAD	chrX	53589660	Missense_Mutation	rs782159467	L1450I	0.08
LUAD	chrX	53607637	Silent	novel	V794V	0.06
LUAD	chrX	53547932	Silent	novel	L3459L	0.32
LUAD	chrX	53583780	Silent	novel	L1766L	0.26
LUAD	chrX	53544710	Missense_Mutation	novel	G3701C	0.07
LUAD	chrX	53548956	Splice_Region	novel		0.36
LUAD	chrX	53565167	Silent	novel	P2260P	0.19
LUAD	chrX	53647453	Missense_Mutation	NA	L89Q	0.19
LUAD	chrX	53559366	Missense_Mutation	novel	T2635S	0.32
LUAD	chrX	53551432	Missense_Mutation	NA	P2977H	0.17
LUAD	chrX	53558746	Missense_Mutation	NA	R2690L	0.34
LUAD	chrX	53615818	Missense_Mutation	novel	L659V	0.14
LUAD	chrX	53538985	Frame_Shift_Del	novel	*H3910Tfs14**	0.52
LUAD	chrX	53533362	Frame_Shift_Del	novel	*H4358Tfs105**	0.15
LUAD	chrX	53591028	Missense_Mutation	NA	P1356H	0.19
LUAD	chrX	53645390	Missense_Mutation	NA	S142T	0.11
LUAD	chrX	53634265	Missense_Mutation	novel	A180T	0.17
LUAD	chrX	53580838	Silent	NA	S1903S	0.2
LUAD	chrX	53552781	Silent	novel	E2869E	0.16
LUAD	chrX	53628861	Silent	novel	V335V	0.22
LUAD	chrX	53583569	Missense_Mutation	NA	T1837A	0.06
LUAD	chrX	53548002	Missense_Mutation	novel	N3436I	0.56
LUAD	chrX	53625858	Intron	novel		0.63
LUAD	chrX	53550955	Missense_Mutation	NA	R3111G	0.08
LUAD	chrX	53546778	Missense_Mutation	rs782795348	G3562W	0.41
LUAD	chrX	53569827	Missense_Mutation	novel	D2105N	0.26
LUAD	chrX	53564666	Missense_Mutation	NA	V2313L	0.18
LUAD	chrX	53536212	Missense_Mutation	NA	G4156C	0.9
LUAD	chrX	53554911	Missense_Mutation	novel	P2739L	0.32
LUAD	chrX	53602586	Silent	novel	T983T	0.25
LUAD	chrX	53536495	Missense_Mutation	novel	L4104V	0.35
LUAD	chrX	53585101	Missense_Mutation	NA	I1638V	0.19
LUAD	chrX	53589785	Missense_Mutation	NA	R1408L	0.32
LUAD	chrX	53625942	Intron	novel		0.2
LUAD	chrX	53534014	Missense_Mutation	novel	H4339N	0.3
LUAD	chrX	53617410	Missense_Mutation	novel	P570L	0.44
LUAD	chrX	53539668	Missense_Mutation	novel	H3874L	0.53
LUAD	chrX	53551077	Missense_Mutation	NA	R3070L	0.24
LUAD	chrX	53551340	Missense_Mutation	NA	V3008L	0.31
LUAD	chrX	53584319	Silent	NA	R1676R	0.25
LUAD	chrX	53627479	Frame_Shift_Ins	novel	*V474Cfs21**	0.25
LUSC	chrX	53591101	Missense_Mutation	novel	R1332W	0.29
LUSC	chrX	53591102	Silent	novel	T1331T	0.27
LUSC	chrX	53554873	Missense_Mutation	novel	D2752H	0.18
LUSC	chrX	53548169	Silent	novel	S3380S	0.14
LUSC	chrX	53604717	Missense_Mutation	novel	R872G	0.13
LUSC	chrX	53632495	Missense_Mutation	NA	E213K	0.7
LUSC	chrX	53583792	Silent	rs782727155	C1762C	0.76
LUSC	chrX	53634235	Splice_Site	novel	X189_splice	0.2
LUSC	chrX	53549046	Silent	novel	A3316A	0.57
LUSC	chrX	53543866	Missense_Mutation	NA	A3785V	0.24
LUSC	chrX	53549478	Silent	novel	L3172L	0.51
LUSC	chrX	53536535	Silent	NA	T4090T	0.48
LUSC	chrX	53554648	Missense_Mutation	novel	P2827T	0.06
LUSC	chrX	53614722	Frame_Shift_Ins	novel	*G692Pfs88**	0.18
LUSC	chrX	53551117	Missense_Mutation	NA	D3057Y	0.51
LUSC	chrX	53562920	Missense_Mutation	novel	S2372N	0.12
LUSC	chrX	53634287	Silent	NA	G172G	0.5
LUSC	chrX	53647372	Missense_Mutation	novel	I116T	0.42
LUSC	chrX	53536630	Missense_Mutation	novel	G4059S	0.29
LUSC	chrX	53589796	Silent	novel	E1404E	0.26
LUSC	chrX	53584244	Missense_Mutation	NA	E1701D	0.11
LUSC	chrX	53600178	Nonsense_Mutation	novel	K1035*	0.32
LUSC	chrX	53614612	Missense_Mutation	novel	E728G	0.15
LUSC	chrX	53546747	Missense_Mutation	NA	V3572E	0.19
LUSC	chrX	53569711	Silent	NA	G2143G	0.2
LUSC	chrX	53647574	Missense_Mutation	NA	C49R	0.46
LUSC	chrX	53589625	Silent	NA	V1461V	0.1
LUSC	chrX	53573902	Nonsense_Mutation	novel	E2054*	0.34
LUSC	chrX	53607687	Missense_Mutation	NA	E778K	0.31
LUSC	chrX	53615803	Missense_Mutation	NA	D664N	0.38
LUSC	chrX	53533306	Missense_Mutation	novel		0.28
LUSC	chrX	53547862	Missense_Mutation	NA	T3483A	0.93
LUSC	chrX	53551067	Silent	novel	V3073V	0.06
LUSC	chrX	53547714	Missense_Mutation	NA	T3532N	0.14
LUSC	chrX	53552404	Missense_Mutation	novel	D2930N	0.13
LUSC	chrX	53607613	Missense_Mutation	novel	L802F	0.42
LUSC	chrX	53631456	Missense_Mutation	novel	M240I	0.32
LUSC	chrX	53537662	Missense_Mutation	NA	G4011W	0.34
LUSC	chrX	53562839	Frame_Shift_Del	novel	*N2399Tfs6**	0.22
LUSC	chrX	53590430	Missense_Mutation	rs782093160	M1389V	0.5
LUSC	chrX	53583831	Silent	NA	G1749G	0.21
LUSC	chrX	53547727	Missense_Mutation	NA	V3528L	0.21
