EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000087274 (Gene tree)
Gene ID: 118
Gene Symbol: ADD1
Alias: N
Full Name: adducin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 86,350 bases
Position: chr4:2,843,727-2,930,076
Accession: 243
RBP type: non-canonical RBP
Summary: Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16116479	Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells.	Oncogene	2005 Dec 8	Syed V	-
26524639	GPR39 activates proliferation and differentiation of porcine intramuscular preadipocytes through targeting the PI3K/AKT cell signaling pathway.	J Recept Signal Transduct Res	2016	Dong X	doi: 10.3109/10799893.2015.1056308

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536078	ADD1-221	423	-	-	- (aa)	-	-
ENST00000264758	ADD1-201	4045	XM_005247934	ENSP00000264758	768 (aa)	XP_005247991	P35611
ENST00000508277	ADD1-212	491	-	ENSP00000426700	142 (aa)	-	D6RF25
ENST00000539108	ADD1-224	244	-	-	- (aa)	-	-
ENST00000540541	ADD1-226	546	-	-	- (aa)	-	-
ENST00000506157	ADD1-211	5179	-	-	- (aa)	-	-
ENST00000514940	ADD1-219	1332	-	ENSP00000424143	444 (aa)	-	H0Y9H2
ENST00000511797	ADD1-216	671	-	ENSP00000421918	137 (aa)	-	D6RAH3
ENST00000513762	ADD1-218	3581	-	-	- (aa)	-	-
ENST00000539149	ADD1-225	460	-	-	- (aa)	-	-
ENST00000541843	ADD1-228	406	-	ENSP00000441388	114 (aa)	-	H0YG19
ENST00000510101	ADD1-215	704	-	ENSP00000425703	69 (aa)	-	D6RJE2
ENST00000538860	ADD1-223	507	-	-	- (aa)	-	-
ENST00000355842	ADD1-202	4743	-	ENSP00000348100	662 (aa)	-	P35611
ENST00000374281	ADD1-203	445	-	-	- (aa)	-	-
ENST00000503169	ADD1-209	2394	-	-	- (aa)	-	-
ENST00000503062	ADD1-208	488	-	-	- (aa)	-	-
ENST00000508684	ADD1-213	3059	-	-	- (aa)	-	-
ENST00000503455	ADD1-210	3206	-	ENSP00000423024	663 (aa)	-	E7ENY0
ENST00000509039	ADD1-214	1569	-	-	- (aa)	-	-
ENST00000398129	ADD1-206	3787	XM_017007705	ENSP00000381197	737 (aa)	XP_016863194	P35611
ENST00000513328	ADD1-217	3107	XM_017007709	ENSP00000421907	632 (aa)	XP_016863198	E7EV99
ENST00000398123	ADD1-204	2361	XM_024453887	ENSP00000381191	662 (aa)	XP_024309655	P35611
ENST00000446856	ADD1-207	3745	-	ENSP00000399828	400 (aa)	-	A0A0A0MSR2
ENST00000398125	ADD1-205	4079	-	ENSP00000381193	662 (aa)	-	P35611
ENST00000541051	ADD1-227	975	-	-	- (aa)	-	-
ENST00000536424	ADD1-222	594	-	ENSP00000438069	105 (aa)	-	H0YFD8
ENST00000534870	ADD1-220	795	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000087274's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000087274	Body Weights and Measures	7.96492241699802E-6	17903300
ENSG00000087274	Blood Cells	2.17464396275359E-6	17903294
ENSG00000087274	Alcohol Drinking	2.3307513343843E-12	-
ENSG00000087274	Echocardiography	1.08236443523306E-6	17903301
ENSG00000087274	Stroke	8.8834442E-004	-
ENSG00000087274	Child Development Disorders, Pervasive	2.8046000E-005	-
ENSG00000087274	Child Development Disorders, Pervasive	4.4736000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000087274	rs6824567	4	2881445	T	Educational attainment (MTAG)	30038396	[0.0094-0.0152] unit increase	0.0123	EFO_0004784
ENSG00000087274	rs114643193	4	2868202	?	Huntington's disease progression	28642124			Orphanet_399\|EFO_0008336
ENSG00000087274	rs6824567	4	2881445	T	Educational attainment (years of education)	30038396	[0.0099-0.0161] unit increase	0.013	EFO_0004784
ENSG00000087274	rs624833	4	2879529	G	Age of smoking initiation (MTAG)	30643251	[0.0083-0.0145] unit increase	0.0114003	EFO_0005670
ENSG00000087274	rs624833	4	2879529	G	Age of smoking initiation	30643251	[0.011-0.021] unit increase	0.016	EFO_0005670

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000087274's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000087274	ADD1	100	98.462	ENSMUSG00000029106	Add1	100	97.872	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000902	cell morphogenesis	-	IEA	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	1840603.	TAS	Function
GO:0005198	structural molecule activity	21873635.	IBA	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005634	nucleus	16289097.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	25978380.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	25978380.	IDA	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0005913	cell-cell adherens junction	25978380.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006884	cell volume homeostasis	-	IEA	Process
GO:0008134	transcription factor binding	16289097.	IPI	Function
GO:0008290	F-actin capping protein complex	8626479.	IDA	Component
GO:0014069	postsynaptic density	21873635.	IBA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0020027	hemoglobin metabolic process	-	IEA	Process
GO:0030036	actin cytoskeleton organization	3693401.	IC	Process
GO:0030218	erythrocyte differentiation	-	IEA	Process
GO:0030507	spectrin binding	21873635.	IBA	Function
GO:0030507	spectrin binding	7642559.	IDA	Function
GO:0032092	positive regulation of protein binding	3693401.7642559.	IDA	Process
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0042803	protein homodimerization activity	7642559.	IPI	Function
GO:0044853	plasma membrane raft	21873635.	IBA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046982	protein heterodimerization activity	7642559.	IPI	Function
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	Process
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051015	actin filament binding	7642559.	IDA	Function
GO:0051016	barbed-end actin filament capping	21873635.	IBA	Process
GO:0051016	barbed-end actin filament capping	8626479.	IDA	Process
GO:0051017	actin filament bundle assembly	21873635.	IBA	Process
GO:0051017	actin filament bundle assembly	3693401.	IDA	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0071277	cellular response to calcium ion	25978380.	IDA	Process
GO:1903142	positive regulation of establishment of endothelial barrier	21873635.	IBA	Process
GO:1903142	positive regulation of establishment of endothelial barrier	25978380.	IDA	Process
GO:1903393	positive regulation of adherens junction organization	21873635.	IBA	Process
GO:1903393	positive regulation of adherens junction organization	25978380.	IDA	Process