EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000086827 (Gene tree)
Gene ID: 9183
Gene Symbol: ZW10
Alias: KNTC1AP
Full Name: zw10 kinetochore protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 40,629 bases
Position: chr11:113,733,183-113,773,811
Accession: 13194
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000538209	ZW10-203	892	-	ENSP00000439197	135 (aa)	-	F5H3C1
ENST00000200135	ZW10-201	2992	XM_017018558	ENSP00000200135	779 (aa)	XP_016874047	O43264
ENST00000535142	ZW10-202	2735	-	ENSP00000440879	672 (aa)	-	O43264

Gene Model

Click here to download ENSG00000086827's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000086827	Respiratory Function Tests	3.61188581941008E-5	17903307
ENSG00000086827	Respiratory Function Tests	6.57952803608808E-5	17903307
ENSG00000086827	Respiratory Function Tests	7.9136556923931E-5	17903307

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000086827	rs73007975	11	113749488	A	Educational attainment (MTAG)	30038396	[0.0064-0.0126] unit decrease	0.0095	EFO_0004784
ENSG00000086827	rs61905747	11	113769120	A	Parental longevity (father's attained age)	29227965	[0.011-0.021] unit decrease	0.016	EFO_0007796

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000086827's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	11146660.	IDA	Process
GO:0000132	establishment of mitotic spindle orientation	19468067.	IMP	Process
GO:0000776	kinetochore	11682612.15485811.19229290.19468067.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000922	spindle pole	11146660.	IDA	Component
GO:0005515	protein binding	11146660.12686595.15029241.15272311.15485811.15824131.16354670.16571679.16732327.19468067.20462495.24056303.	IPI	Function
GO:0005634	nucleus	15485811.	IDA	Component
GO:0005783	endoplasmic reticulum	15029241.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005828	kinetochore microtubule	11146660.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	15029241.	IMP	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007030	Golgi organization	20163571.	IGI	Process
GO:0007030	Golgi organization	20163571.	IMP	Process
GO:0007080	mitotic metaphase plate congression	19468067.	IMP	Process
GO:0007093	mitotic cell cycle checkpoint	11146660.	IDA	Process
GO:0007094	mitotic spindle assembly checkpoint	21873635.	IBA	Process
GO:0007096	regulation of exit from mitosis	11146660.	IDA	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019237	centromeric DNA binding	9700164.	TAS	Function
GO:0034501	protein localization to kinetochore	19468067.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	9298984.	TAS	Process
GO:0065003	protein-containing complex assembly	11146660.	IDA	Process
GO:0070939	Dsl1/NZR complex	20462495.	IDA	Component
GO:1990423	RZZ complex	21873635.	IBA	Component
GO:1990423	RZZ complex	20462495.	IDA	Component