LUSC	chrX	53547728	Silent	rs369048914	V3527V	0.22
LUSC	chrX	53557411	Nonsense_Mutation	NA	S2726*	0.1
LUSC	chrX	53534657	Silent	novel	F4230F	0.76
LUSC	chrX	53563782	Missense_Mutation	novel	E2357Q	0.29
LUSC	chrX	53539003	Missense_Mutation	novel	R3904S	0.3
LUSC	chrX	53569756	Silent	novel	T2128T	0.15
LUSC	chrX	53585105	Missense_Mutation	novel	S1636R	0.18
LUSC	chrX	53536425	Missense_Mutation	novel	Y4127S	0.26
LUSC	chrX	53536426	Missense_Mutation	novel	Y4127N	0.26
LUSC	chrX	53547714	Missense_Mutation	NA	T3532N	0.28
LUSC	chrX	53554642	Missense_Mutation	NA	P2829A	0.95
LUSC	chrX	53585065	Nonsense_Mutation	novel	R1650*	0.05
LUSC	chrX	53595281	Missense_Mutation	novel	P1096S	0.2
LUSC	chrX	53603382	Silent	novel	L954L	0.15
LUSC	chrX	53537661	Missense_Mutation	novel	G4011V	0.16
LUSC	chrX	53573892	Missense_Mutation	novel	Q2057P	0.24
MESO	chrX	53625864	Intron	novel		0.23
OV	chrX	53546536	Silent	NA	L3605L	0.08
OV	chrX	53593571	Silent	novel	G1178G	0.08
OV	chrX	53551166	Missense_Mutation	NA	E3040D	0.5
OV	chrX	53645424	Missense_Mutation	NA	V131L	0.43
OV	chrX	53586901	Missense_Mutation	novel	K1541N	0.21
OV	chrX	53595230	Silent	NA	L1113L	0.15
OV	chrX	53592451	Missense_Mutation	novel	E1307Q	0.25
OV	chrX	53551269	In_Frame_Ins	novel	E3031_E3032insARVQR	0.06
OV	chrX	53549307	Missense_Mutation	novel	I3229M	0.04
OV	chrX	53544595	Missense_Mutation	novel	R3739L	0.48
OV	chrX	53551190	Splice_Site	NA	X3033_splice	0.47
OV	chrX	53549303	Missense_Mutation	NA	Q3231K	0.76
OV	chrX	53617065	Missense_Mutation	novel	F621S	0.91
OV	chrX	53557268	Intron	novel		0.07
OV	chrX	53568848	Missense_Mutation	rs781884032	S2184N	0.24
OV	chrX	53536488	Missense_Mutation	NA	Y4106F	0.83
OV	chrX	53580839	Nonsense_Mutation	NA	S1903*	0.47
OV	chrX	53564574	Missense_Mutation	NA	Q2343H	0.14
OV	chrX	53549025	Silent	novel	H3323H	0.15
OV	chrX	53647372	Frame_Shift_Del	novel	*I116Kfs4**	0.11
OV	chrX	53634297	Missense_Mutation	novel	S169N	0.07
OV	chrX	53632529	Missense_Mutation	novel	E201D	0.1
OV	chrX	53544691	Missense_Mutation	NA	L3707Q	0.4
OV	chrX	53634280	Missense_Mutation	novel	N175D	0.09
OV	chrX	53550950	Silent	rs781848463	L3112L	0.15
OV	chrX	53647523	Missense_Mutation	novel	A66T	0.2
OV	chrX	53593371	Missense_Mutation	novel	T1245N	0.08
OV	chrX	53585095	Missense_Mutation	NA	S1640T	0.24
OV	chrX	53544718	Missense_Mutation	novel	R3698Q	0.04
PAAD	chrX	53548083	Missense_Mutation	novel	K3409M	0.28
PAAD	chrX	53552641	Missense_Mutation	novel	D2916G	0.25
PAAD	chrX	53647542	Silent	novel	D59D	0.23
PCPG	chrX	53575686	Missense_Mutation	novel	R1996L	0.41
PCPG	chrX	53561857	Missense_Mutation	novel	E2469G	0.16
PCPG	chrX	53543882	Missense_Mutation	NA	R3780C	0.45
PRAD	chrX	53559417	Missense_Mutation	novel	R2618G	0.74
PRAD	chrX	53562895	Silent	NA	D2380D	0.08
PRAD	chrX	53591089	Missense_Mutation	rs782123207	M1336V	0.22
PRAD	chrX	53536440	Missense_Mutation	NA	R4122H	0.22
PRAD	chrX	53534040	Missense_Mutation	novel	R4330M	0.82
PRAD	chrX	53593427	Silent	novel	L1226L	0.94
READ	chrX	53538445	Missense_Mutation	NA	R3963H	0.09
READ	chrX	53550756	Missense_Mutation	rs782521336	R3133H	0.84
READ	chrX	53560219	Missense_Mutation	NA	R2569C	0.67
READ	chrX	53569665	Missense_Mutation	novel	A2159T	0.25
READ	chrX	53583719	Missense_Mutation	rs782600084	R1787W	0.27
READ	chrX	53617127	Silent	novel	V600V	0.12
READ	chrX	53627867	Missense_Mutation	novel	L419I	0.08
READ	chrX	53589587	Missense_Mutation	NA	A1474G	0.48
READ	chrX	53534049	Missense_Mutation	NA	R4327Q	0.76
READ	chrX	53547956	Missense_Mutation	novel	E3451D	0.77
READ	chrX	53565065	Splice_Site	novel	X2294_splice	0.27
SARC	chrX	53604705	Missense_Mutation	novel	C876R	0.47
SARC	chrX	53593600	Missense_Mutation	novel	T1169A	0.32
SARC	chrX	53600188	Silent	novel	D1031D	0.07
SARC	chrX	53632558	Splice_Site	novel	X190_splice	0.28
SARC	chrX	53534157	Missense_Mutation	novel	A4291D	0.07
SARC	chrX	53546774	Missense_Mutation	novel	G3563A	0.25
SARC	chrX	53546593	Splice_Site	novel	X3587_splice	0.13
SKCM	chrX	53534083	Missense_Mutation	novel	G4316C	0.1
SKCM	chrX	53589579	Missense_Mutation	NA	R1477C	0.58
SKCM	chrX	53538988	Missense_Mutation	novel	A3909T	0.31
SKCM	chrX	53551158	Missense_Mutation	rs149673252	R3043Q	0.22
SKCM	chrX	53534029	Missense_Mutation	novel	R4334C	0.35
SKCM	chrX	53545127	Silent	rs151180939	L3650L	0.54
