EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000087191 (Gene tree)
Gene ID: 5705
Gene Symbol: PSMC5
Alias: SUG1|p45/SUG|TBP10|p45|S8|TRIP1|SUG-1
Full Name: proteasome 26S subunit, ATPase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 4,876 bases
Position: chr17:63,827,152-63,832,027
Accession: 9552
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000583283	PSMC5-215	602	-	-	- (aa)	-	-
ENST00000581764	PSMC5-210	2107	-	-	- (aa)	-	-
ENST00000375812	PSMC5-202	1494	XM_024450841	ENSP00000364970	398 (aa)	XP_024306609	P62195
ENST00000580265	PSMC5-208	646	-	-	- (aa)	-	-
ENST00000584880	PSMC5-219	597	-	ENSP00000464347	127 (aa)	-	J3QRR3
ENST00000581842	PSMC5-211	809	-	ENSP00000463549	215 (aa)	-	J3QLH6
ENST00000310144	PSMC5-201	1579	XM_024450840	ENSP00000310572	406 (aa)	XP_024306608	P62195
ENST00000578570	PSMC5-203	1680	-	-	- (aa)	-	-
ENST00000584320	PSMC5-216	804	-	ENSP00000462098	241 (aa)	-	J3KRP2
ENST00000582130	PSMC5-213	828	-	ENSP00000463801	263 (aa)	-	J3QQM1
ENST00000581882	PSMC5-212	1474	-	ENSP00000463938	398 (aa)	-	P62195
ENST00000582420	PSMC5-214	394	-	-	- (aa)	-	-
ENST00000580063	PSMC5-207	562	-	-	- (aa)	-	-
ENST00000579147	PSMC5-205	2586	-	-	- (aa)	-	-
ENST00000585123	PSMC5-220	899	-	ENSP00000464602	257 (aa)	-	J3QSA9
ENST00000579031	PSMC5-204	772	-	-	- (aa)	-	-
ENST00000580864	PSMC5-209	1552	-	ENSP00000462495	398 (aa)	-	P62195
ENST00000585242	PSMC5-221	1178	-	ENSP00000463107	52 (aa)	-	J3KTQ9
ENST00000584657	PSMC5-218	576	-	-	- (aa)	-	-
ENST00000584536	PSMC5-217	804	-	ENSP00000464646	169 (aa)	-	J3QSE0
ENST00000579708	PSMC5-206	558	-	ENSP00000464405	143 (aa)	-	J3QRW1

Gene Model

Click here to download ENSG00000087191's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000087191's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000087191	PSMC5	97	51.449	WBGene00004501	rpt-1	71	55.016	Caenorhabditis_elegans
ENSG00000087191	PSMC5	87	50.806	WBGene00004502	rpt-2	73	50.309	Caenorhabditis_elegans
ENSG00000087191	PSMC5	90	45.312	WBGene00004503	rpt-3	78	46.440	Caenorhabditis_elegans
ENSG00000087191	PSMC5	97	51.449	ENSG00000161057	PSMC2	77	56.311	Homo_sapiens
ENSG00000087191	PSMC5	83	55.932	ENSG00000100764	PSMC1	99	65.060	Homo_sapiens
ENSG00000087191	PSMC5	89	51.181	ENSG00000100519	PSMC6	96	54.688	Homo_sapiens
ENSG00000087191	PSMC5	88	48.169	ENSG00000165916	PSMC3	78	51.768	Homo_sapiens
ENSG00000087191	PSMC5	98	76.607	YGL048C	RPT6	96	76.607	Saccharomyces_cerevisiae
ENSG00000087191	PSMC5	90	52.344	YKL145W	RPT1	66	54.870	Saccharomyces_cerevisiae
ENSG00000087191	PSMC5	88	49.206	YDL007W	RPT2	75	49.235	Saccharomyces_cerevisiae
ENSG00000087191	PSMC5	88	48.413	YDR394W	RPT3	76	46.154	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	9464850.17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	9173976.9927201.16189514.16763564.17693435.19490896.20178748.21516116.22078707.22901813.23032291.23824326.25416956.26496610.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	9927201.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	9927201.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	7870181.	IDA	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008134	transcription factor binding	7870181.	IDA	Function
GO:0008134	transcription factor binding	9173976.10816420.	IPI	Function
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016234	inclusion body	-	IEA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	1429620.	ISS	Function
GO:0016887	ATPase activity	9464850.	TAS	Function
GO:0017025	TBP-class protein binding	21873635.	IBA	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0031410	cytoplasmic vesicle	15885686.	IDA	Component
GO:0031531	thyrotropin-releasing hormone receptor binding	7870181.	IPI	Function
GO:0031595	nuclear proteasome complex	21873635.	IBA	Component
GO:0031597	cytosolic proteasome complex	21873635.	IBA	Component
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0036402	proteasome-activating ATPase activity	-	IEA	Function
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043069	negative regulation of programmed cell death	16432160.	NAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	12110588.	IDA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	IEA	Process
GO:0045893	positive regulation of transcription, DNA-templated	7870181.	NAS	Process
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	21873635.	IBA	Process
GO:0050804	modulation of chemical synaptic transmission	21873635.	IBA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090261	positive regulation of inclusion body assembly	-	IEA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0098794	postsynapse	21873635.	IBA	Component
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process