SKCM	chrX	53615832	Missense_Mutation	NA	D654A	0.83
SKCM	chrX	53551370	Missense_Mutation	novel	A2998T	0.83
SKCM	chrX	53583910	Missense_Mutation	NA	P1723L	0.6
SKCM	chrX	53586827	Missense_Mutation	NA	P1566L	0.29
SKCM	chrX	53590496	Missense_Mutation	NA	L1367F	0.16
SKCM	chrX	53603482	Missense_Mutation	NA	S921F	0.67
SKCM	chrX	53558733	Silent	NA	R2694R	0.08
SKCM	chrX	53615833	Missense_Mutation	NA	D654N	0.23
SKCM	chrX	53627465	Silent	NA	K478K	0.34
SKCM	chrX	53573765	Silent	NA	S2099S	0.3
SKCM	chrX	53585049	Missense_Mutation	rs782782151	R1655Q	0.44
SKCM	chrX	53607635	Missense_Mutation	novel	N795I	0.1
SKCM	chrX	53647375	Missense_Mutation	NA	S115F	0.56
SKCM	chrX	53546753	Missense_Mutation	NA	K3570R	0.63
SKCM	chrX	53584342	Missense_Mutation	NA	N1669D	0.67
SKCM	chrX	53547734	Silent	NA	T3525T	0.67
SKCM	chrX	53554797	Missense_Mutation	NA	P2777L	0.59
SKCM	chrX	53631000	Missense_Mutation	NA	G266D	0.7
SKCM	chrX	53568758	Missense_Mutation	NA	R2214Q	0.09
SKCM	chrX	53573961	Missense_Mutation	NA	S2034L	0.6
SKCM	chrX	53594528	Silent	NA	L1158L	0.16
SKCM	chrX	53538995	Silent	NA	S3906S	0.7
SKCM	chrX	53554658	Missense_Mutation	NA	M2823I	0.15
SKCM	chrX	53554710	Missense_Mutation	novel	P2806L	0.4
SKCM	chrX	53549078	Frame_Shift_Ins	novel	*S3306Afs6**	0.29
SKCM	chrX	53616973	Missense_Mutation	NA	L652F	0.3
SKCM	chrX	53627474	Silent	NA	I475I	0.18
SKCM	chrX	53590433	Missense_Mutation	NA	P1388S	0.28
SKCM	chrX	53549352	Silent	novel	Y3214Y	0.58
SKCM	chrX	53550672	Missense_Mutation	NA	H3161R	0.52
SKCM	chrX	53539807	Missense_Mutation	NA	D3828Y	0.77
SKCM	chrX	53627485	Missense_Mutation	NA	P472S	0.34
SKCM	chrX	53539767	Missense_Mutation	NA	P3841L	0.49
SKCM	chrX	53546451	Missense_Mutation	NA	L3634F	0.77
SKCM	chrX	53592463	Missense_Mutation	rs782804715	D1303N	0.27
SKCM	chrX	53539723	Silent	novel	L3856L	0.25
SKCM	chrX	53647553	Missense_Mutation	novel	D56N	0.4
SKCM	chrX	53546819	Missense_Mutation	novel	P3548L	0.14
SKCM	chrX	53593511	Silent	NA	F1198F	0.93
SKCM	chrX	53549077	Missense_Mutation	novel	S3306L	0.34
SKCM	chrX	53549201	Missense_Mutation	NA	E3265K	0.34
SKCM	chrX	53565217	Missense_Mutation	NA	N2244D	0.39
SKCM	chrX	53581016	Missense_Mutation	NA	S1844L	0.63
SKCM	chrX	53604738	Missense_Mutation	NA	P865S	0.54
SKCM	chrX	53537593	Silent	NA	L4034L	0.16
SKCM	chrX	53595196	Missense_Mutation	NA	P1124L	0.93
SKCM	chrX	53614628	Missense_Mutation	novel	E723K	0.43
SKCM	chrX	53536579	Missense_Mutation	NA	P4076S	0.87
SKCM	chrX	53549310	Silent	NA	S3228S	0.53
SKCM	chrX	53645369	Missense_Mutation	novel	T149I	0.77
SKCM	chrX	53549177	Missense_Mutation	novel	H3273Y	0.51
SKCM	chrX	53549178	Silent	novel	L3272L	0.5
SKCM	chrX	53568763	Silent	novel	I2212I	1
SKCM	chrX	53548269	Missense_Mutation	NA	F3347Y	0.29
SKCM	chrX	53536598	Silent	NA	I4069I	0.37
SKCM	chrX	53560388	Silent	novel	I2512I	0.61
STAD	chrX	53586808	Missense_Mutation	novel	K1572N	0.57
STAD	chrX	53647390	Missense_Mutation	NA	R110Q	0.22
STAD	chrX	53600253	Missense_Mutation	novel	E1010Q	0.09
STAD	chrX	53631003	Missense_Mutation	NA	H265R	0.38
STAD	chrX	53559455	Missense_Mutation	rs142176360	R2605H	0.45
STAD	chrX	53559461	Missense_Mutation	rs146149373	R2603Q	0.13
STAD	chrX	53563770	Missense_Mutation	NA	G2361R	0.3
STAD	chrX	53628824	Missense_Mutation	NA	D348N	0.4
STAD	chrX	53647543	Missense_Mutation	novel	D59G	0.15
STAD	chrX	53604706	Silent	NA	A875A	0.29
STAD	chrX	53595332	Missense_Mutation	NA	V1079F	0.1
STAD	chrX	53548067	Silent	rs782459089	S3414S	0.41
STAD	chrX	53628835	Missense_Mutation	NA	S344I	0.1
STAD	chrX	53537559	Missense_Mutation	NA	R4045Q	0.71
STAD	chrX	53560352	Silent	NA	D2524D	0.18
STAD	chrX	53562141	Silent	NA	E2436E	0.41
STAD	chrX	53547729	Missense_Mutation	NA	V3527A	0.67
STAD	chrX	53586528	Missense_Mutation	NA	T1596A	0.79
STAD	chrX	53534689	Missense_Mutation	rs782063282	R4220C	0.93
STAD	chrX	53580944	Missense_Mutation	NA	N1868S	0.13
STAD	chrX	53539044	Missense_Mutation	NA	H3890R	0.33
STAD	chrX	53573875	Missense_Mutation	NA	K2063E	0.21
STAD	chrX	53546523	Missense_Mutation	NA	R3610W	0.44
STAD	chrX	53543863	Missense_Mutation	NA	R3786Q	0.37
STAD	chrX	53588385	Frame_Shift_Del	rs35102400	*F1537Lfs4**	0.21
STAD	chrX	53549300	Missense_Mutation	NA	R3232C	0.11
STAD	chrX	53534171	Silent	novel	R4286R	0.18
STAD	chrX	53552808	Silent	NA	S2860S	0.35
STAD	chrX	53602618	Missense_Mutation	novel	K973E	0.63
STAD	chrX	53583623	Silent	NA	L1819L	0.63
STAD	chrX	53625990	Intron	novel		0.43
STAD	chrX	53634219	Splice_Site	novel	X189_splice	0.24
STAD	chrX	53549069	Frame_Shift_Ins	novel	*R3309Afs2**	0.28
STAD	chrX	53544598	Missense_Mutation	rs782484577	R3738H	0.24
STAD	chrX	53551364	Frame_Shift_Ins	novel	*S3000Lfs4**	0.26
STAD	chrX	53559377	Missense_Mutation	NA	Q2631R	0.36
STAD	chrX	53533276	3'UTR	rs782289677		0.43
STAD	chrX	53547807	Missense_Mutation	rs782741075	T3501M	0.3
STAD	chrX	53554690	Silent	NA	R2813R	0.38
STAD	chrX	53561890	Missense_Mutation	NA	D2458G	0.44
STAD	chrX	53625194	Silent	NA	A518A	0.08
STAD	chrX	53548216	Missense_Mutation	NA	R3365W	0.12
STAD	chrX	53539026	Missense_Mutation	novel	S3896N	0.3
STAD	chrX	53603453	Silent	rs144396302	L931L	0.31
STAD	chrX	53604814	Missense_Mutation	NA	K839N	0.1
STAD	chrX	53548119	Missense_Mutation	NA	N3397S	0.27
STAD	chrX	53549069	Missense_Mutation	NA	R3309C	0.56
STAD	chrX	53536560	Missense_Mutation	rs797045618	R4082H	0.3
STAD	chrX	53563818	Missense_Mutation	NA	E2345K	0.36
STAD	chrX	53535473	Missense_Mutation	NA	R4187H	0.21
STAD	chrX	53548035	Missense_Mutation	NA	S3425N	0.15
STAD	chrX	53542517	Missense_Mutation	NA	A3801V	0.24
STAD	chrX	53614585	Missense_Mutation	NA	A737V	0.4
TGCT	chrX	53552400	Missense_Mutation	novel	S2931Y	0.38
TGCT	chrX	53559023	Nonsense_Mutation	novel	W2651*	0.4
THCA	chrX	53547809	Frame_Shift_Ins	novel	*T3501Hfs32**	0.15
THCA	chrX	53627496	Missense_Mutation	rs782606768	R468Q	0.36
THCA	chrX	53548088	Silent	rs781788404	S3407S	0.3
THCA	chrX	53546773	Silent	novel	G3563G	0.07
THCA	chrX	53608890	Missense_Mutation	novel	R761C	0.31
THCA	chrX	53547805	Frame_Shift_Ins	novel	*P3502Yfs52**	0.15
THCA	chrX	53547806	Frame_Shift_Ins	novel	*P3502Afs50**	0.15
THYM	chrX	53559521	Missense_Mutation	novel	P2583H	0.09
THYM	chrX	53575184	Missense_Mutation	novel	T2023S	0.07
THYM	chrX	53583748	Missense_Mutation	novel	A1777D	0.34
UCEC	chrX	53559468	Missense_Mutation	novel	R2601W	0.16
UCEC	chrX	53645375	Missense_Mutation	novel	Y147C	0.45
UCEC	chrX	53645367	Missense_Mutation	novel	R150C	0.45
UCEC	chrX	53538844	Missense_Mutation	NA	R3957C	0.34
UCEC	chrX	53547695	Silent	rs138042974	T3538T	0.36
UCEC	chrX	53559004	Missense_Mutation	NA	L2658I	0.28
UCEC	chrX	53584222	Nonsense_Mutation	NA	E1709*	0.31
UCEC	chrX	53588386	Missense_Mutation	NA	F1537C	0.31
UCEC	chrX	53588500	Missense_Mutation	NA	A1499D	0.3
UCEC	chrX	53591116	Missense_Mutation	NA	D1327Y	0.28
UCEC	chrX	53647464	Missense_Mutation	NA	E85D	0.27
UCEC	chrX	53534570	Silent	rs782410644	I4259I	0.3
UCEC	chrX	53538340	Missense_Mutation	NA	R3998H	0.24
UCEC	chrX	53544716	Missense_Mutation	rs782725895	P3699S	0.28
UCEC	chrX	53559004	Missense_Mutation	NA	L2658F	0.3
UCEC	chrX	53568776	Missense_Mutation	NA	G2208D	0.28
UCEC	chrX	53583739	Missense_Mutation	NA	R1780H	0.36
UCEC	chrX	53589705	Nonsense_Mutation	NA	E1435*	0.2
UCEC	chrX	53625191	Silent	NA	I519I	0.29
UCEC	chrX	53532850	3'UTR	novel		0.24
UCEC	chrX	53534087	Silent	rs782813587	L4314L	0.38
UCEC	chrX	53536564	Missense_Mutation	novel	F4081L	0.33
UCEC	chrX	53539048	Missense_Mutation	novel	V3889I	0.2
UCEC	chrX	53551078	Missense_Mutation	NA	R3070C	0.12
UCEC	chrX	53557267	Intron	novel		0.12
UCEC	chrX	53600293	Silent	novel	G996G	0.14
UCEC	chrX	53604703	Silent	rs781888845	C876C	0.41
UCEC	chrX	53627862	Silent	rs782704612	G420G	0.16
UCEC	chrX	53532922	3'UTR	novel		0.41
UCEC	chrX	53583904	Missense_Mutation	novel	A1725V	0.42
UCEC	chrX	53535474	Missense_Mutation	rs121918527	R4187C	0.1
UCEC	chrX	53536555	Missense_Mutation	NA	S4084P	0.41
UCEC	chrX	53539778	Missense_Mutation	NA	K3837N	0.38
UCEC	chrX	53548216	Missense_Mutation	NA	R3365W	0.41
UCEC	chrX	53580836	Missense_Mutation	NA	G1904E	0.3
UCEC	chrX	53583821	Missense_Mutation	NA	D1753Y	0.33
UCEC	chrX	53586890	Missense_Mutation	NA	A1545V	0.32
UCEC	chrX	53588406	Silent	NA	I1530I	0.34
UCEC	chrX	53539712	Missense_Mutation	novel	M3859I	0.33
UCEC	chrX	53542476	Missense_Mutation	novel	P3815S	0.35
UCEC	chrX	53617094	Silent	novel	L611L	0.43
UCEC	chrX	53631022	Missense_Mutation	novel	T259A	0.23
UCEC	chrX	53632526	Missense_Mutation	novel	F202L	0.52
UCEC	chrX	53647406	Missense_Mutation	novel	E105Q	0.21
UCEC	chrX	53558780	Missense_Mutation	novel	E2679Q	0.05
UCEC	chrX	53543871	Missense_Mutation	novel	Q3783H	0.32
UCEC	chrX	53533239	3'UTR	novel		0.51
UCEC	chrX	53552381	Silent	novel	G2937G	0.29
UCEC	chrX	53625909	Intron	novel		0.51
UCEC	chrX	53615817	Missense_Mutation	novel	L659P	0.11
UCEC	chrX	53536235	Missense_Mutation	NA	S4148I	0.42
UCEC	chrX	53588406	Silent	NA	I1530I	0.04
UCEC	chrX	53627502	Missense_Mutation	NA	L466S	0.47
UCEC	chrX	53558706	Missense_Mutation	NA	K2703N	0.42
UCEC	chrX	53536640	Silent	novel	G4055G	0.43
UCEC	chrX	53547837	Missense_Mutation	novel	S3491Y	0.34
UCEC	chrX	53560291	Missense_Mutation	novel	R2545C	0.39
UCEC	chrX	53575646	Silent	novel	I2009I	0.4
UCEC	chrX	53627823	Silent	novel	V433V	0.32
UCEC	chrX	53538945	Missense_Mutation	NA	L3923S	0.37
UCEC	chrX	53538356	Missense_Mutation	novel	D3993N	0.44
UCEC	chrX	53550669	Missense_Mutation	novel	N3162S	0.27
UCEC	chrX	53534638	Missense_Mutation	NA	R4237C	0.52
UCEC	chrX	53547716	Silent	rs374253424	S3531S	0.33
UCEC	chrX	53617042	Missense_Mutation	rs797045620	R629C	0.39
UCEC	chrX	53533214	3'UTR	novel		0.13
UCEC	chrX	53546578	Missense_Mutation	novel	H3591Q	0.36
UCEC	chrX	53552412	Missense_Mutation	novel	S2927F	0.33
UCEC	chrX	53557388	Missense_Mutation	novel	L2734I	0.32
UCEC	chrX	53562878	Missense_Mutation	novel	A2386D	0.4
UCEC	chrX	53575752	Missense_Mutation	rs781977690	Q1974R	0.26
UCEC	chrX	53617037	Silent	novel	L630L	0.22
UCEC	chrX	53533156	3'UTR	novel		0.43
UCEC	chrX	53539793	Missense_Mutation	novel	Q3832H	0.43
UCEC	chrX	53546505	Missense_Mutation	novel	R3616W	0.46
UCEC	chrX	53548119	Missense_Mutation	NA	N3397S	0.37
UCEC	chrX	53569756	Silent	novel	T2128T	0.53
UCEC	chrX	53593426	Missense_Mutation	novel	P1227T	0.47
UCEC	chrX	53602627	Missense_Mutation	novel	D970Y	0.43
UCEC	chrX	53625788	Intron	novel		0.31
UCEC	chrX	53576946	Silent	rs782228341	I1946I	0.19
UCEC	chrX	53568765	Missense_Mutation	NA	I2212V	0.48
UCEC	chrX	53583917	Splice_Site	novel	X1721_splice	0.37
UCEC	chrX	53533346	Missense_Mutation	NA	A4363V	0.27
UCEC	chrX	53542537	Splice_Region	NA	S3794S	0.23
UCEC	chrX	53547720	Missense_Mutation	novel	A3530V	0.04
UCEC	chrX	53556326	Intron	novel		0.04
UCEC	chrX	53617126	Missense_Mutation	NA	L601I	0.24
UCEC	chrX	53628510	Missense_Mutation	novel	M409V	0.07
UCEC	chrX	53550954	Missense_Mutation	NA	R3111H	0.34
UCEC	chrX	53564680	Missense_Mutation	NA	V2308A	0.13
UCEC	chrX	53583842	Missense_Mutation	novel	L1746M	0.07
UCEC	chrX	53593421	Silent	novel	G1228G	0.08
UCEC	chrX	53603447	Missense_Mutation	NA	V933I	0.18
UCEC	chrX	53645422	Silent	NA	V131V	0.06
UCEC	chrX	53559013	Missense_Mutation	novel	C2655R	0.29
UCEC	chrX	53594590	Missense_Mutation	novel	T1138A	0.32
UCEC	chrX	53546490	Missense_Mutation	NA	K3621E	0.4
UCEC	chrX	53593451	Silent	NA	S1218S	0.3
UCEC	chrX	53602565	Splice_Region	NA	S990S	0.35
UCEC	chrX	53547771	Missense_Mutation	NA	S3513F	0.22
UCEC	chrX	53549360	Missense_Mutation	NA	L3212I	0.36
UCEC	chrX	53549445	Silent	rs200290782	H3183H	0.29
UCEC	chrX	53552863	Missense_Mutation	NA	S2842Y	0.13
UCEC	chrX	53554850	Missense_Mutation	NA	K2759N	0.26
UCEC	chrX	53564720	Missense_Mutation	NA	E2295K	0.23
UCEC	chrX	53592625	Missense_Mutation	novel	A1249S	0.3
UCEC	chrX	53607660	Missense_Mutation	NA	D787Y	0.15
UCEC	chrX	53654104	Missense_Mutation	NA	K2Q	0.12
UCEC	chrX	53551071	Missense_Mutation	novel	S3072I	0.21
UCEC	chrX	53551421	Missense_Mutation	novel	R2981C	0.11
UCEC	chrX	53556299	Intron	novel		0.15
UCEC	chrX	53559036	Missense_Mutation	novel	A2647V	0.18
UCEC	chrX	53592554	Silent	novel	S1272S	0.2
UCEC	chrX	53594543	Missense_Mutation	novel	M1153I	0.16
UCEC	chrX	53654086	Missense_Mutation	novel	L8M	0.17
UCEC	chrX	53583739	Missense_Mutation	NA	R1780H	0.1
UCEC	chrX	53543866	Missense_Mutation	NA	A3785V	0.23
UCEC	chrX	53534169	Missense_Mutation	NA	S4287Y	0.41
UCEC	chrX	53536578	Missense_Mutation	NA	P4076H	0.38
UCEC	chrX	53544614	Missense_Mutation	NA	L3733I	0.34
UCEC	chrX	53549462	Missense_Mutation	NA	R3178W	0.35
UCEC	chrX	53559491	Missense_Mutation	novel	S2593N	0.46
UCEC	chrX	53573933	Missense_Mutation	NA	K2043N	0.13
UCEC	chrX	53645424	Missense_Mutation	NA	V131M	0.15
UCEC	chrX	53584222	Nonsense_Mutation	NA	E1709*	0.58
UCEC	chrX	53630979	Missense_Mutation	NA	R273Q	0.23
UCEC	chrX	53547900	Missense_Mutation	NA	S3470L	0.32
UCEC	chrX	53533275	3'UTR	rs781948869		0.42
UCEC	chrX	53625805	Intron	novel		0.75
UCEC	chrX	53533388	Missense_Mutation	novel	A4349V	0.07
UCEC	chrX	53543924	Missense_Mutation	NA	R3766W	0.4
UCEC	chrX	53583611	Missense_Mutation	novel	L1823I	0.08
UCEC	chrX	53585099	Missense_Mutation	novel	I1638M	0.06
UCEC	chrX	53608860	Missense_Mutation	novel	L771I	0.2
UCEC	chrX	53549444	Missense_Mutation	NA	E3184K	0.46
UCEC	chrX	53551418	Missense_Mutation	rs373845421	R2982W	0.38
UCEC	chrX	53552664	Silent	novel	G2908G	0.21
UCEC	chrX	53592477	Missense_Mutation	novel	S1298Y	0.08
UCEC	chrX	53628602	Missense_Mutation	novel	Y378C	0.5
UCEC	chrX	53654129	Splice_Region	rs782018361		0.4
UCEC	chrX	53560311	Missense_Mutation	rs370630279	R2538H	0.08
UCEC	chrX	53538951	Missense_Mutation	novel	A3921V	0.3
UCEC	chrX	53569735	Missense_Mutation	novel	F2135L	0.27
UCEC	chrX	53594547	Missense_Mutation	novel	L1152P	0.25
UCEC	chrX	53627853	Missense_Mutation	novel	Q423H	0.27
UCEC	chrX	53533276	3'UTR	rs782289677		0.25
UCEC	chrX	53532920	3'UTR	novel		0.35
UCEC	chrX	53532850	3'UTR	novel		0.38
UCEC	chrX	53534599	Missense_Mutation	novel	L4250F	0.37
UCEC	chrX	53538905	Silent	novel	S3936S	0.56
UCEC	chrX	53539793	Missense_Mutation	novel	Q3832H	0.3
UCEC	chrX	53551077	Missense_Mutation	novel	R3070H	0.33
UCEC	chrX	53554913	Silent	rs782167746	T2738T	0.28
UCEC	chrX	53565111	Missense_Mutation	novel	A2279V	0.45
UCEC	chrX	53584238	Silent	rs782328168	T1703T	0.21
UCEC	chrX	53589804	Missense_Mutation	novel	R1402W	0.52
UCEC	chrX	53593387	Missense_Mutation	rs368191446	R1240C	0.4
UCEC	chrX	53614669	Missense_Mutation	novel	G709D	0.4
UCEC	chrX	53533395	Silent	novel	L4347L	0.35
UCEC	chrX	53534564	Silent	NA	D4261D	0.32
UCEC	chrX	53600118	Missense_Mutation	novel	A1055S	0.17
UCEC	chrX	53617402	Frame_Shift_Del	novel	*S574Lfs25**	0.08
UCEC	chrX	53533263	3'UTR	novel		0.36
UCEC	chrX	53543864	Missense_Mutation	rs781924853	R3786W	0.54
UCEC	chrX	53625155	Splice_Site	novel	X531_splice	0.3
UCEC	chrX	53562878	Missense_Mutation	rs782101800	A2386G	0.43
UCEC	chrX	53544601	Missense_Mutation	NA	T3737M	0.37
UCEC	chrX	53549429	Missense_Mutation	novel	L3189I	0.14
UCEC	chrX	53532937	3'UTR	novel		0.26
UCEC	chrX	53533068	3'UTR	novel		0.33
UCEC	chrX	53634244	Missense_Mutation	novel	H187Y	0.28
UCEC	chrX	53533155	3'UTR	novel		0.37
UCEC	chrX	53537559	Missense_Mutation	NA	R4045Q	0.42
UCEC	chrX	53575655	Silent	novel	G2006G	0.53
UCEC	chrX	53603492	Missense_Mutation	novel	R918C	0.33
UCEC	chrX	53629583	Missense_Mutation	novel	S299I	0.27
UCEC	chrX	53648260	Silent	novel	E32E	0.39
UCEC	chrX	53534054	Silent	novel	I4325I	0.33
UCEC	chrX	53538365	Missense_Mutation	NA	R3990C	0.54
UCEC	chrX	53544612	Silent	NA	L3733L	0.47
UCEC	chrX	53561882	Missense_Mutation	novel	D2461N	0.43
UCEC	chrX	53577053	Missense_Mutation	novel	F1911I	0.43
UCEC	chrX	53584227	Missense_Mutation	novel	S1707N	0.46
UCEC	chrX	53589596	Missense_Mutation	novel	R1471H	0.5
UCEC	chrX	53631478	Nonsense_Mutation	novel	S233*	0.41
UCEC	chrX	53576914	Missense_Mutation	novel	H1957R	0.31
UCEC	chrX	53533276	3'UTR	rs782289677		1
UCEC	chrX	53532920	3'UTR	novel		0.31
UCEC	chrX	53533276	3'UTR	rs782289677		0.42
UCEC	chrX	53533274	3'UTR	novel		0.15
UCEC	chrX	53537675	Missense_Mutation	NA	E4006D	0.31
UCEC	chrX	53549464	Missense_Mutation	NA	G3177E	0.39
UCEC	chrX	53561838	Silent	NA	N2475N	0.45
UCEC	chrX	53568763	Silent	NA	I2212I	0.43
UCEC	chrX	53583832	Missense_Mutation	NA	G1749V	0.37
UCEC	chrX	53648239	Silent	NA	Q39Q	0.34
UCEC	chrX	53625811	Intron	novel		0.6
UCEC	chrX	53631017	Silent	novel	H260H	0.14
UCEC	chrX	53548054	Missense_Mutation	novel	G3419W	0.3
UCEC	chrX	53543882	Missense_Mutation	NA	R3780C	0.08
UCEC	chrX	53600161	Silent	NA	P1040P	0.19
UCEC	chrX	53580878	Missense_Mutation	NA	N1890S	0.15
UCEC	chrX	53536589	Silent	novel	E4072E	0.23
UCEC	chrX	53575778	Silent	novel	S1965S	0.28
UCEC	chrX	53595359	Missense_Mutation	novel	L1070I	0.47
UCEC	chrX	53628581	Missense_Mutation	novel	A385V	0.37
UCEC	chrX	53539047	Missense_Mutation	novel	V3889A	0.22
UCEC	chrX	53604831	Silent	novel	L834L	0.32
UCEC	chrX	53625832	Intron	NA		0.3
UCEC	chrX	53533276	3'UTR	rs782289677		0.61
UCEC	chrX	53544599	Missense_Mutation	novel	R3738C	0.22
UCEC	chrX	53603434	Missense_Mutation	novel	L937R	0.34
UCEC	chrX	53593464	Missense_Mutation	rs782621365	T1214M	0.26
UCEC	chrX	53547728	Silent	rs369048914	V3527V	0.35
UCEC	chrX	53551170	Missense_Mutation	novel	A3039V	0.11
UCEC	chrX	53560362	Missense_Mutation	novel	R2521H	0.35
UCEC	chrX	53561822	Nonsense_Mutation	NA	R2481*	0.13
UCEC	chrX	53592555	Missense_Mutation	NA	S1272L	0.21
UCEC	chrX	53594523	Missense_Mutation	novel	S1160F	0.23
UCEC	chrX	53595385	Missense_Mutation	novel	R1061Q	0.16
UCEC	chrX	53536570	Missense_Mutation	novel	A4079T	0.52
UCEC	chrX	53532660	3'UTR	novel		0.4
UCEC	chrX	53559001	Missense_Mutation	novel	D2659N	0.4
UCEC	chrX	53539035	Missense_Mutation	novel	E3893V	0.08
UCEC	chrX	53533121	3'UTR	novel		0.43
UCEC	chrX	53536601	Silent	novel	I4068I	0.35
UCEC	chrX	53552402	Silent	novel	D2930D	0.38
UCEC	chrX	53592501	Missense_Mutation	novel	R1290K	0.24
UCEC	chrX	53532971	3'UTR	novel		0.35
UCEC	chrX	53533076	3'UTR	novel		0.38
UCEC	chrX	53534133	Missense_Mutation	novel	F4299S	0.47
UCEC	chrX	53543881	Missense_Mutation	NA	R3780H	0.27
UCEC	chrX	53551452	Silent	novel	P2970P	0.31
UCEC	chrX	53559367	Silent	novel	A2634A	0.37
UCEC	chrX	53560417	Splice_Site	novel	X2503_splice	0.33
UCEC	chrX	53576989	Missense_Mutation	rs781999554	P1932H	0.32
UCEC	chrX	53583740	Missense_Mutation	novel	R1780C	0.19
UCEC	chrX	53594617	Missense_Mutation	novel	T1129A	0.12
UCEC	chrX	53600157	Missense_Mutation	novel	M1042L	0.29
UCEC	chrX	53625985	Intron	novel		0.35
UCEC	chrX	53645440	Silent	novel	S125S	0.3
UCEC	chrX	53654094	Missense_Mutation	novel	R5K	0.33
UCEC	chrX	53554870	Missense_Mutation	novel	A2753T	0.33
UCEC	chrX	53532915	3'UTR	novel		0.55
UCEC	chrX	53533276	3'UTR	rs782289677		0.47
UCEC	chrX	53544627	Silent	novel	Q3728Q	0.17
UCEC	chrX	53647391	Missense_Mutation	NA	R110W	0.41
UCEC	chrX	53534570	Silent	rs782410644	I4259I	0.43
UCEC	chrX	53549338	Missense_Mutation	novel	R3219H	0.57
UCEC	chrX	53562190	Missense_Mutation	novel	D2420G	0.52
UCEC	chrX	53589782	Missense_Mutation	novel	K1409R	0.33
UCEC	chrX	53591115	Missense_Mutation	novel	D1327G	0.37
UCEC	chrX	53593442	Silent	rs142126065	S1221S	0.29
UCEC	chrX	53533276	3'UTR	rs782289677		0.33
UCEC	chrX	53544685	Missense_Mutation	novel	S3709Y	0.11
UCEC	chrX	53645330	Missense_Mutation	novel	R162Q	0.37
UCEC	chrX	53647536	Silent	rs782656694	F61F	0.65
UCEC	chrX	53537575	Missense_Mutation	novel	E4040K	0.09
UCEC	chrX	53617342	Missense_Mutation	NA	D593Y	0.29
UCEC	chrX	53551397	Silent	novel	L2989L	0.19
UCEC	chrX	53558706	Missense_Mutation	NA	K2703N	0.09
UCEC	chrX	53584191	Missense_Mutation	novel	G1719D	0.2
UCEC	chrX	53632563	Missense_Mutation	novel	K190I	0.21
UCEC	chrX	53634252	Frame_Shift_Ins	novel	*R184Ifs21**	0.05
UCEC	chrX	53536417	Nonsense_Mutation	novel	R4130*	0.27
UCEC	chrX	53537560	Nonsense_Mutation	novel	R4045*	0.19
UCEC	chrX	53539750	Missense_Mutation	novel	L3847F	0.27
UCEC	chrX	53549057	Missense_Mutation	novel	E3313K	0.17
UCEC	chrX	53557208	Intron	novel		0.25
UCEC	chrX	53583893	Missense_Mutation	novel	T1729A	0.09
UCEC	chrX	53586538	Missense_Mutation	novel	F1592L	0.32
UCEC	chrX	53615760	Missense_Mutation	novel	T678M	0.27
UCEC	chrX	53647418	Missense_Mutation	novel	A101S	0.09
UCEC	chrX	53647526	Missense_Mutation	novel	L65M	0.32
UCEC	chrX	53600167	Silent	rs781848587	I1038I	0.57
UCEC	chrX	53648212	Missense_Mutation	novel	K48N	0.44
UCEC	chrX	53558699	Missense_Mutation	NA	D2706N	0.51
UCEC	chrX	53549300	Missense_Mutation	NA	R3232C	0.46
UCEC	chrX	53560362	Missense_Mutation	novel	R2521H	0.15
UCEC	chrX	53548230	Missense_Mutation	novel	N3360S	0.11
UCEC	chrX	53552352	Missense_Mutation	NA	P2947L	0.3
UCEC	chrX	53583910	Missense_Mutation	NA	P1723L	0.61
UCEC	chrX	53603427	Silent	novel	Q939Q	0.24
UCEC	chrX	53550684	Frame_Shift_Del	NA	*G3157Vfs13**	0.23
UCEC	chrX	53560281	Missense_Mutation	novel	R2548M	0.32
UCEC	chrX	53565154	Frame_Shift_Ins	novel	*G2265Wfs7**	0.13
UCEC	chrX	53585043	Missense_Mutation	novel	R1657I	0.34
UCEC	chrX	53586808	Missense_Mutation	novel	K1572N	0.16
UCEC	chrX	53602576	Missense_Mutation	novel	G987R	0.32
UCEC	chrX	53632535	Silent	novel	H199H	0.32
UCEC	chrX	53634291	Missense_Mutation	novel	G171D	0.43
UCEC	chrX	53552398	Missense_Mutation	novel	A2932T	0.1
UCEC	chrX	53583585	Frame_Shift_Del	novel	*C1832Vfs94**	0.47
UCEC	chrX	53602611	Missense_Mutation	novel	V975A	0.42
UCEC	chrX	53536632	Missense_Mutation	NA	A4058V	0.18
UCEC	chrX	53589718	Silent	rs373465190	P1430P	0.25
UCEC	chrX	53544585	Missense_Mutation	NA	K3742N	0.42
UCEC	chrX	53563771	Silent	NA	G2360G	0.42
UCEC	chrX	53607671	Missense_Mutation	NA	N783S	0.38
UCEC	chrX	53628886	Missense_Mutation	NA	S327Y	0.46
UCEC	chrX	53533280	3'UTR	novel		0.36
UCEC	chrX	53539064	Silent	rs781968871	V3883V	0.23
UCEC	chrX	53607665	Missense_Mutation	NA	T785I	0.25
UCEC	chrX	53547927	Missense_Mutation	NA	S3461L	0.38
UCEC	chrX	53533239	3'UTR	novel		0.16
UCEC	chrX	53583574	Missense_Mutation	rs372535116	R1835H	0.05
UCEC	chrX	53535445	Silent	NA	I4196I	0.29
UCEC	chrX	53549103	Missense_Mutation	NA	R3297S	0.2
UCEC	chrX	53561869	Missense_Mutation	NA	M2465T	0.3
UCEC	chrX	53564623	Nonsense_Mutation	NA	S2327*	0.27
UCEC	chrX	53568759	Missense_Mutation	NA	R2214W	0.14
UCEC	chrX	53569681	Silent	NA	V2153V	0.27
UCEC	chrX	53580837	Nonsense_Mutation	NA	G1904*	0.43
UCEC	chrX	53583611	Missense_Mutation	NA	L1823F	0.3
UCEC	chrX	53600280	Missense_Mutation	NA	M1001V	0.26
UCEC	chrX	53542517	Missense_Mutation	NA	A3801V	0.42
UCEC	chrX	53545113	Missense_Mutation	rs375143574	R3655Q	0.37
UCEC	chrX	53547883	Missense_Mutation	novel	S3476A	0.15
UCEC	chrX	53548115	Missense_Mutation	novel	M3398I	0.3
UCEC	chrX	53614552	In_Frame_Ins	novel	E748delinsGSHRDQQ	0.05
UCEC	chrX	53548966	Missense_Mutation	novel	L3343S	0.46
UCEC	chrX	53564721	Splice_Region	novel	G2294G	0.46
UCEC	chrX	53586891	Missense_Mutation	novel	A1545T	0.26
UCEC	chrX	53625163	Nonsense_Mutation	novel	R529*	0.36
UCEC	chrX	53550909	Missense_Mutation	rs782149436	R3126Q	0.59
UCEC	chrX	53580867	Missense_Mutation	novel	R1894C	0.42
UCEC	chrX	53589780	Missense_Mutation	novel	A1410S	0.17
UCEC	chrX	53591105	Silent	novel	F1330F	0.45
UCEC	chrX	53631441	Missense_Mutation	novel	K245N	0.46
UCEC	chrX	53634252	Missense_Mutation	novel	R184K	0.4
UCEC	chrX	53533121	3'UTR	novel		0.29
UCEC	chrX	53543963	Missense_Mutation	novel	S3753P	0.45
UCEC	chrX	53569813	Silent	NA	L2109L	0.39
UCEC	chrX	53645375	Missense_Mutation	novel	Y147C	0.44
UCEC	chrX	53534121	Missense_Mutation	NA	T4303I	0.23
UCEC	chrX	53538391	Missense_Mutation	NA	P3981H	0.31
UCEC	chrX	53538988	Missense_Mutation	novel	A3909T	0.08
UCEC	chrX	53548061	Silent	rs782197646	G3416G	0.33
UCEC	chrX	53554664	Silent	novel	T2821T	0.09
UCEC	chrX	53569620	Missense_Mutation	NA	A2174T	0.13
UCEC	chrX	53575179	Missense_Mutation	rs782688724	A2025T	0.24
UCEC	chrX	53614711	Missense_Mutation	NA	P695H	0.28
UCEC	chrX	53624601	Missense_Mutation	NA	L556I	0.25
UCEC	chrX	53647442	Missense_Mutation	NA	L93F	0.29
UCEC	chrX	53542480	Missense_Mutation	NA	D3813E	0.33
UCEC	chrX	53569655	Missense_Mutation	novel	R2162Q	0.34
UCEC	chrX	53576917	Missense_Mutation	novel	Y1956C	0.28
UCEC	chrX	53532860	3'UTR	novel		0.29
UCEC	chrX	53549194	Missense_Mutation	rs782566959	R3267H	0.48
UCEC	chrX	53561892	Silent	NA	D2457D	0.42
UCEC	chrX	53562225	Silent	novel	D2408D	0.38
UCEC	chrX	53585069	Silent	novel	S1648S	0.29
UCEC	chrX	53594612	Missense_Mutation	novel	F1130L	0.37
UCEC	chrX	53617065	Missense_Mutation	novel	F621C	0.11
UCEC	chrX	53627431	Missense_Mutation	novel	E490K	0.34
UCEC	chrX	53628756	Missense_Mutation	novel	M370I	0.31
UCEC	chrX	53535474	Missense_Mutation	rs121918527	R4187C	0.36
UCEC	chrX	53539800	Missense_Mutation	novel	T3830I	0.38
UCEC	chrX	53549283	Missense_Mutation	novel	E3237D	0.37
UCEC	chrX	53551077	Missense_Mutation	novel	R3070H	0.38
UCEC	chrX	53562205	Missense_Mutation	novel	H2415R	0.48
UCEC	chrX	53586890	Missense_Mutation	novel	A1545D	0.34
UCS	chrX	53584321	Missense_Mutation	novel	R1676C	0.08
UCS	chrX	53547766	Missense_Mutation	novel	P3515T	0.24
UCS	chrX	53548154	Silent	novel	C3385C	0.21
UCS	chrX	53647391	Missense_Mutation	novel	R110G	0.52
UCS	chrX	53535474	Missense_Mutation	rs121918527	R4187C	0.32
UCS	chrX	53547837	Missense_Mutation	novel	S3491Y	0.32
UVM	chrX	53575665	Missense_Mutation	rs782477771	T2003M	0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LGG	AMP	0.0643	0.00022256
SARC	AMP	0.323	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0064	Kaplan-Meier Survival Analysis
BRCA	0.031	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
UCEC	0.048	Kaplan-Meier Survival Analysis
LIHC	0.018	Kaplan-Meier Survival Analysis
LGG	0.038	Kaplan-Meier Survival Analysis
THCA	0.05	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742